PE20150889A1 - Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodos - Google Patents
Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodosInfo
- Publication number
- PE20150889A1 PE20150889A1 PE2015000436A PE2015000436A PE20150889A1 PE 20150889 A1 PE20150889 A1 PE 20150889A1 PE 2015000436 A PE2015000436 A PE 2015000436A PE 2015000436 A PE2015000436 A PE 2015000436A PE 20150889 A1 PE20150889 A1 PE 20150889A1
- Authority
- PE
- Peru
- Prior art keywords
- surface proteins
- vsp
- variable surface
- modified
- protozoo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/68—Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/10—Protozoa; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invencion describe un procedimiento para purificar el repertorio total de proteinas de superficie variable (VSP) de un protozoo parasito Giardia lamblia modificado en donde los genes Dicer, ARN polimerasa RNA dependiente (RdRP) o ambos, han sido silenciados mediante ingenieria genetica usando ARN antisentido, de esta manera comprendiendo la expresion simultanea en su superficie de multiples proteinas de superficie variables, caracterizado porque comprende: a) Unir un anticuerpo que reconoce la secuencia de aminoacidos CRKGA de las VSP a un soporte solido; b) Contactar el soporte solido con un protozoo parasito Giardia lamblia; y c) Separar el repertorio total de proteinas de superficie variable (VSP)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11905808P | 2008-12-02 | 2008-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150889A1 true PE20150889A1 (es) | 2015-06-07 |
Family
ID=42233679
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001143A PE20110942A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa multiples proteinas variables de superficie (vsp), composicion inmunogenica que lo comprende y procedimientos |
PE2015000436A PE20150889A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001143A PE20110942A1 (es) | 2008-12-02 | 2009-12-02 | Protozoo modificado que expresa multiples proteinas variables de superficie (vsp), composicion inmunogenica que lo comprende y procedimientos |
Country Status (18)
Country | Link |
---|---|
US (1) | US9463229B2 (es) |
EP (1) | EP2364156B1 (es) |
JP (3) | JP2012510286A (es) |
CN (1) | CN102281884B (es) |
AR (1) | AR074458A1 (es) |
AU (1) | AU2009323734B2 (es) |
BR (1) | BRPI0917075B1 (es) |
CA (1) | CA2745470C (es) |
CL (2) | CL2011001309A1 (es) |
CO (1) | CO6390115A2 (es) |
CR (1) | CR20110377A (es) |
EC (1) | ECSP11011171A (es) |
ES (1) | ES2667773T3 (es) |
MX (2) | MX351579B (es) |
NZ (2) | NZ604943A (es) |
PE (2) | PE20110942A1 (es) |
PT (1) | PT2364156T (es) |
WO (1) | WO2010064204A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9457096B2 (en) | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5512288A (en) * | 1992-12-04 | 1996-04-30 | University Technologies International, Inc. | Giardia vaccine |
US5585250A (en) * | 1993-08-20 | 1996-12-17 | The United States Of America As Represented By The Department Of Health & Human Services | Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
US6171820B1 (en) * | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
JP2000083677A (ja) * | 1998-09-17 | 2000-03-28 | Bayer Ltd | ダニワクチン |
GB0000474D0 (en) * | 2000-01-10 | 2000-03-01 | Inal Jameel M | Receptor |
-
2009
- 2009-12-02 EP EP09799724.1A patent/EP2364156B1/en active Active
- 2009-12-02 PE PE2011001143A patent/PE20110942A1/es active IP Right Grant
- 2009-12-02 AU AU2009323734A patent/AU2009323734B2/en active Active
- 2009-12-02 PT PT97997241T patent/PT2364156T/pt unknown
- 2009-12-02 US US13/132,468 patent/US9463229B2/en active Active
- 2009-12-02 NZ NZ604943A patent/NZ604943A/en active IP Right Revival
- 2009-12-02 CN CN200980148055.4A patent/CN102281884B/zh active Active
- 2009-12-02 MX MX2013004560A patent/MX351579B/es unknown
- 2009-12-02 CA CA2745470A patent/CA2745470C/en active Active
- 2009-12-02 WO PCT/IB2009/055470 patent/WO2010064204A2/en active Application Filing
- 2009-12-02 BR BRPI0917075-8A patent/BRPI0917075B1/pt active IP Right Grant
- 2009-12-02 MX MX2011005815A patent/MX2011005815A/es active IP Right Grant
- 2009-12-02 PE PE2015000436A patent/PE20150889A1/es active IP Right Grant
- 2009-12-02 JP JP2011539158A patent/JP2012510286A/ja active Pending
- 2009-12-02 ES ES09799724.1T patent/ES2667773T3/es active Active
- 2009-12-02 NZ NZ593106A patent/NZ593106A/xx active IP Right Revival
- 2009-12-03 AR ARP090104658A patent/AR074458A1/es active IP Right Grant
-
2011
- 2011-06-02 CL CL2011001309A patent/CL2011001309A1/es unknown
- 2011-07-01 CO CO11082854A patent/CO6390115A2/es not_active Application Discontinuation
