NZ514323A - A immunostimulant containing an acitive agent and an adjuvant which increases the effect of the active agent - Google Patents
A immunostimulant containing an acitive agent and an adjuvant which increases the effect of the active agentInfo
- Publication number
- NZ514323A NZ514323A NZ514323A NZ51432300A NZ514323A NZ 514323 A NZ514323 A NZ 514323A NZ 514323 A NZ514323 A NZ 514323A NZ 51432300 A NZ51432300 A NZ 51432300A NZ 514323 A NZ514323 A NZ 514323A
- Authority
- NZ
- New Zealand
- Prior art keywords
- agent
- adjuvant
- active agent
- biologically active
- administered
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 7
- 239000002671 adjuvant Substances 0.000 title abstract 7
- 239000003795 chemical substances by application Substances 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 2
- 229960001438 immunostimulant agent Drugs 0.000 title 1
- 239000003022 immunostimulating agent Substances 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 230000028993 immune response Effects 0.000 abstract 4
- 230000001681 protective effect Effects 0.000 abstract 4
- 239000003085 diluting agent Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 2
- 101710168515 Cell surface glycoprotein Proteins 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 101710099182 S-layer protein Proteins 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 229940106241 cetrimides Drugs 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 239000004584 polyacrylic acid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906696.1A GB9906696D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| GBGB9906694.6A GB9906694D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| PCT/GB2000/001104 WO2000056361A2 (en) | 1999-03-24 | 2000-03-23 | Vaccine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ514323A true NZ514323A (en) | 2003-03-28 |
Family
ID=26315329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ514323A NZ514323A (en) | 1999-03-24 | 2000-03-23 | A immunostimulant containing an acitive agent and an adjuvant which increases the effect of the active agent |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080057083A1 (https=) |
| EP (2) | EP1163001A2 (https=) |
| JP (3) | JP5124066B2 (https=) |
| AT (1) | ATE403436T1 (https=) |
| AU (2) | AU755502C (https=) |
| CA (2) | CA2366908A1 (https=) |
| DE (1) | DE60039754D1 (https=) |
| DK (1) | DK1163002T3 (https=) |
| ES (1) | ES2311451T3 (https=) |
| NZ (1) | NZ514323A (https=) |
| WO (2) | WO2000056362A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050181063A1 (en) * | 2000-03-22 | 2005-08-18 | Alpar Hazire O. | Pharmaceutical composition for administration to mucosal surfaces |
| US7767197B2 (en) | 2000-06-22 | 2010-08-03 | Endo Pharmaceuticals Colorado LLC | Delivery vehicle composition and methods for delivering antigens and other drugs |
| BR0111948A (pt) | 2000-06-26 | 2004-08-24 | Rxkinetix Inc | Composição para entrega de fator de crescimento hematopoiético |
| WO2003005952A2 (en) * | 2001-07-10 | 2003-01-23 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| EP1416916B1 (en) | 2001-08-16 | 2007-10-17 | Cmp Therapeutics Limited | Chitin microparticles and their medical uses |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| ES2272768T3 (es) * | 2001-10-03 | 2007-05-01 | Celator Pharmaceuticals Inc | Composiciones para la administracion de combinaciones de farmacos. |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
| JP2006516609A (ja) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 粘膜髄膜炎菌性ワクチン |
| CA2514667C (en) * | 2003-01-30 | 2013-01-08 | Chiron Corporation | Adjuvanted influenza vaccine |
| JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| JP4669665B2 (ja) * | 2004-04-12 | 2011-04-13 | 正彦 阿部 | 細胞毒性のないポリカチオン修飾リポソームおよびその製造方法 |
| GB0519871D0 (en) | 2005-09-30 | 2005-11-09 | Secr Defence | Immunogenic agents |
| US8431160B2 (en) | 2006-02-24 | 2013-04-30 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| WO2008041703A1 (en) * | 2006-10-02 | 2008-04-10 | Osaka University | Adjuvant for influenza vaccine and influenza vaccine |
| JP5297009B2 (ja) * | 2007-07-24 | 2013-09-25 | 大日精化工業株式会社 | 免疫アジュバント水溶液 |
| MY148321A (en) * | 2007-10-02 | 2013-03-29 | Malaysian Palm Oil Board Mpob | Vitamin e supplementation to tetanus toxoid |
| GB0721937D0 (en) | 2007-11-08 | 2007-12-19 | Secr Defence | Rodenticide |
| CA2733147A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | Microparticles for use in immunogenic compositions |
| GB0900455D0 (en) | 2009-01-13 | 2009-02-11 | Secr Defence | Vaccine |
| CN103747798B (zh) * | 2011-05-18 | 2018-10-26 | 马特里瓦克斯公司 | 包含聚阳离子的蛋白质基质疫苗组合物 |
| WO2012164480A1 (en) * | 2011-05-30 | 2012-12-06 | National Institute Of Immunology | A vaccine composition capable of inducing memory antibody response from single point immunization |
| CN107200788B (zh) * | 2017-05-11 | 2020-04-14 | 暨南大学 | 一种季鏻化壳聚糖及其作为疫苗免疫佐剂的应用 |
| CN107899021A (zh) * | 2017-11-06 | 2018-04-13 | 扬州大学 | 一种表面修饰s‑层蛋白的壳聚糖微球、制备及应用 |
| KR102384808B1 (ko) * | 2018-12-20 | 2022-04-08 | 주식회사 스킨메드 | 키토산으로 코팅된 나노 캡슐 및 이의 용도 |
| EP3960203A1 (en) | 2020-08-25 | 2022-03-02 | Université de Liège | Complexes for the delivery of proteinaceous agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| GB1290141A (https=) * | 1968-05-31 | 1972-09-20 | ||
| FR2306684A1 (fr) * | 1975-04-11 | 1976-11-05 | Crinex Lab | Nouvelle composition a action immunostimulante |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US6024983A (en) * | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| ES2052685T3 (es) * | 1987-03-17 | 1994-07-16 | Akzo Nv | Metodo para producir un adyuvante libre. |
| ATE115862T1 (de) * | 1989-02-04 | 1995-01-15 | Akzo Nobel Nv | Tocole als impfstoffadjuvans. |
| US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5292513A (en) * | 1992-05-18 | 1994-03-08 | Anthony G. Gristina | Method for nonspecific cellular immune stimulation |
| EP0688205A1 (en) * | 1993-03-11 | 1995-12-27 | Secretech, Inc. | Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces |
| US6913767B1 (en) * | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| US5643605A (en) * | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
| US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| ATE252894T1 (de) * | 1995-01-05 | 2003-11-15 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
| DE69625802T2 (de) * | 1995-03-13 | 2003-11-13 | The Secretary Of State For Defence, Salisbury | Impfstoffe gegen die pest |
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| GB9525083D0 (en) * | 1995-12-07 | 1996-02-07 | Danbiosyst Uk | Vaccine compositions |
| DE19603649A1 (de) * | 1996-02-01 | 1997-08-07 | Werner Lubitz | Rekombinante Expression von S-Layer-Proteinen |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB9810126D0 (https=) * | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
| MXPA01004381A (es) * | 1998-11-02 | 2005-09-08 | Elan Corp Plc | Composicion de multiparticulado de liberacion modificada. |
| US20030171258A1 (en) * | 1999-03-24 | 2003-09-11 | Alpar Hazire Oya | Particle based vaccine composition |
| US20020103165A1 (en) * | 2000-02-29 | 2002-08-01 | Alliance Pharmaceutical Corp., | Engineered spray-dried lipid-based microparticles for cellular targeting |
| US20050181063A1 (en) * | 2000-03-22 | 2005-08-18 | Alpar Hazire O. | Pharmaceutical composition for administration to mucosal surfaces |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
-
2000
- 2000-03-23 JP JP2000606266A patent/JP5124066B2/ja not_active Expired - Fee Related
- 2000-03-23 AU AU34435/00A patent/AU755502C/en not_active Ceased
- 2000-03-23 CA CA002366908A patent/CA2366908A1/en not_active Abandoned
- 2000-03-23 JP JP2000606265A patent/JP2002540076A/ja not_active Withdrawn
- 2000-03-23 AT AT00912788T patent/ATE403436T1/de active
- 2000-03-23 DK DK00912788T patent/DK1163002T3/da active
- 2000-03-23 WO PCT/GB2000/001118 patent/WO2000056362A2/en not_active Ceased
- 2000-03-23 DE DE60039754T patent/DE60039754D1/de not_active Expired - Lifetime
- 2000-03-23 ES ES00912788T patent/ES2311451T3/es not_active Expired - Lifetime
- 2000-03-23 NZ NZ514323A patent/NZ514323A/xx unknown
- 2000-03-23 CA CA2366216A patent/CA2366216C/en not_active Expired - Fee Related
- 2000-03-23 EP EP00912777A patent/EP1163001A2/en not_active Withdrawn
- 2000-03-23 WO PCT/GB2000/001104 patent/WO2000056361A2/en not_active Ceased
- 2000-03-23 EP EP00912788A patent/EP1163002B1/en not_active Expired - Lifetime
- 2000-03-23 AU AU34424/00A patent/AU762078B2/en not_active Ceased
-
2007
- 2007-10-29 US US11/926,468 patent/US20080057083A1/en not_active Abandoned
-
2011
- 2011-09-20 JP JP2011204971A patent/JP2012031186A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000056361A3 (en) | 2001-03-01 |
| AU3443500A (en) | 2000-10-09 |
| ES2311451T3 (es) | 2009-02-16 |
| CA2366216C (en) | 2012-10-23 |
| CA2366908A1 (en) | 2000-09-28 |
| WO2000056361A2 (en) | 2000-09-28 |
| DK1163002T3 (da) | 2009-01-19 |
| WO2000056362A2 (en) | 2000-09-28 |
| AU3442400A (en) | 2000-10-09 |
| CA2366216A1 (en) | 2000-09-28 |
| ATE403436T1 (de) | 2008-08-15 |
| EP1163001A2 (en) | 2001-12-19 |
| EP1163002B1 (en) | 2008-08-06 |
| AU755502C (en) | 2003-08-14 |
| JP5124066B2 (ja) | 2013-01-23 |
| EP1163002A2 (en) | 2001-12-19 |
| JP2012031186A (ja) | 2012-02-16 |
| AU762078B2 (en) | 2003-06-19 |
| AU755502B2 (en) | 2002-12-12 |
| US20080057083A1 (en) | 2008-03-06 |
| JP2002540076A (ja) | 2002-11-26 |
| WO2000056362A3 (en) | 2001-02-01 |
| DE60039754D1 (de) | 2008-09-18 |
| JP2002540077A (ja) | 2002-11-26 |
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