NZ509505A - Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies - Google Patents

Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies

Info

Publication number
NZ509505A
NZ509505A NZ509505A NZ50950599A NZ509505A NZ 509505 A NZ509505 A NZ 509505A NZ 509505 A NZ509505 A NZ 509505A NZ 50950599 A NZ50950599 A NZ 50950599A NZ 509505 A NZ509505 A NZ 509505A
Authority
NZ
New Zealand
Prior art keywords
allergies
derivatives
preventing
heterocyclyl
aralkyl
Prior art date
Application number
NZ509505A
Inventor
Hassan Jomaa
Original Assignee
Jomaa Pharmaka Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jomaa Pharmaka Gmbh filed Critical Jomaa Pharmaka Gmbh
Publication of NZ509505A publication Critical patent/NZ509505A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

Use of bisphosphonic acid compounds of formula (I) and their salts, esters or prodrugs for the treatment and prevention of autoimmune disorders, wherein; A1, A2, A3, A4 are hydrogen, optionally substituted alkyl, aryl, aralkyl, cycloalkyl or heterocyclyl, a metal from the first, second or third main group of the periodic table or an ammonium group or substituted ammonium moiety, which is derived from ethylenediamine or an amino acid; X is alkylene, alkenylene or hydroxyalkylene, or a bond; R1, R2 are H, OH, NH2, optionally substituted alkyl, acyl, aryl, aralkyl, cycloalkyl or heterocyclyl, SR3, Cl or NR3R4; and R3, R4 are H, OH, or optionally substituted alkyl, acyl, aryl, aralkyl, cycloalkyl or heterocyclyl. Bisphosphonic acid compounds of formula (I), when co-administered with autoantigens or allergens, act synergistically to treat a range of autoimmune disorders.
NZ509505A 1998-06-26 1999-06-24 Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies NZ509505A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19828450A DE19828450A1 (en) 1998-06-26 1998-06-26 Use of bisphosphonic acid compounds and autoantigens or allergens
PCT/DE1999/001844 WO2000000182A2 (en) 1998-06-26 1999-06-24 Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies

Publications (1)

Publication Number Publication Date
NZ509505A true NZ509505A (en) 2002-11-26

Family

ID=7872064

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ509505A NZ509505A (en) 1998-06-26 1999-06-24 Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies

Country Status (24)

Country Link
EP (1) EP1089761B1 (en)
JP (1) JP2002519319A (en)
KR (1) KR20010053211A (en)
AT (1) ATE224734T1 (en)
AU (1) AU740605B2 (en)
CA (1) CA2334711C (en)
DE (2) DE19828450A1 (en)
DK (1) DK1089761T3 (en)
EA (1) EA200100080A1 (en)
EE (1) EE200000756A (en)
ES (1) ES2184496T3 (en)
HR (1) HRP20000820A2 (en)
HU (1) HUP0102873A3 (en)
ID (1) ID27515A (en)
IL (1) IL139966A0 (en)
IS (1) IS5748A (en)
MX (1) MXPA00012338A (en)
NO (1) NO20006572L (en)
NZ (1) NZ509505A (en)
PL (1) PL345287A1 (en)
PT (1) PT1089761E (en)
SK (1) SK19602000A3 (en)
TR (1) TR200003821T2 (en)
WO (1) WO2000000182A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2356262A1 (en) 1998-12-23 2000-07-06 Jomaa Pharmaka Gmbh Use of bisphosphonates for the prevention and treatment of infectious processes
WO2000038693A1 (en) * 1998-12-25 2000-07-06 Toray Industries, Inc. Interleukin-6 production inhibitors
EP1392325B1 (en) * 2001-05-02 2006-06-21 Novartis AG Method of administration of bisphosphonates by inhalation in the treatment or prevention of bone resorption and osteoporosis
PT1408984E (en) 2001-07-20 2008-12-26 Bioagency Ag Organo-phosphorous compounds for activating gamma/delta t cells
GB0307989D0 (en) * 2003-04-07 2003-05-14 Mcewen Lab Ltd Therapeutic composition
EP1713489B1 (en) * 2004-08-23 2011-01-19 Teva Pharmaceutical Industries Ltd Crystalline form of ibandronate sodium and processes for preparation thereof
EP1931326A4 (en) * 2005-09-12 2009-12-16 Reddys Lab Ltd Dr Crystalline trihydrate of zoledronic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114946T3 (en) * 1991-09-05 1998-06-16 Toray Industries DERIVATIVE OF METHANODIPHOSPHONIC ACID, ITS PRODUCTION AND MEDICINAL USE.
WO1996022790A1 (en) * 1995-01-23 1996-08-01 Xenotech Incorporated Composition to ameliorate osteolysis and metastasis

Also Published As

Publication number Publication date
ATE224734T1 (en) 2002-10-15
KR20010053211A (en) 2001-06-25
DE19828450A1 (en) 1999-12-30
WO2000000182A2 (en) 2000-01-06
HUP0102873A3 (en) 2002-04-29
AU740605B2 (en) 2001-11-08
PL345287A1 (en) 2001-12-03
TR200003821T2 (en) 2001-06-21
DK1089761T3 (en) 2003-02-03
EA200100080A1 (en) 2001-06-25
NO20006572L (en) 2001-02-21
HRP20000820A2 (en) 2001-12-31
HUP0102873A2 (en) 2001-12-28
CA2334711A1 (en) 2000-01-06
NO20006572D0 (en) 2000-12-21
PT1089761E (en) 2003-02-28
CA2334711C (en) 2006-12-05
EP1089761B1 (en) 2002-09-25
MXPA00012338A (en) 2003-04-25
EP1089761A2 (en) 2001-04-11
DE59902856D1 (en) 2002-10-31
IL139966A0 (en) 2002-02-10
JP2002519319A (en) 2002-07-02
AU5503399A (en) 2000-01-17
SK19602000A3 (en) 2001-07-10
ID27515A (en) 2001-04-12
IS5748A (en) 2000-12-01
ES2184496T3 (en) 2003-04-01
EE200000756A (en) 2002-04-15
WO2000000182A3 (en) 2000-03-30

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Legal Events

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Owner name: JOMAA PHARMAKA GMBH, DE

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S881 Correction of error according section 88(1) (mistake in register by reason of an error or omission on the part of the patent office)

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