OA20266A

OA20266A -

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Publication number: OA20266A
Authority: OA; OAPI
Prior art keywords: compound; independently selected; compounds; alkyl; pharmaceutically acceptable
Prior art date: 2018-12-06

Application number

OA1202100252

Other languages

English (en)

Unknown language (us)

Inventor

Eric Brown

Vidyasagar Reddy Gantla

Nadezda Sokolova

Michael Bruno Plewe

Gregory Henkel

Kenneth Mccormack

Original Assignee

Arisan Therapeutics, Inc

Priority date

2018-12-06

Filing date

2019-12-03

Publication date

2022-04-14

2019-12-03 Application filed by Arisan Therapeutics, Inc filed Critical Arisan Therapeutics, Inc

2022-04-14 Publication of OA20266A publication Critical patent/OA20266A/en

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150000001875 compounds Chemical class 0.000 claims abstract description 275
241000712891 Arenavirus Species 0.000 claims abstract description 62
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108090000288 Glycoproteins Proteins 0.000 claims abstract description 33
201000009910 diseases by infectious agent Diseases 0.000 claims abstract description 21
241000700605 Viruses Species 0.000 claims description 42
230000002401 inhibitory effect Effects 0.000 claims description 41
229910052739 hydrogen Inorganic materials 0.000 claims description 34
229910052736 halogen Inorganic materials 0.000 claims description 30
239000003981 vehicle Substances 0.000 claims description 28
239000003937 drug carrier Substances 0.000 claims description 27
150000002367 halogens Chemical class 0.000 claims description 27
229910052757 nitrogen Inorganic materials 0.000 claims description 22
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 21
125000000217 alkyl group Chemical group 0.000 claims description 19
239000003112 inhibitor Substances 0.000 claims description 17
239000008194 pharmaceutical composition Substances 0.000 claims description 14
229910052799 carbon Inorganic materials 0.000 claims description 13
108020004459 Small Interfering RNA Proteins 0.000 claims description 9
229960005486 vaccines Drugs 0.000 claims description 9
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
125000003342 alkenyl group Chemical group 0.000 claims description 8
IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 6
229960000329 Ribavirin Drugs 0.000 claims description 6
125000004093 cyano group Chemical group *C#N 0.000 claims description 6
ZCGNOVWYSGBHAU-UHFFFAOYSA-N Favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims description 5
125000000304 alkynyl group Chemical group 0.000 claims description 5
229950008454 favipiravir Drugs 0.000 claims description 5
239000002955 immunomodulating agent Substances 0.000 claims description 5
230000002584 immunomodulator Effects 0.000 claims description 5
229940121354 immunomodulators Drugs 0.000 claims description 5
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230000001404 mediated Effects 0.000 abstract description 7
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239000006184 cosolvent Substances 0.000 description 8
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MZRVEZGGRBJDDB-UHFFFAOYSA-N n-butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 8
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235000011852 gelatine desserts Nutrition 0.000 description 7
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238000004128 high performance liquid chromatography Methods 0.000 description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
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WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
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KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-Bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 3
QWENRTYMTSOGBR-UHFFFAOYSA-N 1,2,3-triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 description 3
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KTWOOEGAPBSYNW-UHFFFAOYSA-N Ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 3
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OA1202100252 2018-12-06 2019-12-03 OA20266A (fr)