PE20070178A1 - PIRAZOLINE COMPOUNDS AS CANNABINOID RECEPTOR MODULATORS - Google Patents

PIRAZOLINE COMPOUNDS AS CANNABINOID RECEPTOR MODULATORS

Info

Publication number
PE20070178A1
PE20070178A1 PE2006000850A PE2006000850A PE20070178A1 PE 20070178 A1 PE20070178 A1 PE 20070178A1 PE 2006000850 A PE2006000850 A PE 2006000850A PE 2006000850 A PE2006000850 A PE 2006000850A PE 20070178 A1 PE20070178 A1 PE 20070178A1
Authority
PE
Peru
Prior art keywords
phenyl
pyrazole
dichloro
dihydro
chloro
Prior art date
Application number
PE2006000850A
Other languages
Spanish (es)
Inventor
Helmut Heinrich Buschmann
Jover Antonio Torrens
Ruiz Jordi Ramon Quintana
Zueras Alberto Dordal
Prio Jose Mas
Original Assignee
Dr Esteve Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05384018A external-priority patent/EP1743888A1/en
Priority claimed from EP06008579A external-priority patent/EP1849783A1/en
Priority claimed from EP06008612A external-priority patent/EP1849776A1/en
Priority claimed from EP06008580A external-priority patent/EP1849775A1/en
Priority claimed from EP06008581A external-priority patent/EP1849784A1/en
Application filed by Dr Esteve Labor filed Critical Dr Esteve Labor
Publication of PE20070178A1 publication Critical patent/PE20070178A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE PIRAZOLINA DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE FENILO NO SUSTITUIDO O AL MENOS MONOSUSTITUIDO CON -CF3, -C2F5, C3F7, ENTRE OTROS; R3 ES CICLONONILO, CICLODECILO, CICLOUNDECILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON PREFERIDOS: (HEXAHIDRO-CICLOPENTA[c]PIRROL-2-IL)-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, [2-(S)-(1-METOXI-1METIL-ETIL)-PIRROLIDIN-1-IL]-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, [2-(R)-(1-METOXI-1METIL-ETIL)-PIRROLIDIN-1-IL]-AMIDA DEL ACIDO 5-(4-CLORO-FENIL)-1-(2,4-DICLORO-FENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES SELECTIVOS DE RECEPTORES DE CANNABINOIDES 1 (CB1) ES DECIR SON ANTAGONISTAS, AGONISTAS INVERSOS O AGONISTAS. Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS DE SISTEMA NERVIOSO CENTRAL, INMUNITARIO, CARDIOVASCULAR, ENDOCRINO, TRACTO GASTROINTESTINALIT REFERS TO PYRAZOLINE COMPOUNDS OF FORMULA (I), WHERE R1 AND R2 ARE INDEPENDENTLY PHENYL NOT SUBSTITUTED OR AT LEAST MONOSTITUTED WITH -CF3, -C2F5, C3F7, AMONG OTHERS; R3 IS CYCLONONIL, CYCLODECYL, CYCLOUNDECILO, AMONG OTHERS, OPTIONALLY SUBSTITUTED. PREFERRED: (HEXAHYDRO-CYCLOPENTA [c] PYRROL-2-IL) -AMIDE OF THE ACID 5- (4-CHLORO-PHENYL) -1- (2,4-DICHLORO-PHENYL) -4,5-DIHYDRO-1H- PYRAZOLE-3-CARBOXYL, [2- (S) - (1-METOXY-1-METHYL-ETHYL) -PYRROLIDIN-1-IL] -AMIDE OF THE ACID 5- (4-CHLORO-PHENYL) -1- (2,4- DICHLORO-PHENYL) -4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXYL, [2- (R) - (1-METHOXY-1-METHYL-ETHYL) -PYRROLIDIN-1-IL] -AMIDE OF THE ACID 5- (4 -CHLORO-PHENYL) -1- (2,4-DICHLORO-PHENYL) -4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE SELECTIVE MODULATORS OF CANNABINOID 1 (CB1) RECEPTORS, THAT IS, THEY ARE ANTAGONISTS, INVERSE AGONISTS OR AGONISTS. AND THEY ARE USEFUL FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM, IMMUNE, CARDIOVASCULAR, ENDOCRINE, GASTROINTESTINAL TRACT DISORDERS

PE2006000850A 2005-07-15 2006-07-14 PIRAZOLINE COMPOUNDS AS CANNABINOID RECEPTOR MODULATORS PE20070178A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP05384018A EP1743888A1 (en) 2005-07-15 2005-07-15 Carbonyl substituted pyrazoline compounds, their preparation and use as CB1 receptor modulators
US70543305P 2005-08-05 2005-08-05
EP06008579A EP1849783A1 (en) 2006-04-26 2006-04-26 Octahydropentalene-substituted pyrazoline compounds, their preparation and use as medicaments
EP06008612A EP1849776A1 (en) 2006-04-26 2006-04-26 Azepane- or Azocane-substituted pyrazoline compounds, their preparation and use as medicaments
EP06008580A EP1849775A1 (en) 2006-04-26 2006-04-26 Cycloalkane-substituted pyrazoline compounds, their preparation and use as medicaments
EP06008581A EP1849784A1 (en) 2006-04-26 2006-04-26 Indoline-substituted pyrazoline compounds, their preparation and use as medicaments

Publications (1)

Publication Number Publication Date
PE20070178A1 true PE20070178A1 (en) 2007-04-04

Family

ID=43298612

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000850A PE20070178A1 (en) 2005-07-15 2006-07-14 PIRAZOLINE COMPOUNDS AS CANNABINOID RECEPTOR MODULATORS

Country Status (3)

Country Link
AR (1) AR062543A1 (en)
PE (1) PE20070178A1 (en)
TW (1) TW200738640A (en)

Also Published As

Publication number Publication date
AR062543A1 (en) 2008-11-19
TW200738640A (en) 2007-10-16

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