PE20080985A1 - Forma polimorfica de cristal talfa de bromuro de (r)-3-(2-hidroxi-2,2-difenil-acetoxi)-1-(isoxazol-3-il-carbamoil-metil)-1-azonia-biciclo-[2.2.2]-octano - Google Patents
Forma polimorfica de cristal talfa de bromuro de (r)-3-(2-hidroxi-2,2-difenil-acetoxi)-1-(isoxazol-3-il-carbamoil-metil)-1-azonia-biciclo-[2.2.2]-octanoInfo
- Publication number
- PE20080985A1 PE20080985A1 PE2007001164A PE2007001164A PE20080985A1 PE 20080985 A1 PE20080985 A1 PE 20080985A1 PE 2007001164 A PE2007001164 A PE 2007001164A PE 2007001164 A PE2007001164 A PE 2007001164A PE 20080985 A1 PE20080985 A1 PE 20080985A1
- Authority
- PE
- Peru
- Prior art keywords
- biciclo
- azonia
- isoxazol
- carbamoyl
- octane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN CRISTAL POLIMORFICO DE BROMURO DE (R)-3-(2-HIDROXI-2,2-DIFENIL-ACETOXI)-1-(ISOXAZOL-3-IL-CARBAMOIL-METIL)-1-AZONIA-BICICLO-[2.2.2]-OCTANO, DESIGNADO COMO LA FORMA DEL CRISTAL T ALFA, CARACTERIZADA POR UN PUNTO DE FUSION 208ºC, CON LAS LINEAS DE DIFRACION (2 THETA EN GRADOS ANGULARES ± 0.2ºC) EN EL PATRON DE DIFRACCION DE RAYOS X DE: 5.7º, 15.7º, 18.5º, 19.8º, 21.1º, 22.2º Y 24.0º. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA PARA ADMINISTRACION TOPICA O EN AEROSOL CON UN DIAMETRO DE PARTICULA DE HASTA 10 MICRAS, OPCIONALMENTE JUNTO CON SUSTANCIAS ANTIINFLAMATORIAS, BRONCODILATADORAS, ANTIALERGICAS Y UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MUSCARINICO M3 UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS U OBSTRUCTIVAS DE LAS VIAS RESPIRATORIAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06119883A EP1900737A1 (en) | 2006-08-31 | 2006-08-31 | Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080985A1 true PE20080985A1 (es) | 2008-09-05 |
Family
ID=37685707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001164A PE20080985A1 (es) | 2006-08-31 | 2007-08-28 | Forma polimorfica de cristal talfa de bromuro de (r)-3-(2-hidroxi-2,2-difenil-acetoxi)-1-(isoxazol-3-il-carbamoil-metil)-1-azonia-biciclo-[2.2.2]-octano |
Country Status (21)
Country | Link |
---|---|
US (1) | US20090264461A1 (es) |
EP (2) | EP1900737A1 (es) |
JP (1) | JP2010501611A (es) |
KR (1) | KR20090051110A (es) |
CN (1) | CN101506205A (es) |
AR (1) | AR062582A1 (es) |
AU (1) | AU2007291515A1 (es) |
BR (1) | BRPI0716205A2 (es) |
CA (1) | CA2660983A1 (es) |
CL (1) | CL2007002524A1 (es) |
GT (1) | GT200900044A (es) |
IL (1) | IL196808A0 (es) |
MA (1) | MA31412B1 (es) |
MX (1) | MX2009002300A (es) |
NO (1) | NO20091231L (es) |
PE (1) | PE20080985A1 (es) |
RU (1) | RU2009111390A (es) |
TN (1) | TN2009000069A1 (es) |
TW (1) | TW200817399A (es) |
WO (1) | WO2008025541A1 (es) |
ZA (1) | ZA200900449B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
ES2425581T3 (es) * | 2006-11-23 | 2013-10-16 | Sinoxa Pharma Gmbh | Composiciones farmacéuticas para el tratamiento de la arteriopatía capilar |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
-
2006
- 2006-08-31 EP EP06119883A patent/EP1900737A1/en not_active Ceased
-
2007
- 2007-08-28 PE PE2007001164A patent/PE20080985A1/es not_active Application Discontinuation
- 2007-08-29 KR KR1020097006532A patent/KR20090051110A/ko not_active Application Discontinuation
- 2007-08-29 US US12/438,999 patent/US20090264461A1/en not_active Abandoned
- 2007-08-29 CN CNA2007800314914A patent/CN101506205A/zh active Pending
- 2007-08-29 JP JP2009525978A patent/JP2010501611A/ja active Pending
- 2007-08-29 MX MX2009002300A patent/MX2009002300A/es not_active Application Discontinuation
- 2007-08-29 RU RU2009111390/04A patent/RU2009111390A/ru not_active Application Discontinuation
- 2007-08-29 AU AU2007291515A patent/AU2007291515A1/en not_active Abandoned
- 2007-08-29 BR BRPI0716205-7A2A patent/BRPI0716205A2/pt not_active Application Discontinuation
- 2007-08-29 CA CA002660983A patent/CA2660983A1/en not_active Abandoned
- 2007-08-29 AR ARP070103830A patent/AR062582A1/es unknown
- 2007-08-29 EP EP07801981A patent/EP2064210A1/en not_active Withdrawn
- 2007-08-29 WO PCT/EP2007/007560 patent/WO2008025541A1/en active Application Filing
- 2007-08-30 CL CL200702524A patent/CL2007002524A1/es unknown
- 2007-08-30 TW TW096132302A patent/TW200817399A/zh unknown
-
2009
- 2009-01-20 ZA ZA200900449A patent/ZA200900449B/xx unknown
- 2009-01-29 IL IL196808A patent/IL196808A0/en unknown
- 2009-02-27 TN TN2009000069A patent/TN2009000069A1/fr unknown
- 2009-02-27 GT GT200900044A patent/GT200900044A/es unknown
- 2009-03-13 MA MA31715A patent/MA31412B1/fr unknown
- 2009-03-24 NO NO20091231A patent/NO20091231L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TN2009000069A1 (en) | 2010-08-19 |
KR20090051110A (ko) | 2009-05-20 |
NO20091231L (no) | 2009-03-25 |
BRPI0716205A2 (pt) | 2013-11-12 |
IL196808A0 (en) | 2009-11-18 |
EP2064210A1 (en) | 2009-06-03 |
ZA200900449B (en) | 2010-01-27 |
JP2010501611A (ja) | 2010-01-21 |
MX2009002300A (es) | 2009-03-20 |
GT200900044A (es) | 2012-01-16 |
AU2007291515A1 (en) | 2008-03-06 |
MA31412B1 (fr) | 2010-06-01 |
RU2009111390A (ru) | 2010-10-10 |
AR062582A1 (es) | 2008-11-19 |
CN101506205A (zh) | 2009-08-12 |
US20090264461A1 (en) | 2009-10-22 |
EP1900737A1 (en) | 2008-03-19 |
WO2008025541A1 (en) | 2008-03-06 |
CA2660983A1 (en) | 2008-03-06 |
TW200817399A (en) | 2008-04-16 |
CL2007002524A1 (es) | 2008-07-11 |
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