NZ530648A - Oral compositions containing terbinafin in solid dosage form shich si coated or multiparticulate and use thereof in an intermittent cycle - Google Patents
Oral compositions containing terbinafin in solid dosage form shich si coated or multiparticulate and use thereof in an intermittent cycleInfo
- Publication number
- NZ530648A NZ530648A NZ530648A NZ53064802A NZ530648A NZ 530648 A NZ530648 A NZ 530648A NZ 530648 A NZ530648 A NZ 530648A NZ 53064802 A NZ53064802 A NZ 53064802A NZ 530648 A NZ530648 A NZ 530648A
- Authority
- NZ
- New Zealand
- Prior art keywords
- terbinafine
- coated
- minitablets
- coating
- dosage form
- Prior art date
Links
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 239000001509 sodium citrate Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0117760A GB0117760D0 (en) | 2001-07-20 | 2001-07-20 | Organic compounds |
| GB0128993A GB0128993D0 (en) | 2001-12-04 | 2001-12-04 | Organic compounds |
| GB0212209A GB0212209D0 (en) | 2002-05-27 | 2002-05-27 | Organic compounds |
| PCT/EP2002/008095 WO2003022267A1 (en) | 2001-07-20 | 2002-07-19 | Pharmaceutical compositions containing terbinafin and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ530648A true NZ530648A (en) | 2007-04-27 |
Family
ID=27256227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ530648A NZ530648A (en) | 2001-07-20 | 2002-07-19 | Oral compositions containing terbinafin in solid dosage form shich si coated or multiparticulate and use thereof in an intermittent cycle |
Country Status (27)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AR034813A1 (es) † | 2001-07-20 | 2004-03-17 | Novartis Ag | Composiciones farmaceuticas y uso de las mismas |
| AU2003244633A1 (en) * | 2002-07-02 | 2004-01-23 | Novartis Ag | Methods for the treatment of sinusitis |
| JP2005060310A (ja) * | 2003-08-13 | 2005-03-10 | Towa Yakuhin Kk | 不快な味をマスキングする経口投与用製剤 |
| JP2005187339A (ja) * | 2003-12-24 | 2005-07-14 | Iwaki Seiyaku Co Ltd | 耐光性塩酸テルビナフィンフィルムコート錠 |
| JP4999297B2 (ja) * | 2005-08-10 | 2012-08-15 | 高田製薬株式会社 | 高含量塩酸テルビナフィン小型錠剤 |
| US8815285B2 (en) * | 2006-03-28 | 2014-08-26 | Wockhardt Ltd. | Extended release dosage forms of metoprolol |
| CN1820744B (zh) * | 2006-04-04 | 2011-01-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 磷酸奥司他韦颗粒剂及其制备方法 |
| WO2007121537A1 (en) * | 2006-04-26 | 2007-11-01 | Alphapharm Pty Ltd | Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix |
| RU2451504C2 (ru) * | 2006-06-07 | 2012-05-27 | Новартис Аг | Способ получения мультичастиц с применением роликового компактора |
| KR20110117199A (ko) * | 2009-01-28 | 2011-10-26 | 노파르티스 아게 | 유기 화합물의 생약 제제 |
| WO2010086727A1 (en) * | 2009-01-30 | 2010-08-05 | Galderma Pharma Sa | Stable compositions for nail onychomycosis treatment |
| CN102198111A (zh) * | 2011-06-17 | 2011-09-28 | 哈尔滨乐泰药业有限公司 | 一种抗真菌药物片剂的制备方法 |
| WO2013043143A1 (ru) * | 2011-09-21 | 2013-03-28 | Slyusar Viktor Timopheevich | Способ снижения лишнего веса |
| EP2822542A1 (en) * | 2012-03-07 | 2015-01-14 | Santarus, Inc. | Controlled-release solid dosage forms of mesalamine |
| LT3429559T (lt) | 2016-03-15 | 2022-08-10 | Acer Therapeutics Inc. | Skanios kompozicijos, įskaitant natrio fenilbutiratą, ir jų panaudojimas |
| WO2018069388A1 (en) | 2016-10-11 | 2018-04-19 | Khalifa University of Science and Technology | Coated chloride salt particles and methods of making and using the same |
| FR3069545B1 (fr) * | 2017-07-27 | 2020-10-16 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Composition d'enrobage exempte de dioxyde de titane |
| CN109833301A (zh) * | 2017-11-29 | 2019-06-04 | 天津市保灵动物保健品有限公司 | 一种犬猫用盐酸特比萘芬风味片及其制备工艺 |
| CN109925296B (zh) * | 2017-12-19 | 2021-09-07 | 四川济生堂药业有限公司 | 一种中药微丸的包衣方法 |
| CN112156078A (zh) * | 2020-11-11 | 2021-01-01 | 乐泰药业有限公司 | 一种盐酸特比萘芬片、其制备方法以及杂质与质量检测方法 |
| AU2021391823A1 (en) | 2020-12-03 | 2023-06-29 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| IL307454A (en) | 2021-04-07 | 2023-12-01 | Battelle Memorial Institute | Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors |
| CN115869273B (zh) * | 2022-10-31 | 2025-09-30 | 修正药业集团长春高新制药有限公司 | 一种盐酸特比萘芬片及其制备方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK62184D0 (da) † | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
| EP0166315B1 (de) * | 1984-06-19 | 1989-08-23 | BASF Aktiengesellschaft | Magensaftresistent überzogene zylindrische Pankreatin-Mikrotabletten |
| US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
| US4894375A (en) * | 1986-09-29 | 1990-01-16 | Merck & Co., Inc. | Method of controlling mycotic infections and compositions therefor |
| RU2033991C1 (ru) * | 1989-06-08 | 1995-04-30 | Ф.Хоффманн-Ля Рош Аг | Производные аминоалкилбензола или их фармацевтически приемлемые соли с кислотами |
| DE3937455A1 (de) * | 1989-11-10 | 1991-05-16 | Nordmark Arzneimittel Gmbh | Antacidatabletten |
| GB9111477D0 (en) * | 1991-05-29 | 1991-07-17 | Sandoz Ltd | Pharmaceutical composition |
| US5262172A (en) * | 1992-06-19 | 1993-11-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing buffered bile acids |
| US5578304A (en) * | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5415872A (en) * | 1992-06-22 | 1995-05-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| US5234697A (en) * | 1992-06-22 | 1993-08-10 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| US5332727A (en) * | 1993-04-29 | 1994-07-26 | Birkmayer U.S.A. | Stable, ingestable and absorbable NADH and NADPH therapeutic compositions |
| AU1313695A (en) * | 1993-12-14 | 1995-07-03 | Sandoz Ltd. | Pharmaceutical compositions containing alkyl polyoxyalkylene carboxylates |
| FR2722102B1 (fr) * | 1994-07-11 | 1996-08-23 | Cird Galderma | Utilisation de particules creuses deformables dans une composition cosmetique et/ou dermatologique, contenant des matieres grasses |
| GB2290965A (en) * | 1994-07-11 | 1996-01-17 | Therapicon Srl | Multiple layer capsules for drugs |
| NZ280065A (en) * | 1995-09-20 | 1998-04-27 | Apotex Inc | Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives |
| FR2751878B1 (fr) * | 1996-07-30 | 1998-09-04 | Oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
| CA2184535C (en) * | 1996-08-30 | 2000-04-18 | H. Craig Willis | Apparatus and method for separation of solids from liquid |
| DE19637082A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
| FR2755011B1 (fr) * | 1996-10-31 | 1998-11-20 | Cird Galderma | Utilisation des inhibiteurs de l'activite de l'acide retinoique pour traiter les peaux sensibles et/ou les dommages aigus induits par les rayonnements u.v. |
| HUP0002744A3 (en) * | 1997-01-06 | 2001-01-29 | Pfizer | Rapidly releasing and taste-masking pharmaceutical dosage form |
| US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
| FR2771291B1 (fr) † | 1997-11-21 | 2000-02-25 | Ethypharm Lab Prod Ethiques | Spheroides, procede de preparation et compositions pharmaceutiques |
| DE19842753A1 (de) † | 1998-09-18 | 2000-03-23 | Bayer Ag | Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung |
| US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
| US6322819B1 (en) * | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
| WO2000030617A1 (en) * | 1998-11-25 | 2000-06-02 | Cima Labs Inc. | Taste masking rapid release coating system |
| US6740341B1 (en) * | 1998-11-25 | 2004-05-25 | Cima Labs Inc. | Taste masking rapid release coating system |
| DK1146862T3 (da) † | 1999-01-29 | 2003-07-21 | Disphar Int Bv | Farmaceutiske sammensætninger |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| CN1116033C (zh) * | 1999-07-08 | 2003-07-30 | 齐鲁制药厂 | 一种治疗阴道炎的泡腾片剂及其制法 |
| EP1202716A1 (en) * | 1999-08-17 | 2002-05-08 | Novartis Consumer Health S.A. | Rapidly dissolving dosage form and process for making same |
| GB0001315D0 (en) * | 2000-01-20 | 2000-03-08 | Novartis Ag | Organic compounds |
| AU2001239838A1 (en) † | 2000-02-24 | 2001-09-03 | Advancis Pharmaceutical Corporation | Therapeutic product, use and formulation thereof |
| DE10017996A1 (de) * | 2000-04-11 | 2001-10-18 | Pierre Foss | Lamisil-Intervall-System |
| GB0014448D0 (en) * | 2000-06-13 | 2000-08-09 | Novartis Ag | Organic compounds |
| AR034813A1 (es) † | 2001-07-20 | 2004-03-17 | Novartis Ag | Composiciones farmaceuticas y uso de las mismas |
| US20040198828A1 (en) * | 2003-01-17 | 2004-10-07 | Abelson Mark B. | Combinational use of long-acting and short-acting anti-histamines for ocular allergies |
-
2002
- 2002-07-18 AR ARP020102698A patent/AR034813A1/es unknown
- 2002-07-19 KR KR1020047000865A patent/KR100651110B1/ko not_active Expired - Fee Related
- 2002-07-19 CA CA2453263A patent/CA2453263C/en not_active Expired - Fee Related
- 2002-07-19 RU RU2004105263/15A patent/RU2298402C2/ru not_active IP Right Cessation
- 2002-07-19 AU AU2002321249A patent/AU2002321249B2/en not_active Ceased
- 2002-07-19 DK DK02754918.7T patent/DK1411921T4/da active
- 2002-07-19 EP EP02754918A patent/EP1411921B2/en not_active Expired - Lifetime
- 2002-07-19 WO PCT/EP2002/008095 patent/WO2003022267A1/en not_active Ceased
- 2002-07-19 CN CNB028141040A patent/CN100358518C/zh not_active Expired - Fee Related
- 2002-07-19 US US10/483,436 patent/US20040198838A1/en not_active Abandoned
- 2002-07-19 MY MYPI20022738A patent/MY136136A/en unknown
- 2002-07-19 DE DE60224194T patent/DE60224194T3/de not_active Expired - Lifetime
- 2002-07-19 MX MXPA04000627A patent/MXPA04000627A/es active IP Right Grant
- 2002-07-19 AT AT02754918T patent/ATE381329T1/de active
- 2002-07-19 PT PT02754918T patent/PT1411921E/pt unknown
- 2002-07-19 PL PL02365416A patent/PL365416A1/xx not_active Application Discontinuation
- 2002-07-19 NZ NZ530648A patent/NZ530648A/en not_active IP Right Cessation
- 2002-07-19 SI SI200230669T patent/SI1411921T2/sl unknown
- 2002-07-19 BR BR0211198-5A patent/BR0211198A/pt not_active IP Right Cessation
- 2002-07-19 KR KR1020067011980A patent/KR100699958B1/ko not_active Expired - Fee Related
- 2002-07-19 JP JP2003526396A patent/JP2005503399A/ja not_active Withdrawn
- 2002-07-19 IL IL15959102A patent/IL159591A0/xx unknown
- 2002-07-19 HU HU0401200A patent/HUP0401200A3/hu unknown
- 2002-07-19 ES ES02754918T patent/ES2295381T5/es not_active Expired - Lifetime
- 2002-07-19 TW TW091116154A patent/TWI302460B/zh not_active IP Right Cessation
- 2002-07-22 PE PE2002000645A patent/PE20030287A1/es not_active Application Discontinuation
-
2003
- 2003-12-25 IL IL159591A patent/IL159591A/en not_active IP Right Cessation
-
2004
- 2004-01-19 NO NO20040254A patent/NO332268B1/no not_active IP Right Cessation
-
2008
- 2008-01-18 CY CY20081100079T patent/CY1107861T1/el unknown
- 2008-06-17 JP JP2008158153A patent/JP2008280351A/ja active Pending
- 2008-07-18 US US12/218,806 patent/US20080286356A1/en not_active Abandoned
-
2012
- 2012-02-01 JP JP2012020039A patent/JP2012136523A/ja active Pending
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| LAPS | Patent lapsed |