PE20070178A1 - Compuestos de pirazolina como moduladores de receptores cannabinoides - Google Patents
Compuestos de pirazolina como moduladores de receptores cannabinoidesInfo
- Publication number
- PE20070178A1 PE20070178A1 PE2006000850A PE2006000850A PE20070178A1 PE 20070178 A1 PE20070178 A1 PE 20070178A1 PE 2006000850 A PE2006000850 A PE 2006000850A PE 2006000850 A PE2006000850 A PE 2006000850A PE 20070178 A1 PE20070178 A1 PE 20070178A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- pyrazole
- dichloro
- dihydro
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE PIRAZOLINA DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE FENILO NO SUSTITUIDO O AL MENOS MONOSUSTITUIDO CON -CF3, -C2F5, C3F7, ENTRE OTROS; R3 ES CICLONONILO, CICLODECILO, CICLOUNDECILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON PREFERIDOS: (HEXAHIDRO-CICLOPENTA[c]PIRROL-2-IL)-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, [2-(S)-(1-METOXI-1METIL-ETIL)-PIRROLIDIN-1-IL]-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, [2-(R)-(1-METOXI-1METIL-ETIL)-PIRROLIDIN-1-IL]-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES SELECTIVOS DE RECEPTORES DE CANNABINOIDES 1 (CB1) ES DECIR SON ANTAGONISTAS, AGONISTAS INVERSOS O AGONISTAS. Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS DE SISTEMA NERVIOSO CENTRAL, INMUNITARIO, CARDIOVASCULAR, ENDOCRINO, TRACTO GASTROINTESTINAL
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05384018A EP1743888A1 (en) | 2005-07-15 | 2005-07-15 | Carbonyl substituted pyrazoline compounds, their preparation and use as CB1 receptor modulators |
US70543305P | 2005-08-05 | 2005-08-05 | |
EP06008579A EP1849783A1 (en) | 2006-04-26 | 2006-04-26 | Octahydropentalene-substituted pyrazoline compounds, their preparation and use as medicaments |
EP06008581A EP1849784A1 (en) | 2006-04-26 | 2006-04-26 | Indoline-substituted pyrazoline compounds, their preparation and use as medicaments |
EP06008580A EP1849775A1 (en) | 2006-04-26 | 2006-04-26 | Cycloalkane-substituted pyrazoline compounds, their preparation and use as medicaments |
EP06008612A EP1849776A1 (en) | 2006-04-26 | 2006-04-26 | Azepane- or Azocane-substituted pyrazoline compounds, their preparation and use as medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070178A1 true PE20070178A1 (es) | 2007-04-04 |
Family
ID=43298612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000850A PE20070178A1 (es) | 2005-07-15 | 2006-07-14 | Compuestos de pirazolina como moduladores de receptores cannabinoides |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR062543A1 (es) |
PE (1) | PE20070178A1 (es) |
TW (1) | TW200738640A (es) |
-
2006
- 2006-07-14 TW TW095125891A patent/TW200738640A/zh unknown
- 2006-07-14 PE PE2006000850A patent/PE20070178A1/es not_active Application Discontinuation
- 2006-07-14 AR ARP060103040A patent/AR062543A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200738640A (en) | 2007-10-16 |
AR062543A1 (es) | 2008-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |