NZ612185A - Topical combination formulations of macrocyclic lactones with synthetic pyrethroids - Google Patents
Topical combination formulations of macrocyclic lactones with synthetic pyrethroidsInfo
- Publication number
- NZ612185A NZ612185A NZ612185A NZ61218511A NZ612185A NZ 612185 A NZ612185 A NZ 612185A NZ 612185 A NZ612185 A NZ 612185A NZ 61218511 A NZ61218511 A NZ 61218511A NZ 612185 A NZ612185 A NZ 612185A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pyrethroid
- macrocyclic lactone
- macrocyclic lactones
- combination formulations
- synthetic pyrethroids
- Prior art date
Links
- 150000002596 lactones Chemical class 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 239000002728 pyrethroid Substances 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 abstract 1
- NFIHXTUNNGIYRF-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCC NFIHXTUNNGIYRF-UHFFFAOYSA-N 0.000 abstract 1
- 239000005892 Deltamethrin Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 229960002483 decamethrin Drugs 0.000 abstract 1
- PWEOPMBMTXREGV-UHFFFAOYSA-N decanoic acid;octanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCC(O)=O.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O PWEOPMBMTXREGV-UHFFFAOYSA-N 0.000 abstract 1
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 abstract 1
- WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 abstract 1
- 229960002346 eprinomectin Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000375 suspending agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Disclosed is a pharmaceutically or veterinarily acceptable formulation adapted to be topically applied to an animal, which formulation comprises; a) an effective amount of the pyrethroid deltamethrin; b) an effective amount of at least one macrocyclic lactone which is eprinomectin; c) a pharmaceutically acceptable system of solvents and/or suspending agents and excipients wherein the system provides for acceptable storage stability for both the pyrethroid and the macrocyclic lactone; wherein the macrocyclic lactone and the pyrethroid are both dissolved in a solvent (such as propylene glycol dicaprylate/dicaprate (MIGLYOL 840)), or, wherein the macrocyclic lactone is dissolved in an organic solvent (such as propylene glycol) and the pyrethroid is suspended in an aqueous phase; and wherein the system provides storage stability for greater than 3 months.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ627856A NZ627856A (en) | 2010-12-07 | 2011-12-06 | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42074410P | 2010-12-07 | 2010-12-07 | |
| PCT/US2011/063497 WO2012078605A1 (en) | 2010-12-07 | 2011-12-06 | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ612185A true NZ612185A (en) | 2015-10-30 |
Family
ID=45464088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ627856A NZ627856A (en) | 2010-12-07 | 2011-12-06 | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| NZ612185A NZ612185A (en) | 2010-12-07 | 2011-12-06 | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ627856A NZ627856A (en) | 2010-12-07 | 2011-12-06 | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2011338573B2 (en) |
| NZ (2) | NZ627856A (en) |
| WO (1) | WO2012078605A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104483426A (en) * | 2014-11-27 | 2015-04-01 | 黑龙江省乳品工业技术开发中心 | Predicting method of reduction of content of acetochlor in lactation of dairy cattle and application |
| WO2016139331A1 (en) | 2015-03-05 | 2016-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of melanoma |
| WO2017144546A1 (en) | 2016-02-23 | 2017-08-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma |
| EP3956446A1 (en) | 2019-04-17 | 2022-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders |
| EP3760045A1 (en) * | 2019-07-04 | 2021-01-06 | Laboratorios Virbac Mexico SA DE CV | Topical composition against rhipicephalus (boophilus) microplus |
| WO2021198511A1 (en) | 2020-04-03 | 2021-10-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of sars-cov-2 infection |
| WO2022008597A1 (en) | 2020-07-08 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of infectious diseases |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| SE434277B (en) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| EP0237482A1 (en) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | Derivatives of C(29)-carbonyloxy-milbemycine against parasites in animals and plants |
| RU2024527C1 (en) | 1986-03-25 | 1994-12-15 | Санкио Компани Лимитед | Method of macrolide compounds synthesis |
| ES2039258T3 (en) | 1986-07-02 | 1993-09-16 | Ciba-Geigy Ag | PESTICIDES. |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| DE3888936T2 (en) | 1987-11-03 | 1994-07-21 | Beecham Group Plc | Intermediates for the production of macrolide antibiotics with an anthelmintic effect. |
| NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| NZ335166A (en) | 1999-04-14 | 2001-11-30 | Ashmont Holdings Ltd | Anthelmintic composition containing triclabendazole in at least one solvent |
| US5602107A (en) | 1993-05-10 | 1997-02-11 | Merck & Co., Inc. | Pour-on formulations consisting of gylcols, glycerides and avermectin compounds |
| ES2359973T3 (en) | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES. |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| CN1237342A (en) * | 1999-05-26 | 1999-12-08 | 解俊峰 | Avermectin or ivermectin and high-effective chlorocyanogen micro emulsion |
| AU2003101020B4 (en) | 1999-06-04 | 2004-01-29 | Argenta Manufacturing Limited | Stable Biocidal Compositions |
| EG23124A (en) | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
| CR6574A (en) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | SALTS OF SUBSTITUTED FINDINGS IN POSITION 4 WITH PESTICIATED PROPERTIES |
| CN1386419A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Composite insecticide containing macrolide insect repellents for sanitary purpose |
| BR0102126A (en) * | 2001-05-25 | 2003-02-04 | Vallee S A | Synergistic combination of topical or injectable antiparasitics |
| AR036486A1 (en) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | DERIVATIVES 4 "-DESOXI-4" - (S) -AMINO AVERMECTINA, PESTICIDE COMPOSITION, PROCEDURE FOR THE PREPARATION OF THAT COMPOSITION, METHOD FOR CONTROLLING PESTS, AND USE OF THESE DERIVATIVES TO PREPARE A COMPOSITION |
| AR037938A1 (en) | 2001-12-21 | 2004-12-22 | Syngenta Participations Ag | DERIVATIVES OF AVERMECTIN B1 THAT HAVE A SUBSTITUENT OF AMINOSULPHONYLOXYL IN POSITION 4 '' |
| NZ520295A (en) | 2002-07-19 | 2005-04-29 | Ashmont Holdings Ltd | Anthelmintic formulations comprising levamisole and either an avermectin or milbemycin |
| GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
| GB0302310D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties |
| GB0313937D0 (en) | 2003-06-16 | 2003-07-23 | Syngenta Participations Ag | Avermectin B1 monosaccharide derivatives having an aminosulfonyloxy substituentin the 4'-position |
| GB0320176D0 (en) | 2003-08-28 | 2003-10-01 | Syngenta Participations Ag | Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties |
| BRPI0506279B1 (en) | 2005-12-16 | 2018-01-09 | Npa - Núcleo De Pesquisas Aplicadas Ltda | SYNERGY COMPOSITION OF ANTIHELMINTICS AND NON-DECATED |
| CN101156588B (en) * | 2007-11-19 | 2011-05-18 | 广西田园生化股份有限公司 | Compound agricultural chemical |
| CN101518256A (en) * | 2008-02-27 | 2009-09-02 | 潘贞德 | A set of soluble liquid insecticides with cyfluthrin and highly efficient cyfluthrin as raw materials |
-
2011
- 2011-12-06 WO PCT/US2011/063497 patent/WO2012078605A1/en active Application Filing
- 2011-12-06 NZ NZ627856A patent/NZ627856A/en unknown
- 2011-12-06 NZ NZ612185A patent/NZ612185A/en unknown
- 2011-12-06 AU AU2011338573A patent/AU2011338573B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ627856A (en) | 2016-03-31 |
| AU2011338573A1 (en) | 2013-07-11 |
| AU2011338573B2 (en) | 2016-07-28 |
| WO2012078605A1 (en) | 2012-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: MERIAL, INC., US Effective date: 20151022 |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 06 DEC 2018 BY FB RICE Effective date: 20160202 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2019 BY COMPUTER PACKAGES INC Effective date: 20181120 |
|
| ASS | Change of ownership |
Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC., US Effective date: 20190328 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2020 BY COMPUTER PACKAGES INC Effective date: 20191203 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2021 BY COMPUTER PACKAGES INC Effective date: 20201118 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2022 BY DENNEMEYER + CO Effective date: 20211129 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2023 BY DENNEMEYER + CO. Effective date: 20221129 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2024 BY DENNEMEYER + CO. S.A.R.L. Effective date: 20231127 |