PA8799201A1 - Tigeciclina y metodos para preparar intermedios - Google Patents

Tigeciclina y metodos para preparar intermedios

Info

Publication number
PA8799201A1
PA8799201A1 PA20088799201A PA8799201A PA8799201A1 PA 8799201 A1 PA8799201 A1 PA 8799201A1 PA 20088799201 A PA20088799201 A PA 20088799201A PA 8799201 A PA8799201 A PA 8799201A PA 8799201 A1 PA8799201 A1 PA 8799201A1
Authority
PA
Panama
Prior art keywords
tigecicline
methods
reaction
compound
formula
Prior art date
Application number
PA20088799201A
Other languages
English (en)
Inventor
Michael Bernatchez
Warren Chew
Sylvain Daigneault
Ernest Palus
Mahmound Mirmehrabi
Luc Bouchard
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8799201A1 publication Critical patent/PA8799201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN MÉTODOS PARA PREPARAR Y PURIFICAR 9-NITROMINOCICLINA Y 9-AMINOCICLINA Y SALES DE ESTAS UTILIZADAS EN EL PROCESO DE ELABORACIÓN DE LA TIGECICLINA. EN UNA MODALIDAD,LA INVENCIÓN SE DIRIGE A UN MÉTODO PARA PREPARAR EL COMPUESTO DE LA FÓRMULA 1 O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE ESTE,QUE COMPRENDE:(a)HACER REACCIONAR ÁCIDO NÍTRICO CON EL COMPUESTO DE LA FÓRMULA 2, O UNA SAL DE ESTE,PARA PRODUCIR UNA MEZCLA DE REACCIÓN QUE COMPRENDE UN INTERMEDIO;Y (b) HACER REACCIONAR ADICIONALMENTE EL INTERMEDIO PARA FORMAR EL COMPUESTO DE LA FÓRMULA 1,EN DONDE EL INTERMEDIIO SE AÍSLA DE LA MEZCLA DE REACCIÓN,EL MÉTODO COMPRENDE ADICIONALMENTE BURBUJEAR CON UN GAS INERTE ANTES DE LA ETAPA(a).
PA20088799201A 2007-10-16 2008-10-16 Tigeciclina y metodos para preparar intermedios PA8799201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99932207P 2007-10-16 2007-10-16

Publications (1)

Publication Number Publication Date
PA8799201A1 true PA8799201A1 (es) 2009-05-15

Family

ID=40405036

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088799201A PA8799201A1 (es) 2007-10-16 2008-10-16 Tigeciclina y metodos para preparar intermedios

Country Status (6)

Country Link
US (1) US20090099376A1 (es)
CL (1) CL2008003059A1 (es)
PA (1) PA8799201A1 (es)
PE (1) PE20090833A1 (es)
TW (1) TW200922601A (es)
WO (1) WO2009052152A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika
CN102391148B (zh) * 2011-10-24 2014-01-08 江苏奥赛康药业股份有限公司 一种高纯度替加环素的合成方法
CN104515820B (zh) * 2013-10-06 2018-08-14 山东新时代药业有限公司 一种替加环素中间体的分析检测方法
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
PT108978B (pt) * 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
CN106831469B (zh) * 2016-12-21 2018-10-02 江苏豪森药业集团有限公司 一种制备替加环素中间体的方法
CN110922339B (zh) * 2019-12-04 2022-07-12 南京恒道医药科技股份有限公司 一种连续制备硝基米诺环素的绿色生产方法
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
US3219529A (en) * 1962-10-04 1965-11-23 American Cyanamid Co Stable tetracycline solutions
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
PE20070072A1 (es) * 2005-06-16 2007-02-25 Wyeth Corp Proceso de manufactura para tigeciclina como polvo reconstituible

Also Published As

Publication number Publication date
WO2009052152A2 (en) 2009-04-23
TW200922601A (en) 2009-06-01
WO2009052152A3 (en) 2009-08-06
US20090099376A1 (en) 2009-04-16
CL2008003059A1 (es) 2009-01-09
PE20090833A1 (es) 2009-06-26

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