NZ580866A - Method of treating brain cancer - Google Patents
Method of treating brain cancerInfo
- Publication number
- NZ580866A NZ580866A NZ580866A NZ58086608A NZ580866A NZ 580866 A NZ580866 A NZ 580866A NZ 580866 A NZ580866 A NZ 580866A NZ 58086608 A NZ58086608 A NZ 58086608A NZ 580866 A NZ580866 A NZ 580866A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- methoxy
- quinazolin
- phenyl
- amine hydrochloride
- Prior art date
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title description 18
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- 210000003169 central nervous system Anatomy 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 241000124008 Mammalia Species 0.000 claims abstract description 3
- 239000012453 solvate Substances 0.000 claims abstract 6
- 201000007455 central nervous system cancer Diseases 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims description 45
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 25
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 16
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91097507P | 2007-04-10 | 2007-04-10 | |
| PCT/US2008/059905 WO2008124822A1 (en) | 2007-04-10 | 2008-04-10 | Method of treating brain cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ580866A true NZ580866A (en) | 2011-02-25 |
Family
ID=39831435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ580866A NZ580866A (en) | 2007-04-10 | 2008-04-10 | Method of treating brain cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100129470A1 (Direct) |
| EP (1) | EP2144504A4 (Direct) |
| JP (1) | JP2010523696A (Direct) |
| KR (1) | KR20100016385A (Direct) |
| CN (1) | CN101742910A (Direct) |
| AU (1) | AU2008236993A1 (Direct) |
| CA (1) | CA2720982A1 (Direct) |
| NZ (1) | NZ580866A (Direct) |
| WO (1) | WO2008124822A1 (Direct) |
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| NZ562109A (en) * | 2005-06-16 | 2011-03-31 | Myrexis Inc | Pharmaceutical compositions containing substituted (4-Phenyl)-methyl-(quinazolin-4-yl)-amine compounds, uses thereof, and methods of preparing the same |
| WO2008124826A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating cancer |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| WO2008124823A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Method of treating melanoma |
| WO2008124824A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Dosages and methods for the treatment of cancer |
| CN102088854A (zh) * | 2008-07-11 | 2011-06-08 | 美瑞德生物工程公司 | 作为细胞毒素剂的药物化合物及其使用方法 |
| US20110224240A1 (en) * | 2010-01-11 | 2011-09-15 | Myrexis, Inc. | Methods of treating cancer and related diseases |
| KR101343959B1 (ko) | 2012-09-19 | 2013-12-24 | 한국기계연구원 | 통합 코팅 장치 |
| NZ631022A (en) * | 2013-06-05 | 2018-05-25 | Cytrx Corp | Cytotoxic agents for the treatment of cancer |
| CN105288629B (zh) * | 2014-05-28 | 2021-02-19 | 北京大学 | 具有药效叠加作用及毒性分散效应的组合药物 |
| WO2016168637A2 (en) | 2015-04-17 | 2016-10-20 | Duquesne University Of The Holy Spirit | Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents |
| EP3787661B1 (en) * | 2018-05-02 | 2023-10-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Combination of temozolomide and a par-1 conjugate for treating glioblastoma |
| WO2020027100A1 (ja) * | 2018-07-31 | 2020-02-06 | 第一三共株式会社 | 抗体－薬物コンジュゲート投与による転移性脳腫瘍の治療 |
| CN111825610B (zh) * | 2020-06-24 | 2023-03-31 | 中国药科大学 | 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IL139641A0 (en) * | 1998-05-28 | 2002-02-10 | Parker Hughes Inst | Quinazolines for treating brain tumor |
| US7001926B2 (en) * | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| US20040229960A1 (en) * | 2001-07-13 | 2004-11-18 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| AU2002341792B2 (en) * | 2001-09-21 | 2007-09-06 | The Administrators Of The Tulane Educational Fund | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
| US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| US7618975B2 (en) * | 2003-07-03 | 2009-11-17 | Myriad Pharmaceuticals, Inc. | 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| KR20080014144A (ko) * | 2003-08-18 | 2008-02-13 | 화이자 프로덕츠 인크. | ｅｒｂＢ２ 항암제에 대한 투약 스케쥴 |
| GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| KR20070117547A (ko) * | 2005-01-03 | 2007-12-12 | 미리어드 제네틱스, 인크. | 뇌암 치료방법 |
| MX383644B (es) * | 2005-02-18 | 2025-03-14 | Abraxis Bioscience Llc | Combinaciones y metodos de administracion de agentes terapeuticos y terapia de combinacion. |
| US20070249640A1 (en) * | 2005-06-16 | 2007-10-25 | Myriad Genetics, Incorporated | Pharmaceutical compositions and use thereof |
| NZ562109A (en) * | 2005-06-16 | 2011-03-31 | Myrexis Inc | Pharmaceutical compositions containing substituted (4-Phenyl)-methyl-(quinazolin-4-yl)-amine compounds, uses thereof, and methods of preparing the same |
| US20070065449A1 (en) * | 2005-09-16 | 2007-03-22 | Claire Verschraegen | Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab) |
| WO2008124824A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Dosages and methods for the treatment of cancer |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| WO2008124826A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating cancer |
| WO2008124823A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Method of treating melanoma |
| WO2009023876A1 (en) * | 2007-08-16 | 2009-02-19 | Myriad Genetics, Inc. | Method of treating non-small cell lung cancer |
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2008
- 2008-04-10 WO PCT/US2008/059905 patent/WO2008124822A1/en not_active Ceased
- 2008-04-10 NZ NZ580866A patent/NZ580866A/en not_active IP Right Cessation
- 2008-04-10 EP EP08745503A patent/EP2144504A4/en not_active Withdrawn
- 2008-04-10 AU AU2008236993A patent/AU2008236993A1/en not_active Abandoned
- 2008-04-10 CN CN200880019674A patent/CN101742910A/zh active Pending
- 2008-04-10 CA CA2720982A patent/CA2720982A1/en not_active Abandoned
- 2008-04-10 JP JP2010503205A patent/JP2010523696A/ja active Pending
- 2008-04-10 KR KR1020097023414A patent/KR20100016385A/ko not_active Ceased
-
2009
- 2009-10-08 US US12/575,922 patent/US20100129470A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010523696A (ja) | 2010-07-15 |
| EP2144504A1 (en) | 2010-01-20 |
| AU2008236993A1 (en) | 2008-10-16 |
| US20100129470A1 (en) | 2010-05-27 |
| WO2008124822A1 (en) | 2008-10-16 |
| CA2720982A1 (en) | 2008-10-16 |
| CN101742910A (zh) | 2010-06-16 |
| KR20100016385A (ko) | 2010-02-12 |
| EP2144504A4 (en) | 2012-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: MYRIAD PHARMACEUTICALS, INC., US Free format text: OLD OWNER(S): MYRIAD GENETICS, INC. |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |