OA21455A - Liquid composition comprising a neonictonoid - Google Patents
Liquid composition comprising a neonictonoid Download PDFInfo
- Publication number
- OA21455A OA21455A OA1202300364 OA21455A OA 21455 A OA21455 A OA 21455A OA 1202300364 OA1202300364 OA 1202300364 OA 21455 A OA21455 A OA 21455A
- Authority
- OA
- OAPI
- Prior art keywords
- composition
- liquid
- surfactant
- amide solvent
- low polarity
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 218
- 239000007788 liquid Substances 0.000 title claims abstract description 164
- 239000012872 agrochemical composition Substances 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 33
- 230000008569 process Effects 0.000 claims abstract description 19
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims description 80
- 239000002917 insecticide Substances 0.000 claims description 75
- 150000001408 amides Chemical class 0.000 claims description 53
- 239000004094 surface-active agent Substances 0.000 claims description 50
- 239000005875 Acetamiprid Substances 0.000 claims description 38
- WCXDHFDTOYPNIE-RIYZIHGNSA-N (E)-acetamiprid Chemical compound N#C/N=C(\C)N(C)CC1=CC=C(Cl)N=C1 WCXDHFDTOYPNIE-RIYZIHGNSA-N 0.000 claims description 36
- -1 polyoxyethylene monooleate Polymers 0.000 claims description 27
- BNXZHVUCNYMNOS-UHFFFAOYSA-N 1-butylpyrrolidin-2-one Chemical compound CCCCN1CCCC1=O BNXZHVUCNYMNOS-UHFFFAOYSA-N 0.000 claims description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 19
- 239000004530 micro-emulsion Substances 0.000 claims description 18
- 239000000575 pesticide Substances 0.000 claims description 18
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 14
- 239000005907 Indoxacarb Substances 0.000 claims description 12
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 claims description 11
- GCKZANITAMOIAR-XWVCPFKXSA-N dsstox_cid_14566 Chemical compound [O-]C(=O)C1=CC=CC=C1.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H]([NH2+]C)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 GCKZANITAMOIAR-XWVCPFKXSA-N 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 9
- 229920000053 polysorbate 80 Polymers 0.000 claims description 9
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 7
- ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-Ethyl-2-pyrrolidinone Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000004546 suspension concentrate Substances 0.000 claims description 6
- 239000005660 Abamectin Substances 0.000 claims description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
- 239000005906 Imidacloprid Substances 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 claims description 4
- 229940056881 imidacloprid Drugs 0.000 claims description 4
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- KAATUXNTWXVJKI-NSHGMRRFSA-N (1R)-cis-(alphaS)-cypermethrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-NSHGMRRFSA-N 0.000 claims description 3
- PGOOBECODWQEAB-UHFFFAOYSA-N (E)-clothianidin Chemical compound [O-][N+](=O)\N=C(/NC)NCC1=CN=C(Cl)S1 PGOOBECODWQEAB-UHFFFAOYSA-N 0.000 claims description 3
- CFRPSFYHXJZSBI-DHZHZOJOSA-N (E)-nitenpyram Chemical compound [O-][N+](=O)/C=C(\NC)N(CC)CC1=CC=C(Cl)N=C1 CFRPSFYHXJZSBI-DHZHZOJOSA-N 0.000 claims description 3
- HOKKPVIRMVDYPB-UVTDQMKNSA-N (Z)-thiacloprid Chemical compound C1=NC(Cl)=CC=C1CN1C(=N/C#N)/SCC1 HOKKPVIRMVDYPB-UVTDQMKNSA-N 0.000 claims description 3
- QMEQBOSUJUOXMX-UHFFFAOYSA-N 2h-oxadiazine Chemical compound N1OC=CC=N1 QMEQBOSUJUOXMX-UHFFFAOYSA-N 0.000 claims description 3
- OEDUIFSDODUDRK-UHFFFAOYSA-N 5-phenyl-1h-pyrazole Chemical compound N1N=CC=C1C1=CC=CC=C1 OEDUIFSDODUDRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000005888 Clothianidin Substances 0.000 claims description 3
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical compound NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 claims description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000005940 Thiacloprid Substances 0.000 claims description 3
- 239000005941 Thiamethoxam Substances 0.000 claims description 3
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 claims description 3
- RJBIAAZJODIFHR-UHFFFAOYSA-N dihydroxy-imino-sulfanyl-$l^{5}-phosphane Chemical compound NP(O)(O)=S RJBIAAZJODIFHR-UHFFFAOYSA-N 0.000 claims description 3
- 229940079888 nitenpyram Drugs 0.000 claims description 3
- 239000002728 pyrethroid Substances 0.000 claims description 3
- NWWZPOKUUAIXIW-FLIBITNWSA-N thiamethoxam Chemical compound [O-][N+](=O)\N=C/1N(C)COCN\1CC1=CN=C(Cl)S1 NWWZPOKUUAIXIW-FLIBITNWSA-N 0.000 claims description 3
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 claims description 2
- LZTIMERBDGGAJD-SNAWJCMRSA-N (2e)-2-(nitromethylidene)-1,3-thiazinane Chemical compound [O-][N+](=O)\C=C1/NCCCS1 LZTIMERBDGGAJD-SNAWJCMRSA-N 0.000 claims description 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 2
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 claims description 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 2
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 2
- 239000005874 Bifenthrin Substances 0.000 claims description 2
- 239000005886 Chlorantraniliprole Substances 0.000 claims description 2
- 239000005889 Cyantraniliprole Substances 0.000 claims description 2
- 239000005946 Cypermethrin Substances 0.000 claims description 2
- 239000005892 Deltamethrin Substances 0.000 claims description 2
- 239000005894 Emamectin Substances 0.000 claims description 2
- FNELVJVBIYMIMC-UHFFFAOYSA-N Ethiprole Chemical compound N1=C(C#N)C(S(=O)CC)=C(N)N1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl FNELVJVBIYMIMC-UHFFFAOYSA-N 0.000 claims description 2
- 239000005899 Fipronil Substances 0.000 claims description 2
- 239000005903 Gamma-cyhalothrin Substances 0.000 claims description 2
- 239000005912 Lufenuron Substances 0.000 claims description 2
- 241000488581 Panonychus citri Species 0.000 claims description 2
- 241000691880 Planococcus citri Species 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 229950008167 abamectin Drugs 0.000 claims description 2
- YASYVMFAVPKPKE-UHFFFAOYSA-N acephate Chemical compound COP(=O)(SC)NC(C)=O YASYVMFAVPKPKE-UHFFFAOYSA-N 0.000 claims description 2
- OMFRMAHOUUJSGP-IRHGGOMRSA-N bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 claims description 2
- PSOVNZZNOMJUBI-UHFFFAOYSA-N chlorantraniliprole Chemical compound CNC(=O)C1=CC(Cl)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl PSOVNZZNOMJUBI-UHFFFAOYSA-N 0.000 claims description 2
- DVBUIBGJRQBEDP-UHFFFAOYSA-N cyantraniliprole Chemical compound CNC(=O)C1=CC(C#N)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl DVBUIBGJRQBEDP-UHFFFAOYSA-N 0.000 claims description 2
- 229960001591 cyfluthrin Drugs 0.000 claims description 2
- QQODLKZGRKWIFG-QSFXBCCZSA-N cyfluthrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-QSFXBCCZSA-N 0.000 claims description 2
- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 claims description 2
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 claims description 2
- 229960005424 cypermethrin Drugs 0.000 claims description 2
- 229960002483 decamethrin Drugs 0.000 claims description 2
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 claims description 2
- JZUKGAJJLZRHGL-UHFFFAOYSA-N diethoxy-[2-phenyl-5-(trifluoromethyl)pyrazol-3-yl]oxy-sulfanylidene-lambda5-phosphane Chemical compound CCOP(=S)(OCC)OC1=CC(C(F)(F)F)=NN1C1=CC=CC=C1 JZUKGAJJLZRHGL-UHFFFAOYSA-N 0.000 claims description 2
- 229940013764 fipronil Drugs 0.000 claims description 2
- ZXQYGBMAQZUVMI-GCMPRSNUSA-N gamma-cyhalothrin Chemical compound CC1(C)[C@@H](\C=C(/Cl)C(F)(F)F)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-GCMPRSNUSA-N 0.000 claims description 2
- 229960002418 ivermectin Drugs 0.000 claims description 2
- 239000005910 lambda-Cyhalothrin Substances 0.000 claims description 2
- 229960000521 lufenuron Drugs 0.000 claims description 2
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims description 2
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 claims description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 2
- 239000004533 oil dispersion Substances 0.000 claims description 2
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims description 2
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 2
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 claims description 2
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 claims description 2
- QHGVXILFMXYDRS-UHFFFAOYSA-N pyraclofos Chemical compound C1=C(OP(=O)(OCC)SCCC)C=NN1C1=CC=C(Cl)C=C1 QHGVXILFMXYDRS-UHFFFAOYSA-N 0.000 claims description 2
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 2
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 2
- 239000004548 suspo-emulsion Substances 0.000 claims description 2
- KNDVJPKNBVIKML-UHFFFAOYSA-N tetraniliprole Chemical compound CNC(=O)C1=CC(C#N)=CC(C)=C1NC(=O)C1=CC(CN2N=C(N=N2)C(F)(F)F)=NN1C1=NC=CC=C1Cl KNDVJPKNBVIKML-UHFFFAOYSA-N 0.000 claims description 2
- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 claims description 2
- ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims 1
- 229940117013 triethanolamine oleate Drugs 0.000 claims 1
- 229910001868 water Inorganic materials 0.000 description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 43
- 241000196324 Embryophyta Species 0.000 description 27
- 238000010790 dilution Methods 0.000 description 23
- 239000012895 dilution Substances 0.000 description 23
- 239000003921 oil Substances 0.000 description 20
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 18
- 238000009472 formulation Methods 0.000 description 17
- 239000003905 agrochemical Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 14
- 239000006071 cream Substances 0.000 description 13
- 239000013078 crystal Substances 0.000 description 12
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- 235000013399 edible fruits Nutrition 0.000 description 9
- 235000013311 vegetables Nutrition 0.000 description 9
- 229920001296 polysiloxane Polymers 0.000 description 8
- 239000007921 spray Substances 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 6
- 239000002518 antifoaming agent Substances 0.000 description 6
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 6
- 235000020971 citrus fruits Nutrition 0.000 description 6
- 239000006260 foam Substances 0.000 description 6
- 239000012669 liquid formulation Substances 0.000 description 6
- 238000011068 loading method Methods 0.000 description 6
- 230000002085 persistent effect Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 5
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 5
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 5
- 238000012430 stability testing Methods 0.000 description 5
- 241001465977 Coccoidea Species 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 4
- 241000344246 Tetranychus cinnabarinus Species 0.000 description 4
- 150000005215 alkyl ethers Chemical class 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 241000207199 Citrus Species 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 235000014571 nuts Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- QPUYECUOLPXSFR-UHFFFAOYSA-N 1-methylnaphthalene Chemical compound C1=CC=C2C(C)=CC=CC2=C1 QPUYECUOLPXSFR-UHFFFAOYSA-N 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 2
- QIMMUPPBPVKWKM-UHFFFAOYSA-N 2-methylnaphthalene Chemical compound C1=CC=CC2=CC(C)=CC=C21 QIMMUPPBPVKWKM-UHFFFAOYSA-N 0.000 description 2
- LAIUFBWHERIJIH-UHFFFAOYSA-N 3-Methylheptane Chemical compound CCCCC(C)CC LAIUFBWHERIJIH-UHFFFAOYSA-N 0.000 description 2
- 241000234282 Allium Species 0.000 description 2
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 2
- 240000002791 Brassica napus Species 0.000 description 2
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- 235000009854 Cucurbita moschata Nutrition 0.000 description 2
- 240000001980 Cucurbita pepo Species 0.000 description 2
- 229920005682 EO-PO block copolymer Polymers 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 2
- 244000078534 Vaccinium myrtillus Species 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 125000005910 alkyl carbonate group Chemical group 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- SJWFXCIHNDVPSH-UHFFFAOYSA-N octan-2-ol Chemical compound CCCCCCC(C)O SJWFXCIHNDVPSH-UHFFFAOYSA-N 0.000 description 2
- 125000005375 organosiloxane group Chemical group 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000010773 plant oil Substances 0.000 description 2
- 239000003880 polar aprotic solvent Substances 0.000 description 2
- KIWATKANDHUUOB-UHFFFAOYSA-N propan-2-yl 2-hydroxypropanoate Chemical compound CC(C)OC(=O)C(C)O KIWATKANDHUUOB-UHFFFAOYSA-N 0.000 description 2
- 239000000473 propyl gallate Substances 0.000 description 2
- 235000010388 propyl gallate Nutrition 0.000 description 2
- 229940075579 propyl gallate Drugs 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 2
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- KAATUXNTWXVJKI-GGPKGHCWSA-N (1R)-trans-(alphaS)-cypermethrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-GGPKGHCWSA-N 0.000 description 1
- FJDPATXIBIBRIM-QFMSAKRMSA-N (1R)-trans-cyphenothrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 FJDPATXIBIBRIM-QFMSAKRMSA-N 0.000 description 1
- BIIBYWQGRFWQKM-JVVROLKMSA-N (2S)-N-[4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-2-[[(E)-3-(2,4-dichlorophenyl)prop-2-enoyl]amino]-4,4-dimethylpentanamide Chemical group CC(C)(C)C[C@@H](C(NC(C[C@H](CCN1)C1=O)C(C(NC1CC1)=O)=O)=O)NC(/C=C/C(C=CC(Cl)=C1)=C1Cl)=O BIIBYWQGRFWQKM-JVVROLKMSA-N 0.000 description 1
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical group C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- OKIRBHVFJGXOIS-UHFFFAOYSA-N 1,2-di(propan-2-yl)benzene Chemical compound CC(C)C1=CC=CC=C1C(C)C OKIRBHVFJGXOIS-UHFFFAOYSA-N 0.000 description 1
- HVQHXBNMBZJPLK-UHFFFAOYSA-N 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound CC(=C)CNC1=C([S+]([O-])C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl HVQHXBNMBZJPLK-UHFFFAOYSA-N 0.000 description 1
- CUDYYMUUJHLCGZ-UHFFFAOYSA-N 2-(2-methoxypropoxy)propan-1-ol Chemical compound COC(C)COC(C)CO CUDYYMUUJHLCGZ-UHFFFAOYSA-N 0.000 description 1
- DWKNOLCXIFYNFV-HSZRJFAPSA-N 2-[[(2r)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-n,n,6-trimethylpyridine-4-carboxamide Chemical compound CN(C)C(=O)C1=CC(C)=NC(NC(=O)[C@@H]2N(C(=O)CC2)C2CCN(CC=3C=C(C)C(Cl)=CC=3)CC2)=C1 DWKNOLCXIFYNFV-HSZRJFAPSA-N 0.000 description 1
- TZYRSLHNPKPEFV-UHFFFAOYSA-N 2-ethyl-1-butanol Chemical compound CCC(CC)CO TZYRSLHNPKPEFV-UHFFFAOYSA-N 0.000 description 1
- RAMUASXTSSXCMB-UHFFFAOYSA-N 3-bromo-N-{2-bromo-4-chloro-6-[(1-cyclopropylethyl)carbamoyl]phenyl}-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide Chemical compound C1CC1C(C)NC(=O)C1=CC(Cl)=CC(Br)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl RAMUASXTSSXCMB-UHFFFAOYSA-N 0.000 description 1
- UXHQLGLGLZKHTC-CUNXSJBXSA-N 4-[(3s,3ar)-3-cyclopentyl-7-(4-hydroxypiperidine-1-carbonyl)-3,3a,4,5-tetrahydropyrazolo[3,4-f]quinolin-2-yl]-2-chlorobenzonitrile Chemical group C1CC(O)CCN1C(=O)C1=CC=C(C=2[C@@H]([C@H](C3CCCC3)N(N=2)C=2C=C(Cl)C(C#N)=CC=2)CC2)C2=N1 UXHQLGLGLZKHTC-CUNXSJBXSA-N 0.000 description 1
- HFGHRUCCKVYFKL-UHFFFAOYSA-N 4-ethoxy-2-piperazin-1-yl-7-pyridin-4-yl-5h-pyrimido[5,4-b]indole Chemical compound C1=C2NC=3C(OCC)=NC(N4CCNCC4)=NC=3C2=CC=C1C1=CC=NC=C1 HFGHRUCCKVYFKL-UHFFFAOYSA-N 0.000 description 1
- ONILAONOGQYBHW-UHFFFAOYSA-N 5-bromo-n-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-2-(3,5-dichloropyridin-2-yl)pyrazole-3-carboxamide Chemical compound CNC(=O)C1=CC(Cl)=CC(Cl)=C1NC(=O)C1=CC(Br)=NN1C1=NC=C(Cl)C=C1Cl ONILAONOGQYBHW-UHFFFAOYSA-N 0.000 description 1
- RSIWALKZYXPAGW-NSHDSACASA-N 6-(3-fluorophenyl)-3-methyl-7-[(1s)-1-(7h-purin-6-ylamino)ethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one Chemical compound C=1([C@@H](NC=2C=3N=CNC=3N=CN=2)C)N=C2SC=C(C)N2C(=O)C=1C1=CC=CC(F)=C1 RSIWALKZYXPAGW-NSHDSACASA-N 0.000 description 1
- SJVGFKBLUYAEOK-SFHVURJKSA-N 6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile Chemical group FC=1C=C(C=C(C=1)F)[C@@H]1CC=NN1C(=O)C1CCN(CC1)C1=CC(=NC=N1)C#N SJVGFKBLUYAEOK-SFHVURJKSA-N 0.000 description 1
- 244000283070 Abies balsamea Species 0.000 description 1
- 235000007173 Abies balsamea Nutrition 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 239000005877 Alpha-Cypermethrin Substances 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000226021 Anacardium occidentale Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 241000209763 Avena sativa Species 0.000 description 1
- 235000007558 Avena sp Nutrition 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 239000005884 Beta-Cyfluthrin Substances 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 244000178993 Brassica juncea Species 0.000 description 1
- 235000005855 Brassica juncea var. subintegrifolia Nutrition 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 244000304217 Brassica oleracea var. gongylodes Species 0.000 description 1
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 1
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000004160 Capsicum annuum Species 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000000131 Cercis siliquastrum Nutrition 0.000 description 1
- 240000000024 Cercis siliquastrum Species 0.000 description 1
- 235000021538 Chard Nutrition 0.000 description 1
- 235000007871 Chrysanthemum coronarium Nutrition 0.000 description 1
- 244000067456 Chrysanthemum coronarium Species 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- 241001584859 Colocasia <moth> Species 0.000 description 1
- 240000006766 Cornus mas Species 0.000 description 1
- 241000723382 Corylus Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 241000219130 Cucurbita pepo subsp. pepo Species 0.000 description 1
- 235000003954 Cucurbita pepo var melopepo Nutrition 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- 244000019459 Cynara cardunculus Species 0.000 description 1
- 235000019106 Cynara scolymus Nutrition 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- UDSFAEKRVUSQDD-UHFFFAOYSA-N Dimethyl adipate Chemical compound COC(=O)CCCCC(=O)OC UDSFAEKRVUSQDD-UHFFFAOYSA-N 0.000 description 1
- MUXOBHXGJLMRAB-UHFFFAOYSA-N Dimethyl succinate Chemical compound COC(=O)CCC(=O)OC MUXOBHXGJLMRAB-UHFFFAOYSA-N 0.000 description 1
- 240000008955 Dioscorea japonica Species 0.000 description 1
- 235000005251 Dioscorea japonica Nutrition 0.000 description 1
- 235000008597 Diospyros kaki Nutrition 0.000 description 1
- 244000236655 Diospyros kaki Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 241000758791 Juglandaceae Species 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 235000015512 Liquidambar formosana Nutrition 0.000 description 1
- 241000893545 Liquidambar formosana Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000208467 Macadamia Species 0.000 description 1
- 241000218922 Magnoliophyta Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- WPPOGHDFAVQKLN-UHFFFAOYSA-N N-Octyl-2-pyrrolidone Chemical compound CCCCCCCCN1CCCC1=O WPPOGHDFAVQKLN-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- GZMYLSJUNSCMTD-MOPGFXCFSA-N OC[C@@H](C)NC1=NC(=CC(=C1)C=1C=C(C=CC=1C)NC(=O)N1C[C@@H](CC1)CC(F)(F)F)N1CCOCC1 Chemical group OC[C@@H](C)NC1=NC(=CC(=C1)C=1C=C(C=CC=1C)NC(=O)N1C[C@@H](CC1)CC(F)(F)F)N1CCOCC1 GZMYLSJUNSCMTD-MOPGFXCFSA-N 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000488583 Panonychus ulmi Species 0.000 description 1
- 240000004370 Pastinaca sativa Species 0.000 description 1
- 235000017769 Pastinaca sativa subsp sativa Nutrition 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000004348 Perilla frutescens Nutrition 0.000 description 1
- 244000062780 Petroselinum sativum Species 0.000 description 1
- 235000010659 Phoenix dactylifera Nutrition 0.000 description 1
- 244000104275 Phoenix dactylifera Species 0.000 description 1
- 241000218657 Picea Species 0.000 description 1
- 235000005205 Pinus Nutrition 0.000 description 1
- 241000218602 Pinus <genus> Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 235000006485 Platanus occidentalis Nutrition 0.000 description 1
- 244000268528 Platanus occidentalis Species 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 241001290151 Prunus avium subsp. avium Species 0.000 description 1
- 235000011158 Prunus mume Nutrition 0.000 description 1
- 244000018795 Prunus mume Species 0.000 description 1
- 235000006029 Prunus persica var nucipersica Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 244000017714 Prunus persica var. nucipersica Species 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 235000017848 Rubus fruticosus Nutrition 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241000209056 Secale Species 0.000 description 1
- 235000007238 Secale cereale Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 240000003829 Sorghum propinquum Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 241001116500 Taxus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000030601 Thuja standishii Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 241000190021 Zelkova Species 0.000 description 1
- MCRWZBYTLVCCJJ-DKALBXGISA-N [(1s,3r)-3-[[(3s,4s)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[(1s,4s)-5-[6-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone Chemical group C([C@]1(N(C[C@]2([H])C1)C(=O)[C@@]1(C[C@@H](CC1)N[C@@H]1[C@@H](COCC1)OC)C(C)C)[H])N2C1=CC(C(F)(F)F)=NC=N1 MCRWZBYTLVCCJJ-DKALBXGISA-N 0.000 description 1
- QQODLKZGRKWIFG-RUTXASTPSA-N [(R)-cyano-(4-fluoro-3-phenoxyphenyl)methyl] (1S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(Cl)Cl)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-RUTXASTPSA-N 0.000 description 1
- KAATUXNTWXVJKI-QPIRBTGLSA-N [(s)-cyano-(3-phenoxyphenyl)methyl] 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-QPIRBTGLSA-N 0.000 description 1
- OOWCJRMYMAMSOH-UHFFFAOYSA-N [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound FC1=C(F)C(COC)=C(F)C(F)=C1COC(=O)C1C(C)(C)C1C=C(C)C OOWCJRMYMAMSOH-UHFFFAOYSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- ZUQAPLKKNAQJAU-UHFFFAOYSA-N acetylenediol Chemical class OC#CO ZUQAPLKKNAQJAU-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 239000012296 anti-solvent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000016520 artichoke thistle Nutrition 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 235000021029 blackberry Nutrition 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- ZWKKRUNHAVNSFW-UHFFFAOYSA-N dimethyl 2-methylpentanedioate Chemical compound COC(=O)CCC(C)C(=O)OC ZWKKRUNHAVNSFW-UHFFFAOYSA-N 0.000 description 1
- QYMFNZIUDRQRSA-UHFFFAOYSA-N dimethyl butanedioate;dimethyl hexanedioate;dimethyl pentanedioate Chemical compound COC(=O)CCC(=O)OC.COC(=O)CCCC(=O)OC.COC(=O)CCCCC(=O)OC QYMFNZIUDRQRSA-UHFFFAOYSA-N 0.000 description 1
- XTDYIOOONNVFMA-UHFFFAOYSA-N dimethyl pentanedioate Chemical compound COC(=O)CCCC(=O)OC XTDYIOOONNVFMA-UHFFFAOYSA-N 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- SBNNWCXKFFKLMG-UHFFFAOYSA-N dodecan-6-yl benzenesulfonate Chemical compound CCCCCCC(CCCCC)OS(=O)(=O)C1=CC=CC=C1 SBNNWCXKFFKLMG-UHFFFAOYSA-N 0.000 description 1
- QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 description 1
- 229960003997 doramectin Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000001999 effect on insects Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 description 1
- 229960002346 eprinomectin Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 1
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NNKVPIKMPCQWCG-UHFFFAOYSA-N methamidophos Chemical compound COP(N)(=O)SC NNKVPIKMPCQWCG-UHFFFAOYSA-N 0.000 description 1
- WEFZXWJJPHGTTN-UHFFFAOYSA-N methyl 5-(dimethylamino)-2-methyl-5-oxopentanoate Chemical compound COC(=O)C(C)CCC(=O)N(C)C WEFZXWJJPHGTTN-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- VOVZXURTCKPRDQ-CQSZACIVSA-N n-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3r)-3-hydroxypyrrolidin-1-yl]-5-(1h-pyrazol-5-yl)pyridine-3-carboxamide Chemical group C1[C@H](O)CCN1C1=NC=C(C(=O)NC=2C=CC(OC(F)(F)Cl)=CC=2)C=C1C1=CC=NN1 VOVZXURTCKPRDQ-CQSZACIVSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical group C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 description 1
- 229960002245 selamectin Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- KMIOJWCYOHBUJS-HAKPAVFJSA-N vorolanib Chemical group C1N(C(=O)N(C)C)CC[C@@H]1NC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C KMIOJWCYOHBUJS-HAKPAVFJSA-N 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
- 239000005943 zeta-Cypermethrin Substances 0.000 description 1
Abstract
Disclosed herein is a stable liquid agrochemical composition. Also disclosed is a process of preparing the liquid agrochemical composition, use of the liquid compositions for controlling the pests and a method of controlling pests using the liquid agrochemical composition.
Description
Title: LIQUID COMPOSITION COMPRISING A NEONICTONOID
Field of the disclosure: The présent disclosure relates to liquid agrochemical compositions comprising neonicotinoid insecticides, a process of preparing the liquid agrochemical compositions, use of the liquid compositions for controlling the pests and a method of controlling pests using the liquid agrochemical compositions.
Background:
Neonicotinoid pesticides hâve unique mechanism of action. Unlike pesticides that evaporate or disperse shortly after application, neonicotinoids are systemic pesticides. They hâve reduced toxicity compared to organophosphates and carbamates that provide similar broadspectrum control against numerous crop-damaging insects. Neonicotinoids paralyze insects by blocking a pathway that transmits nerve impulses in the insects' central nervous System. Neonicotinoids are used to control a wide variety of insects. The commonly used neonicotinoids available are imidacloprid, acetamiprid, clothianidin, dinotefuran, nitenpyram, thiacloprid, and thiamethoxam.
Acetamiprid is a neonicotinoid pesticide used in foliar as well as seed treatment applications. Acetamiprid is slightly water soluble and hence its liquid formulations often exhibit stability problems. Suspension concentrate (SC), emulsifiable concentrate (EC) and Microemulsion (ME) formulations of Acetamiprid are known to hâve stability problems. Emulsifiable concentrâtes are the stable liquid, homogeneous liquid formulations that comprise, an insecticidal active ingrédient, a solvent and emulsifying agent. When diluted with water, they form an émulsion after dilution in water. A stable suspension comprises active constituent(s) with water as the continuous phase and is intended for dilution with water before use. Microemulsions comprise an active ingrédient, oil- and water, and are to be applied directly or after dilution in water.
Suspension concentrate (SC) formulations comprising acetamiprid are known to be prone to rapid crystal formation, gelling, caking and settling. Emulsifiable concentrate (EC) formulations comprising acetamiprid are known to suffer crystallization upon dilution with water and cause nozzle choking. Microemulsion (ME) comprising acetamiprid too face stability issues and requires large amount of surfactant to achieve thermodynamic stability.
These problems further aggravate when formulators try to achieve high loading of active ingrédients in liquid formulations of acetamiprid alone or in combination with other active ingrédients that can withstand extreme température, especially low températures.
There is a need to develop stable agrochemical compositions comprising neonicotinoid insecticides that do not suffer stability issues and are stable at low température.
Objective of the disclosure:
An objective of the présent disclosure is to provide stable liquid agrochemical compositions comprising neonicotinoid insecticide.
Another objective of the présent disclosure is to provide stable liquid agrochemical compositions comprising high loading neonicotinoid insecticides alone or in combination with an additional pesticide.
Yet another objective of the présent disclosure is to provide stable liquid agrochemical compositions comprising high loading neonicotinoid insecticides alone or in combination with an additional pesticide, capable of withstanding low température.
Yet another objective of the présent disclosure is to provide a process of preparing liquid agrochemical compositions comprising high loading neonicotinoid insecticide alone or in combination with an additional pesticide.
Summary of the disclosure:
In an aspect, the présent disclosure provides a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value from about 10 to aboutie.
In another aspect, the présent disclosure provides a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent;
(c) at least one surfactant with HLB value from 10 to aboutl8; and (d) an additional pesticide.
In yet another aspect, the présent disclosure provides a process of preparing the liquid agrochemical composition, wherein the process comprises: combining at least one neonicotinoid insecticide with at least one low polarity amide solvent and at least one surfactant having HLB value from about 10 to about 18.
In another aspect, the présent disclosure provides a use of a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value from about 10 to about 18, for controlling pests.
In another aspect, the présent disclosure provides the use of the liquid agrochemical composition for controlling pests by applying to the plant or to the locus at which the plant is growing or intended to be grown orto a plant propagation material, or the habitat area.
In another aspect, the présent disclosure provides a method of controlling pests, said method comprising applying to a plant or to a locus at which the plant is growing or intended to be grown or to a plant propagation material, or an habitat area, a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value from about 10 to about 18.
In another aspect, the présent disclosure provides a kit comprises a plurality of components, each of which components may include at least one, or more, of the ingrédients of the liquid composition according to the présent disclosure.
Additional features and advantages of the présent disclosure will be apparent from the detailed description that follows, which illustrâtes by way of example, the most preferred features of the présent disclosure which are not to be construed as limiting the scope of the disclosure described herein.
Detailed Description of the disclosure:
For the purposes of the following detailed description, it is to be understood that the disclosure may assume various alternative variations except where expressly specified to the contrary. Moreover, other than in any operating examples, or where otherwise indicated, ail numbers expressing, for example, quantities of materials/ingredients used in the spécification are to be understood as being modified in ail instances by the term about.
Unless otherwise defined, ail technical and scientific terms used herein hâve the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. In the case of conflict, the présent document, including définitions will prevail.
Recitation of ranges of values are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the spécification as if it were individually recited herein. The endpoints of ail ranges are included within the range and independently combinable. As used herein, ail numerical values or numerical ranges include integers within such ranges and fractions of the values or the integers within ranges unless the context clearly indicates otherwise. Thus, for example, reference to a range of 90-100%, includes 91%, 92%, 93%, 94%, 95%, 95%, 97%, etc., as well as 91.1%, 91.2%, 91.3%, 91.4%, 91.5%, etc., 92.1%, 92.2%, 92.3%, 92.4%, 92.5%, etc., and so forth. AH methods described herein can be performed in a suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.
As used herein, a, an, the, and at least one do not dénoté a limitation of quantity and are intended to cover both the singular and plural, unless the context clearly indicates otherwise. For example, an element has the same meaning as at least one element, unless the context clearly indicates otherwise. The terms first, second etc. as used herein are not meant to dénoté any particular ordering, but simply for convenience to dénoté a plurality of, for example, layers. As used herein, the terms comprising including, having, containing, involving, and the like are to be understood to be open-ended, i.e., to mean including but not limited to, unless otherwise noted. About or approximately as used herein is inclusive of the stated value and means within an acceptable range of déviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system). For example, about can mean within one or more standard déviations, or within ± 10% or ± 5% of the stated value. The use of any and ail examples, or exemplary language (e.g., such as), is intended merely to better illustrate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the spécification should be construed as indicating any non-claimed element as essential to the practice of the invention as used herein.
In any aspect or embodiment described hereinbelow, the phrase comprising may be replaced by the phrases consisting of or consisting essentially of or consisting substantially of. In these aspects or embodiment, the composition described includes or comprises, or consists of, or consists essentially of, or consists substantially of the spécifie components recited therein, to the exclusion of other ingrédients or excipients not specifieally recited therein.
While the invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and équivalents may be substituted for éléments thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include ail embodiments falling within the scope of the appended daims. Any combination of the abovedescribed éléments in ail possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
Alkyl means a straight or branched chain saturated aliphatic hydrocarbon having the specified number of carbon atoms, specifieally 1 to 12 carbon atoms, more specifieally 1 to 6 carbon atoms. Alkyl groups include, for example, groups having from 1 to 50 carbon atoms (Ci to C50 alkyl).
Alkylene means a straight or branched chain, saturated, divalent aliphatic hydrocarbon group, (e.g., methylene (-CH2-) or, propylene (-(CHzjB-)).
As used throughout the disclosure, the neonicotinoid insecticide or other active ingrédients, includes their salts, esters, ethers, isomers, and polymorphs including solvatés and hydrates. A sait includes salts that retain the biological effectiveness and properties of the active ingrédient, and which are not biologically or otherwise undesirable, and include dérivatives of the disclosed compounds in which the parent compound is modified by making inorganic and organic, non-toxic, acid or base addition salts thereof. The salts can be synthesized from the parent compound by conventional Chemical methods. A solvaté means the insecticide or its agricuIturally acceptable sait, wherein molécules of a suitable solvent are incorporated in the crystal lattice. A suitable solvent is physiologicaIly tolerable at the dosage administered. Examples of suitable solvents are éthanol, water and the like. When water is the solvent, the molécule is referred to as a hydrate. The formation of solvatés will vary depending on the compound and the solvaté. In general, solvatés are formed by dissolving the compound in the appropriate solvent and isolating the solvaté by cooling or using an antisolvent. The solvaté is typically dried or azeotroped under ambient conditions. In an aspect, the solvaté is a hydrate.
The term plant refers to ail physical parts of a plant, including seeds, seedlings, saplings, 10 roots, tubers, stems, stalks, foliage and fruits. The term plant includes transgenic and nontransgenic plants.
The term locus as used herein refers to the vicinity, area, or place in which the plants are growing, where plant propagation materials of the plants are sown (e.g., placed into the soil), and/or where plant propagation materials of the plants will be sown.
The term plant propagation material refers to the generative parts of a plant, such as seeds, végétative material such as cuttings ortubers, roots, fruits, tubers, bulbs, rhizomes, and other parts of plants, germinated plants, and/or young plants, which are to be transplanted after germination or after emergence from the soil. These young plants may be protected prior to transplantation by a total or partial immersion treatment/system.
As used herein, effective amount is an amount of active ingrédient, such as the disclosed combinations, which has an adverse effect on insects and/or which prevents diseases caused by them in a plant. The adverse effect can include killing of the insects (insecticidal), preventing growth of the insect, blocking of biosynthetic pathway(s), or a combination thereof.
As used herein, an agriculturally acceptable sait means a sait which is accepted for use in agricultural or horticultural use.
The low température stability is critical requirement of liquid agrochemical formulations such as EC and ME as they often need to be used in cold température régions or be exposed to cold températures. Précipitation of actives or freezing of such liquid formulations at low 30 température in cold climatic régions leads to practical difficulties in handling the products and resuit in poor bio-efficacy. The stability, particularly low température stability has been of w great concern when liquid formulations are exposed to cold températures i.e. from about 20°C to about -10°C.
Surprisingly, inventors of the présent disclosure hâve found that the liquid agrochemical 5 compositions of stable neonicotinoid insecticide alone or in combination with additional pesticides can be obtained by incorporating a low polarity amide solvent and a surfactant with HLB value from about 10 to about 18. It was also found by the inventors that the high loading of neonicotinoid insecticides in the liquid agrochemical compositions is possible by combining low polarity amide solvent and a surfactant with HLB value from 10-18. The high loading 10 compositions thus obtained were found to withstand extremely low température and to remain quite stable throughout storage as well as during application upon dilution with water.
Thus, an embodiment of the présent disclosure provides a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide, (b) at least one low polarity amide solvent, and (c) at least one surfactant having HLB value from 10 to 18.
According to another embodiment, the liquid agrochemical composition is stable at low température.
In another embodiment, the term 'low polarity amide solvent' refers to solvents comprising 20 N-C2-8alkylpyrrolidone group and having polarity value lower than 0.350.
In another embodiment, the term 'low polarity amide solvent' refers to solvents comprising N-C2-8 alkylpyrrolidone and having polarity value lower than 0.340 on Reichardt scale of polarity (Etn).
As used throughout the spécification, the term 'low-temperature' refers to a température 25 ranging from 20 °Cto about-10°C.
According to an embodiment, the liquid agrochemical composition is stable at température lower than 20°C.
According to another embodiment, the liquid agrochemical composition is stable at température lower than 10°C.
According to still another embodiment, the liquid agrochemical composition is stable at température lowerthan 5°C.
According to still another embodiment, the liquid agrochemical composition is stable at température lowerthan 0°C.
According to still another embodiment, the liquid agrochemical composition is stable at température lowerthan -5°C.
According to an embodiment, the liquid agrochemical composition comprises at least one neonicotinoid insecticide.
According to another embodiment, the neonicotinoid insecticide is selected from the group comprising of acetamiprid, clothianidin, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam and combinations thereof.
According to still another embodiment, neonicotinoid insecticide comprises imidacloprid.
According to a preferred embodiment, neonicotinoid insecticide comprises acetamiprid.
According to an embodiment, the liquid agrochemical composition comprises from about 0.1% to about 90% w/w neonicotinoid insecticide of the total weight of the liquid composition.
According to another embodiment, the liquid agrochemical composition comprises from about 10% to about 80% w/w neonicotinoid insecticide of the total weight of the liquid composition.
In a preferred embodiment, the liquid agrochemical composition comprises from about 20% to about 70% w/w neonicotinoid insecticide of the total weight of the liquid composition.
According to an embodiment, the liquid agrochemical composition comprises at least one low polarity amide solvent.
According to another embodiment, the low polarity amide solvent comprises N-C2-8 alkylpyrrolidone group.
According to another embodiment, the présent disclosure provides a liquid composition comprising:
(a) at least one neonicotinoid insecticide, (b) at least one low polarity amide solvent wherein low polarity amide solvent comprises N-C2-8 alkylpyrrolidone, and (c) at least one surfactant with HLB value from 10 to about 18.
According to still another embodiment, the low polarity amide solvent is selected from the group comprising of N-butylpyrrolidone (NBP), N-octylpyrrolidone and N-ethylpyrrolidone (NEP).
According to still another embodiment, the low polarity amide solvent is selected from the group comprising of N-butylpyrrolidone (NBP) and N-ethylpyrrolidone (NEP).
According to still another embodiment of the présent disclosure, the low polarity amide solvent is N-butylpyrrolidone (NBP).
According to an embodiment, the liquid agrochemical composition comprises from about 1% to about 90% w/w low polarity amide solvent of the total weight of the liquid composition.
According to an embodiment, the liquid agrochemical composition comprises from about 10% to about 80% w/w low polarity amide solvent of the total weight of the liquid composition.
In a preferred embodiment, the liquid agrochemical composition comprises from about 20% to about 75% w/w low polarity amide solvent of the total weight of the liquid composition.
According to an embodiment, the liquid agrochemical composition comprises at least one surfactant with HLB ranging from about 10 to about 18.
According to another embodiment, the liquid agrochemical composition comprises at least one surfactant with HLB ranging from about 10 to about 18 is selected from the group comprising of sorbitan dérivatives and ethylene oxide-propylene oxide (EO/PO) block copolymers.
According to an embodiment of the présent disclosure, sorbitan dérivatives are selected from sorbitan esters and ethoxylated sorbitan esters with HLB ranging from about 10 to about 18.
