PE20081474A1 - Formulaciones de inhibidores de enzimas fosfolipasas - Google Patents

Formulaciones de inhibidores de enzimas fosfolipasas

Info

Publication number
PE20081474A1
PE20081474A1 PE2007001500A PE2007001500A PE20081474A1 PE 20081474 A1 PE20081474 A1 PE 20081474A1 PE 2007001500 A PE2007001500 A PE 2007001500A PE 2007001500 A PE2007001500 A PE 2007001500A PE 20081474 A1 PE20081474 A1 PE 20081474A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
phenyl
solubilizer
composition
Prior art date
Application number
PE2007001500A
Other languages
English (en)
Inventor
Frances Anne Donahue
Marc Sadler Tesconi
Mannching Sherry Ku
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20081474A1 publication Critical patent/PE20081474A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE a) UN INHIBIDOR DE LA ENZIMA CITOSOLICA FOSFOLIPASA A2 (PLA2) DE FORMULA (I), EN DONDE R ES -(CH2)n-A, -(CH2)N-S-A Y -(CH2)n-O-A; X1 ES S, O, S(O), ENTRE OTROS; R1 ES ALQUILO(C1-C6), ALQUILO(C1-C6)FLUORADO, FENILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; X2 ES O, CH2, S, SO, ENTRE OTROS; R2 ES UNA PORCION DE ANILLO SELECCIONADO DE FENILO, PIRIDINILO, ENTRE OTROS; R3 ES H, HALOGENO, CN, ENTRE OTROS; R4 ES H, HALOGENO, CN, CHO, ENTRE OTROS; R5 ES H O ALQUILO(C1-C3); n1, n2 Y n3 SON INDEPENDIENTEMENTE DE 0 A 4. SIENDO PREFERIDO EL ACIDO 4-(3-{5-CLORO-1-(DIFENILMETIL)-2-[2-({[2-(TRIFLUOROMETIL)BENCIL]SULFONIL}AMINO)ETIL]-1H-INDOL-3-IL}PROPIL)BENZOICO, EL CUAL SE ENCUENTRA EN UNA CANTIDAD DE 0,1 A 25% EN PESO DE LA COMPOSICION; Y b) UN SISTEMA PORTADOR O EXCIPIENTE QUE CONTIENE UN PRIMER SOLUBILIZANTE SELECCIONADO DE HIDROXIESTEARATO DE POLIETILENGLICOL; UN SEGUNDO SOLUBILIZANTE SELECCIONADO DE ACEITE DE CASTOR POLIOXI 35 Y UN DILUYENTE SELECCIONADO DE MONOCAPRILATO DE PROPILENGLICOL. TAMBIEN SE REFIERA UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION
PE2007001500A 2006-10-31 2007-10-31 Formulaciones de inhibidores de enzimas fosfolipasas PE20081474A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85556906P 2006-10-31 2006-10-31

Publications (1)

Publication Number Publication Date
PE20081474A1 true PE20081474A1 (es) 2008-11-24

Family

ID=39345045

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001500A PE20081474A1 (es) 2006-10-31 2007-10-31 Formulaciones de inhibidores de enzimas fosfolipasas

Country Status (13)

Country Link
US (1) US20100056520A1 (es)
EP (1) EP2077834A2 (es)
JP (1) JP2010508357A (es)
CN (1) CN101573111A (es)
AR (1) AR063746A1 (es)
BR (1) BRPI0718030A2 (es)
CA (1) CA2667864A1 (es)
CL (1) CL2007003145A1 (es)
MX (1) MX2009004611A (es)
PE (1) PE20081474A1 (es)
RU (1) RU2009116423A (es)
TW (1) TW200824686A (es)
WO (1) WO2008055146A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012031763A1 (en) 2010-09-08 2012-03-15 Twincore Zentrum Fuer Experimentelle Und Klinische Infektionsforschung Gmbh Use of inhibitors of phospholipase a2 for the treatment or prevention of flavivirus infection
PT4203919T (pt) * 2021-08-05 2024-04-23 Pharvaris Gmbh Composição à base de lípidos para administração oral de antagonistas do recetor b2 da bradicinina

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
JP4761093B2 (ja) * 1997-12-10 2011-08-31 シクロスポリン セラポイティクス リミテッド オメガ−３脂肪酸油を含む医薬組成物
US6500853B1 (en) * 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US5922754A (en) * 1998-10-02 1999-07-13 Abbott Laboratories Pharmaceutical compositions containing paclitaxel
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
FR2803203B1 (fr) * 1999-12-31 2002-05-10 Fournier Ind & Sante Nouvelles formulations galeniques du fenofibrate
EP1151755B1 (en) * 2000-05-04 2005-03-16 Panacea Biotec Limited Pharmaceutical compositions comprising cyclosporin as active ingredient
AR036852A1 (es) * 2001-10-19 2004-10-06 Isotechnika Inc Preconcentrado de una microemulsion de analogos de ciclosporina, su metodo de preparacion y metodos para producir inmunosupresion
DK1892239T3 (da) * 2001-12-03 2013-03-25 Wyeth Llc Inhibitorer af cytosol-phospholipase A2
EP1340497A1 (en) * 2002-03-01 2003-09-03 Novagali Sas Self emulsifying drug delivery systems for poorly soluble drugs
US20050058670A1 (en) * 2003-09-09 2005-03-17 Jong-Soo Woo Oral itraconazole composition which is not affected by ingested food and process for preparing same
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
EP2077834A2 (en) 2009-07-15
CA2667864A1 (en) 2008-05-08
WO2008055146A2 (en) 2008-05-08
CL2007003145A1 (es) 2008-01-25
BRPI0718030A2 (pt) 2013-11-12
CN101573111A (zh) 2009-11-04
WO2008055146A9 (en) 2008-08-21
MX2009004611A (es) 2009-05-22
WO2008055146A3 (en) 2008-10-09
TW200824686A (en) 2008-06-16
AR063746A1 (es) 2009-02-18
RU2009116423A (ru) 2010-12-10
US20100056520A1 (en) 2010-03-04
JP2010508357A (ja) 2010-03-18

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