NZ599757A - The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders - Google Patents
The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disordersInfo
- Publication number
- NZ599757A NZ599757A NZ599757A NZ59975710A NZ599757A NZ 599757 A NZ599757 A NZ 599757A NZ 599757 A NZ599757 A NZ 599757A NZ 59975710 A NZ59975710 A NZ 59975710A NZ 599757 A NZ599757 A NZ 599757A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dinaline
- treatment
- cognition
- memory
- anxiety disorders
- Prior art date
Links
- VAZAPHZUAVEOMC-UHFFFAOYSA-N tacedinaline Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)NC1=CC=CC=C1N VAZAPHZUAVEOMC-UHFFFAOYSA-N 0.000 title abstract 3
- QGMGHALXLXKCBD-UHFFFAOYSA-N 4-amino-n-(2-aminophenyl)benzamide Chemical compound C1=CC(N)=CC=C1C(=O)NC1=CC=CC=C1N QGMGHALXLXKCBD-UHFFFAOYSA-N 0.000 title abstract 2
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 230000019771 cognition Effects 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 230000003920 cognitive function Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000008434 fear extinction Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25692709P | 2009-10-30 | 2009-10-30 | |
| US26546809P | 2009-12-01 | 2009-12-01 | |
| PCT/US2010/054872 WO2011053876A1 (en) | 2009-10-30 | 2010-10-29 | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ599757A true NZ599757A (en) | 2014-08-29 |
Family
ID=43922604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ599757A NZ599757A (en) | 2009-10-30 | 2010-10-29 | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8563615B2 (enExample) |
| EP (1) | EP2493298A4 (enExample) |
| JP (1) | JP2013509441A (enExample) |
| CN (1) | CN102834002A (enExample) |
| AU (1) | AU2010313255B2 (enExample) |
| CA (1) | CA2779497A1 (enExample) |
| IN (1) | IN2012DN03807A (enExample) |
| NZ (1) | NZ599757A (enExample) |
| WO (1) | WO2011053876A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009475A1 (en) * | 2007-07-13 | 2011-01-13 | Massachusetts Institute Of Technology | Methods for treating stress induced emotional disorders |
| WO2009154697A2 (en) | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| JP2013509441A (ja) | 2009-10-30 | 2013-03-14 | マサチューセッツ インスティテュート オブ テクノロジー | 記憶／認知および不安障害の処置のためのｃｉ−９９４およびジナリンの使用 |
| WO2012003413A1 (en) * | 2010-06-30 | 2012-01-05 | The Broad Institute, Inc. | Novel solid forms of tacedinaline |
| CA2834548C (en) | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US8691875B2 (en) * | 2011-07-01 | 2014-04-08 | Broad Institute, Inc. | Solid forms of tacedinaline |
| SI2734510T1 (sl) | 2011-07-22 | 2019-05-31 | Massachusetts Institute Of Technology | Aktivatorji histon deacetilaz (HDACS) razreda I in njihove uporabe |
| EP2877444B1 (en) | 2012-07-27 | 2020-09-02 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2014046871A1 (en) * | 2012-09-04 | 2014-03-27 | Massachusetts Institute Of Technology | The use of gene expression profiling as a biomarker for assessing the efficacy of hdac inhibitor treatment in neurodegenerative conditions |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| EP3737362B1 (en) | 2018-01-12 | 2025-10-15 | Kdac Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| GB202001023D0 (en) * | 2020-01-24 | 2020-03-11 | Univ Leicester | HDAC Degrader |
| CN112062826A (zh) * | 2020-06-01 | 2020-12-11 | 暨南大学 | 一种与中枢神经衰老相关的乙酰化修饰h2b蛋白标记分子及其应用 |
| WO2023034440A1 (en) * | 2021-09-01 | 2023-03-09 | Case Western Reserve University | Treatment of neurodegenerative diseases with hdac inhibitors |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525727A (en) | 1982-05-18 | 1996-06-11 | University Of Florida | Brain-specific drug delivery |
