OA11522A - Obtention de vaccins destinés à prévenir les effets pathogènes associés à une infection retrovirale. - Google Patents
Obtention de vaccins destinés à prévenir les effets pathogènes associés à une infection retrovirale. Download PDFInfo
- Publication number
- OA11522A OA11522A OA1200000145A OA1200000145A OA11522A OA 11522 A OA11522 A OA 11522A OA 1200000145 A OA1200000145 A OA 1200000145A OA 1200000145 A OA1200000145 A OA 1200000145A OA 11522 A OA11522 A OA 11522A
- Authority
- OA
- OAPI
- Prior art keywords
- protein
- host
- polypeptide
- virus
- retrovirus
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 38
- 230000001717 pathogenic effect Effects 0.000 title claims abstract description 21
- 231100000255 pathogenic effect Toxicity 0.000 title claims abstract description 13
- 206010038997 Retroviral infections Diseases 0.000 title description 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 88
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 87
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 82
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 69
- 229920001184 polypeptide Polymers 0.000 claims abstract description 64
- 238000000034 method Methods 0.000 claims abstract description 42
- 241001430294 unidentified retrovirus Species 0.000 claims abstract description 31
- 101710091045 Envelope protein Proteins 0.000 claims abstract description 30
- 101710188315 Protein X Proteins 0.000 claims abstract description 30
- 241000700605 Viruses Species 0.000 claims abstract description 29
- 239000012634 fragment Substances 0.000 claims abstract description 22
- 230000028993 immune response Effects 0.000 claims abstract description 21
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 208000015181 infectious disease Diseases 0.000 claims abstract description 12
- 102000006240 membrane receptors Human genes 0.000 claims abstract description 9
- 108020004084 membrane receptors Proteins 0.000 claims abstract description 9
- 102100021696 Syncytin-1 Human genes 0.000 claims abstract 9
- 230000035772 mutation Effects 0.000 claims description 71
- 150000001413 amino acids Chemical class 0.000 claims description 46
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims description 35
- 108010002350 Interleukin-2 Proteins 0.000 claims description 32
- 102000000588 Interleukin-2 Human genes 0.000 claims description 32
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 17
- 241000282414 Homo sapiens Species 0.000 claims description 14
- 230000003053 immunization Effects 0.000 claims description 12
- 238000002649 immunization Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 10
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 7
- 108090000695 Cytokines Proteins 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 7
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 108091007466 transmembrane glycoproteins Proteins 0.000 claims description 6
- 241000714266 Bovine leukemia virus Species 0.000 claims description 5
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 241000271566 Aves Species 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 108090000288 Glycoproteins Proteins 0.000 claims description 3
- 102000003886 Glycoproteins Human genes 0.000 claims description 3
- 241000598436 Human T-cell lymphotropic virus Species 0.000 claims description 3
- 241001529934 Simian T-lymphotropic virus 3 Species 0.000 claims description 3
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 3
- 208000010094 Visna Diseases 0.000 claims description 3
- 239000013604 expression vector Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 208000007089 vaccinia Diseases 0.000 claims description 3
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 102000003814 Interleukin-10 Human genes 0.000 claims description 2
- 108090000174 Interleukin-10 Proteins 0.000 claims description 2
- 102000003812 Interleukin-15 Human genes 0.000 claims description 2
- 108090000172 Interleukin-15 Proteins 0.000 claims description 2
- 102000004890 Interleukin-8 Human genes 0.000 claims description 2
- 108090001007 Interleukin-8 Proteins 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 101800000385 Transmembrane protein Proteins 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 229940076144 interleukin-10 Drugs 0.000 claims description 2
- 229940096397 interleukin-8 Drugs 0.000 claims description 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 241000713836 Avian myelocytomatosis virus Species 0.000 claims 1
- 241000714174 Feline sarcoma virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 description 76
- 235000001014 amino acid Nutrition 0.000 description 46
- 210000004027 cell Anatomy 0.000 description 33
- 102100034349 Integrase Human genes 0.000 description 24
- 125000000539 amino acid group Chemical group 0.000 description 16
- 230000004048 modification Effects 0.000 description 16
- 238000012986 modification Methods 0.000 description 16
- 230000002163 immunogen Effects 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 208000030507 AIDS Diseases 0.000 description 9
- 230000001177 retroviral effect Effects 0.000 description 9
- 230000037029 cross reaction Effects 0.000 description 8
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 6
- 108010067390 Viral Proteins Proteins 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 241000713800 Feline immunodeficiency virus Species 0.000 description 5
- 241000713666 Lentivirus Species 0.000 description 5
- 230000001506 immunosuppresive effect Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000013638 trimer Substances 0.000 description 5
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 238000000302 molecular modelling Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000714230 Avian leukemia virus Species 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 241000713730 Equine infectious anemia virus Species 0.000 description 3
- 241000282324 Felis Species 0.000 description 3
- 241000714177 Murine leukemia virus Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000001322 T cell deficiency Diseases 0.000 description 3
- 208000027912 T-cell immunodeficiency Diseases 0.000 description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 230000001363 autoimmune Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 102000055277 human IL2 Human genes 0.000 description 3
- 235000018977 lysine Nutrition 0.000 description 3
- 150000002669 lysines Chemical class 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000713756 Caprine arthritis encephalitis virus Species 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 101710094648 Coat protein Proteins 0.000 description 2
- 101710121417 Envelope glycoprotein Proteins 0.000 description 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- 108010028921 Lipopeptides Proteins 0.000 description 2
- 101710125418 Major capsid protein Proteins 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 101710141454 Nucleoprotein Proteins 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 101710083689 Probable capsid protein Proteins 0.000 description 2
- 241000713675 Spumavirus Species 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010014599 encephalitis Diseases 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 230000008348 humoral response Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 230000002122 leukaemogenic effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 108091005601 modified peptides Proteins 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 231100000590 oncogenic Toxicity 0.000 description 2
- 230000002246 oncogenic effect Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000002864 sequence alignment Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000714195 Aids-associated retrovirus Species 0.000 description 1
- 101100107610 Arabidopsis thaliana ABCF4 gene Proteins 0.000 description 1
- 241000713838 Avian myeloblastosis virus Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102100025698 Cytosolic carboxypeptidase 4 Human genes 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282323 Felidae Species 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 108700010908 HIV-1 proteins Proteins 0.000 description 1
- 101000932590 Homo sapiens Cytosolic carboxypeptidase 4 Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 206010025280 Lymphocytosis Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101001033003 Mus musculus Granzyme F Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 102100037265 Podoplanin Human genes 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 208000005074 Retroviridae Infections Diseases 0.000 description 1
- 241000714474 Rous sarcoma virus Species 0.000 description 1
- 108010072476 SIV envelope protein gp41 Proteins 0.000 description 1
- 101100068078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCN4 gene Proteins 0.000 description 1
- 241000713311 Simian immunodeficiency virus Species 0.000 description 1
- 241001061029 Simianus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 240000003864 Ulex europaeus Species 0.000 description 1
- 235000010730 Ulex europaeus Nutrition 0.000 description 1
- 241000713325 Visna/maedi virus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 108010055246 excisionase Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000021601 lentivirus infection Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9714387A FR2771011B1 (fr) | 1997-11-17 | 1997-11-17 | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| PCT/FR1998/002447 WO1999025377A1 (fr) | 1997-11-17 | 1998-11-17 | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11522A true OA11522A (fr) | 2004-02-09 |
Family
ID=9513450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200000145A OA11522A (fr) | 1997-11-17 | 1998-11-17 | Obtention de vaccins destinés à prévenir les effets pathogènes associés à une infection retrovirale. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6455265B1 (da) |
| EP (1) | EP1034000B1 (da) |
| JP (1) | JP4837823B2 (da) |
| KR (1) | KR20010032210A (da) |
| CN (1) | CN1281371A (da) |
| AP (1) | AP2000001841A0 (da) |
| AT (1) | ATE353017T1 (da) |
| AU (1) | AU1243499A (da) |
| BR (1) | BR9814204A (da) |
| CA (1) | CA2309676C (da) |
| DE (1) | DE69837012T2 (da) |
| DK (1) | DK1034000T3 (da) |
| EA (1) | EA200000528A1 (da) |
| ES (1) | ES2281938T3 (da) |
| FR (1) | FR2771011B1 (da) |
| IL (2) | IL136163A0 (da) |
| OA (1) | OA11522A (da) |
| PT (1) | PT1034000E (da) |
| WO (1) | WO1999025377A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2771011B1 (fr) * | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| CN1396178A (zh) * | 2002-06-17 | 2003-02-12 | 成都阳辉生物科技有限责任公司 | 抗乙肝病毒等包膜病毒感染的工程多肽及其制备方法 |
| ATE508139T1 (de) | 2003-04-11 | 2011-05-15 | Pasteur Institut | Synthetische peptid-hiv-vakzine: das cbd-epitop als effizientes immunogen zur induktion hiv- neutralisierender antikörper |
| EP1680444A1 (en) * | 2003-07-30 | 2006-07-19 | Mymetics Corporation | New soluble and stabilized trimeric form of gp41 polypeptides |
| JP2007505320A (ja) * | 2003-09-11 | 2007-03-08 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルスの検出のための方法と装置 |
| AU2004304348B2 (en) * | 2003-12-18 | 2009-02-26 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| CA2556141A1 (en) * | 2004-02-19 | 2005-09-01 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| EP1732585B1 (en) * | 2004-03-30 | 2010-06-30 | Institut Gustave Roussy | Polypeptide sequence involved in the modulation of the immunosuppresive effect of viral proteins |
| EP1761556A1 (en) * | 2004-06-30 | 2007-03-14 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus (fiv) comprising the use of peptides derived from the v3 region of the fiv env protein |
| EP1761564A1 (en) * | 2004-06-30 | 2007-03-14 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| JP4307505B2 (ja) * | 2004-06-30 | 2009-08-05 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルスの検出のための方法と装置 |
| US7291338B2 (en) * | 2005-03-09 | 2007-11-06 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| JP5020941B2 (ja) * | 2005-05-02 | 2012-09-05 | マイメティクス コーポレーション | Ｈｉｖに対して中和活性を有するがｉｌ２には中和活性を有さない抗体又はその断片 |
| TWI343180B (en) * | 2005-07-01 | 2011-06-01 | Ind Tech Res Inst | The acoustic wave sensing-device integrated with micro channels |
| WO2007099387A1 (en) * | 2006-03-03 | 2007-09-07 | Mymetics Corporation | Virosome-like vesicles comprising gp41-derived antigens |
| CN1869704B (zh) * | 2006-06-14 | 2010-06-30 | 厦门大学 | 快速鉴定与病原菌互作的宿主蛋白的方法 |
| WO2010042760A2 (en) * | 2008-10-08 | 2010-04-15 | The Administrators Of The Tulane Educational Fund | Compositions, methods, and kits for enhancing the immunogenicity of pathogenic antigens |
| AU2010210073B2 (en) | 2009-02-06 | 2016-06-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Splitting gp41 |
| US8765137B2 (en) | 2009-02-06 | 2014-07-01 | Mymetics Corporation | Gp41 antigens |
| WO2011022725A2 (en) * | 2009-08-21 | 2011-02-24 | Dana-Farber Cancer Institute, Inc. | Mimotopes of hiv and uses thereof |
| EP2553452B1 (en) | 2010-04-02 | 2015-03-04 | IDEXX Laboratories, Inc. | Detection of feline immunodeficiency virus |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| AU2013308623B2 (en) | 2012-08-30 | 2017-03-02 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| WO2021185851A1 (en) | 2020-03-17 | 2021-09-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vaccine compositions for hiv prevention and treatment |
| CN111701016A (zh) * | 2020-06-28 | 2020-09-25 | 张全志 | 逆转录病毒原病毒序列在逆转录病毒疫苗设计中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993001304A1 (en) * | 1991-07-10 | 1993-01-21 | Synbiotics Corporation | Synthetic peptides related to fiv-env proteins |
| CA2140663C (en) * | 1992-07-20 | 2004-01-27 | Carl T. Wild | Compounds which inhibit hiv replication |
| GB9219936D0 (en) * | 1992-09-21 | 1992-11-04 | Pitman Moore Inc | Vaccines |
| US6017536A (en) * | 1993-06-07 | 2000-01-25 | Trimeris, Inc. | Simian immunodeficiency virus peptides with antifusogenic and antiviral activities |
| US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| FR2771011B1 (fr) * | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
-
1997
- 1997-11-17 FR FR9714387A patent/FR2771011B1/fr not_active Expired - Fee Related
-
1998
- 1998-11-17 EA EA200000528A patent/EA200000528A1/ru unknown
- 1998-11-17 AP APAP/P/2000/001841A patent/AP2000001841A0/en unknown
- 1998-11-17 OA OA1200000145A patent/OA11522A/fr unknown
- 1998-11-17 CA CA2309676A patent/CA2309676C/fr not_active Expired - Fee Related
- 1998-11-17 JP JP2000520810A patent/JP4837823B2/ja not_active Expired - Fee Related
- 1998-11-17 WO PCT/FR1998/002447 patent/WO1999025377A1/fr active IP Right Grant
- 1998-11-17 DK DK98955673T patent/DK1034000T3/da active
- 1998-11-17 AT AT98955673T patent/ATE353017T1/de active
- 1998-11-17 AU AU12434/99A patent/AU1243499A/en not_active Abandoned
- 1998-11-17 CN CN98811909A patent/CN1281371A/zh active Pending
- 1998-11-17 EP EP98955673A patent/EP1034000B1/fr not_active Expired - Lifetime
- 1998-11-17 BR BR9814204-6A patent/BR9814204A/pt not_active IP Right Cessation
- 1998-11-17 DE DE69837012T patent/DE69837012T2/de not_active Expired - Lifetime
- 1998-11-17 PT PT98955673T patent/PT1034000E/pt unknown
- 1998-11-17 ES ES98955673T patent/ES2281938T3/es not_active Expired - Lifetime
- 1998-11-17 IL IL13616398A patent/IL136163A0/xx active IP Right Grant
- 1998-11-17 KR KR1020007005402A patent/KR20010032210A/ko not_active Application Discontinuation
-
2000
- 2000-05-15 US US09/570,921 patent/US6455265B1/en not_active Expired - Lifetime
- 2000-05-16 IL IL136163A patent/IL136163A/en not_active IP Right Cessation
-
2002
- 2002-07-22 US US10/198,938 patent/US7253270B2/en not_active Expired - Fee Related
-
2007
- 2007-07-16 US US11/826,471 patent/US7829683B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7829683B2 (en) | 2010-11-09 |
| EP1034000A1 (fr) | 2000-09-13 |
| CA2309676C (fr) | 2012-08-07 |
| FR2771011A1 (fr) | 1999-05-21 |
| WO1999025377A1 (fr) | 1999-05-27 |
| EP1034000B1 (fr) | 2007-01-31 |
| ES2281938T3 (es) | 2007-10-01 |
| CN1281371A (zh) | 2001-01-24 |
| AP2000001841A0 (en) | 2000-06-30 |
| DK1034000T3 (da) | 2007-06-04 |
| FR2771011B1 (fr) | 2000-01-28 |
| ATE353017T1 (de) | 2007-02-15 |
| DE69837012D1 (de) | 2007-03-22 |
| KR20010032210A (ko) | 2001-04-16 |
| IL136163A0 (en) | 2001-05-20 |
| CA2309676A1 (fr) | 1999-05-27 |
| BR9814204A (pt) | 2000-10-03 |
| EA200000528A1 (ru) | 2001-02-26 |
| IL136163A (en) | 2007-07-04 |
| US7253270B2 (en) | 2007-08-07 |
| JP2001524456A (ja) | 2001-12-04 |
| US20080003229A1 (en) | 2008-01-03 |
| US6455265B1 (en) | 2002-09-24 |
| US20040014046A1 (en) | 2004-01-22 |
| US20050048478A9 (en) | 2005-03-03 |
| AU1243499A (en) | 1999-06-07 |
| DE69837012T2 (de) | 2007-11-29 |
| PT1034000E (pt) | 2007-05-31 |
| JP4837823B2 (ja) | 2011-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1034000B1 (fr) | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale vih | |
| EP0283327B1 (fr) | Peptides ayant des propriétés immunologiques de HIV-2 | |
| US7364744B2 (en) | Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV | |
| EP1368372B1 (fr) | Peptides presentant une affinite pour la proteine virale gp120, et utilisation de ces peptides | |
| FR2635532A1 (fr) | Particules hbsag recombinantes hybrides : caracteristiques morphologiques de l'antigene hbsag contenant 1 sequence immunogene induisant des anticorps neutralisants diriges contre hiv ou susceptible d'etre reconnue par de tels anticorps; sequences nucleotidiques codant pour de telles particules; vaccins les contenant | |
| FR2687404A1 (fr) | Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques. | |
| EP0656010B8 (fr) | Utilisation de peptide reconnu par une réponse immunitaire pour l'obtention de médicaments déstinés à l'induction de la supression immunitaire. | |
| FR2646606A1 (fr) | Retrovirus hautement cytopathogenique hiv-ndk. fragment d'adn de ce retrovirus, procede de preparation d'une proteine et/ou enzyme de ce virus et leurs utilisations | |
| CA1341520C (fr) | Peptides susceptibles d'etre reconnus par des anticorps induits contre des retrovirus d'immunodeficience humaine (virus hiv) leurs applicationsau diagnostic des infections dues a certains de ces virus et, le cas echeant, a la vaccination contre le sida | |
| EP0424519A1 (fr) | Antigenes de la glycoproteine transmembranaire d'enveloppe d'un retrovirus humain du type hiv-2 (antigenes presentant avec eux une parente immunologique). | |
| FR2829150A1 (fr) | Gene env mute codant pour une glypoproteine du vih-1 et applications | |
| MXPA00004633A (en) | Method for obtaining vaccines for preventing the pathogenic effects related to a retroviral infection | |
| FR2696188A1 (fr) | Molécule CD4 de chat, séquence nucléique codant pour cette molécule et leurs applications. | |
| FR2789590A1 (fr) | Compositions immunogenes utilisables comme vaccins | |
| FR2726006A1 (fr) | Sequences nucleotidiques codant des antigenes d'un retrovirus du type vih-1 groupe o |