PE20090162A1 - Tetrahidro-pirazolo-piridina ligada a carbono como moduladores de catepsina s - Google Patents
Tetrahidro-pirazolo-piridina ligada a carbono como moduladores de catepsina sInfo
- Publication number
- PE20090162A1 PE20090162A1 PE2008000334A PE2008000334A PE20090162A1 PE 20090162 A1 PE20090162 A1 PE 20090162A1 PE 2008000334 A PE2008000334 A PE 2008000334A PE 2008000334 A PE2008000334 A PE 2008000334A PE 20090162 A1 PE20090162 A1 PE 20090162A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- tetrahydro
- pyridine
- pyrazolo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN DERIVADO DE PIRIDINA DE FORMULA (I), DONDE R1 Y R2 TOMADOS JUNTOS CON EL NITROGENO AL CUAL ESTAN ENLAZADOS FORMAN UN GRUPO HETEROCICLOALQUILO MONOCICLICO SATURADO, DONDE CADA GRUPO CONTIENE UN MIEMBRO DEL ANILLO DE HETEROATOMO ADICIONAL QUE ES O, S, NRa, Y CADA GRUPO ESTA OPCIONALMENTE SUSTITUIDO CON Rb; Rb ES ALQUILO C1-C4, OH, CF3, ENTRE OTROS; Ra ES H, ALQUILO C1-C4, FENILO, ENTRE OTROS; R3 ES H, OH, ALQUILO C1-C4, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, CO-FENIL, ENTRE OTROS; R5 ES HALO O CF3; R6 ES H O F; D ES CH=CH-R8, (CH2)2-3-R8, (CH2)3-5-R9, ENTRE OTROS; R8 ES FENILO O UN GRUPO HETEROARILO MONOCICLICO SUSTITUIDO OPCIONALMENTE CON Rk; Rk ES ALQUILO C1-C4, HALO, CN, COOH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[4-CLORO-3-(1H-INDOL-5-ILETINIL)-FENIL]-5-METANOSULFONIL-1-(3-MOROFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, 3-{4-CLORO-3-[2-(1H-INDOL-5-IL)-ETIL]-FENIL}-5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, (4-{2-CLORO-5-[5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDIN-3-IL]-FENILETINIL}-FENIL)-ACETONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE CATEPSINA S Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS INTESTINALES, LUPUS, ASMA, REACCIONES ALERGICAS, TRANSTORNOS DEL SISTEMA INMUNOLOGICO, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88997707P | 2007-02-15 | 2007-02-15 | |
US12/031,010 US20080200454A1 (en) | 2007-02-15 | 2008-02-14 | Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090162A1 true PE20090162A1 (es) | 2009-03-12 |
Family
ID=39512608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000334A PE20090162A1 (es) | 2007-02-15 | 2008-02-15 | Tetrahidro-pirazolo-piridina ligada a carbono como moduladores de catepsina s |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080200454A1 (es) |
AR (1) | AR065377A1 (es) |
CL (1) | CL2008000495A1 (es) |
PA (1) | PA8769601A1 (es) |
PE (1) | PE20090162A1 (es) |
TW (1) | TW200843743A (es) |
UY (1) | UY30921A1 (es) |
WO (1) | WO2008100618A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009102937A1 (en) * | 2008-02-14 | 2009-08-20 | Sunesis Pharmaceuticals, Inc. | Processes for the preparation of carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
WO2011069149A2 (en) * | 2009-12-04 | 2011-06-09 | Dcb-Usa Llc | Cathepsin s inhibitors |
WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
EP2585066B1 (en) * | 2010-06-24 | 2018-09-26 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
BR112013012836A2 (pt) | 2010-11-24 | 2019-09-24 | Allergan Inc | moduladores dos receptores s1p" |
CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
CN106916094B (zh) * | 2017-01-11 | 2019-06-04 | 青岛昌泰和生物科技有限公司 | 一种吲哚二酮化合物的制备方法 |
WO2019074241A1 (ko) * | 2017-10-11 | 2019-04-18 | 정원혁 | 페닐아세틸렌 유도체를 포함하는 pd-1과 pd-l1의 상호작용 억제제 |
US20220193048A1 (en) | 2019-04-05 | 2022-06-23 | Universite De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7332494B2 (en) * | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
DE60126286T2 (de) * | 2000-08-14 | 2007-11-15 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte pyrazole |
US20070117785A1 (en) * | 2000-08-14 | 2007-05-24 | Butler Christopher R | Substituted pyrazoles and methods of treatment with substituted pyrazoles |
AU2001284823B2 (en) * | 2000-08-14 | 2006-11-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
EP1309593B1 (en) * | 2000-08-14 | 2006-03-15 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
US20050101587A9 (en) * | 2000-08-14 | 2005-05-12 | Butler Christopher R. | Method for treating allergies using substituted pyrazoles |
US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
NZ524681A (en) * | 2000-09-06 | 2005-09-30 | Ortho Mcneil Pharm Inc | A method for treating allergies using substituted pyrazoles |
AU2001288714A1 (en) * | 2000-09-06 | 2002-03-22 | Ortho-Mcneil Pharmaceutical, Inc. | A method for treating allergies |
US20030144234A1 (en) * | 2001-08-30 | 2003-07-31 | Buxton Francis Paul | Methods for the treatment of chronic pain and compositions therefor |
US20030073672A1 (en) * | 2001-09-05 | 2003-04-17 | Breitenbucher J. Guy | Method for treating allergies using substituted pyrazoles |
SE0201977D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
SE0201980D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
SE0201976D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
GB0304640D0 (en) * | 2003-02-28 | 2003-04-02 | Novartis Ag | Organic compounds |
US7173051B2 (en) * | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
US7326715B2 (en) * | 2005-09-23 | 2008-02-05 | N.V. Organon | 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives |
US7687515B2 (en) * | 2006-01-17 | 2010-03-30 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
-
2008
- 2008-02-14 US US12/031,010 patent/US20080200454A1/en not_active Abandoned
- 2008-02-15 WO PCT/US2008/002108 patent/WO2008100618A2/en active Application Filing
- 2008-02-15 PA PA20088769601A patent/PA8769601A1/es unknown
- 2008-02-15 CL CL2008000495A patent/CL2008000495A1/es unknown
- 2008-02-15 TW TW097105280A patent/TW200843743A/zh unknown
- 2008-02-15 PE PE2008000334A patent/PE20090162A1/es not_active Application Discontinuation
- 2008-02-15 AR ARP080100663A patent/AR065377A1/es not_active Application Discontinuation
- 2008-02-15 UY UY30921A patent/UY30921A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
PA8769601A1 (es) | 2009-03-31 |
WO2008100618A3 (en) | 2008-10-02 |
WO2008100618A2 (en) | 2008-08-21 |
TW200843743A (en) | 2008-11-16 |
AR065377A1 (es) | 2009-06-03 |
UY30921A1 (es) | 2008-09-02 |
US20080200454A1 (en) | 2008-08-21 |
CL2008000495A1 (es) | 2008-11-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |