NZ703347A - Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism - Google Patents
Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidismInfo
- Publication number
- NZ703347A NZ703347A NZ703347A NZ70334713A NZ703347A NZ 703347 A NZ703347 A NZ 703347A NZ 703347 A NZ703347 A NZ 703347A NZ 70334713 A NZ70334713 A NZ 70334713A NZ 703347 A NZ703347 A NZ 703347A
- Authority
- NZ
- New Zealand
- Prior art keywords
- secondary hyperparathyroidism
- dihydroxyvitamin
- methylene
- treat secondary
- symptoms
- Prior art date
Links
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 title abstract 3
- UHMPCVGLSKFXHR-NFZXMVPNSA-N (1r,3r)-5-[(2e)-2-[(3as,7ar)-1-[(2s)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CCC([C@]2(CCC1)C)[C@H](CCCC(C)(C)O)C)=C\C=C1C[C@@H](O)C(=C)[C@H](O)C1 UHMPCVGLSKFXHR-NFZXMVPNSA-N 0.000 title abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666264P | 2012-06-29 | 2012-06-29 | |
| PCT/US2013/031574 WO2014003849A1 (en) | 2012-06-29 | 2013-03-14 | USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D3 TO TREAT SECONDARY HYPERPARATHYROIDISM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ703347A true NZ703347A (en) | 2016-05-27 |
Family
ID=47997980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ703347A NZ703347A (en) | 2012-06-29 | 2013-03-14 | Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9205096B2 (enExample) |
| EP (1) | EP2866811A1 (enExample) |
| JP (1) | JP2015522015A (enExample) |
| KR (1) | KR20150030673A (enExample) |
| CN (1) | CN104394871A (enExample) |
| AU (1) | AU2013281217B2 (enExample) |
| BR (1) | BR112014032847A2 (enExample) |
| CA (1) | CA2877680C (enExample) |
| CL (1) | CL2014003565A1 (enExample) |
| CO (1) | CO7240358A2 (enExample) |
| HK (1) | HK1206600A1 (enExample) |
| IL (1) | IL236184A0 (enExample) |
| MX (1) | MX2015000076A (enExample) |
| MY (1) | MY172886A (enExample) |
| NZ (1) | NZ703347A (enExample) |
| RU (1) | RU2666995C2 (enExample) |
| SG (1) | SG11201408731WA (enExample) |
| WO (1) | WO2014003849A1 (enExample) |
| ZA (1) | ZA201500119B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY172886A (en) * | 2012-06-29 | 2019-12-13 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1?25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
| WO2015048573A1 (en) | 2013-09-27 | 2015-04-02 | Codexis, Inc. | Structure based predictive modeling |
| DK3049973T3 (en) | 2013-09-27 | 2018-10-22 | Codexis Inc | AUTOMATED SCREENING OF ENZYM VARIENTS |
| CN103533522A (zh) * | 2013-10-25 | 2014-01-22 | 从兴技术有限公司 | 短信稽核的方法及系统 |
| US10220047B2 (en) * | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US9539264B2 (en) * | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) * | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| WO2018044468A1 (en) | 2016-08-30 | 2018-03-08 | Wisconsin Alumni Research Foundation | COMBINATION OF LOW DOSE 2-METHYLENE-19-NOR-(20S)-1α, 25-DIHYDROXYVITAMIN D3 AND CALCIMIMETICS TO TREAT SECONDARY HYPERPARATHYROIDISM |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040043971A1 (en) | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6306844B1 (en) | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6136799A (en) | 1998-04-08 | 2000-10-24 | Abbott Laboratories | Cosolvent formulations |
| US6673782B2 (en) | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
| DK1267886T3 (da) | 2000-03-27 | 2006-07-10 | Wisconsin Alumni Res Found | D-vitaminforbindelser anvendt til at stabilisere nyretransplantater |
| BR0112454A (pt) * | 2000-07-14 | 2003-07-29 | Wisconsin Alumni Res Found | Métodos de tratamento de doença metabólica do osso, psorìase, leucemia, câncer do cólon, do seio ou da próstata e de aumento da força de um osso e uso de composto |
| US20080249068A1 (en) | 2002-09-05 | 2008-10-09 | Deluca Hector F | Method of Extending the Dose Range of Vitamin D Compounds |
| US20050124591A1 (en) | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| US20060171983A1 (en) | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
| NZ545632A (en) * | 2003-09-19 | 2009-09-25 | Wisconsin Alumni Res Found | 2-Alkylidene-19-nor-vitamin D derivatives for the treatment of frailty, muscle damage or sarcopenia |
| US7704980B2 (en) | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| US7214671B2 (en) | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| CA2597624C (en) | 2005-02-11 | 2012-08-14 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dihydroxyvitamin-d2 |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| JP5908402B2 (ja) * | 2009-08-03 | 2016-04-26 | ウィスコンシン・アルムニ・リサーチ・ファウンデーションＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 腎疾患の予防方法およびその症状を処置する方法 |
| WO2011119610A2 (en) | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3 |
| MY172886A (en) * | 2012-06-29 | 2019-12-13 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1?25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
-
2013
- 2013-03-14 MY MYPI2014003594A patent/MY172886A/en unknown
- 2013-03-14 KR KR20147036464A patent/KR20150030673A/ko not_active Ceased
- 2013-03-14 AU AU2013281217A patent/AU2013281217B2/en not_active Ceased
- 2013-03-14 HK HK15107093.4A patent/HK1206600A1/xx unknown
- 2013-03-14 EP EP13712121.6A patent/EP2866811A1/en not_active Withdrawn
- 2013-03-14 WO PCT/US2013/031574 patent/WO2014003849A1/en not_active Ceased
- 2013-03-14 RU RU2015102831A patent/RU2666995C2/ru not_active IP Right Cessation
- 2013-03-14 NZ NZ703347A patent/NZ703347A/en not_active IP Right Cessation
- 2013-03-14 MX MX2015000076A patent/MX2015000076A/es unknown
- 2013-03-14 CA CA2877680A patent/CA2877680C/en not_active Expired - Fee Related
- 2013-03-14 SG SG11201408731WA patent/SG11201408731WA/en unknown
- 2013-03-14 BR BR112014032847A patent/BR112014032847A2/pt not_active Application Discontinuation
- 2013-03-14 US US13/828,090 patent/US9205096B2/en not_active Expired - Fee Related
- 2013-03-14 JP JP2015520165A patent/JP2015522015A/ja active Pending
- 2013-03-14 CN CN201380034681.7A patent/CN104394871A/zh active Pending
-
2014
- 2014-03-07 US US14/201,091 patent/US9034853B2/en not_active Expired - Fee Related
- 2014-12-11 IL IL236184A patent/IL236184A0/en unknown
- 2014-12-29 CL CL2014003565A patent/CL2014003565A1/es unknown
-
2015
- 2015-01-08 ZA ZA2015/00119A patent/ZA201500119B/en unknown
- 2015-01-23 CO CO15013584A patent/CO7240358A2/es unknown
- 2015-11-20 US US14/947,142 patent/US9717744B2/en not_active Expired - Fee Related
-
2017
- 2017-05-24 US US15/604,069 patent/US10046000B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CO7240358A2 (es) | 2015-04-17 |
| SG11201408731WA (en) | 2015-01-29 |
| AU2013281217A1 (en) | 2015-01-22 |
| CA2877680C (en) | 2017-08-29 |
| US20160136184A1 (en) | 2016-05-19 |
| HK1206600A1 (en) | 2016-01-15 |
| RU2666995C2 (ru) | 2018-09-13 |
| AU2013281217B2 (en) | 2017-03-02 |
| MY172886A (en) | 2019-12-13 |
| ZA201500119B (en) | 2017-11-29 |
| EP2866811A1 (en) | 2015-05-06 |
| US9717744B2 (en) | 2017-08-01 |
| US20140187522A1 (en) | 2014-07-03 |
| CN104394871A (zh) | 2015-03-04 |
| US9034853B2 (en) | 2015-05-19 |
| US10046000B2 (en) | 2018-08-14 |
| BR112014032847A2 (pt) | 2017-06-27 |
| CA2877680A1 (en) | 2014-01-03 |
| WO2014003849A1 (en) | 2014-01-03 |
| KR20150030673A (ko) | 2015-03-20 |
| MX2015000076A (es) | 2015-04-10 |
| JP2015522015A (ja) | 2015-08-03 |
| US20140005152A1 (en) | 2014-01-02 |
| IL236184A0 (en) | 2015-01-29 |
| RU2015102831A (ru) | 2016-08-20 |
| US20170252360A1 (en) | 2017-09-07 |
| CL2014003565A1 (es) | 2015-08-28 |
| US9205096B2 (en) | 2015-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 MAR 2018 BY CPA GLOBAL Effective date: 20170203 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 MAR 2019 BY CPA GLOBAL Effective date: 20180201 |
|
| LAPS | Patent lapsed |