PE20020792A1 - ANTAGONISTS OF EXCITING AMINO ACID RECEPTORS - Google Patents

ANTAGONISTS OF EXCITING AMINO ACID RECEPTORS

Info

Publication number
PE20020792A1
PE20020792A1 PE2002000003A PE2002000003A PE20020792A1 PE 20020792 A1 PE20020792 A1 PE 20020792A1 PE 2002000003 A PE2002000003 A PE 2002000003A PE 2002000003 A PE2002000003 A PE 2002000003A PE 20020792 A1 PE20020792 A1 PE 20020792A1
Authority
PE
Peru
Prior art keywords
alkyl
refers
acid
antagonists
amino acid
Prior art date
Application number
PE2002000003A
Other languages
Spanish (es)
Inventor
Michael Edward Letourneau
Khau Vien Van
Michael John Martinelli
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20020792A1 publication Critical patent/PE20020792A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A LA SAL DEL ACIDO D-(-)-MANDELICO O LA SAL DEL ACIDO 1,5-NAFTALENODISULFONICO DEL COMPUESTO DE ISOQUINOLINA DE FORMULA I O DEL COMPUESTO 3S,4Ar,6s,8Ar,6-(((2S)-2-(ACIDO CARBOXILICO)-4,4-DIFLUOROPIRROLIDINIL)METIL-1,2,3,4,4a,5,6,7,8,8a-DECAHIDROISOQUINOLIN-3-CARBOXILICO, TAMBIEN SE REFIERE A UN COMPUESTO DE ISOQUINOLINA DE FORMULA Ia; DONDE R1 Y R2 SON H, ALQUILO C1-C20, ALQUENILO C2-C6, ALQUIL C1-C6-ARILO; ALQUIL C1-C6-CICLOALQUILO C3-C10, ALQUIL C1-C6-N,N-DIALQUIL C1-C6-AMINA, ENTRE OTROS, UNO DE R1 Y R2 ES DIFERENTE DE H. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DEL SUBTIPO DE RECEPTOR Iglur5 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS Y ENFERMEDADES NEURODEGENERATIVAS COMO MIGRANA, DEFICITS CEREBRALES POSTERIORES A CIRUGIA DE BY PASS CARDIACO, INJERTO, APOPLEJIA, ISQUEMIA CEREBRAL, LESIONES DE LA MEDULA ESPINAL, HIPOXIA PERINATALUROLOGICOS Y ENFERMEDADES NEURODEGENERATIVAS COMO MIGRANAREFERS TO THE SALT OF THE ACID D - (-) - MANDELIC OR THE SALT OF THE 1,5-NAPHTHALENODISULPHONIC ACID OF THE ISOQUINOLINE COMPOUND OF THE FORMULA IO OF THE COMPOUND 3S, 4Ar, 6s, 8Ar, 6 - (((2S) -2 - (CARBOXYL ACID) -4,4-DIFLUOROPYRROLIDINYL) METHYL-1,2,3,4,4a, 5,6,7,8,8a-DECAHYDROISOQUINOLIN-3-CARBOXYL, ALSO REFERS TO AN ISOQUINOLINE COMPOUND OF FORMULA Ia; WHERE R1 AND R2 ARE H, C1-C20 ALKYL, C2-C6 ALKYL, C1-C6-ARYL ALKYL; C1-C6-CYCLOALKYL C3-C10 ALKYL, C1-C6-N ALKYL, N-C1-C6-DIALKYL AMINE, AMONG OTHERS, ONE OF R1 AND R2 IS DIFFERENT FROM H. ALSO REFERS TO A PROCEDURE FOR THE PREPARATION. THE COMPOUNDS ARE SELECTIVE ANTAGONISTS OF THE Iglur5 RECEPTOR SUBTYPE AND MAY BE USEFUL FOR THE TREATMENT OF NEU-LEGAL DISORDERS AND NEU-LEGAL DISORDERS. , BRAIN DEFICITS AFTER CARDIAC BY PASS SURGERY, GRAFTING, APOPLEJIA, CEREBRAL ISCHEMIA, SPINAL CORD INJURIES, PERINATALUROLOGICAL HYPOXIA AND NEURODEGENERATIVE DISEASES LIKE MIGRAN

PE2002000003A 2001-01-05 2002-01-04 ANTAGONISTS OF EXCITING AMINO ACID RECEPTORS PE20020792A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26001401P 2001-01-05 2001-01-05

Publications (1)

Publication Number Publication Date
PE20020792A1 true PE20020792A1 (en) 2002-09-06

Family

ID=22987455

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000003A PE20020792A1 (en) 2001-01-05 2002-01-04 ANTAGONISTS OF EXCITING AMINO ACID RECEPTORS

Country Status (23)

Country Link
EP (1) EP1351955A1 (en)
JP (1) JP2004520335A (en)
KR (1) KR20030066797A (en)
CN (1) CN1484642A (en)
AR (1) AR035679A1 (en)
BR (1) BR0116672A (en)
CA (1) CA2431545A1 (en)
CZ (1) CZ20031856A3 (en)
DZ (1) DZ3460A1 (en)
EA (1) EA200300770A1 (en)
EC (1) ECSP034682A (en)
HR (1) HRP20030544A2 (en)
HU (1) HUP0302528A2 (en)
IL (1) IL156138A0 (en)
MX (1) MXPA03005981A (en)
NO (1) NO20032973L (en)
NZ (1) NZ525821A (en)
PE (1) PE20020792A1 (en)
PL (1) PL361934A1 (en)
SK (1) SK8242003A3 (en)
TW (1) TW591023B (en)
WO (1) WO2002053561A1 (en)
ZA (1) ZA200304311B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
EP1053234A1 (en) * 1998-02-06 2000-11-22 Smithkline Beecham Plc Salts of paroxetine
GB9908175D0 (en) * 1999-04-09 1999-06-02 Lilly Co Eli Method of treating neurological disorders
TR200200066T2 (en) * 1999-07-06 2002-04-22 Eli Lilly And Company Selective iGluR5 receptor antagonists for the treatment of migraine

Also Published As

Publication number Publication date
JP2004520335A (en) 2004-07-08
IL156138A0 (en) 2003-12-23
KR20030066797A (en) 2003-08-09
TW591023B (en) 2004-06-11
CA2431545A1 (en) 2002-07-11
MXPA03005981A (en) 2003-09-10
EA200300770A1 (en) 2003-10-30
HRP20030544A2 (en) 2004-08-31
DZ3460A1 (en) 2002-07-11
PL361934A1 (en) 2004-10-18
EP1351955A1 (en) 2003-10-15
SK8242003A3 (en) 2004-01-08
NO20032973D0 (en) 2003-06-27
NZ525821A (en) 2004-07-30
CN1484642A (en) 2004-03-24
CZ20031856A3 (en) 2003-09-17
ECSP034682A (en) 2003-08-29
NO20032973L (en) 2003-06-27
BR0116672A (en) 2003-09-23
HUP0302528A2 (en) 2003-11-28
WO2002053561A1 (en) 2002-07-11
AR035679A1 (en) 2004-06-23
ZA200304311B (en) 2004-09-02

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