According to another embodiment, sorbitan dérivatives are selected from the group comprising ofPolyoxyethylene monooleate, Polyoxyethylene monostearate, Polyoxyethylene monolaurate, Polyoxyethylene sorbitan monolaurate, Polyoxyethylene sorbitan monolaurate, Polyoxyethylene sorbitan monopalmitate, Polyoxyethylene sorbitan monostearate, Polyoxyethylene sorbitan tristearate, Polyoxyethylene sorbitan monooleate, and Polyoxyethylene sorbitan trioleate.
According to still another embodiment, ethoxylated sorbitan ester is Polyoxyethylene sorbitan monooleate.
According to still another embodiment, EO/PO block copolymers with HLB ranging 10-18 are selected from the group comprising of Block Copolymer of Ethylene Oxide, Propylene Oxide and Propylene Glycol, Oxirane, methyl-, polymerwith oxirane and Butyl EO/PO block polymer.
According to an embodiment, the liquid agrochemical composition comprises from about 0.01% w/w to about 50% w/w surfactant with HLB ranging from about 10 to about 18 of the total weight of the liquid composition.
According to another embodiment, the liquid composition comprises from about 0.1% w/w to about 40% w/w surfactant with HLB ranging from about 10 to about 18 of the total weight of the liquid composition.
According to still another embodiment, the liquid agrochemical composition comprises from about 0.5% w/w to about 30% w/w surfactant with HLB ranging 10-18 of the total weight of the liquid composition.
According to an embodiment, the liquid agrochemical composition may be formulated as emulsifiable concentrate, soluble liquid, microemulsion, suspension concentrate, suspoemulsion and oil dispersion.
According to an embodiment, the liquid agrochemical composition comprises:
(a) at least one neonicotinoid insecticide, (b) at least one additional pesticide, (c) at least one low polarity amide solvent, and (d) at least one surfactant having HLB value from about 10 to about 18.
According to an embodiment, the liquid agrochemical composition comprises additional pesticide.
According to an embodiment, the liquid agrochemical composition comprises one or more insecticides selected from oxadiazine insecticides, avermectin insecticides, phosphoramidothioate insecticides, phenylpyrazole insecticides, benzoylurea insecticides, pyrethroid insecticides, their salts, esters, optically active isomers and combinations thereof.
According to an embodiment, the liquid agrochemical composition comprises one or more 10 insecticide selected from oxadiazine insecticide such as indoxacarb, avermectin insecticides such as abamectin, doramectin, emamectin, eprinomectin, ivermectin and selamectin; phosphoramidothioate insecticides such as acephate, methamidophos, monocrotophos; phenylpyrazole insecticides such as flupyrazofos, pyraclofos, pyrolan, ethiprole, fipronil, flufiprole; pyridylpyrazole insecticides such as chlorantraniliprole, cyantraniliprole, 15 cyclaniliprole, tetrachlorantraniliprole, tetraniliprole; benzoyl urea insecticide such as lufenuron, novaluron, dibenzuron, chlorfuazuron; pyrethroid insecticides such as bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zetacypermethrin, cyphenothrin, deltamethrin, dimefluthrin, fenvalerate and transfluthrin.
According to another embodiment, the liquid agrochemical composition comprises from about 1% w/w to about 90% w/w neonicotinoid insecticide, 1% w/w to about 40% w/w additional insecticide, from about 20% w/w to 90% w/w about low polarity amide solvent and from about 0.1% w/w to about 10% w/w surfactant with HLB value ranging from 10 to about 18.
According to still another embodiment, the liquid agrochemical composition comprises from about 1% w/w to 90% w/w acetamiprid, 1% w/w to 40% w/w emamectin-benzoate, from about 20% w/w to 90% w/w low polarity amide solvent comprises n-butylpyrrolidone and from about 0.1% w/w to 10% w/w surfactant with HLB value ranging from 10-18.
According to still another embodiment, the liquid agrochemical composition comprises from 30 about 1% w/w to 90% w/w acetamiprid, 1% w/w to 40% w/w indoxacarb, from about 20% w/w to 90% w/w low polarity amide solvent comprising n-butylpyrrolidone and from about
0.1% w/w to 10% w/w surfactant with HLB value ranging from 10 to about 18.
According to an embodiment, the liquid agrochemical composition may further comprise one or more additional solvents.
According to another embodiment, the additional solvent is selected from the group comprising of a non-polar water-immiscible solvent or a polar aprotic water miscible organic solvent.
According to still another embodiment, additional solvent in the liquid composition is selected from polar and non-polar water-immiscible solvents, substituted or unsubstituted aromatic or aliphatic hydrocarbons and alkyl esters of plant oils or mixtures thereof.
According to an embodiment, the liquid composition comprises the additional polar solvent selected from the group comprising of cyclohexanone; dibasic esters such as, but not limited to, dimethyl 2-methylglutarate, and a dibasic ester mixture composed of dimethyl glutarate, dimethyl succinate and dimethyl adipate; glycol ethers and polyalkylene diglycol ethers such as, but not limited to, dipropylene glycol methyl ether; alkylene carbonates such as, but not limited to, propylene carbonate; methyl-5-(dimethylamino)-2-methyl-5-oxopentanoate; ketones such as, but not limited to, cyclopentanone and cyclohexanone; water-miscible polar aprotic solvents include, for example, alkyl lactates, isopropyl lactate, alkyl carbonates, polyethylene glycols, polyethylene glycol alkyl ethers, monopropylene glycol, polypropylene glycols, and polypropylene glycol alkyl ethers, or mixtures thereof.
According to an embodiment, the additional solvent in the liquid composition is fatty acid ester solvent such as Ce-Cu fatty acid ester prepared from plant oils.
According to an embodiment, additional solvent in the liquid composition is selected from one or more of aromatic hydrocarbons derived from benzene, such as, for example, toluene, xylenes, mesitylene, diisopropylbenzene and its higher homologs, indane and naphthalene dérivatives, such as 1-methylnaphthalene, 2-methylnaphthalene; C5-C12 aliphatic hydrocarbons (straight, branched or cyclic), such as, pentane, hexane, cyclohexane, octane, 2-ethylhexane, decane; C4-C10 aliphatic alcohols (straight or branched), such as butan-l-ol, hexanol, 2-ethyl butanol, heptanol, octanol, 2-octanol, and 2-ethylhexanol; and aromatic alcohols such as benzyl alcohol.
According to an embodiment, solvent in the liquid composition is selected from minerai oils.
According to an embodiment, solvent in the liquid composition is selected from water5 miscible polar aprotic solvents including, for example, from alkyl lactates, isopropyl lactate, alkyl carbonates, polyethylene glycols, polyethylene glycol alkyl ethers, monopropylene glycol, polypropylene glycols, and polypropylene glycol alkyl ethers, or mixtures thereof.
According to an embodiment, the liquid composition comprises from about 1% w/w to about 99% w/w additional solvent of the total weight of the liquid composition.
According to another embodiment, the liquid composition comprises from about 10% w/w to about 90% w/w additional solvent of the total weight of the liquid composition.
According to another embodiment, the additional solvent comprises water.
According to preferred embodiment of the présent disclosure, the liquid composition comprises from about 30% w/w to about 80% w/w solvent of the total weight of the liquid 15 composition.
According to an embodiment, the liquid composition may include one or more adjuvants selected from surfactants (emulsifier), crop oil, fertilizers, dispersing agents, compatibility agents, defoamers, antimicrobial agents, antioxidants, correctives, and spray colorants 20 (dyes).
According to an embodiment, the liquid composition comprises antioxidant selected from the group comprising of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiary butylhydroquinone (TBHQ) and propyl gallate (PG) and mixtures thereof.
According to another embodiment, the liquid composition comprises defoamer selected from the group comprising of silicone-based compounds, alcohols, glycol ethers, minerai spirits, acetylene diols, polysiloxanes, organosiloxanes, siloxane glycols, reaction products of Silicon dioxide and organosiloxane polymer, polydimethylsiloxanes or polyalkylene glycols alone or in combination.
According to an embodiment, the liquid composition optionally comprises from about 0.1% 5 w/w to about 40% w/w of one or more adjuvants of the total weight of the emulsifiable concentrate composition.
According to an embodiment, the liquid composition optionally comprises from about 0.5% w/w to about 30% w/w of one or more adjuvants of the total weight of the emulsifiable 10 concentrate composition.
According to an embodiment, the liquid composition comprises from about 0.1% w/w to about 90% w/w neonicotinoid insecticide, from 0.01% w/w to about 90% w/w low polarity amide solvent, from about 0.01% w/w to about 50% w/w surfactant with HLB value from 15 about 10 to about 18 of the total weight of the liquid composition.
According to another embodiment, the liquid composition comprises from about 1% w/w to about 40% w/w neonicotinoid insecticide, 10% w/w to about 80% w/w low polarity amide solvent, from about 0.01% w/w to about 30% w/w surfactant with HLB value from about 10 to about 18 of the total weight of the liquid composition.
According to another embodiment, the liquid composition comprises from about 1% w/w to about 40% w/w neonicotinoid insecticide, 20% w/w to about 75% w/w low polarity amide solvent, from about 0.01% w/w to about 20% w/w surfactant with HLB value from about 10 to about 18 of the total weight of the liquid composition.
According to another embodiment of the présent invention, the liquid composition comprises 25 from about 0.1% w/w to about 90% w/w acetamiprid, 0.01% w/w to about 90% w/w low polarity amide solvent comprising n-butylpyrrolidone, from about 0.01% w/w to about 50% w/w surfactant with HLB value ranging from about 10 to about 18 comprising polyoxyethylene sorbitan monooleate of the total weight of the liquid composition.
Unless the context otherwise requires, the liquid agrochemical composition as described in 30 any of the embodiments in this spécification may be Microemulsion (ME).
Unless the context otherwise requires, the liquid agrochemical composition as described in any of the embodiments in this spécification may be Soluble Liquid (SL).
Unless the context otherwise requires, the liquid agrochemical composition as described in any of the embodiments in this spécification may be Emulsifiable Concentrate (EC).
In an embodiment, the présent disclosure provides a process of preparing the liquid agrochemical composition, wherein the process comprises: combining at least one neonicotinoid insecticide with at least one low polarity amide solvent and at least one surfactant having HLB value from about 10 to about 18.