| US5994392A (en) | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
| US5177064A (en) | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| US6110697A (en) | 1995-09-20 | 2000-08-29 | Merck & Co., Inc. | Histone deacetylase as target for antiprotozoal agents |
| EP1212357B1 (en) | 1999-09-08 | 2007-05-02 | Sloan-Kettering Institute For Cancer Research | Crystal structure of a deacetylase and inhibitors thereof |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| EP1748046A3 (en) | 1999-11-23 | 2007-08-22 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| JP2001149081A (ja) | 1999-11-29 | 2001-06-05 | Cyclex Co Ltd | 脱アセチル化酵素の活性測定方法、並びにこれら酵素の阻害剤もしくは促進剤のスクリーニング方法 |
| JP4975941B2 (ja) * | 2000-09-29 | 2012-07-11 | トポターゲット ユーケー リミテッド | （ｅ）−ｎ−ヒドロキシ−３−（３−スルファモイル−フェニル）アクリルアミド化合物及びその治療用途 |
| US20060148743A1 (en) | 2001-05-18 | 2006-07-06 | Vasant Jadhav | RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA) |
| AU2002318364A1 (en) | 2001-06-14 | 2003-01-02 | Bristol-Myers Squibb Company | Novel human histone deacetylases |
| CN101851173A (zh) | 2001-09-14 | 2010-10-06 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
| AU2002340253C1 (en) * | 2001-10-16 | 2011-03-31 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| AU2002361022A1 (en) | 2001-12-07 | 2003-06-17 | Novartis Ag | Use of alpha-tubulin acetylation levels as a biomarker for protein deacetylase inhibitors |
| AU2003209060A1 (en) | 2002-02-07 | 2003-09-02 | Axys Pharmaceuticals, Inc. | Assay for acytyltransferase or deacetylase activity |
| AU2003214055A1 (en) | 2002-02-08 | 2003-09-02 | Novartis Ag | Method for screening for compounds having hdac inhibitory activity |
| JP2005525345A (ja) * | 2002-02-15 | 2005-08-25 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Ｔｒｘ媒介性疾患を処置する方法 |
| US20050288227A1 (en) | 2002-02-15 | 2005-12-29 | Marks Paul A | Use of thioredoxin measurements for diagnostics and treatments |
| US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
| AU2003226014A1 (en) * | 2002-03-28 | 2003-10-13 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
| US20030224473A1 (en) | 2002-05-23 | 2003-12-04 | Mccafferty Dewey G. | Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors |
| AU2003273701A1 (en) | 2002-10-17 | 2004-05-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| TW200424174A (en) | 2003-02-06 | 2004-11-16 | Hoffmann La Roche | New TP diamide |
| US20050037992A1 (en) * | 2003-07-22 | 2005-02-17 | John Lyons | Composition and method for treating neurological disorders |
| WO2005030705A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2005048942A2 (en) * | 2003-11-13 | 2005-06-02 | Pharmacia Corporation | Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent |
| MXPA06010900A (es) | 2004-03-26 | 2007-02-21 | Methylgene Inc | Inhibidores de histona desacetilasa. |
| WO2005102358A2 (en) * | 2004-04-20 | 2005-11-03 | Rnd Pharmaceuticals | Silicone-substituted cox-2 selective inhibitors |
| DK1591109T3 (da) | 2004-04-30 | 2008-10-06 | Topotarget Germany Ag | Formulering, der omfatter histondeacetylaseinhibitorer, der udviser tofaset frigivelse |
| US20060008517A1 (en) * | 2004-07-09 | 2006-01-12 | Lynch Marina A | Treatment of age-related memory impairment |
| US20060018921A1 (en) * | 2004-07-16 | 2006-01-26 | Baylor College Of Medicine | Histone deacetylase inhibitors and cognitive applications |
| US20060160902A1 (en) | 2004-11-08 | 2006-07-20 | Wiech Norbert L | Histone deacetylase inhibitors |
