ES2075798A1 - Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine. - Google Patents
Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine.Info
- Publication number
- ES2075798A1 ES2075798A1 ES09301819A ES9301819A ES2075798A1 ES 2075798 A1 ES2075798 A1 ES 2075798A1 ES 09301819 A ES09301819 A ES 09301819A ES 9301819 A ES9301819 A ES 9301819A ES 2075798 A1 ES2075798 A1 ES 2075798A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- medicine
- preparation
- amino acid
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine. This invention relates to therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them and the use of the said compounds in medicine, specifically compounds of formula (I) in which R2 is an R6-A- group in which A is a saturated or unsaturated, straight or branched divalent hydrocarbon chain having up to 6 C atoms, R3 is a side chain characteristic of a natural alpha amino acid other than proline, R4 is hydrogen or methyl, R5 is hydrogen, or an alkyl or amine group, or R3 and R5, taken together, represent a divalent hydrocarbon chain. These compounds have the property of inhibiting the action of metal proteinases and are useful for the treatment or prophylaxis of conditions which give rise to tissue disintegration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301819A ES2075798B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301819A ES2075798B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2075798A1 true ES2075798A1 (en) | 1995-10-01 |
ES2075798B1 ES2075798B1 (en) | 1996-03-01 |
Family
ID=8282878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301819A Expired - Lifetime ES2075798B1 (en) | 1993-08-18 | 1993-08-18 | DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2075798B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991002716A2 (en) * | 1989-08-24 | 1991-03-07 | British Bio-Technology Limited | Hydroxamic acid based collagenase inhibitors |
WO1994002447A1 (en) * | 1992-07-23 | 1994-02-03 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as metalloproteinase inhibitors |
-
1993
- 1993-08-18 ES ES9301819A patent/ES2075798B1/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991002716A2 (en) * | 1989-08-24 | 1991-03-07 | British Bio-Technology Limited | Hydroxamic acid based collagenase inhibitors |
WO1994002447A1 (en) * | 1992-07-23 | 1994-02-03 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as metalloproteinase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ES2075798B1 (en) | 1996-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent |
Owner name: BRITISH BIOTECH PHARMACEUTICALS LIMITED |