PE20001388A1 - Composiciones de flint y usos de estas - Google Patents

Composiciones de flint y usos de estas

Info

Publication number
PE20001388A1
PE20001388A1 PE1999001217A PE00121799A PE20001388A1 PE 20001388 A1 PE20001388 A1 PE 20001388A1 PE 1999001217 A PE1999001217 A PE 1999001217A PE 00121799 A PE00121799 A PE 00121799A PE 20001388 A1 PE20001388 A1 PE 20001388A1
Authority
PE
Peru
Prior art keywords
flint
polypeptide
ile
val
gly
Prior art date
Application number
PE1999001217A
Other languages
English (en)
Inventor
Wen Su Eric
Robert Rosteck Junior Paul
Yeong Song Ho
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20001388A1 publication Critical patent/PE20001388A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE REFIERE A UN ACIDO NUCLEICO AISLADO CARACTERIZADO PORQUE CODIFICA UNA PROTEINA INHIBIDORA DEL LIGANDO FAS (FLINT) CON AL MENOS UNA SUSTITUCION TAL COMO: a)DE SERINA EN POSICION 10 POR THR, LEU, VAL, ILE, GLY O ALA; LEUCINA EN POSICION 16 POR ILE, VAL, ALA O GLY, ENTRE OTRAS SUSTITUCIONES. TAMBIEN SE REFIERE A UN VECTOR RECOMBINANTE, CELULA HUESPED, UN PROCEDIMIENTO PARA LA PRODUCCION DE UN POLIPEPTIDO FLINT RECOMBINANTE QUE COMPRENDE EL CULTIVO DE UNA CELULA HUESPED EN CONDICIONES QUE PERMITAN LA EXPRESION DEL POLIPEPTIDO EN CANTIDADES DETECTABLES O RECUPERABLES, UNA COMPOSICION QUE COMPRENDE EL POLIPEPTIDO AISLADO, UN ANTICUERPO O FRAGMENTO DE ESTE QUE SE UNE POR UN EPITOPO ESPECIFICO A UN POLIPEPTIDO FLINT
PE1999001217A 1998-12-09 1999-12-07 Composiciones de flint y usos de estas PE20001388A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11157598P 1998-12-09 1998-12-09
US11158098P 1998-12-09 1998-12-09
US11506999P 1999-01-07 1999-01-07

Publications (1)

Publication Number Publication Date
PE20001388A1 true PE20001388A1 (es) 2000-12-15

Family

ID=27381019

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001217A PE20001388A1 (es) 1998-12-09 1999-12-07 Composiciones de flint y usos de estas

Country Status (5)

Country Link
EP (1) EP1020521A1 (es)
AU (1) AU2164400A (es)
CO (1) CO5241360A1 (es)
PE (1) PE20001388A1 (es)
WO (1) WO2000034782A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
AU3739400A (en) * 1999-03-30 2000-10-16 Eli Lilly And Company Flint polypeptide analogs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712115A (en) * 1996-03-19 1998-01-27 Incyte Pharmaceuticals, Inc. Human cell death-associated protein
CA2277925A1 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US5885800A (en) * 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5

Also Published As

Publication number Publication date
WO2000034782A1 (en) 2000-06-15
CO5241360A1 (es) 2003-01-31
EP1020521A1 (en) 2000-07-19
AU2164400A (en) 2000-06-26

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