| EP1896436A2 (en) * | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20070015183A1 (en) | 2005-06-03 | 2007-01-18 | The General Hospital Corporation | Biomarkers for huntington's disease |
| EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| EP1937236A2 (en) * | 2005-09-07 | 2008-07-02 | Braincells, Inc. | Modulation of neurogenesis by hdac inhibition |
| WO2007049262A1 (en) * | 2005-10-27 | 2007-05-03 | Berand Limited | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders |
| WO2007055942A2 (en) | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Substituted nicotinamide compounds |
| WO2007056435A2 (en) * | 2005-11-08 | 2007-05-18 | The General Hospital Corporation | Dynamin mediated diseases and associated methods and products |
| WO2007100657A2 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| CN101466670B (zh) | 2006-04-07 | 2013-04-17 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| CA2649861A1 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
| EP2023924B1 (en) | 2006-05-18 | 2016-08-03 | Merck Sharp & Dohme Corp. | Aryl-fused spirocyclic compounds |
| US20100112600A1 (en) | 2006-07-13 | 2010-05-06 | Azard Bonni | Methods and compositions for modulating synapse formation |
| US8088951B2 (en) * | 2006-11-30 | 2012-01-03 | Massachusetts Institute Of Technology | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss |
| US8030344B2 (en) | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US20110009475A1 (en) * | 2007-07-13 | 2011-01-13 | Massachusetts Institute Of Technology | Methods for treating stress induced emotional disorders |
| WO2009154697A2 (en) * | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| KR20110033304A (ko) * | 2008-07-23 | 2011-03-30 | 메사추세츠 인스티튜트 오브 테크놀로지 | Ｄｎａ 손상에 대해 보호하고 신경세포 생존을 증가시키는 히스톤 디아세틸라제 1 (ｈｄａｃ1)의 활성화 |
| NZ593447A (en) * | 2008-12-03 | 2012-12-21 | Harvard College | Inhibition of hdac2 to promote memory |
| WO2010098888A1 (en) * | 2009-02-27 | 2010-09-02 | Massachusetts Institute Of Technology | Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders |
| JP2013509441A (ja) * | 2009-10-30 | 2013-03-14 | マサチューセッツ インスティテュート オブ テクノロジー | 記憶／認知および不安障害の処置のためのｃｉ−９９４およびジナリンの使用 |
| SI2734510T1 (sl) * | 2011-07-22 | 2019-05-31 | Massachusetts Institute Of Technology | Aktivatorji histon deacetilaz (HDACS) razreda I in njihove uporabe |
-
2010
- 2010-10-29 JP JP2012537154A patent/JP2013509441A/ja active Pending
- 2010-10-29 NZ NZ599757A patent/NZ599757A/en not_active IP Right Cessation
- 2010-10-29 IN IN3807DEN2012 patent/IN2012DN03807A/en unknown
- 2010-10-29 AU AU2010313255A patent/AU2010313255B2/en not_active Ceased
- 2010-10-29 CA CA2779497A patent/CA2779497A1/en not_active Abandoned
- 2010-10-29 CN CN201080060203XA patent/CN102834002A/zh active Pending
- 2010-10-29 WO PCT/US2010/054872 patent/WO2011053876A1/en not_active Ceased
- 2010-10-29 EP EP10827583.5A patent/EP2493298A4/en not_active Withdrawn
- 2010-11-01 US US12/917,402 patent/US8563615B2/en not_active Expired - Fee Related
-
2012
- 2012-08-27 US US13/595,048 patent/US8841346B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010313255B2 (en) | 2015-04-30 |
| AU2010313255A1 (en) | 2012-05-31 |
| IN2012DN03807A (enExample) | 2015-08-28 |
| EP2493298A4 (en) | 2013-04-10 |
| WO2011053876A1 (en) | 2011-05-05 |
| CN102834002A (zh) | 2012-12-19 |
| US20120322879A1 (en) | 2012-12-20 |
| CA2779497A1 (en) | 2011-05-05 |
| EP2493298A1 (en) | 2012-09-05 |
| JP2013509441A (ja) | 2013-03-14 |
| US8841346B2 (en) | 2014-09-23 |
| US8563615B2 (en) | 2013-10-22 |
| US20110224303A1 (en) | 2011-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ599757A (en) | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders | |
| MX377802B (es) | Metodos y composiciones para trastornos del sueño y otros trastornos. | |
| IL243287B (en) | Crystalline form -ii- of 2-{4-[-n-(5,6-diphenylpyrazin-2-yl)--n-isopropylamino]butyloxy}-n-(methylsulfonyl)acetamide, pharmaceutical compositions containing it and its therapeutic uses | |
| EA201290310A1 (ru) | Производные имидазолидиндиона | |
| PL2442814T3 (pl) | Bifidobacteria do leczenia cukrzycy i pokrewnych chorób | |
| TN2012000231A1 (en) | Quinoline amide m1 receptor positive allosteric modulators | |
| EP2282795A4 (en) | TREATMENT OF RESPIRATORY DISEASES | |
| MX2012012952A (es) | Compuestos de 2, 5, 6, 7,-tetrahidro-[1, 4] oxazepin-3-ilamina o 2, 3, 6, 7-tetrahidro-[1, 4] oxazepin-5-ilamina. | |
| GEP20156216B (en) | Heterocyclic compound and usage thereof | |
| ZA201003350B (en) | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity | |
| NZ589764A (en) | NMDA receptor antagonists for the treatment of neuropsychiatric disorders | |
| CU24037B1 (es) | Dicianopiridinas alquilamino-sustituidas y sus profármacos de éster de aminoácido | |
| IL211694A0 (en) | Use of-anti-connexin agents for modulating the therapeutic effect of psychotropic drugs | |
| HUE043807T2 (hu) | GLYX Alzheimer-kór, Parkinson-kór vagy Huntington-kór kezelésében történõ alkalmazásra | |
| IL200956A0 (en) | 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of pain or residual symptoms in depression relating to sleep and cognition | |
| SI2355822T1 (sl) | Zdravljenje kognitivnih motenj z (R)-7-kloro-N-(kinuklidin-3-il)benzo(b)tiofen-2-karboksamidom in njegovimi farmacevtsko sprejemljivimi solmi | |
| BRPI0915428A2 (pt) | derivados de benzoxazinona atuando como agonistas adrenorreceptor beta2 para o tratamento de distúrbios respiratórios | |
| NZ596000A (en) | Carboxamide compounds and their use as calpain inhibitors | |
| MX2011010782A (es) | Compuestos agonistas del receptor 5-ht4 para el tratamiento de trastornos cognitivos. | |
| IL260078B (en) | Therapy used to treat Gaucher disease | |
| EP2320939A4 (en) | TISSUE CALLICLE FOR THE TREATMENT OF PARKINSON DISEASE | |
| HRP20171742T1 (hr) | 2,4,6-trifluor-n-[6-(1-metilpiperidin-4-karbonil)piridin-2-il]benzamid, namijenjen liječenju migrene oralnom ili intravenskom primjenom | |
| IL237332B (en) | Pyrazolecarboxamide derivatives as taar modulators for use in the treatment of serious diseases such as depression, diabetes and Parkinson's disease | |
| IL210489A0 (en) | Use of hdac inhibitors for the treatment of hodgkin's disease | |
| EP2421554A4 (en) | TISSUE KALLICREIN FOR THE TREATMENT OF HUNTINGTON'S DISEASE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ERR | Error or correction |
Free format text: THE TITLE HAS BEEN CORRECTED TO TITLE: THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS; FILING DATE: 03 MAY 2012; STATUS: REJECTED; TITLE: THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS; FILING DATE: 12 MAR 2014; STATUS: REJECTED; TITLE: THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS; FILING DATE: 09 JUL 2014; STATUS: REJECTED; TITLE: THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS; FILING DATE: 11 AUG 2014; STATUS: ACCEPTED; PUBLICATION DATE: 29 AUG 2014; Effective date: 20141210 |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 29 OCT 2017 BY COMPUTER PACKAGES INC Effective date: 20150131 |
|
| LAPS | Patent lapsed |