PE20120114A1 - Sal de sodio de acido 5-ciclopropil-2-{[2-(2,6-difluorofenil)pirimidin-5-il]amino}benzoico como inhibidor de dhodh - Google Patents
Sal de sodio de acido 5-ciclopropil-2-{[2-(2,6-difluorofenil)pirimidin-5-il]amino}benzoico como inhibidor de dhodhInfo
- Publication number
- PE20120114A1 PE20120114A1 PE2011001598A PE2011001598A PE20120114A1 PE 20120114 A1 PE20120114 A1 PE 20120114A1 PE 2011001598 A PE2011001598 A PE 2011001598A PE 2011001598 A PE2011001598 A PE 2011001598A PE 20120114 A1 PE20120114 A1 PE 20120114A1
- Authority
- PE
- Peru
- Prior art keywords
- sodium salt
- pyrimidin
- cyclopropyl
- amino
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
REFERIDA A LA SAL DE SODIO CRISTALNA DE ACIDO 5-CICLOPROPIL-2-{[2-(2,6-DIFLUOROFENIL)PIRIMIDIN-5-IL]AMINO}BENZOICO. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A LA SAL CRISTALINA Y UN VEHICULO FARMACEUTICAMENTE ACEPTABLE, DONDE DICHA SAL TAMBIEN PUEDE CONTENER OTRO AGENTE TERAPEUTICO TAL COMO UN ANTICUERPO MONOCLONAL ANTI-TNF-ALFA (INFLIXIMAB, CERTOLIZUMAB, ENTRE OTROS), UN ANTAGONISTA DE TNF-ALFA (ETANERCPT, LENERCEPT, ENTRE OTROS), UN INHIBIDOR DE LA ACTIVACION DE NF-KAPPAB (SULFASALAZINA, IGURATIMOD), UN AGONISTA DE S1P1 (FINGOLIMOD), ENTRE OTROS. DICHA SAL DE SODIO CRISTALINA TIENE ACTIVIDAD INHIBIDORA DE LA DIHIDROOROATO DESHIDROGENSAS (DHODH) Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, INMUNES, INFLAMATORIAS, ENFERMEDADES NEOPLASICAS MALIGNAS, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09382033A EP2239256A1 (en) | 2009-03-13 | 2009-03-13 | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120114A1 true PE20120114A1 (es) | 2012-02-20 |
Family
ID=40903239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001598A PE20120114A1 (es) | 2009-03-13 | 2010-03-11 | Sal de sodio de acido 5-ciclopropil-2-{[2-(2,6-difluorofenil)pirimidin-5-il]amino}benzoico como inhibidor de dhodh |
Country Status (22)
Country | Link |
---|---|
US (1) | US8501943B2 (es) |
EP (2) | EP2239256A1 (es) |
JP (1) | JP2012520250A (es) |
KR (1) | KR20110125653A (es) |
CN (1) | CN102348687B (es) |
AR (1) | AR075736A1 (es) |
AU (1) | AU2010223526A1 (es) |
CA (1) | CA2754801A1 (es) |
CL (1) | CL2011002215A1 (es) |
CO (1) | CO6420336A2 (es) |
EA (1) | EA020218B1 (es) |
EC (1) | ECSP11011383A (es) |
IL (1) | IL214518A0 (es) |
MX (1) | MX2011009148A (es) |
NZ (1) | NZ594492A (es) |
PE (1) | PE20120114A1 (es) |
SG (1) | SG173825A1 (es) |
TW (1) | TW201032811A (es) |
UA (1) | UA105788C2 (es) |
UY (1) | UY32466A (es) |
WO (1) | WO2010102824A2 (es) |
ZA (1) | ZA201105742B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
US9040508B2 (en) | 2008-12-08 | 2015-05-26 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
EP2444088A1 (en) * | 2010-10-22 | 2012-04-25 | Almirall, S.A. | Amino derivatives for the treatment of proliferative skin disorders |
US20120195933A1 (en) * | 2011-01-27 | 2012-08-02 | Ralph Stefan | Pharmaceutical compositions comprising tasocitinib |
US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
EP3193874A4 (en) | 2014-09-17 | 2018-04-25 | Mundipharma International Corporation Limited | Crystalline forms of tyrosine kinase inhibitors and their salts |
WO2018136009A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
CN114957650B (zh) * | 2022-06-11 | 2024-05-10 | 新疆腾域鸿源农业科技有限公司 | 一种聚天冬氨酸钾的制备方法及其在植物生长促进剂中的应用 |
Family Cites Families (29)
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ATE209518T1 (de) | 1995-06-21 | 2001-12-15 | Asta Medica Ag | Arzneipulverkartusche mit integrierter dosiereinrichtung, sowie pulverinhalator |
DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
EP1225886A2 (en) | 1999-06-10 | 2002-07-31 | Warner-Lambert Company | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
SI1381356T1 (sl) | 2001-04-05 | 2008-12-31 | Aventis Pharma Inc | Uporaba (Z)-2-ciano-3-hidroksi-but-2-enojska kislina-(4'-trifluorometilfenil)-amida za zdravljenje multiple skleroze |
