NZ548659A - Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof - Google Patents
Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereofInfo
- Publication number
- NZ548659A NZ548659A NZ548659A NZ54865905A NZ548659A NZ 548659 A NZ548659 A NZ 548659A NZ 548659 A NZ548659 A NZ 548659A NZ 54865905 A NZ54865905 A NZ 54865905A NZ 548659 A NZ548659 A NZ 548659A
- Authority
- NZ
- New Zealand
- Prior art keywords
- substituted
- kpu
- atom
- tbu
- nitro
- Prior art date
Links
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US54207304P | 2004-02-04 | 2004-02-04 | |
US62426204P | 2004-11-01 | 2004-11-01 | |
PCT/US2005/003636 WO2005077940A1 (en) | 2004-02-04 | 2005-02-04 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
Publications (1)
Publication Number | Publication Date |
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NZ548659A true NZ548659A (en) | 2011-01-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NZ548659A NZ548659A (en) | 2004-02-04 | 2005-02-04 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
Country Status (9)
Country | Link |
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EP (1) | EP1711487A1 (pt) |
JP (1) | JP2007520565A (pt) |
KR (1) | KR101228104B1 (pt) |
AU (1) | AU2005212399B2 (pt) |
BR (1) | BRPI0506655A (pt) |
CA (1) | CA2553630A1 (pt) |
IL (1) | IL176932A0 (pt) |
NZ (1) | NZ548659A (pt) |
WO (1) | WO2005077940A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
PT1529044E (pt) | 2002-08-02 | 2008-01-14 | Nereus Pharmaceuticals Inc | Desidrofenila-histinas e os seus análogos e a síntese de desidrofenila-histinas e os seus análogos |
WO2007035841A1 (en) * | 2005-09-21 | 2007-03-29 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
NZ719049A (en) * | 2013-10-11 | 2020-06-26 | Beyondspring Inc | Cancer treatment with combination of plinabulin and taxane |
RU2723021C2 (ru) * | 2015-02-12 | 2020-06-08 | Бейондспринг Фармасьютикалс, Инк. | Применение плинабулина в комбинации с ингибиторами контрольной точки иммунного ответа |
MY190034A (en) * | 2015-03-06 | 2022-03-22 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
RU2728796C2 (ru) | 2015-03-06 | 2020-07-31 | Бейондспринг Фармасьютикалс, Инк. | Способ лечения опухоли головного мозга |
PE20180528A1 (es) * | 2015-07-13 | 2018-03-19 | Beyondspring Pharmaceuticals Inc | Composiciones de plinabulina |
MX2018009413A (es) | 2016-02-08 | 2019-05-15 | Beyondspring Pharmaceuticals Inc | Composiciones que contienen tucaresol o sus analogos. |
TWI777957B (zh) | 2016-06-06 | 2022-09-21 | 中國大陸商大連萬春布林醫藥有限公司 | 降低嗜中性白血球減少症之組合物及方法 |
CN109563079B (zh) * | 2016-08-12 | 2021-10-26 | 深圳华大海洋科技有限公司 | 脱氢苯基阿夕斯丁类化合物的多晶型及其制备纯化方法和应用 |
EP3565812B1 (en) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
EP3595653B1 (en) * | 2017-03-13 | 2023-03-08 | Beyondspring Pharmaceuticals, Inc. | Compositions of plinabulin and use thereof |
KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
CN108524442B (zh) * | 2018-06-05 | 2022-01-28 | 深圳海王医药科技研究院有限公司 | 一种抗肿瘤药物的注射剂及其制备方法 |
JP2018199726A (ja) * | 2018-09-26 | 2018-12-20 | ビヨンドスプリング インコーポレイテッド | プリナブリン及びタキサンの組合せがん治療 |
EP4412613A1 (en) * | 2021-10-07 | 2024-08-14 | Beyondspring Pharmaceuticals, Inc. | Methods for treating cancers and tumors |
Family Cites Families (7)
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DE3318789C2 (de) * | 1983-05-24 | 1987-04-02 | Eduard Gerlach GmbH Chemische Fabrik, 4990 Lübbecke | Deodorant |
GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
US6069146A (en) * | 1998-03-25 | 2000-05-30 | The Regents Of The University Of California | Halimide, a cytotoxic marine natural product, and derivatives thereof |
US6358957B1 (en) * | 1998-11-12 | 2002-03-19 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
EP1264831A4 (en) * | 2000-01-18 | 2005-11-23 | Nereus Pharmaceuticals Inc | Cell division inhibitors and a method for fixing the same |
US6635649B2 (en) * | 2000-05-09 | 2003-10-21 | Che-Ming Teng | Piperazinedione compounds |
PT1529044E (pt) * | 2002-08-02 | 2008-01-14 | Nereus Pharmaceuticals Inc | Desidrofenila-histinas e os seus análogos e a síntese de desidrofenila-histinas e os seus análogos |
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2005
- 2005-02-04 WO PCT/US2005/003636 patent/WO2005077940A1/en active Application Filing
- 2005-02-04 JP JP2006552282A patent/JP2007520565A/ja active Pending
- 2005-02-04 AU AU2005212399A patent/AU2005212399B2/en not_active Ceased
- 2005-02-04 EP EP05712910A patent/EP1711487A1/en not_active Withdrawn
- 2005-02-04 KR KR1020067017883A patent/KR101228104B1/ko active IP Right Grant
- 2005-02-04 NZ NZ548659A patent/NZ548659A/en unknown
- 2005-02-04 CA CA002553630A patent/CA2553630A1/en not_active Abandoned
- 2005-02-04 BR BRPI0506655-7A patent/BRPI0506655A/pt not_active IP Right Cessation
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2006
- 2006-07-18 IL IL176932A patent/IL176932A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL176932A0 (en) | 2006-12-10 |
KR20060124743A (ko) | 2006-12-05 |
JP2007520565A (ja) | 2007-07-26 |
BRPI0506655A (pt) | 2007-05-08 |
AU2005212399B2 (en) | 2011-09-22 |
EP1711487A1 (en) | 2006-10-18 |
AU2005212399A1 (en) | 2005-08-25 |
CA2553630A1 (en) | 2005-08-25 |
KR101228104B1 (ko) | 2013-02-01 |
WO2005077940A1 (en) | 2005-08-25 |
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