In an embodiment, the présent disclosure provides a process of preparing a soluble liquid agrochemical composition, wherein the process comprises:
combining at least one neonicotinoid insecticide with at least one low polarity amide solvent to obtain a mixture;
combining water and a surfactant with HLB value ranging from about 10 to about 18 with the mixture; and homogenizing the mixture at least one neonicotinoid insecticide, at least one low polarity amide solvent, water and the surfactant to obtain the soluble liquid agrochemical composition.
In an embodiment, the présent disclosure provides a process of preparing an emulsifiable concentrate agrochemical composition, wherein the process comprises:
combining at least one neonicotinoid insecticide with at least one low polarity amide solvent to obtain a mixture;
combining water and a surfactant with HLB value ranging from about 10 to about 18 with the mixture; and homogenizing the mixture at least one neonicotinoid insecticide, at least one low polarity amide solvent, water and the surfactant to obtain the emulsifiable concentrate agrochemical composition.
In an embodiment, the présent disclosure provides a process of preparing a microemulsion agrochemical composition, wherein the process comprises:
combining water and at least one neonicotinoid insecticide to obtain a mixture combining a surfactant with HLB value ranging from about 10 to about 18 with the mixture; and homogenizing the mixture at least one neonicotinoid insecticide, at least one low polarity amide solvent, water and the surfactant to obtain the microemulsion agrochemical composition.
In another embodiment, the process of combining at least one neonicotinoid insecticide with at least one low polarity amide solvent to obtain a mixture involves stirring.
In still another embodiment, the process of combining at least one neonicotinoid insecticide with water to obtain a mixture involves stirring.
In still another embodiment, the process of combining at least one neonicotinoid insecticide, water and at least one low polarity amide solvent to obtain a mixture involves stirring.
In still another embodiment, wherein the liquid agrochemical composition comprises at least one neonicotinoid insecticide, and an additional pesticide, the process comprises combining at least one neonicotinoid insecticide, and the additional pesticide with at least one low polarity amide solvent.
According to an embodiment, the homogenization comprises particle size réduction.
According to another embodiment, the particle size réduction is done by applying shear to the mixture of active ingrédients, low polarity amide solvent and surfactant with HLB ranging from 10-18 and optionally other auxiliary agents. Suitable devices for applying shear include any high shear devices, e.g. high shear mixers, such as Ultra-Turrax apparatus, and dissolvers, static mixers, e.g. Systems having mixing nozzles, bead mills, vibratory mills, agitator bead mills, colloid mills, cône mills, circulating mills (agitator bail mills with pin grinding System), disk mills, annular chamber mills, double cône mills, sprocket dispersers or homogenizers and other homogenizers.
According to an embodiment, the liquid composition is intended to be diluted with water (or a water-based liquid) to form the corresponding end-use agrochemical formulations, typically spray formulations.
According to an embodiment, the liquid composition has a pH ranging from 5-7.
According to an embodiment, the liquid composition has a variation in pH of no more than 20% when at 54°C between 24 hours and 28 days.
According to an embodiment of the présent invention, the liquid composition has a variation in pH of no more than 10% when at 54°C between 24 hours and 28 days.
According to an embodiment of the présent invention, the liquid composition has a variation in pH of no more than 5% when at 54°C between 24 hours and 28 days.
According to an embodiment, the liquid composition provides a formulation that allows the active compounds to be taken up by the plant/the target organisms.
According to an embodiment, the liquid composition is used as the source of active agrochemical ingrédients and is diluted to form end-use formulations, typically spray formulations.
In an embodiment, the dilution may be with water at from 1 to 10,000, particularly 10 to 1,000, times the total weight of the composition to form the spray formulation.
In an embodiment, in the diluted composition, the agrochemical active concentration may be in the range from about 0.001 wt.% to about 1 wt.% of the total spray formulation.
In an embodiment, the spray formulations can be made by simple dilution of the liquid agrochemical compositions.
In another embodiment, the spray formulations can be made by combining individual components used in preparing the liquid agrochemical compositions and water.
Typically, such end use mixing is carried out in the tankfrom which the formulation is sprayed, or alternatively in a holding tank for filling the spray tank. Such mixing and mixtures are typically termed tank mixing and tank mixtures.
According to another embodiment, provided is a method of controlling pests, said method comprising applying to a plant or to a locus at which the plant is growing or intended to be grown or to a plant propagation material, or an habitat area, a liquid composition comprising: (a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value from 10-18.
According to another embodiment, the method of controlling pests comprises applying the liquid compositions comprising acetamiprid.
According to another embodiment of the présent invention, the method of controlling pests comprises applying the liquid compositions comprising acetamiprid and the additional pesticides.
Examples of the crops on which the présent compositions may be used include, are not limited to, corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc., trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.
In an embodiment, the pests controlled by the présent compositions include but are not limited to Planococcus citri and Panonychus citri.
According to an embodiment, the kit comprising liquid composition comprises a plurality of components, each of which components may include at least one, or more, of the ingrédients of the liquid composition.
The compositions described throughout the présent disclosure are insecticidally active and are stable. It has been found that the combination of low polarity amide solvent and a surfactant with HLB ranging from about 10 to about 18 provides excellent stability over time and at various températures, and even when said liquid composition is subjected to shear forces for example on mixing. Also, the liquid composition obtained has excellent suspensibility, dispersibility, very low or no sédimentation and little particle dégradation.
Ail the features described in this disclosure may be combined with any of the other aspects 5 or embodiments, in any combination.
These and other advantages of the disclosure may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the disclosure and are not intended to be construed as a limitation thereof.
Ail tests and physical properties listed hâve been determined at atmospheric pressure and room température (i.e. 25°C), unless otherwise stated herein, or unless otherwise stated in the referenced test methods and procedures.
Examples
Example 1: Acetamiprid 200g/L Soluble Liquid (SL) (working example)
The materials in Table 1 were used to préparé a 200 g/L soluble liquid composition of Acetamiprid.
Table 1
Ingrédients | Quantity (g/l) |
Acetamiprid Technical | 200 |
N-butylpyrrolidone | 654.5 |
Polyoxyethylene sorbitan monooleate (HLB value 15) | 43 |
Silicone antifoam | 2 |
Water | Q. S. |
654.5g N-butylpyrrolidone was charged in a mixing vessel followed by addition of 200g acetamiprid and mixed until dissolved. Water was added to the same mixing vessel to obtain a mixture. 43g polyoxyethylene sorbitan monooleate and 2g silicone antifoam were added to the mixture and homogenized for about 5 minutes to obtain soluble liquid formulation.
Stability Data
The composition of Example-1 was taken for physico-chemical study at various testing conditions such as ambient température (at room température) testing, and at low température. Testing at low température was performed after keeping the composition of Example-1 for 7 days at 0°C, oven stability performed as accelerated heat stability (AHS) after 10 keeping sample in oven for 2 weeks at 54°C and also for 8 weeks at 40°C. The low température study was performed as per CIPAC method no. 39.3 wherein compositions were maintained at 0°C for 1 h and the volume of any separated solid or oily matter was then recorded. Storage at 0°C is continued for 7 days, any solid matter is settled by centrifuging and its volume recorded. In ail the four stability conditions, composition of Example-1 remained as clear 15 yellowish liquid. Density of the composition remained at about 1, and dégradation of active remained within acceptable range. Persistent foam in the composition remained within acceptable range. And pH of the composition was found to be around 7 in ail the conditions.
Table 2
Parameters | Spécification | Ambient (25°C) | Low Température Stability (0°C) 7 days | Oven Stability (54°C) 2 weeks |
Appearance | Clear Yellowish liquid | Clear Yellowish liquid | Clear Yellowish liquid | Clear Yellowish liquid |
Active Ingrédient content - Acetamiprid | 188->212g/l | 196.48 | 194.68 | 196.55 |
Density @ 255C | 1.024+0.005g/cm 3 | 1.025 | 1.025 | 1.025 |
pH @ 1% distilled water | 06-08 | 7.39 | 7.38 | 7.39 |
Persistent Foam | Max 40ml | Nil | Nil | Nil |
Example 2: Acetamiprid 120 g/l + Emamectin Benzoate 15 g/l ME (working example)
The materials in Table 3 were used to préparé Acetamiprid 120 g/l + Emamectin Benzoate 15 g/l ME.
Table 3
Ingrédients | Quantity (g/€) |
Acetamiprid (98%) | 122.4 |
Emamectin Benzoate (95,1%) | 16.0 |
Butylated hydroxyanisole | 7.0 |
Propylene Glycol | 12.5 |
Butan-l-ol (AR Grade) | 38.5 |
N, Butylpyrrolidone | 764.8 |
Polyoxyethylene(20) sorbitan monooleate (HLB value 15) | 8.0 |
Silicone antifoam | 0.3 |
Water | Q. S. |
12.5g of propylene glycol was charged in a mixing vessel followed by the addition of 38.5g
Butan-l-ol under agitation to obtain a mixture. 7g butylated hydroxyanisole and water were added to the mixture and mixed for around 5 minutes. In the same mixture, 16g Emamectinbenzoate was added under continuous mixture followed by addition of 764.8g nbutylpyrrolidone. Further 122.4g acetamiprid was added and mixed for around 30 minutes 10 until dissolved completely. 8g polyoxyethylene(20) sorbitan monooleate and 0.3g silicone antifoam was added and mixed to obtain microemulsion.
Stability Data
The composition of Example-2 was taken for physico-chemical study at various testing 15 conditions such as ambient température (at room température) testing, and at low température. Testing at low température was performed after keeping the composition of Example-2 in refrigerator for 7 days at 0°C, oven stability was performed as accelerated heat stability (AHS) testing after keeping sample in oven for 2 weeks at 54°C and also for 8 weeks at 40°C. In all the four stability conditions, composition of Example-2 remained as homogeneous and transparent liquid. Density of the composition remained as 0.993, Dégradation of active remained within acceptable range. Persistent foam in the composition remained within acceptable range. And pH of the composition was found to be around 6 in 5 all the conditions.
Table-4
Test | Spécifications | Ambient | Low température (0°C) 7 days | Oven Stability (54°C) 2 weeks | Oven Stability (40°C) 8 weeks |
Physical State | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent |
Density | 0.993 ± 0.005 g/m€ | 0.993 | 0.993 | 0.993 | 0.993 |
Active ingrédient content- Acetamiprid | 114 -126 g/β | 123.98 | 122.30 | 123.50 | 123.91 |
Active ingrédient content - Emamectin Benzoate | 12.75 - 17.25 g/β | 14.50 | 14.49 | 13.94 | 15.66 |
Persistent Foam (1% dil. @ 1min.) | Max. 60 m£ | 40 | - | 45 | 40 |
pH (1% in 342ppm) | - | 6.06 | 6.04 | 6.10 | 6.08 |
Example 3: Acetamiprid 146 + Indoxacarb 54 emulsifiable concentrate (EC)
The materials in Table 5 were used to préparé Acetamiprid 146 + Indoxacarb 54 emulsifiable 10 concentrate (EC).
Table 5
Ingrédients | Quantity (g/£) |
Acetamiprid Technical | 149.00 g |
Indoxacarb Technical | 56.84 g |
n-butylpyrrolidone | 350.00 g |
Cyclohexanone | 360.00 g |
Butyl EO.PO block polymer | 100.00 g |
360g cyclohexanone was charged in a mixing vessel. 350g n-butylpyrrolidone was added to the same mixing vessel under continuous agitation. Further, 56.84g indoxacarb and 149g acetamiprid were added under continuous stirring to obtain a mixture. Further 100g butyl 5 EO.PO block polymer and remaining 60g cyclohexanone were added to the mixture and mixed for around 30 minutes to obtain emulsifiable concentrate.
Stability Data
The composition of Example-3 was taken for physico-chemical study at various testing conditions such as ambient (at room température) testing, low température testing performed after keeping the composition of Example-3 in refrigerator for 7 days at 0°C, oven stability performed as accelerated heat stability (AHS) after keeping sample in oven for 2 weeks at 54°C and also for 8 weeks at 40°C. In ail the four stability conditions, composition of Example-1 remained as homogeneous and transparent liquid. Density of the composition maintained as 1.02. Dégradation of active remained within acceptable range. Persistent foam in the composition remained within acceptable range. And pH of the composition was found to be around 5 in ail the conditions.
Table-6
Spécifications | Ambient | Low température stability (0°C) 7 days | Oven Stability (54°C) 2 weeks | Oven Stability (40°C) 8 weeks | |
Physical State Aspect | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent | Liquid Homogenous & Transparent |
Density | 1.020 ± 0.005 g/mC | 1.02 | 1.02 | 1.02 | 1.021 |
Active ingrédient contentAcetamiprid | 137 -154 g/fi | 146.74 | 146.72 | 146.20 | 145.11 |
Active ingrédient content - Indoxacarb | 49 - 59 g/£ | 54.52 | 54.55 | 53.44 | 52.59 |
Persistent Foam (1% dil. @ 1min.) | Max. 40 mfi | 6 | 6 | 5 | 6 |
pH (1% in distilled water) | - | 5.26 | 5.32 | 5.1 | 5.14 |
Stability upon dilution
The compositions of Example 1-3 were tested for dilution stability wherein each composition was diluted with standard water to make 1% dilution aliquot. The stability of the diluted composition was assessed at various time intervals. Further assessment was done after 24.5 hours post re-emulsifying the compositions. This was also repeated twice. The composition of Example-1 remained as homogeneous and stable liquid throughout in ail the above specified time intervals. Similarly, composition of Exampel-2 and Example-3 remained quite stable without any noticeable cream or oil formation.
Table-7
Emulsion (0.5hr) (Std. H20 A @ 1% dil.) | Emulsion (0.5hr) (Std. H20 D @ 1% dil.) | Emulsion (2.0hr) (Std. H20 A @ 1% dil.) | Emulsion (2.0hr) (Std. H2O D @ 1% dil.) | Reemulsification -(24.5hr) (Std. H20 A @ 1% dil.) | Reemulsification — (24.5hr) (Std. H20 D @ 1% dil.) | |
Example | Homogeneous | Homogeneous | Homogeneous | Homogeneous | Homogeneous | Homogeneous |
1 | & stable | & stable | & stable | & stable | & stable | & stable |
Exàmple | No Cream, | No Cream, | No Cream, | No Cream, | No Cream, | No Cream, |
2 | No oil | No oil | No oil | No oil | No oil | No oil |
Example | No Cream, | No Cream, | No Cream, | No Cream, | No Cream, | No Cream, |
3 | No oil | No oil | No oil | No oil | No oil | No oil |
Std. H2O A stands for CIPAC Standard water A with 20 ppm hardness; Std. H2O D stands for
CIPAC Standard water D with 342ppm hardness.
Screening of solvents and surfactants suitable for liquid composition stable at low température
Example 4-7 are for compositions of ME formulation of acetamiprid and Emamectinbenzoate. Various solvent and surfactant were tried in preparing neonicotinoid based liquid compositions that remain stable at low température. The Compositions were taken for dilution stability study as per CIPAC 41.1 wherein said compositions were diluted in water and 5 allowed to stand for 24 hours after which the quantity and nature of any separated material were assessed. Composition of Example-4 was prepared using anionic/non-ionic blend of surfactants with HLB value 9.6. On performing dilution stability, 1ml crème and some oil observed after 0.5. Thus, it failed in test and could not be considered for further stability testing. Composition of Example-5 was prepared using sait of dodecylbenzene sulfonate 10 having HLB 8.6. BHA remained immiscible in the solvent. Composition failed to form ME formulation and was therefore, found to be unsuitable for low température testing. Similarly, composition of Example-6 and Example-7 were prepared using dimethylsulfoxide (DMSO) and propylene carbonate respectively. Both compositions exhibited crystallization in dilution stability testing which indicated crystal formation upon keeping at 0°C.
Table-8
Ingrédients | *Ex-4 | *Ex-5 | *Ex-6 | *Ex-7 | |
1 | Emamectin Benzoate | 1.6 | 1.61 | 1.6 | 1.6 |
2 | Acetamiprid | 12.4 | 12.36 | 12.4 | 12.4 |
3 | Water | 2.1 | 2.15 | 2.1 | 2.1 |
4 | BHA - Butylated Hydroxy Anisole | 0.7 | 0.71 | 0.7 | 0.7 |
5 | Propylene Glycol | 1.3 | 1.26 | 1.3 | 1.3 |
6 | Butan-l-ol (AR Grade) | 3.9 | 3.89 | 3.9 | 3.9 |
7 | N-Butylpyrollidone | 77 | 77 | - | - |
8 | Dimethylsulfoxide (DMSO) | - | - | Qs | - |
9 | Propylene carbonate | - | - | - | qs |
10 | Silicone antifoam | 0.03 | 0.03 | 0.03 | 0.03 |
11 | Dodecylbenzene sulfonate sait | 0.8 | - | - | |
12 | Anionic/Non-ionic blend | 0.8 | - | - | - |
Re marks | 1ml crème and some oil observed after 0.5 | BHA remained immiscible in the solvent. | Solution found turbid upon dilution. Crystal s | Solution crystallised upon dilution in water. |
hours when kept for dilution stability. | Composition failed to form ME formulation. | observed in low temp. |
*Ex= Example
Compositions of example 8-11 are EC compositions comprising acetamiprid and indoxacarb. Composition of Example-8 was prepared using anionic/non-ionic blend of surfactants with HLB value 9.6. Similarly, composition of Example-9 was prepared using sait of dodecylbenzene 5 sulfonate having HLB 8.6. In both the compositions, 1ml oil and 2ml crème was observed when kept for dilution stability and could not be considered for further stability testing. Composition of Example-10 and Example-11 were prepared using dimethylsulfoxide (DMSO) and propylene carbonate respectively. Both compositions exhibited crystallization in dilution stability testing which indicated crystal formation upon keeping at 0°C.
Table-9
Compositions | Ex-8 | Ex-9 | Ex-10 | Ex-11 | |
1 | Acetamiprid | 149.00 | 149.00 | 149.00 | 149.00 |
2 | Indoxacarb | 56.84 | 56.84 | 56.84 | 56.84 |
3 | Cyclohexanone | 360.00 | 360.00 | 360.00 | 360.00 |
4 | N-Butylpyrollidone | 350.00 | 350.00 | - | - |
5 | Ethopropoxylated alcohol | - | - | 100.00 | 100.00 |
6 | Dodecylbenzene sulfonate sait | - | 100 | - | - |
7 | Mixture of ethoxylated tristyryiphenol and of calcium dodecylbenzenesulfonate in isobutanol | 100 | |||
8 | Mixture of heavy-aromatic Petroleum solvent, medium-aliphatic Petroleum solvent and benzene | 350 | |||
9 | Propylene Carbonate | - | - | - | 350 |
Remarks | 1ml oil and 2ml crème observed after 0.5 | 1ml oil and 2ml crème observed after 0.5 | Active found to be insoluble in | Fine crystals observed within 3 days of formation |
hours when kept for dilution stability. | hours when kept for dilution stability. |
Compositions of example 12-15 are SL compositions comprising acetamiprid and indoxacarb. Composition of Example-12 was prepared using sait of dodecylbenzene sulfonate having HLB 8.6. Similarly, composition of Example-13 was prepared using anionic/non-ionic blend with
HLB value 9.6. In both the compositions, crystals observed within 24 hours when kept for dilution stability. Composition of Example-14 and Example-15 were prepared using dimethylsulfoxide (DMSO) and propylene carbonate respectively. Both compositions exhibited crystallization in dilution stability testing which indicated crystal formation upon keeping at 0°C.
Table-10
Compositions | Ex-12 | Ex-13 | Ex-14 | Ex-15 | |
1 | Acetamiprid Technical | 200 | 200 | 200 | 200 |
2 | Polyoxyethylene sorbitan monooleate | - | - | 43 | 43 |
3 | Silicone antifoam | 2 | 2 | - | - |
4 | Water | 126 | 126 | 126 | 126 |
5 | N-butylpyrrolidone | 654.6 | 654.7 | - | - |
9 | DMSO | - | - | qs | |
11 | Propylene Carbonate | - | - | - | qs |
14 | Dodecylbenzene sulfonate sait | 43 | - | - | - |
15 | Mixture of ethoxylated tristyryiphenol and of calcium dodecylbenzenesulfonate in isobutanol | 43 | |||
Re marks | Crystals observed within 24hrs. | Crystals observed within 24hrs. | Fine crystals observed | Fine crystals observed |
Field Application Study
Crop: Sweet Orange
Location for Trial 1: Groblersdal, Limpopo in South Africa
Location for Trial 2: Mooinooi,North West in South Africa
The effectiveness of compositions of Example-2 and Example-3 were assessed on citrus for control of mealy bugs. Mealybug causes physical and cosmetic damage to citrus fruit, making them unsuitable for export. Composition of Example-2 was tested at dosage rate of 54 m£. Composition of Example-3 was tested at dosage rate of 36 m£. The effectiveness of the compositions was studied against untreated control. The number of mealy bugs were counted per plot on 25 citrus fruits sampled per plot at various intervals viz. 7DAT (Days After Treatment), 14DAT and 21DAT. The study was performed on two different locations (Trial 1 and Trial 2) for both the compositions of Example-2 and Example-3. Composition of Example2 and Example-3 at both doses found to control more than 96% mealy bugs and successfully protected the crop.
Table-11
Treatments | Dose rate/lOOL water | Percentage Control % | |||||
Trial 1 | Trial 2 | ||||||
7 DAT | 14 DAT | 21 DAT | 7 DAT | 14 DAT | 21 DAT | ||
Untreated | 0% | 0% | 0% | 0% | 0% | 0% | |
Example-2 | 54ml | 98 | 98 | 98 | 96 | 97 | 94 |
Example-3 | 36ml | 97 | 98 | 98 | 96 | 96 | 97 |
The effectiveness of compositions of Example-2 and Example-3 were assessed on citrus for control of red spider mites. The Red spider mite (P. ulmi) is one of the pests common to citrus that cause damage to older leaves and fruit. Composition of Example-2 was tested at dosage rate of 54 m£. Composition of Example-3 was tested at dosage rate of 36 m€. The 20 effectiveness of the compositions was studied against untreated control. The number of mites counted on a 30-leaf sample per plot and percentage control of red spider mites were calculated at various intervals viz. 7DAT (Days After Treatment), 14DAT and 21DAT. The study was performed on two different locations (Trial 1 and Trial 2) for both the compositions of Example-2 and Example-3. Compositions of Example-2 and Example-3 at both doses and in both trials found to control more than 90% red spider mites and successfully protected the crop.
Table-12
Treatments | Dose rate/lOOL water | Percentage Control % | |||||
Trial 1 | Trial 2 | ||||||
7 DAT | 14 DAT | 21 DAT | 7 DAT | 14 DAT | 21 DAT | ||
Untreated | 0% | 0% | 0% | 0% | 0% | 0% | |
Example-2 | 54ml | 97 | 98 | 98 | 96 | 96 | 97 |
Example-3 | 36ml | 98 | 98 | 98 | 96 | 97 | 94 |
Therefore, inventors of the présent disclosure successfully stabilized various liquid composition of neonicotinoid insecticides alone and in combination with other pesticides using a low polarity amide solvent and a surfactant with HLB ranging from 10-18. The combination of low polarity amide solvent and a surfactant with HLB ranging from about 10 to about 18 successfully stabilized neonicotinoid insecticide in the composition as well as 10 imparted low température stability to the composition. The stable liquid composition also exhibited stability upon dilution. The liquid compositions were found to be highly efficacious in controlling pests. It is to be understood that the disclosure is not to be limited to the details of the above embodiments, which are described by way of example only.
Claims (19)
1. A liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value ranging from about 10 to about 18.
2. The liquid composition as claimed in claim 1 wherein the neonicotinoid insecticide is selected from the group comprising of acetamiprid, clothianidin, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam and combinations thereof.
3. The liquid composition as claimed in claim 1 wherein the composition comprises from about 0.1% w/w to about 90% w/w neonicotinoid insecticide of the total weight of the liquid composition.
4. The liquid composition as claimed in claim 1 wherein the low polarity amide solvent comprises N-C2-8 alkylpyrrolidone group.
5. The liquid composition as claimed in claim 1 wherein the composition comprises from 0.01% w/w to about 90% w/w low polarity amide solvent of the total weight of the liquid composition.
6. The liquid composition as claimed in claim 1 and claim 3 wherein said low polarity amide solvent is selected from the group comprising of N-butylpyrrolidone (NBP), Noctylpyrrolidone and N-ethylpyrrolidone (NEP).
7. The liquid composition as claimed in claim 1 wherein the composition comprises from about 0.01% w/w to about 50% w/w surfactant with HLB value from about 10 to about 18 of the total weight of the liquid composition.
8. The liquid composition as claimed in claim 1 wherein surfactant with HLB value ranging from about 10 to about 18 is selected from the group comprising of polyoxyethylene monooleate, polyoxyethylene monostearate, polyoxyethylene monolaurate, sodium oleate, triethanolamine oleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, 5 polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, block copolymer of ethylene oxide, propylene oxide, block copolymer of ethylene oxide, propylene oxide and propylene glycol.
9. The liquid composition as claimed in claim 1 wherein said composition comprises from 10 about 0.1% w/w to about 90% w/w neonicotinoid insecticide, 0.01% w/w to about
90% w/w low polarity amide solvent, from about 0.01% w/w to about 50% w/w surfactant with HLB value from about 10 to about 18 of the total weight of the liquid composition.
15
10. The liquid composition as claimed in claim 1 wherein said composition is in the form of emulsifiable concentrate, soluble liquid, microemulsion, suspension concentrate, suspoemulsion or oil dispersion.
11. The liquid agrochemical composition as claimed in claim 1 further comprising an 20 additional pesticide.
12. The liquid composition as claimed in claim 8 wherein the additional pesticide is selected from the group comprising of oxadiazine insecticides, avermectin insecticides, phosphoramidothioate insecticides, phenyl pyrazole insecticides, diamide insecticides, benzoylurea insecticides, pyrethroid insecticides, their salts, 25 esters, optically active isomers and combinations thereof.
13. The liquid composition as claimed in claim 11 wherein the additional pesticide is selected from one or more from the group comprising of indoxacarb, abamectin, emamectin, ivermectin, acephate, monocrotophos, flupyrazofos, pyraclofos, 30 ethiprole, fipronil, chlorantraniliprole, cyantraniliprole, tetraniliprole, lufenuron, novaluron, dibenzuron, chlorfuazuron, bifenthrin, cyfluthrin, cyhalothrin, gamma cyhalothrin, lambda-cyhalothrin, cypermethrin, beta-cypermethrin, deltamethrin, fenvalerate and transfluthrin.
14. A liquid agrochemical composition comprising from about 1% w/w to 90% w/w acetamiprid, 1% w/w to 40% w/w emamectin-benzoate, from about 20% w/w to 90% w/w low polarity amide solvent comprises n-butylpyrrolidone and from about 0.1% w/w to 10% w/w surfactant with HLB value ranging from 10-18.
15. A liquid agrochemical composition comprising from about 1% w/w to 90% w/w acetamiprid, 1% w/w to 40% w/w indoxacarb, from about 20% w/w to 90% w/w low polarity amide solvent comprising n-butylpyrrolidone and from about 0.1% w/w to 10% w/w surfactant with HLB value ranging from 10 to about 18.
16. A process of preparing a liquid agrochemical composition, wherein the process comprises: combining at least one neonicotinoid insecticide with at least one low polarity amide solvent and at least one surfactant having HLB value from about 10 to about 18.
17. A method of controlling pests, said method comprising applying to a plant or to a locus at which the plant is growing or intended to be grown or to a plant propagation material, or an habitat area, a liquid agrochemical composition comprising:
(a) at least one neonicotinoid insecticide;
(b) at least one low polarity amide solvent; and (c) at least one surfactant with HLB value from about 10 to about 18.
18. Use of a liquid agrochemical composition comprising:
at least one neonicotinoid insecticide;
at least one low polarity amide solvent; and at least one surfactant with HLB valuefrom about 10to about 18, for controlling pests.
19. Use of a liquid agrochemical composition comprising:
at least one neonicotinoid insecticide;
at least one low polarity amide solvent; and at least one surfactant with HLB value from about 10 to about 18, for controlling pests selected from planococcus citri and panonychus citri.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN202121010121 | 2021-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA21455A true OA21455A (en) | 2024-06-20 |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9770021B2 (en) | Pesticidal compositions | |
CA2611848C (en) | Seed treatment method and pesticidal composition | |
AU2017100047A4 (en) | An aqueous suspoemulsion containing lambda-cyhalothrin and methods for making and using the same | |
CA1337505C (en) | Aqueous formulations and their use | |
BR112021001409A2 (en) | stable liquid agrochemical formulation | |
AU2022231890A1 (en) | Liquid composition comprising a neonictonoid | |
KR20130136578A (en) | Liquid insecticide composition | |
TWI543709B (en) | A novel aqueous suspoemulsion comprising lufenuron and lambda-cyhalothrin | |
UA127879C2 (en) | Pesticidal compositions | |
OA21455A (en) | Liquid composition comprising a neonictonoid | |
AU2018272316B2 (en) | A stable agrochemical composition and process thereof | |
AU2014311085B2 (en) | A novel aqueous suspoemulsion and a process for preparing the same | |
WO2022190133A1 (en) | A tank mix compatible composition | |
US20220279779A1 (en) | Liquid herbicidal compositions | |
US12089594B2 (en) | Stabilized cyclohexanedione oxime composition | |
KR20230119667A (en) | Isocycloceram Formulation | |
KR20220088841A (en) | Synergistic antiseptic composition | |
US10660337B2 (en) | Stable agrochemical composition and process thereof | |
US20230078970A1 (en) | Insecticidal compositions | |
EA044515B1 (en) | STABLE LIQUID AGROCHEMICAL COMPOSITION | |
WO2023232559A1 (en) | Formulation | |
OA21213A (en) | Stable herbicidal compositions. | |
OA20007A (en) | A stable liquid agrochemical formulation. | |
BR102022017717A2 (en) | INSECTICIDE COMPOSITIONS | |
AU2011253579B2 (en) | Seed treatment method and pesticidal composition |