PE20040797A1 - Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacion - Google Patents
Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacionInfo
- Publication number
- PE20040797A1 PE20040797A1 PE2003001178A PE2003001178A PE20040797A1 PE 20040797 A1 PE20040797 A1 PE 20040797A1 PE 2003001178 A PE2003001178 A PE 2003001178A PE 2003001178 A PE2003001178 A PE 2003001178A PE 20040797 A1 PE20040797 A1 PE 20040797A1
- Authority
- PE
- Peru
- Prior art keywords
- growth hormone
- human growth
- sticked
- preparation
- terminal
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 4
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 4
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 4
- 239000002202 Polyethylene glycol Substances 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UN CONJUGADO DE HORMONA DE CRECIMIENTO HUMANA-PEG DE FORMULAS I o II, EN LA QUE n Y m SON, INDEPENDIENTEMENTE ENTRE SI, UN NUMERO ENTERO ENTRE 1 A 10; R ES UNA HORMONA DE CRECIMIENTO HUMANA u HORMONA DE CRECIMIENTO HUMANA METIONILO; EN DONDE DICHA HORMONA DE CRECIMIENTO HUMANA COMPRENDE UNA SECUENCIA AMINOACIDICA DE SEC Nº ID 1 Y QUE SE CONJUGA CON EL POLIETILENGLICOL (PEG) A TRAVES DE UNA FENILALANINA AMINOTERMINAL Y EN LA QUE CADA PEG TIENE UN PESO APROXIMADO DE 20 Kda. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE DICHO CONJUGADO Y AL MENOS UN VEHICULO FARMACEUTICAMENTE ACEPTABLE Y QUE ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS DE CRECIMIENTO O DESARROLLO DEBIDO A UNA DEFICIENCIA DE HORMONA DE CRECIMIENTO (DHC), SINDROME DE TURNER, INSUFICIENCIA CRONICA RENAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42782302P | 2002-11-20 | 2002-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040797A1 true PE20040797A1 (es) | 2004-12-10 |
Family
ID=32825103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003001178A PE20040797A1 (es) | 2002-11-20 | 2003-11-20 | Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacion |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040127417A1 (es) |
AR (1) | AR042103A1 (es) |
GT (1) | GT200300250A (es) |
NL (3) | NL1024831C2 (es) |
PA (1) | PA8588901A1 (es) |
PE (1) | PE20040797A1 (es) |
SV (1) | SV2004001674A (es) |
TW (1) | TWI281864B (es) |
UY (1) | UY28085A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
BR0314172A (pt) | 2002-09-09 | 2005-07-26 | Nektar Therapeutics Al Corp | Polìmero solúvel em água, composição, forma de hidrato ou acetal, composto,composição, usos do composto e do conjugado, e, processo para preparar o conjugado |
CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
WO2004060300A2 (en) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
BR0317742A (pt) * | 2002-12-26 | 2005-11-22 | Mountain View Pharmaceuticals | Conjugados poliméricos de interferon-beta com potência biológica aumentada |
US20070105770A1 (en) * | 2004-01-21 | 2007-05-10 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
BRPI0507436A (pt) * | 2004-02-09 | 2007-07-03 | Pharmacia Corp | conjugados antagonistas de receptor do hormÈnio do crescimento humano quimicamente modificados |
US20080182783A1 (en) * | 2004-10-18 | 2008-07-31 | Novo Nordisk A/S | Growth Hormone Conjugates |
WO2006042847A2 (en) * | 2004-10-18 | 2006-04-27 | Novo Nordisk A/S | Method for the preparation of oxime, thiazolidine, dithiane, dithiolane or hydrazone linked analogues of growth hormone |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
EP1861125A2 (en) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Conjugates of an hgh moiety and peg derivatives |
AU2006286486A1 (en) * | 2005-08-30 | 2007-03-08 | Novo Nordisk Health Care Ag | Liquid formulations of pegylated growth hormone |
WO2007097934A2 (en) * | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Methods and compositions for using erythrocytes as carriers for delivery of drugs |
EP2040757A2 (en) * | 2006-07-07 | 2009-04-01 | Novo Nordisk Health Care AG | New protein conjugates and methods for their preparation |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
EP2157432A1 (en) * | 2008-08-15 | 2010-02-24 | Qiagen GmbH | Method for analysing a complex sample by mass spectrometry |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
EP3355384A1 (en) * | 2017-01-31 | 2018-08-01 | Universite De Liege | Flexible thin-films for battery electrodes |
CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US5618697A (en) * | 1982-12-10 | 1997-04-08 | Novo Nordisk A/S | Process for preparing a desired protein |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5342940A (en) * | 1989-05-27 | 1994-08-30 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, process for preparing the same |
JP3051145B2 (ja) * | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
DE122006000003I1 (de) * | 1995-09-21 | 2006-05-04 | Genentech Inc | Varianten des Menschlichen Wachstumshormons |
JP2002534119A (ja) * | 1999-01-14 | 2002-10-15 | ボルダー バイオテクノロジー, インコーポレイテッド | 自由システイン残基を有するタンパク質の生産方法 |
SE9904502D0 (sv) * | 1999-12-09 | 1999-12-09 | Pharmacia & Upjohn Ab | Production of peptides |
-
2003
- 2003-11-19 PA PA20038588901A patent/PA8588901A1/es unknown
- 2003-11-19 TW TW092132405A patent/TWI281864B/zh not_active IP Right Cessation
- 2003-11-20 GT GT200300250A patent/GT200300250A/es unknown
- 2003-11-20 NL NL1024831A patent/NL1024831C2/nl not_active IP Right Cessation
- 2003-11-20 AR ARP030104295A patent/AR042103A1/es unknown
- 2003-11-20 SV SV2003001674A patent/SV2004001674A/es not_active Application Discontinuation
- 2003-11-20 UY UY28085A patent/UY28085A1/es not_active Application Discontinuation
- 2003-11-20 US US10/718,340 patent/US20040127417A1/en not_active Abandoned
- 2003-11-20 PE PE2003001178A patent/PE20040797A1/es not_active Application Discontinuation
-
2005
- 2005-04-21 NL NL1028837A patent/NL1028837C2/nl not_active IP Right Cessation
-
2006
- 2006-08-07 NL NL1032282A patent/NL1032282C2/nl not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PA8588901A1 (es) | 2005-02-04 |
TW200418878A (en) | 2004-10-01 |
NL1028837A1 (nl) | 2005-08-30 |
US20040127417A1 (en) | 2004-07-01 |
NL1028837C2 (nl) | 2006-08-14 |
GT200300250A (es) | 2004-08-18 |
UY28085A1 (es) | 2004-07-30 |
SV2004001674A (es) | 2004-05-17 |
NL1032282C2 (nl) | 2007-03-09 |
AR042103A1 (es) | 2005-06-08 |
TWI281864B (en) | 2007-06-01 |
NL1024831A1 (nl) | 2004-05-26 |
NL1032282A1 (nl) | 2006-11-07 |
NL1024831C2 (nl) | 2005-04-28 |
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