NZ598585A - Storage-stable formulation of paracetamol in aqueous solution - Google Patents

Storage-stable formulation of paracetamol in aqueous solution

Info

Publication number
NZ598585A
NZ598585A NZ598585A NZ59858510A NZ598585A NZ 598585 A NZ598585 A NZ 598585A NZ 598585 A NZ598585 A NZ 598585A NZ 59858510 A NZ59858510 A NZ 59858510A NZ 598585 A NZ598585 A NZ 598585A
Authority
NZ
New Zealand
Prior art keywords
paracetamol
degree
solution
storage
aqueous solution
Prior art date
Application number
NZ598585A
Inventor
Dandachi Atassi Khaled Al
Original Assignee
Neogen N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neogen N V filed Critical Neogen N V
Priority claimed from PCT/EP2010/061856 external-priority patent/WO2011018522A1/en
Publication of NZ598585A publication Critical patent/NZ598585A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is a liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: (i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65 DEGREE C and 95 DEGREE C, and having pH between 5.0 and 6.0; (ii) cooling the solution so formed to a temperature equal to or above 35 DEGREE C and below 400C under an atmosphere of nitrogen; (iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring; (iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere. It further relates to a method for preparing the formulation
NZ598585A 2009-08-13 2010-08-13 Storage-stable formulation of paracetamol in aqueous solution NZ598585A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09060478 2009-08-13
PCT/EP2010/061856 WO2011018522A1 (en) 2009-08-13 2010-08-13 Storage-stable formulation of paracetamol in aqueous solution

Publications (1)

Publication Number Publication Date
NZ598585A true NZ598585A (en) 2013-01-25

Family

ID=48570596

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ598585A NZ598585A (en) 2009-08-13 2010-08-13 Storage-stable formulation of paracetamol in aqueous solution

Country Status (1)

Country Link
NZ (1) NZ598585A (en)

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