OA12056A - Use of the NN'dibenzylthiourea compound as a medicament - Google Patents

Abstract

The invention concerns the use of a compound chemically called N,N'-dibenzyl-thiourea, a biological antioxidant extracted from a plant of the family of Pentadiplandraceae: Pentadiplandra brazzeana, brazzeana variety for preventive treatment of diseases mediated in human subjects or animals by the action of the hydroxyl radical (OH DEG ). The hydroxyl radical which exists naturally in human subjects bears an unpaired orbital electron. It is aggressive and destroys human and animal cells. There results cell degeneration and death, hence the occurrence in human subjects of diseases such as Parkinson's disease and Alzheimer's disease. N,N'-dibenzyl-thiourea eliminates the hydroxyl radical (OH DEG ) from the human or animal system. This treatment should be preventive and curative in targeted subjects such as children and old people.

Description

1 2056.

The present invention relates to the use of N'N DIBENZYLTHIOUREE, compound extracted from PENTADEPLANDRA BRAZZEANA variety BRAZZEANAdans the therapeutic treatment of humans or animals.

THERAPEUTIC INDICATIONS -........ .. .. - - ,

This medicinal product is indicated for the treatment of all diseases caused by the presence of the oxygenated free radical (hydroxyl radical: OH °) in the human or animal organism, in particular: ALSHEIMER'S DISEASE, PARKINSON'S DISEASE, Cancer of the elderly and children, Vitamin A deficiency in adults and children (kwashiorkor), Cardrovascular disease, Diabetes and complications, Aging of the body, Diseases caused by smoking.

The hydroxyl radical OH ° is responsible for the alteration of the state and the functioning of many cells. It induces the degeneration of cells irrespective of their membership. Until now the drugs used in the treatment of these diseases were intended to combat only their symptoms. Thus dopaminergics (apomorphine), tranquillizers, lesser substances, antidepressants, neuroleptics, oxygenators and vasodilators are used.

Treatment with N'N DIBENZYLTHIOUREE is intended to rid the body of the hydroxyl radical (OH °). This preventive and curative treatment regenerates dead tissue and restores normal cell function. ·

Free radicals are atoms, groups of atoms, or molecules with an unpaired or single electron on the outer orbital. The tendency to match this external orbital electron explains their biological aggressivity.

Indeed, by tearing this electron to another molecule, since then converted to estour free radical, they cause chain reactions leading to the alteration of many cell structures. The appearance of the hydroxyl radical in the organism occurs in the following way: Hydrogen peroxide appears naturally in the organism but it is regularly destroyed by catalase, so that the reaction of formation of this oxygenated water from the water and oxygen is reversible. H2O2 '<.....- H2O + Ά O2 (under the action of catalase). * 1 1 2056

In the child of 0 to 5 years old and senior, there is a deficiency of catalase secretion and the above reaction is no longer reversible - the oxygenated water undergoes the reaction, fenton during which it decomposes into a "common OH ion" and a hydroxyl radical OH ° very reactive.

This reaction is in the presence of Fe2 + present in the human or animal organism.

Fe2 + + H2O2-> Fe3 + + ΟΗΓ + OH ° The OH ° radical appearance in the body can also be directly induced by heat, light or energetic radiation. The alteration of many cellular structures is generally related to the nuclei: modification of the structures of noble elements, particularly of ribonucleic and deoxyribonucleic acids, as well as on the double bonds of the polyunsaturated fatty acids of the cell membrane.

The diseases constituting the therapeutic indications in man or in the animal of NN 'DIBENZYLTHIOUREE are caused in the body by the aggressivity of the hydroxyl radical.

The fight against these diseases consists of the use of biological molecules that can give a hydrogen atom to the hydroxyl radical. To transform it into water (H2O). For example: NN 'DIBENZILTHIOUREE gives the mobile H or mobile hydrogen to the hydroxyl radical according to the following mechanism:

S + 4HO °

POLYMER

STABLE

The medicinal product which is the subject of the present invention having the active ingredient NN'DIBENZILTHIOUREE extracted from PENTAPLANDRA BRAZZEANAVARIETE BRAZZEANA supplies the "H" to the hydroxyl radical OH °, thereby transforming it into water (H2O) which is eliminated from the urinary organism and the formed polymer which is neutral is also eliminated by the urinary tract. ? The advantage of this antioxidant is that it is organic. * 5 NN 'DIBENZYTHIOUREE is not toxic apart from its oxytocic action on the pregnant uterus.

This medicine is presented in the following dosage forms: 10 Syrup

COMPOSITION - NN 'DIBENZYL THIOUREE 108 mg 15 Excipient: syrup sucrose QSP 250 ml

ADULT DOSAGE: 2 tablespoons Morning and evening 20 '· CHILD: 2 teaspoons Morning and evening Other oral forms (capsules, tablets) and rectal route (suppository) can be made. It is simply necessary to protect the NN 'DIBENZYLTHIOUREE against the oxygen of the air. 3

Claims (3)

1) Use of the compound NN 'DIBENZYLTHIOUREE for the preparation of 3medicament in the treatment of diseases, including diseases resulting from the alteration of the state or operation of human or animal cells by hydroxyl radical. 5 2) A medicament according to claim 1 characterized in that its composition isde - NN 'DIBENZYLTHIOUREE 108 mg - sucrose syrup QSP - 250 ml 10 3) Drug according to claims 1 and 2 characterized in that it is obtained in the following galenic forms: - syrup, capsule, suppository tablet. iT 4