PE20110942A1 - Protozoo modificado que expresa multiples proteinas variables de superficie (vsp), composicion inmunogenica que lo comprende y procedimientos - Google Patents
Protozoo modificado que expresa multiples proteinas variables de superficie (vsp), composicion inmunogenica que lo comprende y procedimientosInfo
- Publication number
- PE20110942A1 PE20110942A1 PE2011001143A PE2011001143A PE20110942A1 PE 20110942 A1 PE20110942 A1 PE 20110942A1 PE 2011001143 A PE2011001143 A PE 2011001143A PE 2011001143 A PE2011001143 A PE 2011001143A PE 20110942 A1 PE20110942 A1 PE 20110942A1
- Authority
- PE
- Peru
- Prior art keywords
- protozoo
- variable surface
- modified
- vsp
- procedures
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/68—Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/10—Protozoa; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
REFERIDA A UN PROTOZOO PARASITO MODIFICADO QUE COMPRENDE LA EXPRESION SIMULTANEA EN SU SUPERFICIE DE MAS DE UNA PROTEINA VARIABLE DE SUPERFICIE Y LA EXPRESION REDUCIDA DE LAS ENZIMAS DICER, ARN POLIMERASA RNA DEPENDIENTE (RdRP) O AMBAS, DONDE EL PROTOZOOSE SELECCIONA DE GIARDIA, PLASMODIUM, BABESIA Y TRYPANOSOMA. TAMBIEN ESTA REFERIDA A UNA VACUNA QUE COMPRENDE DICHO PROTOZOO Y A UN PROCEDIMIENTO PARA PURIFICAR EL REPERTORIO TOTAL DE PROTEINAS DE SUPERFICIE VARIABLE DE PROTOZOOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11905808P | 2008-12-02 | 2008-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110942A1 true PE20110942A1 (es) | 2011-12-30 |
Family
ID=42233679
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001143A PE20110942A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa multiples proteinas variables de superficie (vsp), composicion inmunogenica que lo comprende y procedimientos |
PE2015000436A PE20150889A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015000436A PE20150889A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodos |
Country Status (18)
Country | Link |
---|---|
US (1) | US9463229B2 (es) |
EP (1) | EP2364156B1 (es) |
JP (3) | JP2012510286A (es) |
CN (1) | CN102281884B (es) |
AR (1) | AR074458A1 (es) |
AU (1) | AU2009323734B2 (es) |
BR (1) | BRPI0917075B1 (es) |
CA (1) | CA2745470C (es) |
CL (2) | CL2011001309A1 (es) |
CO (1) | CO6390115A2 (es) |
CR (1) | CR20110377A (es) |
EC (1) | ECSP11011171A (es) |
ES (1) | ES2667773T3 (es) |
MX (2) | MX351579B (es) |
NZ (2) | NZ604943A (es) |
PE (2) | PE20110942A1 (es) |
PT (1) | PT2364156T (es) |
WO (1) | WO2010064204A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9457096B2 (en) | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5512288A (en) * | 1992-12-04 | 1996-04-30 | University Technologies International, Inc. | Giardia vaccine |
US5585250A (en) * | 1993-08-20 | 1996-12-17 | The United States Of America As Represented By The Department Of Health & Human Services | Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
US6171820B1 (en) * | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
JP2000083677A (ja) * | 1998-09-17 | 2000-03-28 | Bayer Ltd | ダニワクチン |
GB0000474D0 (en) * | 2000-01-10 | 2000-03-01 | Inal Jameel M | Receptor |
-
2009
- 2009-12-02 CN CN200980148055.4A patent/CN102281884B/zh active Active
- 2009-12-02 CA CA2745470A patent/CA2745470C/en active Active
- 2009-12-02 PE PE2011001143A patent/PE20110942A1/es active IP Right Grant
- 2009-12-02 PE PE2015000436A patent/PE20150889A1/es active IP Right Grant
- 2009-12-02 AU AU2009323734A patent/AU2009323734B2/en active Active
- 2009-12-02 WO PCT/IB2009/055470 patent/WO2010064204A2/en active Application Filing
- 2009-12-02 NZ NZ604943A patent/NZ604943A/en active IP Right Revival
- 2009-12-02 EP EP09799724.1A patent/EP2364156B1/en active Active
- 2009-12-02 MX MX2013004560A patent/MX351579B/es unknown
- 2009-12-02 US US13/132,468 patent/US9463229B2/en active Active
- 2009-12-02 PT PT97997241T patent/PT2364156T/pt unknown
- 2009-12-02 NZ NZ593106A patent/NZ593106A/xx active IP Right Revival
- 2009-12-02 JP JP2011539158A patent/JP2012510286A/ja active Pending
- 2009-12-02 MX MX2011005815A patent/MX2011005815A/es active IP Right Grant
- 2009-12-02 BR BRPI0917075-8A patent/BRPI0917075B1/pt active IP Right Grant
- 2009-12-02 ES ES09799724.1T patent/ES2667773T3/es active Active
- 2009-12-03 AR ARP090104658A patent/AR074458A1/es active IP Right Grant
-
2011
- 2011-06-02 CL CL2011001309A patent/CL2011001309A1/es unknown
- 2011-07-01 CR CR20110377A patent/CR20110377A/es unknown
- 2011-07-01 EC EC2011011171A patent/ECSP11011171A/es unknown
