PE20091731A1 - Derivados de sulfonamida sustituida - Google Patents

Derivados de sulfonamida sustituida

Info

Publication number
PE20091731A1
PE20091731A1 PE2009000495A PE2009000495A PE20091731A1 PE 20091731 A1 PE20091731 A1 PE 20091731A1 PE 2009000495 A PE2009000495 A PE 2009000495A PE 2009000495 A PE2009000495 A PE 2009000495A PE 20091731 A1 PE20091731 A1 PE 20091731A1
Authority
PE
Peru
Prior art keywords
piperidin
aryl
ethyl
metoxy
pyrrolidin
Prior art date
Application number
PE2009000495A
Other languages
English (en)
Inventor
Stefan Oberborsch
Melanie Tracey Reich
Stefan Schunk
Michael Franz-Martin Engels
Ruth Jostock
Tieno Heiner Germann
Sabine Maria Hees
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20091731A1 publication Critical patent/PE20091731A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDA DE FORMULA (I) DONDE Q ES UNA SOLA UNION, -O- O -CH2-, R1 ES ARILO O HETEROARILO OPCIONALMENTE UNIDOS POR ALQUILENO(C1-C3); R2 ES H, ALQUILO(C1-C6), CH(ARILO)2, ENTRE OTROS; R3 ES H, ALQUILO(C1-C6), ARILO, ENTRE OTROS; R4 ES ARILO O HETEROARILO OPCIONALMENTE UNIDOS POR ALQUILENO(C1-C6); R5 Y R6 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS; m, o Y p SON CADA UNO DE 0 A 2; n ES 1 O 2; q ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-(3-OXO-1-FENILO-3-(4-(PIRIDIN-3-IL)-4-(2-(PIRROLIDIN-1-IL)ETILO)PIPERIDIN-1-IL)PROPILO)NAFTALENO-2-SULFONAMIDA, 2-((1-(4-METOXI-2,6-DIMETILOFENILOSULFONILO)PIPERIDIN-2-IL)METOXI)-1-(4-(PIRIDIN-3-IL)-4-(2-(PIRROLIDIN-1-IL)ETILO)PIPERIDIN-1-IL)ETANONA, 4-METOXI-N,2,6-TRIMETILO-N-(2-(2-OXO-2-(4-(PIRIDIN-3-IL)-4-(2-(PIRROLIDIN-1-IL)ETILO)PIPERIDIN-1-IL)ETOXI)ETILO)BENZENOSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE BRADIQUININA 1 (B1R) SIENDO UTILES PARA EL TRATAMIENTO DEL DOLOR AGUDO, MIGRANA, DIABETES, SHOCK SEPTICO
PE2009000495A 2008-04-08 2009-04-08 Derivados de sulfonamida sustituida PE20091731A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08006959 2008-04-08

Publications (1)

Publication Number Publication Date
PE20091731A1 true PE20091731A1 (es) 2009-11-11

Family

ID=39769182

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000495A PE20091731A1 (es) 2008-04-08 2009-04-08 Derivados de sulfonamida sustituida

Country Status (9)

Country Link
US (1) US8124624B2 (es)
EP (1) EP2262791A2 (es)
JP (1) JP2011516514A (es)
AR (1) AR071193A1 (es)
CA (1) CA2720735A1 (es)
CL (1) CL2009000852A1 (es)
PE (1) PE20091731A1 (es)
TW (1) TW201000464A (es)
WO (1) WO2009124734A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ575566A (en) * 2006-09-29 2011-05-27 Gruenenthal Chemie Substituted sulfonamide derivatives
RU2503674C2 (ru) * 2008-04-08 2014-01-10 Грюненталь Гмбх Замещенные производные сульфонамида

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026335B2 (en) * 2002-04-30 2006-04-11 The Procter & Gamble Co. Melanocortin receptor ligands
BRPI0408689B8 (pt) * 2003-03-25 2021-05-25 Laboratoires Fournier S A derivados de benzenosulfonamida, método para preparação e utilização disso para o tratamento da dor
WO2007101007A2 (en) * 2006-02-23 2007-09-07 Neurogen Corporation Aryl sulfonyl heterocycles
WO2007140383A2 (en) 2006-05-30 2007-12-06 Neurogen Corporation Spirocyclic sulfonamides and related compounds
WO2008024692A1 (en) * 2006-08-23 2008-02-28 Neurogen Corporation N-oxide aryl sulfones and sulfoxides

Also Published As

Publication number Publication date
US8124624B2 (en) 2012-02-28
CA2720735A1 (en) 2009-10-15
AR071193A1 (es) 2010-06-02
EP2262791A2 (en) 2010-12-22
TW201000464A (en) 2010-01-01
WO2009124734A3 (en) 2010-04-01
CL2009000852A1 (es) 2009-07-17
US20090264407A1 (en) 2009-10-22
WO2009124734A2 (en) 2009-10-15
JP2011516514A (ja) 2011-05-26

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