PA8632601A1 - PIRIMIDINE DERIVATIVES TO TREAT ANOMAL CELL GROWTH - Google Patents

PIRIMIDINE DERIVATIVES TO TREAT ANOMAL CELL GROWTH

Info

Publication number
PA8632601A1
PA8632601A1 PA20058632601A PA8632601A PA8632601A1 PA 8632601 A1 PA8632601 A1 PA 8632601A1 PA 20058632601 A PA20058632601 A PA 20058632601A PA 8632601 A PA8632601 A PA 8632601A PA 8632601 A1 PA8632601 A1 PA 8632601A1
Authority
PA
Panama
Prior art keywords
cell growth
anomal
treat
derivatives
pirimidine derivatives
Prior art date
Application number
PA20058632601A
Other languages
Spanish (es)
Inventor
John Charles Kath
Michael Joseph Luzzio
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8632601(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8632601A1 publication Critical patent/PA8632601A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE FORMULA 1 EN LA QUE R1-R4 SON COMO SE DEFINE EN ESTA MEMORIA. DICHOS DERIVADOS DE PIRIMIDINA NUEVOS SON UTILES EN EL TRATAMIENTO DEL CRECIMIENTO CELULAR ANOMALO, TAL COMO EL CANCER, EN MAMIFEROS. ESTA INVENCION TAMBIEN SE REFIERE A UN METODO PARA USAR DICHOS COMPUESTOS EN EL TRATAMIENTO DEL CRECIMIENTO CELULAR ANOMALO EN MAMIFEROS, ESPECIALMENTE SERES HUMANOS, Y A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS.THE PRESENT INVENTION REFERS TO A FORMULA 1 COMPOUND IN WHICH R1-R4 ARE AS DEFINED IN THIS MEMORY. SUCH DERIVATIVES OF NEW PYRIMIDINE ARE USEFUL IN THE TREATMENT OF ANOMALUS CELL GROWTH, SUCH AS CANCER, IN MAMMALS. THIS INVENTION ALSO REFERS TO A METHOD FOR USING SUCH COMPOUNDS IN THE TREATMENT OF ANOMAL CELL GROWTH IN MAMMALS, ESPECIALLY HUMAN BEINGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS.

PA20058632601A 2004-05-14 2005-05-11 PIRIMIDINE DERIVATIVES TO TREAT ANOMAL CELL GROWTH PA8632601A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57131204P 2004-05-14 2004-05-14

Publications (1)

Publication Number Publication Date
PA8632601A1 true PA8632601A1 (en) 2006-06-02

Family

ID=34966230

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058632601A PA8632601A1 (en) 2004-05-14 2005-05-11 PIRIMIDINE DERIVATIVES TO TREAT ANOMAL CELL GROWTH

Country Status (27)

Country Link
EP (1) EP1751143A1 (en)
JP (1) JP4099212B2 (en)
KR (1) KR100886990B1 (en)
CN (2) CN102127058A (en)
AP (1) AP2241A (en)
AR (1) AR049097A1 (en)
AU (2) AU2005243397A1 (en)
BR (1) BRPI0511138A (en)
CA (1) CA2566707A1 (en)
CR (1) CR8749A (en)
EA (1) EA200601796A1 (en)
EC (1) ECSP066997A (en)
GE (1) GEP20104875B (en)
GT (1) GT200500113A (en)
IL (1) IL178828A0 (en)
MA (1) MA28583B1 (en)
MX (1) MXPA06011890A (en)
NL (2) NL1029045C2 (en)
NO (1) NO20064576L (en)
NZ (1) NZ550448A (en)
PA (1) PA8632601A1 (en)
PE (1) PE20060240A1 (en)
TN (1) TNSN06370A1 (en)
TW (1) TWI303635B (en)
UY (1) UY28894A1 (en)
WO (1) WO2005111023A1 (en)
ZA (1) ZA200608394B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566531A1 (en) * 2004-05-18 2005-12-15 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
US20070032514A1 (en) * 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors
AU2006327871A1 (en) * 2005-12-21 2007-06-28 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
MX2009011090A (en) * 2007-04-18 2009-11-02 Pfizer Prod Inc Sulfonyl amide derivatives for the treatment of abnormal cell growth.
KR20100049068A (en) * 2007-07-17 2010-05-11 리겔 파마슈티칼스, 인크. Cyclic amine substituted pyrimidinediamines as pkc inhibitors
WO2009071535A1 (en) * 2007-12-03 2009-06-11 Boehringer Ingelheim International Gmbh Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
CA2723961C (en) * 2008-05-21 2017-03-21 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US8410126B2 (en) * 2009-05-29 2013-04-02 Boehringer Ingelheim International Gmbh Pyrimidine inhibitors of PKTK2
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
JP5539518B2 (en) 2009-08-14 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
WO2014174745A1 (en) * 2013-04-26 2014-10-30 国立大学法人京都大学 Eg5 INHIBITOR
CN109608444B (en) * 2018-11-27 2022-02-11 中国药科大学 Isoindolinone-containing ERK inhibitor and preparation method and application thereof
CN111732548B (en) * 2020-06-11 2022-06-17 浙江大学 N2-carbamyl aromatic ring-2-aminopyrimidine derivatives and medical application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
AR042586A1 (en) 2001-02-15 2005-06-29 Sugen Inc 3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
WO2004056807A1 (en) * 2002-12-20 2004-07-08 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
NL1029045C2 (en) 2006-06-02
AP2241A (en) 2011-06-01
EA200601796A1 (en) 2007-04-27
NL1031845A1 (en) 2006-07-31
ECSP066997A (en) 2007-02-28
CA2566707A1 (en) 2005-11-24
PE20060240A1 (en) 2006-04-01
GT200500113A (en) 2006-01-10
UY28894A1 (en) 2005-12-30
JP2007537234A (en) 2007-12-20
KR100886990B1 (en) 2009-03-04
JP4099212B2 (en) 2008-06-11
GEP20104875B (en) 2010-01-11
NO20064576L (en) 2006-11-07
MXPA06011890A (en) 2006-12-14
ZA200608394B (en) 2008-05-28
AP2006003790A0 (en) 2006-10-31
NZ550448A (en) 2010-11-26
MA28583B1 (en) 2007-05-02
AR049097A1 (en) 2006-06-28
NL1029045A1 (en) 2005-11-15
CR8749A (en) 2006-12-05
TWI303635B (en) 2008-12-01
NL1031845C2 (en) 2006-11-23
CN1953974A (en) 2007-04-25
CN102127058A (en) 2011-07-20
TNSN06370A1 (en) 2008-02-22
AU2005243397A1 (en) 2005-11-24
KR20070012477A (en) 2007-01-25
WO2005111023A1 (en) 2005-11-24
BRPI0511138A (en) 2007-11-27
TW200539871A (en) 2005-12-16
AU2009238255A1 (en) 2009-12-03
EP1751143A1 (en) 2007-02-14
IL178828A0 (en) 2007-03-08

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