- 2011-07-01 CO CO11082854A patent/CO6390115A2/es not_active Application Discontinuation
-
2015
- 2015-08-14 JP JP2015160055A patent/JP2016000045A/ja active Pending
-
2017
- 2017-11-03 JP JP2017213330A patent/JP6793621B2/ja active Active
-
2018
- 2018-10-04 CL CL2018002834A patent/CL2018002834A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2745470C (en) | 2018-09-25 |
ES2667773T3 (es) | 2018-05-14 |
BRPI0917075B1 (pt) | 2019-11-12 |
JP2018024700A (ja) | 2018-02-15 |
EP2364156B1 (en) | 2018-01-31 |
MX351579B (es) | 2017-10-20 |
US20120093871A1 (en) | 2012-04-19 |
JP2012510286A (ja) | 2012-05-10 |
CN102281884A (zh) | 2011-12-14 |
CN102281884B (zh) | 2015-09-30 |
WO2010064204A2 (en) | 2010-06-10 |
US9463229B2 (en) | 2016-10-11 |
JP2016000045A (ja) | 2016-01-07 |
CO6390115A2 (es) | 2012-02-29 |
EP2364156A2 (en) | 2011-09-14 |
NZ593106A (en) | 2013-05-31 |
BRPI0917075A2 (pt) | 2016-08-02 |
PE20150889A1 (es) | 2015-06-07 |
NZ604943A (en) | 2014-08-29 |
AR074458A1 (es) | 2011-01-19 |
PT2364156T (pt) | 2018-04-24 |
CL2018002834A1 (es) | 2019-04-05 |
AU2009323734B2 (en) | 2016-06-30 |
CR20110377A (es) | 2011-10-20 |
ECSP11011171A (es) | 2011-09-30 |
CA2745470A1 (en) | 2010-06-10 |
JP6793621B2 (ja) | 2020-12-02 |
MX2011005815A (es) | 2011-09-30 |
CL2011001309A1 (es) | 2012-03-16 |
WO2010064204A3 (en) | 2010-12-02 |
AU2009323734A1 (en) | 2010-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NI200900093A (es) | Compuestos que modulan la actividad de c-fms y/o c-kit y uso de los mismos. | |
CO6491045A2 (es) | Composiciones de proteina f de virus sincitial respiratorio (rsv) y metodos para producir las mismas | |
UY33297A (es) | Composiciones farmaceuticas que comprenden un polipéptido que comprende al menos un motivo cxxc y antígenos heterólogos y usos de las mismas | |
ECSP12011685A (es) | Inmunoconjugados dirigidos | |
ECSP10010433A (es) | Composición que comprende anticuerpo que se fija al dominio ii de her2, y sus variantes ácidas | |
CL2011002082A1 (es) | Composicion farmaceutica que comprende un inhibidor de nucleosido polimerasa y un inhibidor de proteasa macrociclica; proceso para preparar dicha composicion farmaceutica; metodo para tratar o mejorar una infeccion con virus de la hepatitis c, fibrosis hepatica y alteracion de la funcion hepatica. | |
EA201300987A1 (ru) | Фармацевтические композиции, включающие метформин и ингибитор dpp-4 или ингибитор sglt-2 | |
DOP2006000179A (es) | 7-aza-indazoles sustituidos, composiciones que les contienen, procedimiento de fabricación y utilización | |
CR10290A (es) | Metodos para reducir la aglomeracion de proteina | |
DOP2013000185A (es) | Compuestos antivirales | |
ECSP12012211A (es) | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) | |
BR112014007852A2 (pt) | nucleosídeos, nucleotídeos e ácidos nucleicos modificados e usos dos mesmos | |
PE20230684A1 (es) | Analogos de carba-nucleosidos sustituidos con 2'-fluoro como inhibidores de la arn polimerasa | |
BR112012015721A2 (pt) | modificação covalente de proteínas dirigida por ligante | |
CO6551721A2 (es) | Moduladores de cinasa novedosos | |
CR10555A (es) | Vacunas para malaria | |
NI201100025A (es) | Métodos de administración de las formulaciones tópicas antimicóticas para el tratamiento de las infecciones por hongos. | |
CL2009001195A1 (es) | Adyuvante inmune que comprende un inhibidor de iap capaz de modular la actividad inmune; composicion farmaceutica y vacuna que lo comprenden; metodo para mejorar una respuesta inmune de un individuo; metodo para tratar un cancer en un individuo; metodo para tratar infeccion; metodo para tratar trastornos autoinmune. | |
BR112012014925A2 (pt) | compostos promotores de replicação de células beta e métodos de uso dos mesmos | |
CO2018004323A2 (es) | Una composición que comprende dihidrato de n4–(ciclopropilmetil)–6– [(3r)–3–(metilamino)pirrolidin–1–il]pirimidin–2,4–diamina tartrato | |
ECSP23025065A (es) | Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas | |
DOP2022000229A (es) | Anticuerpos de cadena pesada multiespecíficos con regiones constantes de cadena pesada modificadas | |
CL2018002430A1 (es) | Proteínas de fusión de enzimas lisosomales terapéuticas dirigidas, formulaciones asociadas y usos de las mismas | |
WO2013055418A3 (en) | Cross-protective arenavirus vaccines and their method of use | |
WO2012145582A3 (en) | Methods and compositions for the specific inhibitions of egfr by double-stranded rna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |