PE20081757A1 - Polimorfos del acido [1-(4-terc-butilbencil)-5-(3-metilfenil)-1h-indol-3-il](oxo)acetico - Google Patents

Polimorfos del acido [1-(4-terc-butilbencil)-5-(3-metilfenil)-1h-indol-3-il](oxo)acetico

Info

Publication number
PE20081757A1
PE20081757A1 PE2008000252A PE2008000252A PE20081757A1 PE 20081757 A1 PE20081757 A1 PE 20081757A1 PE 2008000252 A PE2008000252 A PE 2008000252A PE 2008000252 A PE2008000252 A PE 2008000252A PE 20081757 A1 PE20081757 A1 PE 20081757A1
Authority
PE
Peru
Prior art keywords
polymorphes
terc
butylbenzyl
indol
methylphenyl
Prior art date
Application number
PE2008000252A
Other languages
English (en)
Inventor
Abdolsamad Tadayon
Hsueh-Ling Wu
Mannching Sherry Ku
David Zenan Li
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20081757A1 publication Critical patent/PE20081757A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A POLIMORFOS DEL ACIDO [1-(4-TERC-BUTILBENCIL)-5-(3-METILFENIL)-1H-INDOL-3-IL](OXO)ACETICO EN DONDE A) EL POLIMORFO FORMA A TIENE UN PATRON DE DIFRACCION DE RAYOS X EN POLVO QUE COMPRENDE PICOS CARACTERISTICOS EN GRADOS 2O SELECCIONADOS DE 13.7, 15.2, 16.2, 17.4, 18.6, 19.8, 20.4, 21.0, 22.0, 24.2, ENTRE OTROS; B) EL POLIMORFO FORMA B TIENE UN PATRON DE DIFRACCION DE RAYOS X EN POLVO QUE COMPRENDE PICOS CARACTERISTICOS EN GRADOS 2O SELECCIONADOS DE 10.3, 10.8, 11.1, 15.2, 15.5, 16.1, 16.4, 16.6, 17.0, 17.4, ENTRE OTROS; C) EL POLIMORFO FORMA C TIENE UN PATRON DE DIFRACCION DE RAYOS X EN POLVO QUE COMPRENDE PICOS CARACTERISTICOS EN GRADOS 2O SELECCIONADOS DE 6.0, 9.9, 10.9, 13.2, 13.5, 16.2, 17.0, 17.3, 19.5, 19.9, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE CADA UNO DE LOS POLIMORFOS Y A PROCEDIMIENTOS DE PREPARACION DE LOS MISMOS. DICHOS POLIMORFOS SON UTILES EN EL TRATAMIENTO DE TROMBOSIS, ISQUEMIA MIOCARDICA, ENFERMEDAD DE ALZHEIMER, DEMENCIA SENIL
PE2008000252A 2007-02-05 2008-02-05 Polimorfos del acido [1-(4-terc-butilbencil)-5-(3-metilfenil)-1h-indol-3-il](oxo)acetico PE20081757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89947307P 2007-02-05 2007-02-05

Publications (1)

Publication Number Publication Date
PE20081757A1 true PE20081757A1 (es) 2009-01-21

Family

ID=39676711

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000252A PE20081757A1 (es) 2007-02-05 2008-02-05 Polimorfos del acido [1-(4-terc-butilbencil)-5-(3-metilfenil)-1h-indol-3-il](oxo)acetico

Country Status (8)

Country Link
US (1) US20080188542A1 (es)
EP (1) EP2061757A2 (es)
AR (1) AR065176A1 (es)
CL (1) CL2008000354A1 (es)
PA (1) PA8768801A1 (es)
PE (1) PE20081757A1 (es)
TW (1) TW200840564A (es)
WO (1) WO2008097938A2 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1397130B1 (en) * 2001-06-20 2007-07-25 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)

Also Published As

Publication number Publication date
EP2061757A2 (en) 2009-05-27
AR065176A1 (es) 2009-05-20
WO2008097938A3 (en) 2009-09-11
US20080188542A1 (en) 2008-08-07
WO2008097938A2 (en) 2008-08-14
CL2008000354A1 (es) 2008-03-14
TW200840564A (en) 2008-10-16
PA8768801A1 (es) 2009-02-09

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Legal Events

Date Code Title Description
FX Voluntary withdrawal