PE20061110A1 - Derivados de imidazopiridina como antagonistas de la bomba de acido (apa) - Google Patents

Derivados de imidazopiridina como antagonistas de la bomba de acido (apa)

Info

Publication number
PE20061110A1
PE20061110A1 PE2006000313A PE2006000313A PE20061110A1 PE 20061110 A1 PE20061110 A1 PE 20061110A1 PE 2006000313 A PE2006000313 A PE 2006000313A PE 2006000313 A PE2006000313 A PE 2006000313A PE 20061110 A1 PE20061110 A1 PE 20061110A1
Authority
PE
Peru
Prior art keywords
alkyl
alpha
dimethyl
apa
methyl
Prior art date
Application number
PE2006000313A
Other languages
English (en)
Inventor
Mark James Bramford
Richard Leonard Elliott
Jason Witherington
Emmanuel Hubert Demont
Terence Aaron Panchal
Gerard Martin Paul Giblin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0506137A external-priority patent/GB0506137D0/en
Priority claimed from GB0507101A external-priority patent/GB0507101D0/en
Priority claimed from GB0512923A external-priority patent/GB0512923D0/en
Priority claimed from GB0521274A external-priority patent/GB0521274D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20061110A1 publication Critical patent/PE20061110A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE X ES NH, O, N(ALQUILO C1-C4), ENTRE OTROS; R1 ES H, ALQUILO C1-C4, CH2CN, CICLOALQUILO C3-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES ALQUILO C1-C4, NH2, CICLOALQUILO C3-C6, ALCOXI C1-C4, ENTRE OTROS; R3 ES H, ALQUILO C1-C4; R4 Y R5 SON CADA UNO H, ALQUILO C1-C4, OH, HALOGENO, ALCOXI C1-C4, ENTRE OTROS; R6 ES H, ALQUILO C1-C4, HALOGENO, OH, NHCO2(ALQUILO C1-C4), ENTRE OTROS; Ar ES ARILO, HETEROARILO MONOCICLICO DE 5-6 MIEMBROS, BICICLICO DE 7-12 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8-{[(2,6-DIMETILFENIL)METIL]OXI}-2,3-DIMETIL-6-FENILIMIDAZO[1,2-ALFA]PIRIDINA; FORMIATO DE N-[(2,6-DIMETILFENIL)METIL]-2,3-DIMETIL-6-(3-METILFENIL)IMIDAZO[1,2-ALFA]PIRIDIN-8-AMINA; HIDROCLORURO DE N-[(2-ETIL-6-METILFENIL)METIL]-2,3-DIMETIL-6-(1H-1,2,4-TRIAZOL-3-IL)IMIDAZO[1,2-ALFA]PIRIDIN-8-AMINA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LA BOMBA DE ACIDO (APA) UTILES EN EL TRATAMIENTO DE TRASTORNOS DIGESTIVOS ASOCIADO CON UN DESEQUILIBRIO EN EL ACIDO GASTRICO
PE2006000313A 2005-03-24 2006-03-22 Derivados de imidazopiridina como antagonistas de la bomba de acido (apa) PE20061110A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0506137A GB0506137D0 (en) 2005-03-24 2005-03-24 Novel compounds
GB0507101A GB0507101D0 (en) 2005-04-07 2005-04-07 Novel compounds
GB0512923A GB0512923D0 (en) 2005-06-24 2005-06-24 Novel compounds
GB0521274A GB0521274D0 (en) 2005-10-19 2005-10-19 Novel compounds

Publications (1)

Publication Number Publication Date
PE20061110A1 true PE20061110A1 (es) 2006-10-20

Family

ID=36579471

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000313A PE20061110A1 (es) 2005-03-24 2006-03-22 Derivados de imidazopiridina como antagonistas de la bomba de acido (apa)

Country Status (7)

Country Link
US (1) US20080255358A1 (es)
EP (1) EP1861095A1 (es)
JP (1) JP2008536817A (es)
AR (1) AR055321A1 (es)
PE (1) PE20061110A1 (es)
TW (1) TW200700064A (es)
WO (1) WO2006100119A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026218A2 (en) * 2005-09-01 2007-03-08 Pfizer Japan Inc. Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists
WO2009077334A1 (en) * 2007-12-14 2009-06-25 F. Hoffmann-La Roche Ag Novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives
US8426441B2 (en) * 2007-12-14 2013-04-23 Roche Palo Alto Llc Inhibitors of bruton's tyrosine kinase
CN102131805A (zh) 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
FI20086158A0 (fi) 2008-12-03 2008-12-03 Mikael Dahlstroem Imidatsopyridiinijohdannaiset
BRPI1013288A2 (pt) 2009-07-09 2016-03-29 Raqualia Pharma Inc uso de um composto, método de composição farmacêutica para o tratamento de doenças em que a motilidade gastrointestinal anormal está envolvida, kit e embalagem comercial que compreende uma composição farmacêutica contendo o composto
AU2010284254B2 (en) * 2009-08-17 2015-09-17 Intellikine, Llc Heterocyclic compounds and uses thereof
MX2012004990A (es) 2009-10-30 2012-06-12 Janssen Pharmaceutica Nv Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10.
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
CA2872216C (en) 2012-06-26 2021-07-20 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
BR112015000459B1 (pt) 2012-07-09 2022-02-08 Janssen Pharmaceutica N.V. Inibidores da enzima fosfodiesterase 10, seu uso, composição farmacêutica que os compreende, seus processo de preparação e produto
CN104822679B (zh) * 2012-11-29 2016-10-19 霍夫曼-拉罗奇有限公司 咪唑并吡啶衍生物
CA2904089C (en) * 2013-03-08 2017-05-02 Wockhardt Limited A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
WO2018125815A1 (en) * 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0882048B1 (de) * 1996-01-26 2005-05-04 ALTANA Pharma AG 3-alkylimidazopyridine
SE9700661D0 (sv) * 1997-02-25 1997-02-25 Astra Ab New compounds
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
SE9802793D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
TWI351405B (en) * 2002-09-19 2011-11-01 Schering Corp Novel imidazopyridines as cyclin dependent kinase
JP2006508142A (ja) * 2002-11-19 2006-03-09 アルタナ　ファルマ　アクチエンゲゼルシャフト ８−置換イミダゾピリジン

Also Published As

Publication number Publication date
TW200700064A (en) 2007-01-01
US20080255358A1 (en) 2008-10-16
EP1861095A1 (en) 2007-12-05
WO2006100119A1 (en) 2006-09-28
JP2008536817A (ja) 2008-09-11
AR055321A1 (es) 2007-08-15

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