PE20060271A1 - STEROID DEPTH DRUGS WITH ANDROGENIC ACTION - Google Patents
STEROID DEPTH DRUGS WITH ANDROGENIC ACTIONInfo
- Publication number
- PE20060271A1 PE20060271A1 PE2005000556A PE2005000556A PE20060271A1 PE 20060271 A1 PE20060271 A1 PE 20060271A1 PE 2005000556 A PE2005000556 A PE 2005000556A PE 2005000556 A PE2005000556 A PE 2005000556A PE 20060271 A1 PE20060271 A1 PE 20060271A1
- Authority
- PE
- Peru
- Prior art keywords
- steroid
- drugs
- methyl
- halogen
- depth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE n ES 0-4; R1 ES RADICAL -SO2NH2, -NHSO2NH2; R2, R3 Y X, X1 SON CADA UNO H, ATOMO DE HALOGENO, NITRILO, ALQUILO C1-C5, ENTRE OTROS; ESTEROIDE ES UN SISTEMA CICLICO DE PREFERENCIA DERIVADOS DEL ANDROSTANO, ESTRANO; Y ES O,C; R4 ES H, HALOGENO, METILO, CF3, ENTRE OTROS; R7 Y R10 ES H, CH3, C2H6; R11 HALOGENO, H, OH, METOXI, ENTRE OTROS; R12 ES H, METILO, ETILO; R13 ES H, METILO, ETILO, ETINILO, ENTRE OTROS; R14 ES H, OH, O; R15 ES OH, ALCOXI C1-C5, HETEROCICLOALQUILOXI C2-C5, ENTRE OTROS. SON PROFARMACOS PREFERIDOS: 3'-SULFAMOILBENZOATO DE 3-OXO-7A-METILESTR-4-EN-17B-ILO; 3'-SULFAMOILBENZOATO DE 3-OXO-7A-METILANDROST-4-EN-17B-ILO; ENTRE OTROS. DICHO COMPUESTO ES UN PROFARMACO DE DISPONIBILIDAD ORAL Y GARANTIZAN EL NIVEL TERAPEUTICO DEL PRINCIPIO ACTIVO, SIENDO UTILES EN EN LA PREPARACION DE UNA COMPOSCION FARMACEUTICA DE ACCION ANDROGENICAREFERS TO A COMPOUND OF FORMULA I, WHERE n IS 0-4; R1 IS RADICAL -SO2NH2, -NHSO2NH2; R2, R3 AND X, X1 ARE EACH H, HALOGEN ATOM, NITRILE, C1-C5 ALKYL, AMONG OTHERS; STEROID IS A CYCLICAL SYSTEM OF PREFERENCE DERIVED FROM ANDROSTAN, ESTRANUS; Y IS O, C; R4 IS H, HALOGEN, METHYL, CF3, AMONG OTHERS; R7 AND R10 IS H, CH3, C2H6; R11 HALOGEN, H, OH, METOXY, AMONG OTHERS; R12 IS H, METHYL, ETHYL; R13 IS H, METHYL, ETHYL, ETHINYL, AMONG OTHERS; R14 IS H, OH, O; R15 IS OH, C1-C5 ALCOXY, C2-C5 HETERO CYCLOALKYLOXY, AMONG OTHERS. PREFERRED PRO-DRUGS ARE: 3'-OXO-7A-METHYLESTR-4-EN-17B-ILO 3'-SULFAMOYLBENZOATE; 3-OXO-7A-METHYLANDROST-4-EN-17B-ILO 3'-SULFAMOYLBENZOATE; AMONG OTHERS. SAID COMPOUND IS AN ORAL AVAILABLE PRO-DRUG AND GUARANTEES THE THERAPEUTIC LEVEL OF THE ACTIVE PRINCIPLE, BEING USEFUL IN THE PREPARATION OF A PHARMACEUTICAL COMPOSTION OF ANDROGENIC ACTION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004025986A DE102004025986A1 (en) | 2004-05-21 | 2004-05-21 | Steroid prodrugs with androgenic effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060271A1 true PE20060271A1 (en) | 2006-05-25 |
Family
ID=34968657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000556A PE20060271A1 (en) | 2004-05-21 | 2005-05-20 | STEROID DEPTH DRUGS WITH ANDROGENIC ACTION |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1747229A1 (en) |
| JP (1) | JP2007538026A (en) |
| CN (1) | CN1993375A (en) |
| AR (1) | AR049547A1 (en) |
| AU (1) | AU2005245568A1 (en) |
| BR (1) | BRPI0510136A (en) |
| CA (1) | CA2564963A1 (en) |
| CR (1) | CR8785A (en) |
| DE (1) | DE102004025986A1 (en) |
| EA (1) | EA200602049A1 (en) |
| EC (1) | ECSP067028A (en) |
| GT (1) | GT200500122A (en) |
| IL (1) | IL179293A0 (en) |
| MX (1) | MXPA06013469A (en) |
| NO (1) | NO20065885L (en) |
| PA (1) | PA8633601A1 (en) |
| PE (1) | PE20060271A1 (en) |
| SV (1) | SV2006002123A (en) |
| TW (1) | TW200613317A (en) |
| UY (1) | UY28911A1 (en) |
| WO (1) | WO2005113575A1 (en) |
| ZA (1) | ZA200610769B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027887A1 (en) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
| US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
| DE102005057224A1 (en) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | New 9-alpha substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders |
| DE102005057408A1 (en) * | 2005-11-30 | 2007-05-31 | Bayer Schering Pharma Ag | New sulfamoylsulfonate prodrugs e.g. useful for protecting red blood cells from attack by parasites or for hormone replacement therapy, female fertility control or treating hormone-associated diseases |
| CN101708338B (en) * | 2008-12-26 | 2014-06-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Prodrug containing sterides structures and high dispersion preparation thereof |
| CN102964417A (en) * | 2012-11-30 | 2013-03-13 | 华中药业股份有限公司 | Synthetic method of 17-hydroxy tetrahydropyran ether steroid |
| CN107556258B (en) * | 2017-08-22 | 2021-06-04 | 湖北江田精密化学有限公司 | Preparation method of 4-amino-2-chloro-5 (1H-tetrazolyl-5) benzenesulfonamide |
| EP3533619A1 (en) | 2018-03-02 | 2019-09-04 | Basf Se | Heat sensitive recording material and color developer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH545316A (en) * | 1970-07-17 | 1973-12-15 | Hoffmann La Roche | Process for the preparation of acyl derivatives |
| US5001234A (en) * | 1987-04-16 | 1991-03-19 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
| DE19712488A1 (en) * | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroid sulfamates, processes for their preparation and use thereof |
| DE10027887A1 (en) * | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
-
2004
- 2004-05-21 DE DE102004025986A patent/DE102004025986A1/en not_active Ceased
-
2005
- 2005-05-10 EA EA200602049A patent/EA200602049A1/en unknown
- 2005-05-10 CN CNA200580016339XA patent/CN1993375A/en active Pending
- 2005-05-10 AU AU2005245568A patent/AU2005245568A1/en not_active Abandoned
- 2005-05-10 MX MXPA06013469A patent/MXPA06013469A/en not_active Application Discontinuation
- 2005-05-10 EP EP05742657A patent/EP1747229A1/en not_active Withdrawn
- 2005-05-10 WO PCT/EP2005/005256 patent/WO2005113575A1/en active Application Filing
- 2005-05-10 CA CA002564963A patent/CA2564963A1/en not_active Abandoned
- 2005-05-10 JP JP2007517047A patent/JP2007538026A/en active Pending
- 2005-05-10 BR BRPI0510136-0A patent/BRPI0510136A/en not_active Application Discontinuation
- 2005-05-20 PE PE2005000556A patent/PE20060271A1/en not_active Application Discontinuation
- 2005-05-20 GT GT200500122A patent/GT200500122A/en unknown
- 2005-05-20 TW TW094116504A patent/TW200613317A/en unknown
- 2005-05-20 PA PA20058633601A patent/PA8633601A1/en unknown
- 2005-05-20 AR ARP050102084A patent/AR049547A1/en not_active Application Discontinuation
- 2005-05-20 UY UY28911A patent/UY28911A1/en not_active Application Discontinuation
- 2005-05-23 SV SV2005002123A patent/SV2006002123A/en not_active Application Discontinuation
-
2006
- 2006-11-15 IL IL179293A patent/IL179293A0/en unknown
- 2006-11-27 EC EC2006007028A patent/ECSP067028A/en unknown
- 2006-12-05 CR CR8785A patent/CR8785A/en not_active Application Discontinuation
- 2006-12-19 NO NO20065885A patent/NO20065885L/en unknown
- 2006-12-20 ZA ZA200610769A patent/ZA200610769B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY28911A1 (en) | 2005-12-30 |
| EA200602049A1 (en) | 2007-06-29 |
| IL179293A0 (en) | 2007-03-08 |
| BRPI0510136A (en) | 2007-10-02 |
| ECSP067028A (en) | 2006-12-29 |
| SV2006002123A (en) | 2006-02-15 |
| PA8633601A1 (en) | 2006-07-03 |
| JP2007538026A (en) | 2007-12-27 |
| CA2564963A1 (en) | 2005-12-01 |
| MXPA06013469A (en) | 2007-01-23 |
| TW200613317A (en) | 2006-05-01 |
| NO20065885L (en) | 2006-12-19 |
| DE102004025986A1 (en) | 2005-12-15 |
| AU2005245568A1 (en) | 2005-12-01 |
| WO2005113575A1 (en) | 2005-12-01 |
| GT200500122A (en) | 2006-01-24 |
| EP1747229A1 (en) | 2007-01-31 |
| ZA200610769B (en) | 2008-08-27 |
| CR8785A (en) | 2007-02-05 |
| AR049547A1 (en) | 2006-08-16 |
| CN1993375A (en) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |