PE20030361A1 - Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas - Google Patents
Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activasInfo
- Publication number
- PE20030361A1 PE20030361A1 PE2002000742A PE2002000742A PE20030361A1 PE 20030361 A1 PE20030361 A1 PE 20030361A1 PE 2002000742 A PE2002000742 A PE 2002000742A PE 2002000742 A PE2002000742 A PE 2002000742A PE 20030361 A1 PE20030361 A1 PE 20030361A1
- Authority
- PE
- Peru
- Prior art keywords
- agents
- butyl
- alkyl
- methyl
- inhibiting agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
SE REFIERE FORMULACIONES EN COMBINACION DE DERIVADOS DE 1,4-BENZOTIEPINA-1,1-DIOXIDO DE FORMULA I DONDE R1 ES METILO, ETILO PROPILO, BUTILO; R2 ES H, OH, NH2, NH-ALQUILO(C1-C6); R3 ES UN RADICAL AZUCAR, UNA RADICAL AMINOACIDO, UN DIAMINOACIDO, CON GRUPOS PROTECTORES DE AZUCARES Y AMINOACIDOS; R4 ES METILO, ETILO, PROPILO, BUTILO; R5 ES METILO, ETILO, PROPILO, BUTILO; Z ES -(C=O)n-ALQUILO C0-C16, -(C=O)n-ALQUIL C0-C16-NH-, ENTRE OTROS; n ES 0-1; m ES 0-1. SE REFIERE TAMBIEN A UNA MEZCLA DE SUSTANCIAS QUE COMPRENDE LA SUSTANCIA ACTIVA JUNTO A AGENTES ANTIDIABETICOS , SUSTANCIAS ACTIVAS HIPOGLUCEMICAS, AGENTES INHIBIDORES DE HMG-CoA-REDUCTASA, AGENTES INHIBIDORES DE LA RESORCION DEL COLESTEROL (EZETIMIBE, TIQUESIDE, PAMAQUESIDE), AGENTES INHIBIDORES DE MTP, ANTIOXIDANTES, INHIBIDORES DE SINTETASA ESCUALENO. LA FORMULACION ES UTIL PARA EL TRATAMIENTO DE HIPERLIPIDEMIA, TRASTORNOS DEL METABOLISMO DE LIPIDOS, ARTERIOESCLEROSIS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10140169A DE10140169A1 (de) | 2001-08-22 | 2001-08-22 | Kombinationspräparate von 1,4-Benzothiepin-1,1-dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung |
| DE10142456A DE10142456A1 (de) | 2001-08-31 | 2001-08-31 | Kombinationspräparate von 1,4-Benzothiepin-1,1dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030361A1 true PE20030361A1 (es) | 2003-05-27 |
Family
ID=26009944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000742A PE20030361A1 (es) | 2001-08-22 | 2002-08-16 | Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20030158119A1 (es) |
| EP (1) | EP1425018B1 (es) |
| JP (1) | JP2005501861A (es) |
| KR (1) | KR20040032937A (es) |
| CN (1) | CN1655792A (es) |
| AR (1) | AR035285A1 (es) |
| AT (1) | ATE411802T1 (es) |
| AU (1) | AU2002333373B2 (es) |
| BR (1) | BR0212031A (es) |
| CA (1) | CA2457976A1 (es) |
| CO (1) | CO5560550A2 (es) |
| DE (1) | DE50212937D1 (es) |
| HN (1) | HN2002000235A (es) |
| HR (1) | HRP20040171A2 (es) |
| HU (1) | HUP0401318A3 (es) |
| IL (1) | IL160474A0 (es) |
| MA (1) | MA26317A1 (es) |
| MX (1) | MXPA04001328A (es) |
| NO (1) | NO20040702L (es) |
| NZ (1) | NZ531293A (es) |
| OA (1) | OA12654A (es) |
| PA (1) | PA8553201A1 (es) |
| PE (1) | PE20030361A1 (es) |
| PL (1) | PL366851A1 (es) |
| RS (1) | RS11104A (es) |
| RU (1) | RU2297222C2 (es) |
| TN (1) | TNSN04034A1 (es) |
| UY (1) | UY27419A1 (es) |
| WO (1) | WO2003018024A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006053635B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| WO2008058631A1 (de) | 2006-11-14 | 2008-05-22 | Sanofi-Aventis Deutschland Gmbh | Neue 1,4-benzothiepin-1,1-dioxidderivate mit verbesserten eigenschaften, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| DE102006053637B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE102006053636B4 (de) * | 2006-11-14 | 2008-09-18 | Sanofi-Aventis Deutschland Gmbh | Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung |
| US9339480B2 (en) | 2008-11-26 | 2016-05-17 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| WO2011150286A2 (en) | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals,Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US9339543B2 (en) | 2011-10-12 | 2016-05-17 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions that inhibit disproportionation |
| CN104023727B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| CN104023718B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| AU2014228850A1 (en) | 2013-03-15 | 2015-10-29 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| KR20150079373A (ko) | 2013-12-30 | 2015-07-08 | 한미약품 주식회사 | 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제 |
| JP2022520121A (ja) | 2019-02-12 | 2022-03-28 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁うっ滞を治療する方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| BR9707003A (pt) | 1996-01-17 | 1999-07-20 | Novo Nordisk As | Composto processos para preparar o mesmo para tratamento ou de prevenção de doenças do sistema endócrino e para a manufatura de medicamento coposção farmacêutica e utilização de um composto |
| WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| EP1826216A1 (en) | 1996-08-30 | 2007-08-29 | Novo Nordisk A/S | Glp-1 derivatives |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| CA2294830A1 (en) | 1997-07-16 | 1999-01-28 | John Bondo Hansen | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
| CO4970713A1 (es) | 1997-09-19 | 2000-11-07 | Sanofi Synthelabo | Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen |
| DE19825804C2 (de) * | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| EP1140187B1 (en) * | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of an ibat inhibitor and a mtp inhibitor for cardiovascular indications |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| AU3956900A (en) | 1999-04-16 | 2000-11-02 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
| JP2002543200A (ja) | 1999-04-30 | 2002-12-17 | ニューロゲン コーポレイション | ９Ｈ−ピリミド［４、５−ｂ］インドール誘導体：ＣＲＦ１特異性リガンド |
| GB9911863D0 (en) | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| US6399640B1 (en) | 1999-06-18 | 2002-06-04 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| WO2001009111A1 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists |
| CA2383781A1 (en) | 1999-09-01 | 2001-03-08 | Aventis Pharma Deutschland Gmbh | Sulfonyl carboxamide derivatives, method for their production and their use as medicaments |
| CN1430603A (zh) | 2000-04-28 | 2003-07-16 | 旭化成株式会社 | 新型双环化合物 |
| ATE310728T1 (de) | 2000-05-11 | 2005-12-15 | Bristol Myers Squibb Co | Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga |
| AU6497701A (en) | 2000-05-30 | 2001-12-11 | Merck & Co Inc | Melanocortin receptor agonists |
| IL156552A0 (en) | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
-
2002
- 2002-08-09 PL PL02366851A patent/PL366851A1/xx not_active Application Discontinuation
- 2002-08-09 AU AU2002333373A patent/AU2002333373B2/en not_active Ceased
- 2002-08-09 NZ NZ531293A patent/NZ531293A/en not_active IP Right Cessation
- 2002-08-09 MX MXPA04001328A patent/MXPA04001328A/es active IP Right Grant
- 2002-08-09 WO PCT/EP2002/008908 patent/WO2003018024A1/de active IP Right Grant
- 2002-08-09 CA CA002457976A patent/CA2457976A1/en not_active Abandoned
- 2002-08-09 EP EP02796213A patent/EP1425018B1/de not_active Expired - Lifetime
- 2002-08-09 AT AT02796213T patent/ATE411802T1/de not_active IP Right Cessation
- 2002-08-09 IL IL16047402A patent/IL160474A0/xx unknown
- 2002-08-09 OA OA1200400057A patent/OA12654A/en unknown
- 2002-08-09 KR KR10-2004-7002440A patent/KR20040032937A/ko not_active Application Discontinuation
- 2002-08-09 RS YU11104A patent/RS11104A/sr unknown
- 2002-08-09 DE DE50212937T patent/DE50212937D1/de not_active Expired - Lifetime
- 2002-08-09 HU HU0401318A patent/HUP0401318A3/hu unknown
- 2002-08-09 CN CNA028163109A patent/CN1655792A/zh active Pending
- 2002-08-09 BR BR0212031-3A patent/BR0212031A/pt not_active Withdrawn
- 2002-08-09 RU RU2004108119/15A patent/RU2297222C2/ru not_active IP Right Cessation
- 2002-08-09 JP JP2003522542A patent/JP2005501861A/ja active Pending
- 2002-08-16 PE PE2002000742A patent/PE20030361A1/es not_active Application Discontinuation
- 2002-08-20 AR ARP020103125A patent/AR035285A1/es not_active Application Discontinuation
- 2002-08-20 PA PA20028553201A patent/PA8553201A1/es unknown
- 2002-08-20 UY UY27419A patent/UY27419A1/es unknown
- 2002-08-20 HN HN2002000235A patent/HN2002000235A/es unknown
- 2002-08-22 US US10/225,841 patent/US20030158119A1/en not_active Abandoned
-
2003
- 2003-11-03 US US10/699,967 patent/US7179792B2/en not_active Expired - Lifetime
-
2004
- 2004-02-11 MA MA27524A patent/MA26317A1/fr unknown
- 2004-02-18 NO NO20040702A patent/NO20040702L/no not_active Application Discontinuation
- 2004-02-19 CO CO04014418A patent/CO5560550A2/es not_active Application Discontinuation
- 2004-02-20 TN TNP2004000034A patent/TNSN04034A1/en unknown
- 2004-02-20 HR HR20040171A patent/HRP20040171A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0401318A2 (hu) | 2004-10-28 |
| EP1425018A1 (de) | 2004-06-09 |
| NO20040702L (no) | 2004-05-19 |
| US7179792B2 (en) | 2007-02-20 |
| RS11104A (en) | 2006-12-15 |
| PA8553201A1 (es) | 2004-08-31 |
| UY27419A1 (es) | 2003-04-30 |
| US20040097424A1 (en) | 2004-05-20 |
| ATE411802T1 (de) | 2008-11-15 |
| KR20040032937A (ko) | 2004-04-17 |
| BR0212031A (pt) | 2004-08-03 |
| CA2457976A1 (en) | 2003-03-06 |
| IL160474A0 (en) | 2004-07-25 |
| DE50212937D1 (de) | 2008-12-04 |
| HN2002000235A (es) | 2003-02-18 |
| AR035285A1 (es) | 2004-05-05 |
| AU2002333373B2 (en) | 2006-12-14 |
| US20030158119A1 (en) | 2003-08-21 |
| CN1655792A (zh) | 2005-08-17 |
| CO5560550A2 (es) | 2005-09-30 |
| NZ531293A (en) | 2005-08-26 |
| PL366851A1 (en) | 2005-02-07 |
| HUP0401318A3 (en) | 2008-03-28 |
| MA26317A1 (fr) | 2004-10-01 |
| HRP20040171A2 (en) | 2004-10-31 |
| EP1425018B1 (de) | 2008-10-22 |
| OA12654A (en) | 2006-06-15 |
| WO2003018024A1 (de) | 2003-03-06 |
| RU2297222C2 (ru) | 2007-04-20 |
| JP2005501861A (ja) | 2005-01-20 |
| TNSN04034A1 (en) | 2006-06-01 |
| MXPA04001328A (es) | 2004-05-05 |
| RU2004108119A (ru) | 2005-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |