CN101156588B - Compound agricultural chemical - Google Patents
Compound agricultural chemical Download PDFInfo
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- CN101156588B CN101156588B CN 200710187294 CN200710187294A CN101156588B CN 101156588 B CN101156588 B CN 101156588B CN 200710187294 CN200710187294 CN 200710187294 CN 200710187294 A CN200710187294 A CN 200710187294A CN 101156588 B CN101156588 B CN 101156588B
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- diamond
- ivermectin hcl
- gamma cyhalothrin
- cyhalothrin
- back moth
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Abstract
The invention relates to a compound pesticide, which is made into by compounding high efficiency lambda-cyhalothrin with ivermectin. The compound pesticide of the invention not only can eliminate the resistance of lepidopteran agricultural pests such as diamondback moth, prodenia litura litura, beet armyworm, cabbage caterpillar, cotton bollworm, and so on to the high efficiency lambda-cyhalothrin; but also can improve the preventing effect greatly.
Description
Technical field
The present invention relates to pesticide field, particularly a kind of Recompounded pesticide.
Background technology
Lepidoptera comprises moth, butterfly two class insects.Belong to Pterigota, Holo metabola.Known about 200,000 kinds of the whole world, kind surplus in the of Chinese known about 8000.This order is the 2nd the big order that is only second to coleoptera in the Insecta.Distribution is extremely wide, and is the abundantest with tropical kind.The larva of the most kinds all kinds of cultivated plants of causing harm, the normal food of bodily form the greater are blade or bore moth limb to the greatest extent.Bodily form smaller often leaf roll, sew leaf, the knot sheath, weave silk knot or pierce plant tissue get the food cause harm.Adult is many with nutrition as a supplement such as nectar, or mouthpart degenerates and no longer get food, does not generally cause direct harm.Body is little of big shape.Be covered with scale on adult wing, body and the appendage, mouthpart hydrocone type or degeneration.Larva Candle-sticks shape, the mouthpart chewing type, densely covered bristle that disperses of each joint of health or verruca, tuft, scolus etc. have 2～5 pairs of abdominal foots, and in the majority with 5 couples of persons, tool crochets, multipotency are weaved silk and are cocoond or knot.Pupa is an obtected pupa.Ovum mostly is circle, hemispherical or oblateness etc.
Ivermectin
Other Chinese name: Ivermectin HCL
English common name: Ivermectin
Chemical name: 5-O-demethyl-22, the two hydrogen Avermectin A1 structural formulas of 23-:
Molecular formula: B1a C48H74O14 (R=C2H5) molecular weight: B1a:874
B1b C47H72O14 (R=CH3) molecular weight: B1b:860
Structural formula:
Physicochemical property:
Pure product are that white is to light yellow crystallization or amorphous powder.Outward appearance is a white solid, fusing point 145-150 ℃; Dissolubility (21 ℃): water 0.01mg/L, acetone 100g/L, n-butanol 10g/L, chloroform 25g/L, cyclohexane 6g/L, ethanol 20g/L, isopropyl alcohol 70g/L, kerosene 0.5g/L, methyl alcohol 19.5g/L, toluene 350g/L; More stable to ratio of specific heat, to the ultraviolet light sensitivity.Fusing point, 150～155 ℃, vapour pressure, 199.98nPa.
Toxicity:
Toxicity LD50 (mg/kg): former medicine: small white mouse acute oral 13.6 (sesame oil), 29.7 (methylcellulose), big white mouse acute oral 10.0 (sesame oil); Rabbit acute through skin greater than 2000, the lagophthalmos eyeball is had the minimal irritation effect, the rabbit skin is had no stimulation; Salmonella reversion test shows no mutagenicity.Missible oil: big white mouse acute oral 650 (another document is greater than 5000) has slight extremely medium spread effect to the lagophthalmos eyeball, and the rabbit skin is had slightly or extremely slight spread effect.
