NZ534874A - Co-therapy for the treatment of migraine comprising a topiramate and a triptan - Google Patents
Co-therapy for the treatment of migraine comprising a topiramate and a triptanInfo
- Publication number
- NZ534874A NZ534874A NZ534874A NZ53487403A NZ534874A NZ 534874 A NZ534874 A NZ 534874A NZ 534874 A NZ534874 A NZ 534874A NZ 53487403 A NZ53487403 A NZ 53487403A NZ 534874 A NZ534874 A NZ 534874A
- Authority
- NZ
- New Zealand
- Prior art keywords
- migraine
- topiramate
- triptan
- formula
- subjects
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title claims abstract description 187
- 206010027599 migraine Diseases 0.000 title claims abstract description 165
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 title claims abstract description 116
- 229960004394 topiramate Drugs 0.000 title claims abstract description 93
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 238000011262 co‐therapy Methods 0.000 title claims description 18
- 238000011282 treatment Methods 0.000 title description 71
- 239000003814 drug Substances 0.000 claims abstract description 80
- -1 sulfamate compound Chemical class 0.000 claims abstract description 46
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 38
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 29
- 239000001257 hydrogen Substances 0.000 claims abstract description 29
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910052760 oxygen Chemical group 0.000 claims abstract description 19
- 239000001301 oxygen Chemical group 0.000 claims abstract description 19
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims abstract description 13
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 11
- 229960002133 almotriptan Drugs 0.000 claims abstract description 9
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- SIBNYOSJIXCDRI-SECBINFHSA-N frovatriptan Chemical compound C1=C(C(N)=O)[CH]C2=C(C[C@H](NC)CC3)C3=NC2=C1 SIBNYOSJIXCDRI-SECBINFHSA-N 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 229960000425 rizatriptan Drugs 0.000 claims abstract description 7
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- OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 claims abstract 4
- UNHGSHHVDNGCFN-UHFFFAOYSA-N naratriptan Chemical compound C=12[CH]C(CCS(=O)(=O)NC)=CC=C2N=CC=1C1CCN(C)CC1 UNHGSHHVDNGCFN-UHFFFAOYSA-N 0.000 claims abstract 4
- TXHZXHICDBAVJW-UHFFFAOYSA-N rizatriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1CN1C=NC=N1 TXHZXHICDBAVJW-UHFFFAOYSA-N 0.000 claims abstract 4
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 claims abstract 4
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 9
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35989402P | 2002-02-26 | 2002-02-26 | |
| PCT/US2003/005463 WO2003072138A1 (en) | 2002-02-26 | 2003-02-25 | Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ534874A true NZ534874A (en) | 2007-03-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ534874A NZ534874A (en) | 2002-02-26 | 2003-02-25 | Co-therapy for the treatment of migraine comprising a topiramate and a triptan |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20030225002A1 (https=) |
| EP (1) | EP1478400A1 (https=) |
| JP (1) | JP2005518439A (https=) |
| KR (1) | KR101008326B1 (https=) |
| CN (1) | CN100352506C (https=) |
| AU (1) | AU2003213242A1 (https=) |
| BR (1) | BR0307951A (https=) |
| CA (1) | CA2419989A1 (https=) |
| HR (1) | HRP20040846A2 (https=) |
| IL (2) | IL163720A0 (https=) |
| MX (1) | MXPA04008259A (https=) |
| NO (1) | NO20043984L (https=) |
| NZ (1) | NZ534874A (https=) |
| PL (1) | PL372393A1 (https=) |
| RU (1) | RU2004126093A (https=) |
| UA (1) | UA81110C2 (https=) |
| WO (1) | WO2003072138A1 (https=) |
| ZA (1) | ZA200407729B (https=) |
Families Citing this family (21)
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| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| WO2005079787A1 (en) * | 2004-02-17 | 2005-09-01 | Sepracor Inc. | Treatment or prophylaxis of migraine or headache disorders using citalopram, escitalopram or citalopram metabolites |
| US20060233892A1 (en) * | 2005-04-19 | 2006-10-19 | Curt Hendrix | Topiramate compositions for treatment of headache |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| FR2890564B1 (fr) * | 2005-09-09 | 2007-10-19 | Servier Lab | Nouvelle association entre l'agomelatine et un inhibiteur de la recapture de la noradrenaline et les compositions pharmaceutiques qui la contiennent |
| CN101472644B (zh) * | 2006-04-13 | 2014-04-23 | 纽帕特公司 | 递送抗偏头痛化合物的透皮方法和系统 |
| WO2007127207A2 (en) * | 2006-04-25 | 2007-11-08 | Proethic Pharmaceuticals, Inc. | Fixed combination dosage forms for the treatment of migraine |
| WO2008027557A2 (en) | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2124556B1 (en) | 2006-10-09 | 2014-09-03 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| ES2555066T3 (es) | 2006-11-17 | 2015-12-28 | Supernus Pharmaceuticals, Inc. | Formulaciones de liberación sostenida de topiramato |
| ES2645719T3 (es) * | 2006-12-04 | 2017-12-07 | Supernus Pharmaceuticals, Inc. | Formulaciones de topiramato de liberación inmediata mejoradas |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| ES2620672T3 (es) | 2008-01-09 | 2017-06-29 | Charleston Laboratories, Inc. | Comprimidos de doble capa que comprenden oxicodona y prometazina |
| EP2331100B1 (en) * | 2008-09-17 | 2014-07-16 | The McLean Hospital Corporation | Methods and kits for treating cluster headache disorders |
| WO2011006012A1 (en) | 2009-07-08 | 2011-01-13 | Charleston Laboratories Inc. | Pharmaceutical compositions |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| JP2019507181A (ja) | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ，インコーポレイテッド | 医薬組成物 |
| CA3039169A1 (en) * | 2016-10-06 | 2018-04-12 | Baylor College Of Medicine | Photochromatic modulation with fluorescein for the treatment of photo-oculodynia and blepharospasm |
| JP7476229B2 (ja) * | 2019-04-15 | 2024-04-30 | フェリン・ファーマシューティカルズ・インコーポレイテッド | 片頭痛の治療 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| IL103172A (en) * | 1991-09-19 | 1997-01-10 | Mcneilab Inc | Preparation of chlorosulfate and sulfamate derivatives of 2, 3:4, 5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl) methanol |
| US5242942A (en) * | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US5384327A (en) * | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| CA2264182A1 (en) * | 1996-08-23 | 1998-02-26 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| US20020015713A1 (en) * | 1996-10-24 | 2002-02-07 | Murdock Robert W. | Methods and transdermal compositions for pain relief |
| AU1930897A (en) * | 1997-03-03 | 1998-09-22 | Laboratoires Remilea | Plant extract compositions, method of preparation, and pharmaceutical comp ositions containing them |
| US5855907A (en) * | 1997-03-24 | 1999-01-05 | Peyman; Gholam A. | Method of treatment of migraine |
| US5935933A (en) * | 1997-07-16 | 1999-08-10 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating neuropathic pain |
| US5760007A (en) * | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
| GB9720270D0 (en) * | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
| US6068999A (en) * | 1998-06-25 | 2000-05-30 | Hendrix; Curt | Dietary supplement for supporting cerebrovascular tone and treating migraine headaches |
| ES2228465T3 (es) * | 1999-01-19 | 2005-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Uso derivados anticonvulsionantes para el tratamiento de cefaleas en brotes. |
| HUP0203198A3 (en) * | 1999-08-20 | 2005-07-28 | Ortho Mcneil Pharm Inc | Pharmaceutical composition comprising a tramadol material and an anticonvulsant drug, process for its preparation and its use |
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2003
- 2003-02-25 WO PCT/US2003/005463 patent/WO2003072138A1/en not_active Ceased
- 2003-02-25 MX MXPA04008259A patent/MXPA04008259A/es unknown
- 2003-02-25 PL PL03372393A patent/PL372393A1/xx not_active Application Discontinuation
- 2003-02-25 BR BR0307951-1A patent/BR0307951A/pt not_active Application Discontinuation
- 2003-02-25 JP JP2003570882A patent/JP2005518439A/ja active Pending
- 2003-02-25 US US10/373,488 patent/US20030225002A1/en not_active Abandoned
- 2003-02-25 EP EP03709289A patent/EP1478400A1/en not_active Withdrawn
- 2003-02-25 CN CNB038091135A patent/CN100352506C/zh not_active Expired - Lifetime
- 2003-02-25 AU AU2003213242A patent/AU2003213242A1/en not_active Abandoned
- 2003-02-25 NZ NZ534874A patent/NZ534874A/en not_active IP Right Cessation
- 2003-02-25 UA UA20040807114A patent/UA81110C2/uk unknown
- 2003-02-25 IL IL16372003A patent/IL163720A0/xx unknown
- 2003-02-25 KR KR1020047013261A patent/KR101008326B1/ko not_active Expired - Fee Related
- 2003-02-25 RU RU2004126093/14A patent/RU2004126093A/ru not_active Application Discontinuation
- 2003-02-25 HR HR20040846A patent/HRP20040846A2/hr not_active Application Discontinuation
- 2003-02-26 CA CA002419989A patent/CA2419989A1/en not_active Abandoned
-
2004
- 2004-08-24 IL IL163720A patent/IL163720A/en active IP Right Grant
- 2004-09-23 ZA ZA200407729A patent/ZA200407729B/en unknown
- 2004-09-23 NO NO20043984A patent/NO20043984L/no unknown
-
2006
- 2006-12-08 US US11/608,276 patent/US20070099849A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003213242A1 (en) | 2003-09-09 |
| IL163720A (en) | 2012-06-28 |
| JP2005518439A (ja) | 2005-06-23 |
| KR101008326B1 (ko) | 2011-01-13 |
| KR20040091074A (ko) | 2004-10-27 |
| HRP20040846A2 (en) | 2005-06-30 |
| CN1646168A (zh) | 2005-07-27 |
| US20030225002A1 (en) | 2003-12-04 |
| WO2003072138A1 (en) | 2003-09-04 |
| RU2004126093A (ru) | 2005-04-10 |
| NO20043984L (no) | 2004-09-23 |
| PL372393A1 (en) | 2005-07-25 |
| BR0307951A (pt) | 2004-12-21 |
| CN100352506C (zh) | 2007-12-05 |
| IL163720A0 (en) | 2005-12-18 |
| EP1478400A1 (en) | 2004-11-24 |
| ZA200407729B (en) | 2006-06-28 |
| UA81110C2 (en) | 2007-12-10 |
| CA2419989A1 (en) | 2003-08-05 |
| US20070099849A1 (en) | 2007-05-03 |
| HK1080731A1 (en) | 2006-05-04 |
| MXPA04008259A (es) | 2005-05-27 |
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