PE20071420A1 - Pirrolopiridinas sustituidas, composiciones que las contienen y proceso de fabricacion - Google Patents

Pirrolopiridinas sustituidas, composiciones que las contienen y proceso de fabricacion

Info

Publication number
PE20071420A1
PE20071420A1 PE2006000435A PE2006000435A PE20071420A1 PE 20071420 A1 PE20071420 A1 PE 20071420A1 PE 2006000435 A PE2006000435 A PE 2006000435A PE 2006000435 A PE2006000435 A PE 2006000435A PE 20071420 A1 PE20071420 A1 PE 20071420A1
Authority
PE
Peru
Prior art keywords
phenyl
pyrrolopyridines
substitute
carboxamide
pyridin
Prior art date
Application number
PE2006000435A
Other languages
English (en)
Inventor
Michel Tabart
Eric Bacque
Baptiste Ronan
Fabrice Viviani
Catherine Souaille
Pascal Desmazeau
Frank Halley
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20071420A1 publication Critical patent/PE20071420A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE A Y Ar SON ARILO C6-C14, HETEROARILO QUE TIENE DE 1 A 4 HETEROATOMOS O CICLOALQUILO C3-C12, ENTRE OTROS; L ES UN ENLACE, CO, NH, CO-NH, NH-SO, ENTRE OTROS; UNO DE Y Y Z SE ELIGE ENTRE N Y NO, Y EL OTRO DE Y Y Z ES C(R5); W ES C(R6), DONDE R5 Y R6 SON H, HALOGENO, CN, ENTRE OTROS; R1 ES H, HALOGENO, R2, O(R2), OC(O)(R2), ENTRE OTROS, DONDE R2 ES H, ALQUILO C1-C12, ALQUINILO C2-C12, CICLOALQUILO C3-C12, ENTRE OTROS, Ra ES H, ALQUILO C1-C4 O CICLOALQUILO C3-C4. SON COMPUESTOS PREFERIDOS: 3-{4-[3-(2-FLUORO-5-TRIFLUOROMETIL-FENIL)-UREIDO]-FENIL}-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, 3-{4-[3-(2-FLUORO-FENIL)-UREIDO]-FENIL}-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, 3-{4-[3-(2-METOXI-FENIL)-UREIDO]-FENIL}-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS SIENDO UTILES EN EL TRATAMIENTO DEL CANCER
PE2006000435A 2005-04-26 2006-04-25 Pirrolopiridinas sustituidas, composiciones que las contienen y proceso de fabricacion PE20071420A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0504173A FR2884821B1 (fr) 2005-04-26 2005-04-26 Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
PE20071420A1 true PE20071420A1 (es) 2007-01-20

Family

ID=35517344

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000435A PE20071420A1 (es) 2005-04-26 2006-04-25 Pirrolopiridinas sustituidas, composiciones que las contienen y proceso de fabricacion

Country Status (33)

Country Link
US (1) US7947706B2 (es)
EP (1) EP1877409B1 (es)
JP (1) JP2008539211A (es)
KR (1) KR20080007229A (es)
CN (1) CN101166739A (es)
AR (1) AR061386A1 (es)
AT (1) ATE433976T1 (es)
AU (1) AU2006239105A1 (es)
BR (1) BRPI0613161A2 (es)
CA (1) CA2605744A1 (es)
CR (1) CR9463A (es)
CY (1) CY1109369T1 (es)
DE (1) DE602006007337D1 (es)
DK (1) DK1877409T3 (es)
DO (1) DOP2006000096A (es)
EA (1) EA012983B1 (es)
ES (1) ES2328629T3 (es)
FR (1) FR2884821B1 (es)
GT (1) GT200600174A (es)
HR (1) HRP20090494T1 (es)
IL (1) IL186523A0 (es)
MA (1) MA29480B1 (es)
MX (1) MX2007013084A (es)
NO (1) NO20075918L (es)
PA (1) PA8671301A1 (es)
PE (1) PE20071420A1 (es)
PL (1) PL1877409T3 (es)
PT (1) PT1877409E (es)
RS (1) RS51136B (es)
SI (1) SI1877409T1 (es)
TN (1) TNSN07360A1 (es)
TW (1) TW200718701A (es)
WO (1) WO2006114520A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
GEP20135728B (en) * 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US8513276B2 (en) 2006-12-22 2013-08-20 Astex Therapeutics Limited Imidazo[1,2-a]pyridine compounds for use in treating cancer
US8895745B2 (en) * 2006-12-22 2014-11-25 Astex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0810902D0 (en) * 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
DE102008052943A1 (de) 2008-10-23 2010-04-29 Merck Patent Gmbh Azaindolderivate
MX349923B (es) 2009-04-03 2017-08-21 Hoffmann La Roche Composiciones del ácido propano-1-sulfónico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil]-amida y el uso de las mismas.
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
US20110030037A1 (en) * 2009-07-07 2011-02-03 Vadim Olshansky Zone migration in network access
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
WO2013181075A1 (en) * 2012-05-29 2013-12-05 Merck Sharp & Dohme Corp. Isotopically labeled biaryl urea compounds
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
GB201310460D0 (en) * 2013-06-12 2013-07-24 Lytix Biopharma As Compounds
GB201310464D0 (en) * 2013-06-12 2013-07-24 Lytix Biopharma As Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3254843B2 (ja) * 1993-08-09 2002-02-12 三菱ウェルファーマ株式会社 新規縮合ヘテロ環誘導体
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
EP1425284A2 (en) * 2001-09-11 2004-06-09 Smithkline Beecham Corporation Furo- and thienopyrimidine derivatives as angiogenesis inhibitors
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
MXPA04003758A (es) * 2001-10-22 2005-06-20 Univ New York State Res Found Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos.
KR20040111445A (ko) * 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
FR2878849B1 (fr) 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
US7947706B2 (en) 2011-05-24
ATE433976T1 (de) 2009-07-15
BRPI0613161A2 (pt) 2010-12-21
AU2006239105A1 (en) 2006-11-02
PT1877409E (pt) 2009-09-16
DOP2006000096A (es) 2007-04-15
TW200718701A (en) 2007-05-16
WO2006114520A2 (fr) 2006-11-02
JP2008539211A (ja) 2008-11-13
EA012983B1 (ru) 2010-02-26
ES2328629T3 (es) 2009-11-16
DE602006007337D1 (de) 2009-07-30
FR2884821A1 (fr) 2006-10-27
SI1877409T1 (sl) 2009-12-31
EP1877409B1 (fr) 2009-06-17
EA200702329A1 (ru) 2008-02-28
FR2884821B1 (fr) 2007-07-06
CY1109369T1 (el) 2014-07-02
GT200600174A (es) 2006-12-26
CA2605744A1 (fr) 2006-11-02
TNSN07360A1 (en) 2008-12-31
MA29480B1 (fr) 2008-05-02
KR20080007229A (ko) 2008-01-17
IL186523A0 (en) 2008-01-20
HRP20090494T1 (hr) 2009-10-31
CR9463A (es) 2008-02-21
NO20075918L (no) 2007-11-19
AR061386A1 (es) 2008-08-27
WO2006114520A3 (fr) 2007-03-01
DK1877409T3 (da) 2009-10-05
PA8671301A1 (es) 2006-12-07
RS51136B (sr) 2010-10-31
US20080139606A1 (en) 2008-06-12
MX2007013084A (es) 2008-01-11
PL1877409T3 (pl) 2009-12-31
EP1877409A2 (fr) 2008-01-16
CN101166739A (zh) 2008-04-23

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