- 2011-07-01 EC EC2011011171A patent/ECSP11011171A/es unknown
- 2011-07-01 CR CR20110377A patent/CR20110377A/es unknown
-
2015
- 2015-08-14 JP JP2015160055A patent/JP2016000045A/ja active Pending
-
2017
- 2017-11-03 JP JP2017213330A patent/JP6793621B2/ja active Active
-
2018
- 2018-10-04 CL CL2018002834A patent/CL2018002834A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2018002834A1 (es) | 2019-04-05 |
US9463229B2 (en) | 2016-10-11 |
AR074458A1 (es) | 2011-01-19 |
PE20110942A1 (es) | 2011-12-30 |
EP2364156A2 (en) | 2011-09-14 |
PT2364156T (pt) | 2018-04-24 |
NZ593106A (en) | 2013-05-31 |
MX351579B (es) | 2017-10-20 |
JP2012510286A (ja) | 2012-05-10 |
ECSP11011171A (es) | 2011-09-30 |
JP2018024700A (ja) | 2018-02-15 |
US20120093871A1 (en) | 2012-04-19 |
JP6793621B2 (ja) | 2020-12-02 |
CN102281884B (zh) | 2015-09-30 |
WO2010064204A3 (en) | 2010-12-02 |
ES2667773T3 (es) | 2018-05-14 |
JP2016000045A (ja) | 2016-01-07 |
CA2745470C (en) | 2018-09-25 |
BRPI0917075A2 (pt) | 2016-08-02 |
EP2364156B1 (en) | 2018-01-31 |
AU2009323734B2 (en) | 2016-06-30 |
CL2011001309A1 (es) | 2012-03-16 |
CO6390115A2 (es) | 2012-02-29 |
NZ604943A (en) | 2014-08-29 |
MX2011005815A (es) | 2011-09-30 |
WO2010064204A2 (en) | 2010-06-10 |
CA2745470A1 (en) | 2010-06-10 |
CR20110377A (es) | 2011-10-20 |
CN102281884A (zh) | 2011-12-14 |
AU2009323734A1 (en) | 2010-06-10 |
BRPI0917075B1 (pt) | 2019-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP12011685A (es) | Inmunoconjugados dirigidos | |
WO2011079902A3 (en) | Biological inhibitors of ror1 capable of inducing cell death | |
AR057614A1 (es) | Composiciones y metodos para producir moleculas de union con antigeno hibridas y usos de las mismas | |
WO2006081546A3 (en) | Inhibitor nucleic acids | |
AR047897A1 (es) | Composiciones y metodos que usan interferencia de arn para el control de nematodos | |
BR112014007852A2 (pt) | nucleosídeos, nucleotídeos e ácidos nucleicos modificados e usos dos mesmos | |
AR061685A1 (es) | Plantas de cultivo transgenicas con mayor tolerancia al estres | |
CR10290A (es) | Metodos para reducir la aglomeracion de proteina | |
CL2013003053A1 (es) | Compuesto que comprende un oligonucleotido modificado que consiste en de 10 a 30 nucleósidos unidos y definidos por un grupo de secuencias específicas; composicion que comprende dicho compuesto; uso para tratar enfermedades relacionadas con el virus de la hepatitis b (vhb). | |
CO6680656A2 (es) | Anticuerpos para metaloproteinasa -9 de matriz | |
WO2004035765A3 (en) | Double-stranded rna structures and constructs, and methods for generating and using the same | |
ECSP066559A (es) | ||
BRPI0708771B8 (pt) | anticorpos anti-5t4, conjugado de fármaco/ anticorpo para liberação de fármaco, usos dos mesmos e ácido nucléico isolado codificando uma região variável de cadeias pesada e leve anti-5t4 | |
WO2007145612A8 (en) | Paired end sequencing | |
CR20110118A (es) | Tratamiento de enfermedades autoinmunes e inflamatorias | |
EA200800837A1 (ru) | Иммуностимулирующая одноцепочечная рибонуклеиновая кислота с фосфодиэфирным остовом | |
BRPI0814644A2 (pt) | Anticorpos para cd200 e usos destes na inibição de respostas imunes. | |
BR112015005987A2 (pt) | vacina, métodos para induzir uma resposta imune contra um antígeno hbv, para proteção de um sujeito da infeção por hbv, para proteger o sujeito que foi diagnosticado com uma infecção por hbv, para induzir uma resposta imune contra um antígeno do hbv, para proteger um indivíduo da infecção pelo hbv, para proteger um indivíduo que foi diagnosticado com infecção pelo hbv, para proteger um indivíduo da infecção pelo hbv, para proteger um indivíduo que foi diagnosticado com infecção pelo hbv, para proteger um sujeito contra infecção por hbv e para proteger o sujeito que foi diagnosticado com uma infecção por hbv, molécula de ácido nucleico, e, proteína | |
IN2012DN02345A (es) | ||
CO2020002989A2 (es) | Ácidos nucleicos estabilizados que codifican el ácido ribonucleico mensajero (arnm) | |
BRPI0909566A2 (pt) | Linhagem de h. Polymorpha recombinante, processo de elaboração de etanol que compreende o cultivo da linhagem de h. Polymorpha recombinante e ácido nucleico recombinante | |
AR088647A1 (es) | Metodo para reducir el estres abiotico en la planta | |
WO2011057254A3 (en) | Simian adenoviral vector-based vaccines | |
PE20150889A1 (es) | Protozoo modificado que expresa al menos dos proteinas variables de superficie (vsp), vacuna que lo comprende, procedimientos, usos y metodos | |
WO2012145582A3 (en) | Methods and compositions for the specific inhibitions of egfr by double-stranded rna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |