OA11515A - Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. - Google Patents
Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. Download PDFInfo
- Publication number
- OA11515A OA11515A OA9900253A OA9900253A OA11515A OA 11515 A OA11515 A OA 11515A OA 9900253 A OA9900253 A OA 9900253A OA 9900253 A OA9900253 A OA 9900253A OA 11515 A OA11515 A OA 11515A
- Authority
- OA
- OAPI
- Prior art keywords
- compound
- alkyl
- formula
- group
- aryl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9710750.2A GB9710750D0 (en) | 1997-05-23 | 1997-05-23 | Novel compounds |
IT002354 IT1295358B1 (it) | 1997-10-17 | 1997-10-17 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
ITMI972775 IT1296976B1 (it) | 1997-12-16 | 1997-12-16 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA11515A true OA11515A (en) | 2004-02-04 |
Family
ID=27268859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA9900253A OA11515A (en) | 1997-05-23 | 1999-11-23 | Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0983262B1 (fr) |
JP (1) | JP2002500645A (fr) |
CN (1) | CN1264378A (fr) |
AP (1) | AP9901695A0 (fr) |
AR (1) | AR012732A1 (fr) |
AT (1) | ATE244711T1 (fr) |
AU (1) | AU8209898A (fr) |
BG (1) | BG104009A (fr) |
BR (1) | BR9809652A (fr) |
CA (1) | CA2291111A1 (fr) |
CO (1) | CO4950515A1 (fr) |
DE (1) | DE69816290T2 (fr) |
DZ (1) | DZ2498A1 (fr) |
EA (1) | EA199901062A1 (fr) |
ES (1) | ES2201509T3 (fr) |
HU (1) | HUP0002300A3 (fr) |
ID (1) | ID22876A (fr) |
IL (1) | IL133036A0 (fr) |
MA (1) | MA26501A1 (fr) |
NO (1) | NO995711L (fr) |
OA (1) | OA11515A (fr) |
PE (1) | PE75199A1 (fr) |
PL (1) | PL336942A1 (fr) |
SK (1) | SK159299A3 (fr) |
TR (1) | TR199902883T2 (fr) |
WO (1) | WO1998052942A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
JP2002530377A (ja) * | 1998-11-20 | 2002-09-17 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | Nk−3およびnk−2受容体アンタゴニストとしてのキノリン−4−カルボキシアミド誘導体 |
GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
DE60004654T2 (de) | 1999-03-29 | 2004-06-24 | Neurogen Corp., Branford | 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden |
AU4802500A (en) * | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
WO2002013825A1 (fr) * | 2000-08-11 | 2002-02-21 | Smithkline Beecham P.L.C. | Nouvelle utilisation pharmaceutique de dérivés quinnoliniques |
EP1334089A1 (fr) * | 2000-11-13 | 2003-08-13 | GlaxoSmithKline S.p.A. | Derives de la quinoline en tant qu'antagonistes de nk-3 et nk-2 |
GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
WO2002044165A1 (fr) * | 2000-11-28 | 2002-06-06 | Glaxosmithkline Spa | Derives de quinoline utilises comme antagonistes de nk-3 |
US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
EP1385839B1 (fr) * | 2001-04-11 | 2006-02-22 | GlaxoSmithKline S.p.A. | Derives de 3-substitue quinoline-4-carboxamide utilises comme antagonistes du recepteur nk3 et du recepteur nk2 |
GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425075D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
CN101189211A (zh) * | 2005-06-03 | 2008-05-28 | 阿斯利康(瑞典)有限公司 | 作为nk3拮抗剂的喹啉衍生物 |
GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
DE202007017299U1 (de) * | 2007-12-12 | 2009-04-23 | Drebo Werkzeugfabrik Gmbh | Bohrer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL186665B1 (pl) * | 1994-05-27 | 2004-02-27 | Smithkline Beecham Spa | Pochodne chinoliny jako antagoniści receptorów NKtachykininy, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca pochodne chinoliny oraz ich zastosowanie |
AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
-
1998
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 EP EP98932069A patent/EP0983262B1/fr not_active Expired - Lifetime
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/fr not_active Application Discontinuation
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 CA CA002291111A patent/CA2291111A1/fr not_active Abandoned
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/fr active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
-
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL133036A0 (en) | 2001-03-19 |
HUP0002300A3 (en) | 2002-01-28 |
BR9809652A (pt) | 2001-09-11 |
DZ2498A1 (fr) | 2003-01-25 |
NO995711D0 (no) | 1999-11-22 |
DE69816290D1 (de) | 2003-08-14 |
ID22876A (id) | 1999-12-16 |
JP2002500645A (ja) | 2002-01-08 |
CN1264378A (zh) | 2000-08-23 |
CO4950515A1 (es) | 2000-09-01 |
EP0983262B1 (fr) | 2003-07-09 |
PL336942A1 (en) | 2000-07-17 |
WO1998052942A1 (fr) | 1998-11-26 |
SK159299A3 (en) | 2000-06-12 |
MA26501A1 (fr) | 2004-12-20 |
CA2291111A1 (fr) | 1998-11-26 |
EA199901062A1 (ru) | 2000-08-28 |
PE75199A1 (es) | 1999-10-22 |
TR199902883T2 (xx) | 2000-05-22 |
BG104009A (en) | 2000-07-31 |
AU8209898A (en) | 1998-12-11 |
ES2201509T3 (es) | 2004-03-16 |
EP0983262A1 (fr) | 2000-03-08 |
HUP0002300A2 (hu) | 2001-06-28 |
AR012732A1 (es) | 2000-11-08 |
AP9901695A0 (en) | 1999-12-31 |
DE69816290T2 (de) | 2004-05-27 |
ATE244711T1 (de) | 2003-07-15 |
NO995711L (no) | 2000-01-19 |
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