The effect characteristics:
Be to be lead compound with the Avermectin, by two key hydrogenations, structure optimization and the novel synthetic pesticide succeeded in developing.Structure optimization product as agricultural antibiotic, compare with the parent Avermectin, its expelling parasite and acaricidal activity have not only been kept, and safety is higher, be difficult for to produce produce resistance, for the production of vegetables, fruit, cotton etc. provide efficient a, high security and with the good biological source insecticide of Environmental compatibility.This product has stomach toxicity and action of contace poison to mite class and insect, and the horizontal infiltration conduction is arranged.Also can be used as feed addictive and get antiparasitic agent.Nematode, insect and Man Junyou are killed effect, be used for the treatment of intestines and stomach nematodosis, acariasis and the parasitic insect disease of fowl poultry.
Diamond-back moth, lima bean pod borer, looper, prodenia litura, beet armyworm, cotton bollworm, oriental tobacco budworm, cabbage caterpillar etc. all are the primary pests of China economic crops in the lepidoptera pest, and chemical control is also basic identical.In recent years, because using the not science of agricultural chemicals, people caused problems such as pest resistance to insecticide, residue of pesticide and environmental toxicity.Continuously, a large amount of, single use chemical insecticide is to cause lepidoptera pest to produce the main cause of resistance rapidly.Agricultural chemicals is carried out composite, making that complex preparation uses is the mode effectively and efficiently that overcomes the above problems.
Summary of the invention
The present invention relates to a kind of insecticide pesticide that is become with the Ivermectin HCL agriculture chemical compounding by gamma cyhalothrin.Particularly by the 0.1-99.9% gamma cyhalothrin, 0.01-50% Ivermectin HCL and proper assistant and carrier are composite to form.Gamma cyhalothrin content is 0.1-99% in the complex preparation, and Ivermectin HCL content is 0.01-50%.
The objective of the invention is according to above-mentioned situation, provide a kind of by gamma cyhalothrin and the composite insecticide pesticide that forms of Ivermectin HCL.Not only can eliminate Lepidoptera pest such as diamond-back moth, prodenia litura, beet armyworm, cabbage caterpillar, cotton bollworm to the resistance that gamma cyhalothrin produces, its control efficiency is obviously improved.
Embodiment
The present invention relates to a kind ofly by gamma cyhalothrin and the insecticide pesticide that the Ivermectin HCL agriculture chemical compounding is become, it is characterized in that it by the 0.1-99.9% gamma cyhalothrin, 0.01-50% Ivermectin HCL and proper assistant and carrier are composite to form.Gamma cyhalothrin content is 0.1-99% in the complex preparation, and Ivermectin HCL content is 0.01-50%.
Gamma cyhalothrin and Ivermectin HCL are to the control efficiency of diamond-back moth
For clear and definite gamma cyhalothrin and Ivermectin HCL list with and when using with to the control efficiency of diamond-back moth, we had carried out drug effect test of field zone in 2007.
1 materials and methods
1.1 reagent agent
2.5% efficient cyhalothrin emulsifiable concentrate (the fair chemical industry (Shanghai) Co., Ltd. of sending out);
0.5% Ivermectin HCL missible oil (Zhejiang Hisun Chemical Co., Ltd)
1.2 overview experimental field
Test arrangement carries out on a wild cabbage ground of Nanning City's heart country fair.
1.3 test is handled and method
4 processing are established in test altogether:
(1) 2.5% efficient cyhalothrin emulsifiable concentrate 600ml/hm2;
(2) 0.5% Ivermectin HCL missible oil 600ml/hm2,
(3) 2.5% gamma cyhalothrin aqueous emulsions+0.5% Ivermectin HCL missible oil 300+300ml/hm2,
(the active ingredient ratio is 5: 1)
(4) handle the clear water contrast
October 10, (diamond-back moth low instar larvae peak period) dispenser was 1 time, adopted Guilin-16 type sprayer even spraying, repeated 3 times.District's group is arranged at random, and isolation channel is established in the minizone.
1.4 investigation method
1.4.1 the effect research of control diamond-back moth: every sub-district random labelling 25 strain wild cabbages, investigate the diamondback moth larvae insect population radix on every strain cabbage leaves respectively.Respectively carry out foliar spray control with sprayer afternoon, this moment gentle breeze, duration of test weather cloudy with some sunny periods, 30 ℃ of the maximum air temperatures.Behind the medicine the 2nd, 3,7 days, the remaining larva of the investigation worm amount of living on the wild cabbage of mark was respectively calculated insect population go down rate and control efficiency.
1.4.2 safety is observed: behind the medicine 1,3,5,7,10,15d observes chemicals treatment district wild cabbage and have or not poisoning, the type and the degree of record poisoning.
2 results and analysis
2.1 the effect (table 4) of control diamond-back moth: 2.5% efficient cyhalothrin emulsifiable concentrate+0.5% Ivermectin HCL missible oil has good control efficiency to diamond-back moth.Handle the effect of single time spent apparently higher than each.
The effect of table 4 different disposal control diamond-back moth
2.2 safety to the wild cabbage growth
Behind the medicine 1,3,5,7,10, the 15d visual observations, each applying area wild cabbage growth is normal, does not have tangible symptom of chemical damage, shows in institute's reagent weight range, each reagent agent is to the wild cabbage safety of growing.
3 brief summaries and discussion
In diamond-back moth low instar larvae peak period, with 2.5% efficient cyhalothrin emulsifiable concentrate+0.5% Ivermectin HCL missible oil 300+300ml/hm2,, diamond-back moth there is good control efficiency to the water even spraying, and to wild cabbage growth safety.
Gamma cyhalothrin, Ivermectin HCL and be mixed to the Toxicity Determination of diamond-back moth
Test basis: NY/T 1154.1-2006NY/T 1154.7-2006
Test site: Nanning
1 test objective
Adopt topical application method gamma cyhalothrin, Ivermectin HCL and different proportion thereof be mixed to the virulence of diamond-back moth, and adopt the abundant method of Sun Yun to estimate the synergy type of two medicaments to diamond-back moth, be that two composite reagents are used to prevent and treat the suitable prescription of diamond-back moth selection.
2 experimental conditions
2.1 for examination worm source
Diamond-back moth [Plutella xylostella (L.)], Tanaka takes diamondback moth larvae at random from Nanning periphery vegetables, indoor choose grow normal, polypide is active, long consistent diamond-back moth 3 instar larvaes of body are made toxicity test and used.
2.2 condition of culture
Indoor temperature is 20-28 ℃, illumination every day 16 hours, humidity 55-80%.
2.3 instrument and equipment
Writing brush, beaker, tweezers, glass rod, micro-dropper, electronic balance, diameter are the culture dish of 9cm, pipette, 10ml graduated cylinder etc.
3 experimental scheme
3.1 reagent
3.1.1 reagent agent
The former medicine of 95% gamma cyhalothrin (Lambda-cyhalothrin), the rich Tian Nonghua in Jiangsu Co., Ltd provides;
The former medicine of 95% Ivermectin HCL (Ivermectin), Zhejiang Hisun Chemical Co., Ltd provides;
3.1.2 other reagent
Reagent such as acetone.
3.2 test is handled
3.2.1 dosage is handled
Respectively an amount of each former medicine and the different proportionings of two former medicines are fully dissolved with small amount of acetone earlier, be settled to 10ml with acetone then and promptly get mother liquor, it is stand-by to adopt double dilution method that two former medicines and different proportioning are mixed with 5 series concentration gradients respectively again.Wherein gamma cyhalothrin be mixed with 8,4,2,1,0.5mg/L; Ivermectin HCL is mixed with 1.6,0.8,0.4,0.2,0.1mg/L; Gamma cyhalothrin sees Table 6 with Ivermectin HCL concentration that different proportioning is joined.
3.2.2 test repeats
Every processing repeats four times, 20 3 instar larvaes of every repetition, and every processing is totally 80 larvas.
4 test methods
The drop method that adopts NY/T 1154.1-2006 to recommend during mensuration, places worm the 9cm culture dish slightly to anaesthetize with CO2 earlier, then with 10 μ L microsyringes 1.0 μ L soup points on polypide chest backboard, be contrast with 1.0 μ L acetone treatment.Add fresh blade then, moisture releasing profit cotton balls is preserved moisture, and places under 25 ℃, the condition of illumination // dark=16h/8h and raises 48h, looks into lethality, and the contrast lethality is lower than 3% for effectively measuring.Calculate virulence regression equation formula, LC50, LC90 and correlation values with the DPS2000 data processing software.And adopt the abundant method of Sun Yun to obtain the co-toxicity coefficient of each mixed ratio with reference to NY/T 1154.7-2006, select optimal proportion.
5 data surveys and statistical analysis
5.1 computational methods
According to survey data, calculate the lethality that each is handled, unit is percentage (%).Calculate by following formula, result of calculation all remains into 2 significant digits:
P1 is a lethality in P1=(K/N) * 100 formula; K represents dead borer population; N handles total borer population.This experimental control lethality is 1.25%, need not to proofread and correct.
5.2 statistical analysis
Utilization DPS software carries out statistical analysis, it is equivalent and adopt the abundant method of Sun Yun to obtain the co-toxicity coefficient of each mixed ratio with reference to NY/T 1154.7-2006 to obtain test toxicity regression line (Y=a+bx) of medicament and correlation coefficient (r) value, LC50, LC90, selects optimal proportion.
5.3 result of the test
Adopt said method that diamond-back moth is carried out toxicity test and carries out statistical analysis gamma cyhalothrin, Ivermectin HCL and 5 different blended preparatons respectively, it the results are shown in Table 5, by data in the table as seen, gamma cyhalothrin, 5 different proportionings of Ivermectin HCL all greater than 100, illustrate that two composite reagents have synergistic effect to diamond-back moth to the co-toxicity coefficient of diamond-back moth.Gamma cyhalothrin wherein: Ivermectin HCL active ingredient ratio is 5: 1 o'clock, and co-toxicity coefficient is the highest, is 197.5.
Table 5: Ivermectin HCL, gamma cyhalothrin and 5 different proportionings are to diamond-back moth toxicity test result
6 interpretations of result and discussion
Toxicity Determination result shows, 5 different proportions of gamma cyhalothrin and Ivermectin HCL are mixed co-toxicity coefficient to diamond-back moth all greater than 100, illustrate that two composite reagents are used to prevent and treat diamond-back moth and have certain synergistic effect, can use in practice.
Table 6: gamma cyhalothrin, Ivermectin HCL and 5 different proportionings are to diamond-back moth toxicity test raw data table
Claims (3)
1. Recompounded pesticide is characterized in that by gamma cyhalothrin and Ivermectin HCL is composite forms.
2. according to the Recompounded pesticide of claim 1, it is characterized in that gamma cyhalothrin content is 0.1-99%, Ivermectin HCL content is 0.01-50%.。
3. according to the Recompounded pesticide of claim 1, it is characterized in that gamma cyhalothrin and Ivermectin HCL percentage composition are 100: 1-0.2: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710187294 CN101156588B (en) | 2007-11-19 | 2007-11-19 | Compound agricultural chemical |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710187294 CN101156588B (en) | 2007-11-19 | 2007-11-19 | Compound agricultural chemical |
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| Publication Number | Publication Date |
|---|---|
| CN101156588A CN101156588A (en) | 2008-04-09 |
| CN101156588B true CN101156588B (en) | 2011-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200710187294 Expired - Fee Related CN101156588B (en) | 2007-11-19 | 2007-11-19 | Compound agricultural chemical |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012078605A1 (en) * | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
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Granted publication date: 20110518 Termination date: 20161119 |
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