NZ556158A - Trefoil factors and methods of treating proliferation disorders using same - Google Patents
Trefoil factors and methods of treating proliferation disorders using sameInfo
- Publication number
- NZ556158A NZ556158A NZ556158A NZ55615805A NZ556158A NZ 556158 A NZ556158 A NZ 556158A NZ 556158 A NZ556158 A NZ 556158A NZ 55615805 A NZ55615805 A NZ 55615805A NZ 556158 A NZ556158 A NZ 556158A
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/53—Physical structure partially self-complementary or closed
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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Applications Claiming Priority (4)
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| AU2004907263A AU2004907263A0 (en) | 2004-12-22 | Methods of treatment | |
| AU2004907226A AU2004907226A0 (en) | 2004-12-22 | TFF3 antagonists | |
| AU2004907262A AU2004907262A0 (en) | 2004-12-22 | Methods of treatment | |
| PCT/US2005/046634 WO2006069253A2 (en) | 2004-12-22 | 2005-12-22 | Trefoil factors and methods of treating proliferation disorders using same |
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| JP2010505847A (ja) * | 2006-10-03 | 2010-02-25 | ニューレン ファーマシューティカルズ リミテッド | トレフォイル因子に結合する高次構造特異的抗体とこれを用いた癌および増殖障害の治療法 |
| WO2009147530A2 (en) * | 2008-06-06 | 2009-12-10 | Neuren Pharmaceuticals Ltd | Conformation specific antibodies that bind trefoil factors |
| WO2011068865A1 (en) * | 2009-12-01 | 2011-06-09 | Board Of Trustees Of Southern Illinois University | Micro-rna-101 promotes estrogen-independent growth and confers tamoxifen resistance in er-positive cancer cells |
| EP2575864A1 (en) | 2010-06-04 | 2013-04-10 | Trifoilium ApS | Trefoil factors (tff) for the treatment of chronic pulmonary diseases |
| WO2012038825A2 (en) * | 2010-09-21 | 2012-03-29 | Auckland Uniservices Limited | Methods of increasing radiosensitivity using inhibitors of trefoil factor 1 (tff1) |
| WO2012150869A1 (en) * | 2011-05-05 | 2012-11-08 | Neuren Pharmaceuticals Limited | Antibodies that bind trefoil factors and methods of using same |
| CN104736157B (zh) | 2012-05-09 | 2019-06-11 | 香港科技大学 | 抑制mcm蛋白复合物的方法和化合物及其在治疗癌症上的应用 |
| KR102291465B1 (ko) * | 2014-01-24 | 2021-08-18 | 삼성전자주식회사 | c-Met 저해제의 효능 예측을 위한 바이오마커 TFF1 |
| JP2020507350A (ja) * | 2017-02-10 | 2020-03-12 | ヴィヴィババ インコーポレイテッド | 組換え神経成長因子のための組成物及び方法 |
| WO2021038296A2 (en) * | 2019-08-27 | 2021-03-04 | Tonix Pharma Holdings Limited | Modified tff2 polypeptides |
| CN114929742A (zh) * | 2019-11-26 | 2022-08-19 | 万能溶剂有限公司 | 用三叶因子家族成员2调节剂治疗衰老相关损伤的方法和组合物 |
| AU2022274703A1 (en) * | 2021-05-12 | 2023-08-17 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators |
| CN113721019A (zh) * | 2021-09-05 | 2021-11-30 | 苏州银湾细胞生物科技有限公司 | 胆管癌术后生存预测方法、试剂盒以及试剂盒的应用方法 |
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| US650559A (en) * | 1900-01-31 | 1900-05-29 | American Type Founders Co | Gas-burner. |
| WO1992006180A1 (en) | 1990-10-01 | 1992-04-16 | University Of Connecticut | Targeting viruses and cells for selective internalization by cells |
| EP0584279B1 (en) | 1991-05-14 | 2001-03-14 | The University Of Connecticut | Targeted delivery of genes encoding immunogenic proteins |
| WO1992022635A1 (en) | 1991-06-05 | 1992-12-23 | University Of Connecticut | Targeted delivery of genes encoding secretory proteins |
| AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
| CA2133411A1 (en) | 1992-04-03 | 1993-10-14 | Alexander T. YOUNG | Gene therapy using targeted viral vectors |
| US6525018B1 (en) * | 1999-05-17 | 2003-02-25 | The General Hospital Corp. | Treating eye disorders using intestinal trefoil proteins |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO2001051628A2 (en) * | 2000-01-14 | 2001-07-19 | Millennium Pharmaceuticals, Inc. | Genes compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20030125265A1 (en) * | 2001-05-09 | 2003-07-03 | Mien-Chie Hung | Anti-estrogen receptor agents for chemotherapy |
| US20030193682A1 (en) * | 2002-04-10 | 2003-10-16 | Parry Travis J. | Method and system for partitioning multiple media handling jobs |
| WO2002102399A2 (en) * | 2001-06-14 | 2002-12-27 | Novo Nordisk A/S | Mucosal repair by tff2 peptides |
| EP1401481A1 (en) * | 2001-06-14 | 2004-03-31 | Novo Nordisk A/S | Mucosal repair by tff dimer peptides |
| AU2002322280A1 (en) * | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20030215431A1 (en) * | 2002-02-11 | 2003-11-20 | Lars Thim | Management of mucosal viscosity by TFF monomer peptides |
| DE10215320A1 (de) * | 2002-04-02 | 2003-10-23 | Metagen Pharmaceuticals Gmbh | Verwendungen von TFF3 bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen |
| EP1581623A2 (en) * | 2002-10-31 | 2005-10-05 | The GI Company, Inc | Trefoil domain-containing polypeptides and uses thereof |
| WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| CA2534658A1 (en) * | 2003-08-07 | 2005-02-17 | Chiron Corporation | Trefoil factor 3 (tff3) as a target for anti-cancer therapy |
| WO2005042010A1 (en) * | 2003-10-30 | 2005-05-12 | Novo Nordisk A/S | Use of trefoil polypeptides in the treatment of diabetes |
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2005
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- 2005-12-22 US US11/794,025 patent/US20090022708A1/en not_active Abandoned
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Also Published As
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| JP2008525479A (ja) | 2008-07-17 |
| EP1833991A4 (en) | 2011-11-16 |
| WO2006069253A3 (en) | 2007-08-02 |
| WO2006069253A2 (en) | 2006-06-29 |
| JP2014088393A (ja) | 2014-05-15 |
| EP1833991A2 (en) | 2007-09-19 |
| US20100129370A1 (en) | 2010-05-27 |
| US20090022708A1 (en) | 2009-01-22 |
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