ES2075798A1 - Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine. - Google Patents

Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine.

Info

Publication number
ES2075798A1
ES2075798A1 ES09301819A ES9301819A ES2075798A1 ES 2075798 A1 ES2075798 A1 ES 2075798A1 ES 09301819 A ES09301819 A ES 09301819A ES 9301819 A ES9301819 A ES 9301819A ES 2075798 A1 ES2075798 A1 ES 2075798A1
Authority
ES
Spain
Prior art keywords
compounds
medicine
preparation
amino acid
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301819A
Other languages
Spanish (es)
Other versions
ES2075798B1 (en
Inventor
Jonathon Philip Dickens
Michael John Crimmin
Raymond Paul Beckett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd filed Critical British Bio Technology Ltd
Priority to ES9301819A priority Critical patent/ES2075798B1/en
Publication of ES2075798A1 publication Critical patent/ES2075798A1/en
Application granted granted Critical
Publication of ES2075798B1 publication Critical patent/ES2075798B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

Natural amino acid derivatives as inhibitors of metal proteinases, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine. This invention relates to therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them and the use of the said compounds in medicine, specifically compounds of formula (I) in which R2 is an R6-A- group in which A is a saturated or unsaturated, straight or branched divalent hydrocarbon chain having up to 6 C atoms, R3 is a side chain characteristic of a natural alpha amino acid other than proline, R4 is hydrogen or methyl, R5 is hydrogen, or an alkyl or amine group, or R3 and R5, taken together, represent a divalent hydrocarbon chain. These compounds have the property of inhibiting the action of metal proteinases and are useful for the treatment or prophylaxis of conditions which give rise to tissue disintegration.
ES9301819A 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. Expired - Lifetime ES2075798B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301819A ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301819A ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Publications (2)

Publication Number Publication Date
ES2075798A1 true ES2075798A1 (en) 1995-10-01
ES2075798B1 ES2075798B1 (en) 1996-03-01

Family

ID=8282878

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301819A Expired - Lifetime ES2075798B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Country Status (1)

Country Link
ES (1) ES2075798B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002716A2 (en) * 1989-08-24 1991-03-07 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
WO1994002447A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002716A2 (en) * 1989-08-24 1991-03-07 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
WO1994002447A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors

Also Published As

Publication number Publication date
ES2075798B1 (en) 1996-03-01

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Legal Events

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Owner name: BRITISH BIOTECH PHARMACEUTICALS LIMITED