WO2002102374A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Amine salt of an integrin receptor antagonist |
DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
WO2003006424A1 (en) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
AR042206A1 (es) | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
WO2004056747A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
CN1993125A (zh) | 2004-05-21 | 2007-07-04 | Uab研究基金会 | 涉及嘧啶合成抑制剂的组合物和方法 |
WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
EP1804782A1 (en) | 2004-10-19 | 2007-07-11 | Aventis Pharmaceuticals Inc. | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
ES2303758B1 (es) | 2006-02-20 | 2009-08-13 | Laboratorios Almirall S.A. | Nuevos derivados de piridin-3-amina. |
ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
ATE508108T1 (de) | 2007-02-06 | 2011-05-15 | Chelsea Therapeutics Inc | Neue verbindungen, verfahren zu deren herstellung und deren verwendung |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
EP2210615A1 (en) | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Combinations comprising methotrexate and DHODH inhibitors |
EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
-
2009
- 2009-03-13 EP EP09382033A patent/EP2239256A1/en not_active Withdrawn
-
2010
- 2010-02-24 UY UY0001032466A patent/UY32466A/es unknown
- 2010-03-08 TW TW099106629A patent/TW201032811A/zh unknown
- 2010-03-11 SG SG2011060837A patent/SG173825A1/en unknown
- 2010-03-11 WO PCT/EP2010/001548 patent/WO2010102824A2/en active Application Filing
- 2010-03-11 MX MX2011009148A patent/MX2011009148A/es active IP Right Grant
- 2010-03-11 CN CN201080011541.4A patent/CN102348687B/zh not_active Expired - Fee Related
- 2010-03-11 AU AU2010223526A patent/AU2010223526A1/en not_active Abandoned
- 2010-03-11 UA UAA201111805A patent/UA105788C2/uk unknown
- 2010-03-11 JP JP2011553358A patent/JP2012520250A/ja active Pending
- 2010-03-11 PE PE2011001598A patent/PE20120114A1/es not_active Application Discontinuation
- 2010-03-11 EP EP10708145A patent/EP2406221A2/en not_active Withdrawn
- 2010-03-11 US US13/256,127 patent/US8501943B2/en not_active Expired - Fee Related
- 2010-03-11 EA EA201101301A patent/EA020218B1/ru not_active IP Right Cessation
- 2010-03-11 NZ NZ594492A patent/NZ594492A/xx not_active IP Right Cessation
- 2010-03-11 AR ARP100100739A patent/AR075736A1/es not_active Application Discontinuation
- 2010-03-11 CA CA2754801A patent/CA2754801A1/en not_active Abandoned
- 2010-03-11 KR KR1020117021316A patent/KR20110125653A/ko not_active Application Discontinuation
-
2011
- 2011-08-04 ZA ZA2011/05742A patent/ZA201105742B/en unknown
- 2011-08-08 IL IL214518A patent/IL214518A0/en unknown
- 2011-09-01 CO CO11112334A patent/CO6420336A2/es not_active Application Discontinuation
- 2011-09-08 CL CL2011002215A patent/CL2011002215A1/es unknown
- 2011-10-07 EC EC2011011383A patent/ECSP11011383A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20110125653A (ko) | 2011-11-21 |
CA2754801A1 (en) | 2010-09-16 |
WO2010102824A2 (en) | 2010-09-16 |
ECSP11011383A (es) | 2011-11-30 |
IL214518A0 (en) | 2011-09-27 |
EP2239256A1 (en) | 2010-10-13 |
CO6420336A2 (es) | 2012-04-16 |
US8501943B2 (en) | 2013-08-06 |
EA201101301A1 (ru) | 2012-04-30 |
MX2011009148A (es) | 2011-09-28 |
NZ594492A (en) | 2013-11-29 |
CN102348687B (zh) | 2014-04-02 |
TW201032811A (en) | 2010-09-16 |
CN102348687A (zh) | 2012-02-08 |
SG173825A1 (en) | 2011-09-29 |
ZA201105742B (en) | 2012-04-25 |
US20120003184A1 (en) | 2012-01-05 |
EP2406221A2 (en) | 2012-01-18 |
UY32466A (es) | 2010-09-30 |
UA105788C2 (uk) | 2014-06-25 |
WO2010102824A3 (en) | 2010-11-18 |
AU2010223526A1 (en) | 2011-08-25 |
CL2011002215A1 (es) | 2012-03-09 |
EA020218B1 (ru) | 2014-09-30 |
AR075736A1 (es) | 2011-04-20 |
JP2012520250A (ja) | 2012-09-06 |
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