NZ574717A - Methods for treating and limiting fibrotic disorders and keloids using a polypeptide comprising the sequences WLRRASAPLPGLK and YARAAARQARA - Google Patents
Methods for treating and limiting fibrotic disorders and keloids using a polypeptide comprising the sequences WLRRASAPLPGLK and YARAAARQARAInfo
- Publication number
- NZ574717A NZ574717A NZ574717A NZ57471707A NZ574717A NZ 574717 A NZ574717 A NZ 574717A NZ 574717 A NZ574717 A NZ 574717A NZ 57471707 A NZ57471707 A NZ 57471707A NZ 574717 A NZ574717 A NZ 574717A
- Authority
- NZ
- New Zealand
- Prior art keywords
- leu
- ala
- prt
- artificial
- synthetic
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 80
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 74
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 74
- 230000003176 fibrotic effect Effects 0.000 title claims abstract description 37
- 230000000670 limiting effect Effects 0.000 title claims abstract description 18
- 208000002260 Keloid Diseases 0.000 title claims description 60
- 210000001117 keloid Anatomy 0.000 title claims description 60
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 35
- 208000035475 disorder Diseases 0.000 title claims description 31
- 238000000034 method Methods 0.000 title claims description 29
- 230000026683 transduction Effects 0.000 claims abstract description 17
- 238000010361 transduction Methods 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 5
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- 150000001413 amino acids Chemical class 0.000 claims description 58
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- 208000032544 Cicatrix Diseases 0.000 claims description 31
- 230000037387 scars Effects 0.000 claims description 31
- 230000001969 hypertrophic effect Effects 0.000 claims description 29
- UCBPDSYUVAAHCD-UWVGGRQHSA-N Leu-Pro-Gly Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O UCBPDSYUVAAHCD-UWVGGRQHSA-N 0.000 claims description 18
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical class OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims description 15
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- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical class NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83027906P | 2006-07-12 | 2006-07-12 | |
| US84904106P | 2006-10-02 | 2006-10-02 | |
| PCT/US2007/073144 WO2008008772A2 (en) | 2006-07-12 | 2007-07-10 | Methods for treating and limiting fibrotic disorders and keloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ574717A true NZ574717A (en) | 2011-11-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ574717A NZ574717A (en) | 2006-07-12 | 2007-07-10 | Methods for treating and limiting fibrotic disorders and keloids using a polypeptide comprising the sequences WLRRASAPLPGLK and YARAAARQARA |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110028398A1 (enExample) |
| EP (1) | EP2051727A4 (enExample) |
| JP (1) | JP5048772B2 (enExample) |
| KR (1) | KR101267217B1 (enExample) |
| AU (1) | AU2007272578B2 (enExample) |
| BR (1) | BRPI0714383A2 (enExample) |
| CA (1) | CA2657263A1 (enExample) |
| CR (1) | CR10552A (enExample) |
| DO (1) | DOP2009000005A (enExample) |
| MX (1) | MX2009000359A (enExample) |
| NZ (1) | NZ574717A (enExample) |
| SG (1) | SG173369A1 (enExample) |
| WO (1) | WO2008008772A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2617431B1 (en) | 2007-01-10 | 2017-04-12 | Purdue Research Foundation | Polypeptide inhibitors of HSP27 kinase and uses therefor |
| JP5703466B2 (ja) | 2007-08-07 | 2015-04-22 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | キナーゼ阻害薬およびその使用 |
| WO2010027831A1 (en) * | 2008-08-25 | 2010-03-11 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to ctgf |
| BRPI0922448A2 (pt) | 2008-12-10 | 2021-02-17 | Purdue Research Foundation | inibidor com base em peptídeo penetrante celular de quinases |
