PE20070332A1 - Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasas - Google Patents
Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasasInfo
- Publication number
- PE20070332A1 PE20070332A1 PE2006001056A PE2006001056A PE20070332A1 PE 20070332 A1 PE20070332 A1 PE 20070332A1 PE 2006001056 A PE2006001056 A PE 2006001056A PE 2006001056 A PE2006001056 A PE 2006001056A PE 20070332 A1 PE20070332 A1 PE 20070332A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- heteroaryl
- inhibitors
- alkylen
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROARIL-NITRILOS SUSTITUIDOS DE FORMULA (I) EN DONDE R4 ES HALOGENO; R2 ES FENIL-ALQUILEN(C1-C3)-X, PIRIDIL-FENIL-ALQUILEN(C1-C3)-X O FENIL-ALQUILEN(C1-C3)-X-RJ; RJ ES Z -ALQUILEN(C1-C3)-Z O -C(O)Z; X E Y SON INDEPENDIENTEMENTE UN GRUPO HIDROCARBONADO SATURADO MONOCICLICO DE 6 MIEMBROS QUE CONTIENE 1 A 2 ATOMOS DE NITROGENO Y OPCIONALMENTE UN OXIGENO OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C4), OH, ALQUIL(C1-C4)OH, ENTRE OTROS. SON PREFERIDOS: N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(CICLOPENTILMETIL)-4-[(4-METIL-1-PIPERAZINIL)METIL]BENZOHIDRAZIDA, N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(CICLOPENTILMETIL)-4-[(4-HIDROXI-1-PIPERIDINIL)METIL]BENZOHIDRAZIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CISTEINA PROTEASA HALLADAS EN EL PARASITO DEL PALUDISMO PLASMODIUM FALCIPARUM POR LO QUE SON UTILES EN EL TRATAMIENTO DE MALARIA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05381043 | 2005-09-02 | ||
EP06110666 | 2006-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070332A1 true PE20070332A1 (es) | 2007-05-11 |
Family
ID=37770277
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001056A PE20070332A1 (es) | 2005-09-02 | 2006-08-31 | Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasas |
PE2006001057A PE20070612A1 (es) | 2005-09-02 | 2006-08-31 | Nuevos inhibidores de cisteina proteasas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001057A PE20070612A1 (es) | 2005-09-02 | 2006-08-31 | Nuevos inhibidores de cisteina proteasas |
Country Status (4)
Country | Link |
---|---|
AR (2) | AR057110A1 (es) |
PE (2) | PE20070332A1 (es) |
TW (2) | TW200804351A (es) |
WO (3) | WO2007025776A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2030621A1 (en) * | 2007-08-21 | 2009-03-04 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
WO2008052934A1 (en) * | 2006-10-30 | 2008-05-08 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
EP2168600A1 (en) | 2007-06-08 | 2010-03-31 | Nippon Chemiphar Co., Ltd. | Therapeutic or prophylactic agent for cerebral aneurysm |
US20100331545A1 (en) | 2007-10-24 | 2010-12-30 | Nippon Chemiphar Co., Ltd. | Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
DE102008063561A1 (de) * | 2008-12-18 | 2010-08-19 | Bayer Cropscience Ag | Hydrazide, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Insektizide |
CN102267964B (zh) * | 2011-06-15 | 2014-06-18 | 浙江师范大学 | 3-羟基-2,3-二氢苯并呋喃衍生物及其合成方法和应用 |
JP7271566B2 (ja) * | 2018-03-28 | 2023-05-11 | ハンリム ファーマシューティカル カンパニー リミテッド | 2-シアノピリミジン-4-イル カルバメート誘導体もしくはウレア誘導体またはその塩及びそれを含む医薬組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR036375A1 (es) * | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
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2006
- 2006-08-31 AR ARP060103809A patent/AR057110A1/es not_active Application Discontinuation
- 2006-08-31 PE PE2006001056A patent/PE20070332A1/es not_active Application Discontinuation
- 2006-08-31 AR ARP060103810A patent/AR055624A1/es not_active Application Discontinuation
- 2006-08-31 TW TW095132087A patent/TW200804351A/zh unknown
- 2006-08-31 WO PCT/EP2006/008580 patent/WO2007025776A2/en active Application Filing
- 2006-08-31 TW TW095132088A patent/TW200804352A/zh unknown
- 2006-08-31 PE PE2006001057A patent/PE20070612A1/es not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008579 patent/WO2007025775A2/en active Application Filing
- 2006-08-31 WO PCT/EP2006/008578 patent/WO2007025774A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AR055624A1 (es) | 2007-08-29 |
WO2007025774A3 (en) | 2007-04-26 |
WO2007025776A2 (en) | 2007-03-08 |
AR057110A1 (es) | 2007-11-14 |
TW200804351A (en) | 2008-01-16 |
TW200804352A (en) | 2008-01-16 |
PE20070612A1 (es) | 2007-06-23 |
WO2007025775A2 (en) | 2007-03-08 |
WO2007025774A2 (en) | 2007-03-08 |
WO2007025776A3 (en) | 2007-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |