NZ593088A - 8-([Hetero]aryl)-6-(4-alkyl-piperazin-1-yl)-9H-purine derivatives and uses thereof in the treatment of pain - Google Patents
8-([Hetero]aryl)-6-(4-alkyl-piperazin-1-yl)-9H-purine derivatives and uses thereof in the treatment of painInfo
- Publication number
- NZ593088A NZ593088A NZ593088A NZ59308809A NZ593088A NZ 593088 A NZ593088 A NZ 593088A NZ 593088 A NZ593088 A NZ 593088A NZ 59308809 A NZ59308809 A NZ 59308809A NZ 593088 A NZ593088 A NZ 593088A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- piperazin
- alkyl
- purine
- pain
- Prior art date
Links
- 125000005842 heteroatom Chemical group 0.000 title abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- WGBFSSQNXAZCGW-UHFFFAOYSA-N 2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)-8-[2-(trifluoromethyl)phenyl]purine Chemical compound C1CN(C)CCN1C1=NC(C)=NC2=C1N=C(C=1C(=CC=CC=1)C(F)(F)F)N2C1CCOCC1 WGBFSSQNXAZCGW-UHFFFAOYSA-N 0.000 abstract 1
- UCMNDPDJRSEZPL-UHFFFAOYSA-N 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine Chemical compound C1CN(C)CCN1C1=NC(C)=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1CCOCC1 UCMNDPDJRSEZPL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- PCLIUMMFWRGXRK-UHFFFAOYSA-N methyl azetidine-1-carboxylate Chemical group COC(=O)N1CCC1 PCLIUMMFWRGXRK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003349 osteoarthritic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical group O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13858908P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/067249 WO2010080306A1 (en) | 2008-12-18 | 2009-12-09 | Purine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ593088A true NZ593088A (en) | 2012-12-21 |
Family
ID=41719189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ593088A NZ593088A (en) | 2008-12-18 | 2009-12-09 | 8-([Hetero]aryl)-6-(4-alkyl-piperazin-1-yl)-9H-purine derivatives and uses thereof in the treatment of pain |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8252798B2 (https=) |
| EP (1) | EP2379555B1 (https=) |
| JP (1) | JP5559812B2 (https=) |
| KR (1) | KR101319630B1 (https=) |
| CN (1) | CN102256977B (https=) |
| AR (1) | AR075104A1 (https=) |
| AU (1) | AU2009335997B2 (https=) |
| BR (1) | BRPI0923195A2 (https=) |
| CA (1) | CA2746740C (https=) |
| CL (1) | CL2011001464A1 (https=) |
| CO (1) | CO6390101A2 (https=) |
| CR (1) | CR20110340A (https=) |
| DO (1) | DOP2011000196A (https=) |
| EA (1) | EA018386B1 (https=) |
| EC (1) | ECSP11011151A (https=) |
| ES (1) | ES2536880T3 (https=) |
| HN (1) | HN2011001700A (https=) |
| IL (1) | IL213167A (https=) |
| MA (1) | MA32904B1 (https=) |
| MX (1) | MX2011006442A (https=) |
| NZ (1) | NZ593088A (https=) |
| PA (1) | PA8851501A1 (https=) |
| PE (1) | PE20110999A1 (https=) |
| SG (1) | SG172253A1 (https=) |
| TN (1) | TN2011000291A1 (https=) |
| TW (1) | TWI376378B (https=) |
| UA (1) | UA104010C2 (https=) |
| WO (1) | WO2010080306A1 (https=) |
| ZA (1) | ZA201103943B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010103130A2 (en) * | 2009-03-13 | 2010-09-16 | Katholieke Universiteit Leuven, K.U.Leuven R&D | Novel bicyclic heterocycles |
| IN2012DN02474A (https=) | 2009-08-28 | 2015-08-21 | Arena Pharm Inc | |
| US20130096104A1 (en) * | 2010-03-17 | 2013-04-18 | Genentech, Inc. | Imidazopyridine compounds, compositions and methods of use |
| AR080711A1 (es) | 2010-03-31 | 2012-05-02 | Lilly Co Eli | Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor |
| BR112012024587A2 (pt) * | 2010-03-31 | 2016-05-31 | Lilly Co Eli | compostos de purina usados como agonistas de cb2 |
| TW201217387A (en) | 2010-09-15 | 2012-05-01 | Hoffmann La Roche | Azabenzothiazole compounds, compositions and methods of use |
| BR112013011520A2 (pt) | 2010-11-19 | 2019-09-24 | Hoffmann La Roche | pirazolo piridinas e pirazolo piridinas e seu uso como inibidores de tyk2 |
| US9597340B2 (en) | 2011-02-25 | 2017-03-21 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| AU2012222149B2 (en) | 2011-02-25 | 2017-06-29 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| EP2678330A1 (en) | 2011-02-25 | 2014-01-01 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of condensed azacycles ( cannabinoid receptor modulators) |
| CN103827115A (zh) * | 2011-09-20 | 2014-05-28 | 弗·哈夫曼-拉罗切有限公司 | 咪唑并吡啶化合物、组合物和使用方法 |
| US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
| CN104903316B (zh) * | 2012-08-16 | 2017-11-28 | 詹森药业有限公司 | 作为n型钙通道阻滞剂的取代的吡唑 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| HUE035333T2 (en) * | 2013-05-02 | 2018-05-02 | Hoffmann La Roche | Pyrrolo [2,3-d] pyrimidine derivatives as CB2 receptor agonists |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| WO2017052394A1 (en) * | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
| WO2017181317A1 (en) * | 2016-04-18 | 2017-10-26 | Eli Lilly And Company | Treatment for nonalcoholic steatohepatitis and fibrosis |
| WO2018137176A1 (en) * | 2017-01-25 | 2018-08-02 | Eli Lilly And Company | Treatment for nonalcoholic steatohepatitis and fibrosis |
| WO2017184412A1 (en) | 2016-04-18 | 2017-10-26 | Eli Lilly And Company | Purine cannabinoid agonist for treating nonalcoholic steatohepatitis and fibrosis |
| CA3036382A1 (en) * | 2016-12-21 | 2018-06-28 | Research Triangle Institute | Diaryl purine derivatives with improved bioavailability |
| US20200078358A1 (en) | 2017-05-08 | 2020-03-12 | Arena Pharmaceuticals, Inc. | Compounds and Methods for Treatment of Visceral Pain |
| WO2024017227A1 (zh) * | 2022-07-21 | 2024-01-25 | 长春金赛药业有限责任公司 | 取代的稠环大麻素受体化合物及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60260579A (ja) * | 1984-01-13 | 1985-12-23 | Yoshitomi Pharmaceut Ind Ltd | プリン誘導体 |
| US5057517A (en) * | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
| NZ225447A (en) | 1987-07-20 | 1991-12-23 | Merck & Co Inc | Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions |
| GB0003960D0 (en) * | 2000-02-18 | 2000-04-12 | Pfizer Ltd | Purine derivatives |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050239806A1 (en) | 2004-01-13 | 2005-10-27 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| KR20070054737A (ko) * | 2004-10-22 | 2007-05-29 | 화이자 프로덕츠 인코포레이티드 | 퓨린 화합물의 제조 방법 |
| US20070032493A1 (en) | 2005-05-26 | 2007-02-08 | Synta Pharmaceuticals Corp. | Method for treating B cell regulated autoimmune disorders |
| KR101450535B1 (ko) * | 2006-02-02 | 2014-10-14 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｅ１ 활성화 효소의 억제제 |
| US20120295915A1 (en) * | 2009-11-24 | 2012-11-22 | Chaudhari Amita M | Azabenzimidazoles as fatty acid synthase inhibitors |
| AR080711A1 (es) * | 2010-03-31 | 2012-05-02 | Lilly Co Eli | Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor |
-
2009
- 2009-09-12 UA UAA201107563A patent/UA104010C2/ru unknown
- 2009-12-01 AR ARP090104628A patent/AR075104A1/es not_active Application Discontinuation
- 2009-12-01 PA PA20098851501A patent/PA8851501A1/es unknown
- 2009-12-04 TW TW098141555A patent/TWI376378B/zh not_active IP Right Cessation
- 2009-12-09 MX MX2011006442A patent/MX2011006442A/es active IP Right Grant
- 2009-12-09 BR BRPI0923195A patent/BRPI0923195A2/pt not_active Application Discontinuation
- 2009-12-09 CN CN200980150689.3A patent/CN102256977B/zh not_active Expired - Fee Related
- 2009-12-09 PE PE2011001219A patent/PE20110999A1/es not_active Application Discontinuation
- 2009-12-09 WO PCT/US2009/067249 patent/WO2010080306A1/en not_active Ceased
- 2009-12-09 JP JP2011542246A patent/JP5559812B2/ja not_active Expired - Fee Related
- 2009-12-09 ES ES09768474.0T patent/ES2536880T3/es active Active
- 2009-12-09 AU AU2009335997A patent/AU2009335997B2/en not_active Ceased
- 2009-12-09 NZ NZ593088A patent/NZ593088A/xx not_active IP Right Cessation
- 2009-12-09 US US12/633,812 patent/US8252798B2/en not_active Expired - Fee Related
- 2009-12-09 CA CA2746740A patent/CA2746740C/en not_active Expired - Fee Related
- 2009-12-09 KR KR1020117014000A patent/KR101319630B1/ko not_active Expired - Fee Related
- 2009-12-09 EA EA201170832A patent/EA018386B1/ru not_active IP Right Cessation
- 2009-12-09 EP EP09768474.0A patent/EP2379555B1/en not_active Not-in-force
- 2009-12-09 SG SG2011044773A patent/SG172253A1/en unknown
-
2011
- 2011-05-26 IL IL213167A patent/IL213167A/en not_active IP Right Cessation
- 2011-05-27 ZA ZA2011/03943A patent/ZA201103943B/en unknown
- 2011-06-09 TN TN2011000291A patent/TN2011000291A1/fr unknown
- 2011-06-14 MA MA33947A patent/MA32904B1/fr unknown
- 2011-06-16 CL CL2011001464A patent/CL2011001464A1/es unknown
- 2011-06-17 DO DO2011000196A patent/DOP2011000196A/es unknown
- 2011-06-17 EC EC2011011151A patent/ECSP11011151A/es unknown
- 2011-06-17 CR CR20110340A patent/CR20110340A/es unknown
- 2011-06-17 HN HN2011001700A patent/HN2011001700A/es unknown
- 2011-06-23 CO CO11079298A patent/CO6390101A2/es active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 09 DEC 2016 BY THOMSON REUTERS Effective date: 20130920 |
|
| LAPS | Patent lapsed |