PE20071432A1 - Derivados de dihidrobenzofurano como agonistas o agonistas parciales de receptores metaloninergicos - Google Patents

Derivados de dihidrobenzofurano como agonistas o agonistas parciales de receptores metaloninergicos

Info

Publication number
PE20071432A1
PE20071432A1 PE2006000416A PE2006000416A PE20071432A1 PE 20071432 A1 PE20071432 A1 PE 20071432A1 PE 2006000416 A PE2006000416 A PE 2006000416A PE 2006000416 A PE2006000416 A PE 2006000416A PE 20071432 A1 PE20071432 A1 PE 20071432A1
Authority
PE
Peru
Prior art keywords
agonists
receptors
derivatives
metalloninergic
dihidrobenzofuran
Prior art date
Application number
PE2006000416A
Other languages
English (en)
Inventor
Gary Paul Stack
Jonathan Laird Gross
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071432A1 publication Critical patent/PE20071432A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Abstract

SE REFIERE A DERIVADOS DE DIHIDROBENZOFURANO DE FORMULA (I) DONDE X ES O, S, SO(1-2), O -CH2-; R1 ES CN, HALOGENO, -R U -OR; R ES H O ALIFATICO(C1-C4) OPCIONALMENTE SUSTITUIDO CON F; Ar ES TIENILO, FURILO, PIRIDILO, O FENILO, OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO(C1-C4); m ES 1 o 2; n ES 0 o 1; y ES 0 A 3. SON COMPUESTOS PREFERIDOS: (R)-N-[7-(2,6-DICLORO-FENIL)-5-FLUOR-2,3-DIHIDRO-BENZOFURAN-2-ILMETIL]-ACETAMIDA, N-[7-(2,6-DICLORO-FENIL)-2,3-DIHIDRO-BENZOFURAN-2-ILMETIL]-ACETAMIDA, CLORHIDRATO DE N-[7-(2-CLORO-FENIL)-2,3-DIHIDRO-BENZOFURAN-2-ILMETIL]-ACETAMIDA, ENTRE OTROS. ESTOS COMPUESTOS SON AGONISTAS O AGONISTAS PARCIALES DE RECEPTORES MELATONINERGICOS MT1 Y MT2 PUDIENDO SER UTILES EN EL TRATAMIENTO DEL DESORDEN DEL SUENO, DEPRESION, ANSIEDAD, STRESS
PE2006000416A 2005-04-22 2006-04-21 Derivados de dihidrobenzofurano como agonistas o agonistas parciales de receptores metaloninergicos PE20071432A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67406005P 2005-04-22 2005-04-22

Publications (1)

Publication Number Publication Date
PE20071432A1 true PE20071432A1 (es) 2007-01-24

Family

ID=36955708

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000416A PE20071432A1 (es) 2005-04-22 2006-04-21 Derivados de dihidrobenzofurano como agonistas o agonistas parciales de receptores metaloninergicos

Country Status (13)

Country Link
US (1) US7470799B2 (es)
EP (1) EP1871754A1 (es)
JP (1) JP2008538571A (es)
CN (1) CN101180283A (es)
AR (1) AR055916A1 (es)
AU (1) AU2006239910A1 (es)
BR (1) BRPI0609988A2 (es)
CA (1) CA2605435A1 (es)
GT (1) GT200600167A (es)
MX (1) MX2007013065A (es)
PE (1) PE20071432A1 (es)
TW (1) TW200716584A (es)
WO (1) WO2006116136A1 (es)

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US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
WO2006116149A1 (en) * 2005-04-22 2006-11-02 Wyeth New therapeutic combianations for the treatment or prevention of depression
US20060258713A1 (en) * 2005-04-22 2006-11-16 Wyeth Treatment of pain
EP1871356A1 (en) * 2005-04-22 2008-01-02 Wyeth a Corporation of the State of Delaware Dihydrobenzofuran derivatives and uses thereof
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AU2006239910A1 (en) 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
US20060258713A1 (en) 2005-04-22 2006-11-16 Wyeth Treatment of pain
JP2008538573A (ja) 2005-04-22 2008-10-30 ワイス ベンゾフラニルアルカナミン誘導体およびその５−ｈｔ２ｃアゴニストとしての使用
WO2006116149A1 (en) 2005-04-22 2006-11-02 Wyeth New therapeutic combianations for the treatment or prevention of depression
MX2007013151A (es) 2005-04-22 2008-01-16 Wyeth Corp Derivados de benzodioxano y benzodioxolano y usos de los mismos.
EP1871356A1 (en) 2005-04-22 2008-01-02 Wyeth a Corporation of the State of Delaware Dihydrobenzofuran derivatives and uses thereof
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WO2006116221A2 (en) 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
GT200600164A (es) 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
EP1874292A2 (en) 2005-04-24 2008-01-09 Wyeth Methods for modulating bladder function

Also Published As

Publication number Publication date
AU2006239910A1 (en) 2006-11-02
CA2605435A1 (en) 2006-11-02
TW200716584A (en) 2007-05-01
WO2006116136A1 (en) 2006-11-02
JP2008538571A (ja) 2008-10-30
CN101180283A (zh) 2008-05-14
US7470799B2 (en) 2008-12-30
BRPI0609988A2 (pt) 2010-05-18
US20060246551A1 (en) 2006-11-02
EP1871754A1 (en) 2008-01-02
AR055916A1 (es) 2007-09-12
GT200600167A (es) 2007-03-14
MX2007013065A (es) 2008-01-14

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