PE20040671A1 - Derivados de la 4-hidroximetil-1-aril-ciclohexilamina - Google Patents

Derivados de la 4-hidroximetil-1-aril-ciclohexilamina

Info

Publication number
PE20040671A1
PE20040671A1 PE2003001133A PE2003001133A PE20040671A1 PE 20040671 A1 PE20040671 A1 PE 20040671A1 PE 2003001133 A PE2003001133 A PE 2003001133A PE 2003001133 A PE2003001133 A PE 2003001133A PE 20040671 A1 PE20040671 A1 PE 20040671A1
Authority
PE
Peru
Prior art keywords
aryl
cycloalkyl
heteroaryl
substituted
branched
Prior art date
Application number
PE2003001133A
Other languages
English (en)
Inventor
Bernd Sundermann
Hans Schick
Claudia Hinze
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10252872A external-priority patent/DE10252872A1/de
Priority claimed from DE10253323A external-priority patent/DE10253323A1/de
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20040671A1 publication Critical patent/PE20040671A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE 4-HIDROXIMETIL-1-ARIL-CICLOHEXILAMINA DE FORMULA I, EN DONDE R1 Y R2 SON H, ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS, Y SUSTITUIDOS UNO O MAS VECES, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS O ARILO, CICLOALQUILO(C3-C8) O HETEROARILO OPCIONALMENTE SUSTITUIDO, ENLAZADO A TRAVES DE ALQUILO(C1-C3); O R1 Y R2 FORMAN JUNTOS UN ANILLO Y REPRESENTAN CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 O (CH2)3-6); R3 ES ALQUILO(C1-C8) O CICLOALQUILO(C3-C8) OPCIONALMENTE SATURADOS, RAMIFICADOS, Y UNA O MAS VECES SUSTITUIDOS, ARILO O HETEROARILO, OPCIONALMENTE SUSTITUIDOS, ARILO, CICLOALQUILO(C3-C8) O HETEROARILO SUSTITUIDOS O NO Y ENLAZADOS A TRAVES DE UN GRUPO ALQUILO(C1-C4) OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS; R5 ES CICLOALQUILO(C3-C8), ARILO O HETEROARILO SUSTITUIDOS O NO, POR -CH2R12, -CH2CH2R12, -CH2CH2CH2R12. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE (4-BENCILOXIMETIL-1-FENILCICLOHEXIL)-DIMETILAMINA, CLORHIDRATO DE [4-(4-FLUOROBENCIL-OXIMETIL)-1-FENILCICLOHEXIL]-DIMETILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS Y FORMULACIONES FARMACEUTICAS QUE LOS CONTENGAN. ESTOS COMPUESTOS TIENE INFLUENCIA SOBRE EL SISTEMA NOCICEPTINA /RECEPTOR ORL1 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, EN ESPECIAL DOLOR AGUDO, VISCERAL, NEUROPATICO O CRONICO
PE2003001133A 2002-11-12 2003-11-10 Derivados de la 4-hidroximetil-1-aril-ciclohexilamina PE20040671A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10252872A DE10252872A1 (de) 2002-11-12 2002-11-12 4-Hydroxymethyl-1-Aryl-Cyclohexylamin-Derivate
DE10253323A DE10253323A1 (de) 2002-11-14 2002-11-14 4-Oxymethyl-1-Aryl-Cyclohexylamin-Derivate

Publications (1)

Publication Number Publication Date
PE20040671A1 true PE20040671A1 (es) 2004-09-25

Family

ID=32313558

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001133A PE20040671A1 (es) 2002-11-12 2003-11-10 Derivados de la 4-hidroximetil-1-aril-ciclohexilamina

Country Status (9)

Country Link
US (1) US7232847B2 (es)
EP (1) EP1560807B1 (es)
AR (1) AR041933A1 (es)
AT (1) ATE457299T1 (es)
AU (1) AU2003296564A1 (es)
DE (1) DE50312412D1 (es)
ES (1) ES2340766T3 (es)
PE (1) PE20040671A1 (es)
WO (1) WO2004043902A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
CN104840416A (zh) * 2005-09-28 2015-08-19 奥里斯医学股份有限公司 治疗内耳疾病的药用组合物
AU2005337107B2 (en) * 2005-09-28 2012-05-24 Auris Medical Ag Pharmaceutical compositions for the treatment of inner ear disorders
US20090215725A1 (en) * 2008-02-26 2009-08-27 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
TWI466866B (zh) 2008-03-27 2015-01-01 被取代之環己基二胺
BRPI0910607A2 (pt) 2008-03-27 2015-09-22 Gruenenthal Gmbh derivados do ciclohexano espirocíclicos substituídos
WO2009118163A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
US20090247530A1 (en) 2008-03-27 2009-10-01 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
RU2514192C2 (ru) 2008-03-27 2014-04-27 Грюненталь Гмбх Гидроксиметилциклогексиламины
WO2009118169A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Spiro(5.5)undecan derivate
WO2013087090A1 (en) 2011-12-12 2013-06-20 Auris Medical Ag Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US5968737A (en) * 1996-11-12 1999-10-19 The University Of Mississippi Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
EA200000683A1 (ru) * 1998-01-19 2000-12-25 Пфайзер Инк. Производные ряда 4-(2-кето-1-бензимидазолинил)пиперидина в качестве агонистов orl1-рецептора
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate

Also Published As

Publication number Publication date
EP1560807A1 (de) 2005-08-10
US20050267218A1 (en) 2005-12-01
DE50312412D1 (en) 2010-03-25
AU2003296564A1 (en) 2004-06-03
ATE457299T1 (de) 2010-02-15
ES2340766T3 (es) 2010-06-09
EP1560807B1 (de) 2010-02-10
WO2004043902A1 (de) 2004-05-27
US7232847B2 (en) 2007-06-19
AR041933A1 (es) 2005-06-01

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