| WO2011017132A2 (en) | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| WO2013134177A1 (en) * | 2012-03-05 | 2013-09-12 | Capstone Therapeutics Corp. | Methods and compositions for improving spinal surgery outcomes |
| US9452218B2 (en) | 2012-03-09 | 2016-09-27 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| KR102166543B1 (ko) * | 2014-06-02 | 2020-10-16 | 주식회사 젬백스앤카엘 | 켈로이드 억제용 조성물 및 그 억제 방법 |
| US20170275650A1 (en) * | 2014-07-22 | 2017-09-28 | The Regents Of The University Of California | Endosomal escape domains for delivery of macromolecules into cells |
| KR101667900B1 (ko) * | 2016-01-15 | 2016-10-21 | 테고사이언스 (주) | 켈로이드성 피부 또는 켈로이드 흉터 진단용 바이오마커 단백질 및 이의 이용 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5280038A (en) * | 1992-03-13 | 1994-01-18 | Virginia Commonwealth University | Histidine as a protective agent in cardiac surgery and myocardial ischemic syndrome |
| US5985635A (en) * | 1996-11-15 | 1999-11-16 | Incyte Pharmaceuticals, Inc. | Nucleic acids encoding novel human serine/threonine protein kinases |
| US7556722B2 (en) * | 1996-11-22 | 2009-07-07 | Metzger Hubert F | Electroplating apparatus |
| US6475490B1 (en) * | 1998-10-19 | 2002-11-05 | Fordham University | Compositions and methods for promoting tissue repair using heat shock proteins |
| AU2001249214A1 (en) * | 2000-03-15 | 2001-09-24 | The Brigham And Women's Hospital, Inc. | Suppression of vascular disorders by mucosal administration of heat shock protein peptides |
| ES2432225T3 (es) * | 2001-08-23 | 2013-12-02 | Arizona Board Of Regents | Reactivos y procedimientos para terapias del músculo liso |
| AU2003260668A1 (en) * | 2002-04-01 | 2003-10-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Biological affinity based delivery systems |
| ATE332703T1 (de) * | 2003-02-21 | 2006-08-15 | Univ Arizona | Verwendung von hsp20 zur förderung der wundheilung und / oder zur reduzierung von narbenbildung |
| CA2542639A1 (en) * | 2003-10-17 | 2005-04-28 | Arizona Board Of Regents | Novel heat shock protein 20-related polypeptides and uses therefor |
| JP2009033589A (ja) * | 2007-07-30 | 2009-02-12 | Ricoh Co Ltd | 画像形成装置、プログラムおよび記録媒体 |
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2007
- 2007-07-10 KR KR1020097000515A patent/KR101267217B1/ko not_active Expired - Fee Related
- 2007-07-10 CA CA002657263A patent/CA2657263A1/en not_active Abandoned
- 2007-07-10 MX MX2009000359A patent/MX2009000359A/es active IP Right Grant
- 2007-07-10 WO PCT/US2007/073144 patent/WO2008008772A2/en not_active Ceased
- 2007-07-10 SG SG2011050457A patent/SG173369A1/en unknown
- 2007-07-10 JP JP2009519633A patent/JP5048772B2/ja not_active Expired - Fee Related
- 2007-07-10 US US12/305,885 patent/US20110028398A1/en not_active Abandoned
- 2007-07-10 EP EP07799441A patent/EP2051727A4/en not_active Withdrawn
- 2007-07-10 AU AU2007272578A patent/AU2007272578B2/en not_active Ceased
- 2007-07-10 NZ NZ574717A patent/NZ574717A/en not_active IP Right Cessation
- 2007-07-10 BR BRPI0714383-4A patent/BRPI0714383A2/pt not_active IP Right Cessation
-
2009
- 2009-01-09 CR CR10552A patent/CR10552A/es unknown
- 2009-01-09 DO DO2009000005A patent/DOP2009000005A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2009000005A (es) | 2009-04-30 |
| SG173369A1 (en) | 2011-08-29 |
| EP2051727A4 (en) | 2012-03-14 |
| JP5048772B2 (ja) | 2012-10-17 |
| EP2051727A2 (en) | 2009-04-29 |
| CA2657263A1 (en) | 2008-01-17 |
| WO2008008772A2 (en) | 2008-01-17 |
| WO2008008772A3 (en) | 2008-10-16 |
| US20110028398A1 (en) | 2011-02-03 |
| CR10552A (es) | 2009-05-04 |
| JP2009543800A (ja) | 2009-12-10 |
| MX2009000359A (es) | 2009-05-08 |
| KR101267217B1 (ko) | 2013-05-31 |
| KR20090023685A (ko) | 2009-03-05 |
| BRPI0714383A2 (pt) | 2013-04-30 |
| AU2007272578A1 (en) | 2008-01-17 |
| AU2007272578B2 (en) | 2012-11-08 |
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