PE20031044A1 - Derivados de fenilimidazolidina y proceso de preparacion - Google Patents

Derivados de fenilimidazolidina y proceso de preparacion

Info

Publication number
PE20031044A1
PE20031044A1 PE2003000383A PE2003000383A PE20031044A1 PE 20031044 A1 PE20031044 A1 PE 20031044A1 PE 2003000383 A PE2003000383 A PE 2003000383A PE 2003000383 A PE2003000383 A PE 2003000383A PE 20031044 A1 PE20031044 A1 PE 20031044A1
Authority
PE
Peru
Prior art keywords
compound
refers
phenylimidazolidine
derivatives
preparation process
Prior art date
Application number
PE2003000383A
Other languages
English (en)
Inventor
Karl Theodor Kraemer
Karl-Heinz Nietsch
Rainer Pooth
Uwe Muenster
Wolfgang Mehnert
Monika Schaefer-Korting
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20031044A1 publication Critical patent/PE20031044A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) Y/O UNA FORMA ESTEREOISOMERA DE (I) Y/O UNA SAL FISIOLOGICAMENTE TOLERADA DE (I), EN LA CUAL R1 ES ALQUILO C5-C17 O ALQUENILO C5-C17. SE REFIERE TAMBIEN A UNA PREPARACION FARMACEUTICA QUE COMPRENDE AL MENOS UNA NANOPARTICULA LIPIDA Y AL MENOS UN COMPUESTO DE LA FORMULA (I). SE REFIERE TAMBIEN A UN PROCESO PARA PREPARAR EL COMPUESTO (I). DICHO COMPUESTO SE UTILIZA EN EL TRATAMIENTO DE LA ALOPECIA ANDROGENICA, HIRSUTISMO, SEBORREA, ACNE, ENTRE OTROS
PE2003000383A 2002-04-27 2003-04-15 Derivados de fenilimidazolidina y proceso de preparacion PE20031044A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10218963A DE10218963A1 (de) 2002-04-27 2002-04-27 Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen

Publications (1)

Publication Number Publication Date
PE20031044A1 true PE20031044A1 (es) 2004-02-09

Family

ID=29264882

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000383A PE20031044A1 (es) 2002-04-27 2003-04-15 Derivados de fenilimidazolidina y proceso de preparacion

Country Status (17)

Country Link
EP (1) EP1501806B1 (es)
JP (1) JP4633459B2 (es)
AR (1) AR039662A1 (es)
AT (1) ATE321756T1 (es)
AU (1) AU2003229658B2 (es)
BR (1) BRPI0309579B8 (es)
CA (1) CA2483786C (es)
DE (2) DE10218963A1 (es)
DK (1) DK1501806T3 (es)
ES (1) ES2256735T3 (es)
IL (1) IL164814A0 (es)
MX (1) MXPA04009571A (es)
MY (1) MY129714A (es)
PE (1) PE20031044A1 (es)
PT (1) PT1501806E (es)
TW (1) TWI285637B (es)
WO (1) WO2003093243A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271188B2 (en) 2003-06-12 2007-09-18 Chugai Seikayu Kabushiki Kaisha Imidazolidine derivatives
AU2004305075A1 (en) 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
CN100475781C (zh) * 2004-02-13 2009-04-08 沃尼尔·朗伯有限责任公司 雄激素受体调节剂
CA2554696C (en) * 2004-02-13 2009-06-30 Warner-Lambert Company Llc Androgen receptor modulators
NZ550102A (en) 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7507860B2 (en) 2004-04-13 2009-03-24 Pfizer Inc. Androgen modulators
JP2007533726A (ja) 2004-04-22 2007-11-22 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲンモジュレーター
MXPA06015169A (es) * 2004-07-08 2007-08-21 Warner Lambert Co Moduladores de androgenos.
KR20070049238A (ko) * 2004-08-31 2007-05-10 워너-램버트 캄파니 엘엘씨 안드로겐 조절제
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
HUE027894T2 (en) 2006-03-27 2016-11-28 Univ California An androgen receptor modulator for the treatment of prostate cancer and androgen receptor related diseases
SG10201408699TA (en) 2006-03-29 2015-02-27 Univ California Diarylthiohydantoin compounds
EP2620432A3 (en) 2007-10-26 2013-12-18 The Regents Of the University of California Diarylhydantoin compounds
EP3124481B1 (en) 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
RU2503446C2 (ru) * 2012-02-07 2014-01-10 Алексей Валентинович Одинцов Средство для роста волос (варианты) и способ лечения облысения
SG10201912719TA (en) 2012-09-26 2020-02-27 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
PL222631B1 (pl) * 2012-11-14 2016-08-31 Gdański Univ Medyczny Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję
US20150313829A1 (en) * 2012-11-26 2015-11-05 Roberto Queiroga Lautner Topical formulations for the prevention and treatment of alopecia and inhibition of hair growth
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
CN103965112A (zh) * 2014-05-13 2014-08-06 上海孚一生物科技有限公司 一种具有抗雄激素活性的化合物、制备方法及其应用
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
AU2018351714A1 (en) 2017-10-16 2020-04-30 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2716110B1 (fr) * 1994-02-16 1996-04-05 Roussel Uclaf Compositions cosmétiques ou pharmaceutiques comprenant des liposomes.
AU726572B2 (en) * 1994-02-16 2000-11-09 Aventis Pharma S.A. Cosmetics or pharmaceutical compositions consisting of liposomes

Also Published As

Publication number Publication date
IL164814A0 (en) 2005-12-18
CA2483786C (en) 2011-08-09
BR0309579B1 (pt) 2014-10-07
AU2003229658B2 (en) 2010-07-29
TW200407312A (en) 2004-05-16
WO2003093243A1 (de) 2003-11-13
AR039662A1 (es) 2005-03-02
TWI285637B (en) 2007-08-21
DE10218963A1 (de) 2003-11-20
MY129714A (en) 2007-04-30
BR0309579A (pt) 2005-03-01
EP1501806B1 (de) 2006-03-29
DK1501806T3 (da) 2006-05-29
AU2003229658A1 (en) 2003-11-17
ATE321756T1 (de) 2006-04-15
ES2256735T3 (es) 2006-07-16
PT1501806E (pt) 2006-06-30
EP1501806A1 (de) 2005-02-02
BRPI0309579B8 (pt) 2021-05-25
JP2005535584A (ja) 2005-11-24
JP4633459B2 (ja) 2011-02-16
MXPA04009571A (es) 2005-01-11
DE50302818D1 (de) 2006-05-18
CA2483786A1 (en) 2003-11-13

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