PE20001607A1 - 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS - Google Patents

4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS

Info

Publication number
PE20001607A1
PE20001607A1 PE2000000283A PE0002832000A PE20001607A1 PE 20001607 A1 PE20001607 A1 PE 20001607A1 PE 2000000283 A PE2000000283 A PE 2000000283A PE 0002832000 A PE0002832000 A PE 0002832000A PE 20001607 A1 PE20001607 A1 PE 20001607A1
Authority
PE
Peru
Prior art keywords
alkyl
het
dioxocin
ona
benzo
Prior art date
Application number
PE2000000283A
Other languages
English (en)
Spanish (es)
Inventor
Dennis Shinji Yamashita
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20001607A1 publication Critical patent/PE20001607A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PE2000000283A 1999-03-31 2000-03-31 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS PE20001607A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12725099P 1999-03-31 1999-03-31

Publications (1)

Publication Number Publication Date
PE20001607A1 true PE20001607A1 (es) 2001-03-07

Family

ID=22429122

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000283A PE20001607A1 (es) 1999-03-31 2000-03-31 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS

Country Status (8)

Country Link
EP (1) EP1173429A4 (fr)
JP (1) JP2002540199A (fr)
AU (1) AU4066900A (fr)
CO (1) CO5180536A1 (fr)
HK (1) HK1044758A1 (fr)
PE (1) PE20001607A1 (fr)
UY (1) UY26088A1 (fr)
WO (1) WO2000058296A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
AU1474801A (en) 1999-11-10 2001-06-06 Smithkline Beecham Corporation Protease inhibitors
US6583137B1 (en) 1999-11-10 2003-06-24 Smithkline Beecham Corporation Protease inhibitors
US6596715B1 (en) 1999-11-10 2003-07-22 Smithkline Beecham Corporation Protease inhibitors
US7071184B2 (en) 2000-03-21 2006-07-04 Smithkline Beecham Corporation Protease inhibitors
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
JP2004196696A (ja) * 2002-12-18 2004-07-15 Kyowa Hakko Kogyo Co Ltd 関節炎の予防剤または治療剤
CN113651795B (zh) * 2021-09-14 2022-09-02 江西开源香料有限公司 一种西瓜酮的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use

Also Published As

Publication number Publication date
AU4066900A (en) 2000-10-16
EP1173429A1 (fr) 2002-01-23
UY26088A1 (es) 2000-10-31
WO2000058296A1 (fr) 2000-10-05
CO5180536A1 (es) 2002-07-30
HK1044758A1 (zh) 2002-11-01
JP2002540199A (ja) 2002-11-26
EP1173429A4 (fr) 2002-06-19

Similar Documents

Publication Publication Date Title
MXPA03007249A (es) Compuestos triazolo como inhibidores de mmp.
DE60015927D1 (en) Phenylharnstoff und phenylthioharnstoffderivate
PE99198A1 (es) Inhibidores de proteasas
PE20001340A1 (es) 4-amino-azepan-3-ona como inhibidores de proteasas
PE20020509A1 (es) Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih
ATE326454T1 (de) Neue bernsteinsäure derivative als cysteine- protease-inhibitoren
DE69720773T2 (de) SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
BG106013A (en) New compounds and compositions as protease inhibitors
HUP0302962A2 (hu) Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
ES2164164T3 (es) Derivados de aminotetrazol utiles como inhibidores de oxido nitrico sintasa.
HUP0100669A2 (hu) Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
ES2111654T3 (es) Derivados de piperazina como antagonistas de 5-ht1a.
TR200003037T2 (tr) CGMP-Fosfodiesteraz önleyicileri olarak antiranilik asit türevleri.
PE20121157A1 (es) Compuestos heterociclicos como inhibidores de proteasas serinas
PE71599A1 (es) Inhibidores de proteasas
PE115999A1 (es) Secretagogos de la hormona del crecimiento
PE20001607A1 (es) 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS
ES2189941T3 (es) Derivados de nucleosidos aciclicos.
UY25211A1 (es) Inhibidores de isoquinolinilguanidina uroquinasa
UY24425A1 (es) Derivados de tiol con actividad inhibidora de metalopeptidasa.
PE20001241A1 (es) Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
PE20001486A1 (es) Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas
ATE497966T1 (de) Pseudoprolindipeptide
PE20001355A1 (es) 1,3-diamino-cetonas como inhibidores de proteasas
AR028606A1 (es) Nuevos inhibidores de mmp-2/mmp-9

Legal Events

Date Code Title Description
FD Application declared void or lapsed