CA2334711A1 - Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies - Google Patents
Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies Download PDFInfo
- Publication number
- CA2334711A1 CA2334711A1 CA002334711A CA2334711A CA2334711A1 CA 2334711 A1 CA2334711 A1 CA 2334711A1 CA 002334711 A CA002334711 A CA 002334711A CA 2334711 A CA2334711 A CA 2334711A CA 2334711 A1 CA2334711 A1 CA 2334711A1
- Authority
- CA
- Canada
- Prior art keywords
- acid
- derivatives
- bisphosphonic
- autoimmune diseases
- bisphosphonic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention relates to the use of bisphosphonic acids and the derivatives thereof for producing medicaments for preventing and treating autoimmune diseases or allergies combined with the autoantigens specifically used for treating the respective autoimmune disease or combined with the allergens specifically used for treating the respective allergy.
Some examples of the bisphosphonic acids or derivatives thereof which are used according to the invention include amino-hydroxy-methylidene-bisphosphonic acid (AMP), 2-amino-1-hydroxyethylidene-1,1-bisphosphonic acid (AEP), pamidronic acid, alendronic acid, 2-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (AEP), amidinomethylene-bisphosphonic acid (AEP), ibandronic acid. risedronic acid, zoledronic acid, cimadronic acid, and tiludronic acid. Some examples of autoimmune diseases in which bisphosphonic acids or the derivatives thereof can be used include rheumatoid arthritis, severe myasthenia, diabetes mellitus, uveitis, and scleroderma. The bisphosphonic acids or the derivatives thereof and the autoantigens or allergens can be applied simultaneously or in succession. The preparations of the combinations can be used in solid form, as ointments, as solutions or as sprays.
Some examples of the bisphosphonic acids or derivatives thereof which are used according to the invention include amino-hydroxy-methylidene-bisphosphonic acid (AMP), 2-amino-1-hydroxyethylidene-1,1-bisphosphonic acid (AEP), pamidronic acid, alendronic acid, 2-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (AEP), amidinomethylene-bisphosphonic acid (AEP), ibandronic acid. risedronic acid, zoledronic acid, cimadronic acid, and tiludronic acid. Some examples of autoimmune diseases in which bisphosphonic acids or the derivatives thereof can be used include rheumatoid arthritis, severe myasthenia, diabetes mellitus, uveitis, and scleroderma. The bisphosphonic acids or the derivatives thereof and the autoantigens or allergens can be applied simultaneously or in succession. The preparations of the combinations can be used in solid form, as ointments, as solutions or as sprays.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19828450A DE19828450A1 (en) | 1998-06-26 | 1998-06-26 | Use of bisphosphonic acid compounds and autoantigens or allergens |
| DE19828450.0 | 1998-06-26 | ||
| PCT/DE1999/001844 WO2000000182A2 (en) | 1998-06-26 | 1999-06-24 | Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2334711A1 true CA2334711A1 (en) | 2000-01-06 |
| CA2334711C CA2334711C (en) | 2006-12-05 |
Family
ID=7872064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002334711A Expired - Fee Related CA2334711C (en) | 1998-06-26 | 1999-06-24 | Medicaments containing bisphosphonic acids and derivatives thereof which are provided for preventing and treating autoimmune diseases and allergies |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1089761B1 (en) |
| JP (1) | JP2002519319A (en) |
| KR (1) | KR20010053211A (en) |
| AT (1) | ATE224734T1 (en) |
| AU (1) | AU740605B2 (en) |
| CA (1) | CA2334711C (en) |
| DE (2) | DE19828450A1 (en) |
| DK (1) | DK1089761T3 (en) |
| EA (1) | EA200100080A1 (en) |
| EE (1) | EE200000756A (en) |
| ES (1) | ES2184496T3 (en) |
| HR (1) | HRP20000820A2 (en) |
| HU (1) | HUP0102873A3 (en) |
| ID (1) | ID27515A (en) |
| IL (1) | IL139966A0 (en) |
| IS (1) | IS5748A (en) |
| MX (1) | MXPA00012338A (en) |
| NO (1) | NO20006572L (en) |
| NZ (1) | NZ509505A (en) |
| PL (1) | PL345287A1 (en) |
| PT (1) | PT1089761E (en) |
| SK (1) | SK19602000A3 (en) |
| TR (1) | TR200003821T2 (en) |
| WO (1) | WO2000000182A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399756B2 (en) | 2001-07-20 | 2008-07-15 | Bioagency Ag | Organo-phosphorous compounds for activating gamma/delta T cells |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2356262A1 (en) | 1998-12-23 | 2000-07-06 | Jomaa Pharmaka Gmbh | Use of bisphosphonates for the prevention and treatment of infectious processes |
| WO2000038693A1 (en) * | 1998-12-25 | 2000-07-06 | Toray Industries, Inc. | Interleukin-6 production inhibitors |
| EP1392325B1 (en) * | 2001-05-02 | 2006-06-21 | Novartis AG | Method of administration of bisphosphonates by inhalation in the treatment or prevention of bone resorption and osteoporosis |
| GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
| EP1713489B1 (en) * | 2004-08-23 | 2011-01-19 | Teva Pharmaceutical Industries Ltd | Crystalline form of ibandronate sodium and processes for preparation thereof |
| EP1931326A4 (en) * | 2005-09-12 | 2009-12-16 | Reddys Lab Ltd Dr | Crystalline trihydrate of zoledronic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2114946T3 (en) * | 1991-09-05 | 1998-06-16 | Toray Industries | DERIVATIVE OF METHANODIPHOSPHONIC ACID, ITS PRODUCTION AND MEDICINAL USE. |
| WO1996022790A1 (en) * | 1995-01-23 | 1996-08-01 | Xenotech Incorporated | Composition to ameliorate osteolysis and metastasis |
-
1998
- 1998-06-26 DE DE19828450A patent/DE19828450A1/en not_active Withdrawn
-
1999
- 1999-06-24 AT AT99941383T patent/ATE224734T1/en active
- 1999-06-24 EP EP99941383A patent/EP1089761B1/en not_active Expired - Lifetime
- 1999-06-24 EA EA200100080A patent/EA200100080A1/en unknown
- 1999-06-24 DK DK99941383T patent/DK1089761T3/en active
- 1999-06-24 AU AU55033/99A patent/AU740605B2/en not_active Ceased
- 1999-06-24 JP JP2000556767A patent/JP2002519319A/en active Pending
- 1999-06-24 WO PCT/DE1999/001844 patent/WO2000000182A2/en not_active Application Discontinuation
- 1999-06-24 HU HU0102873A patent/HUP0102873A3/en unknown
- 1999-06-24 DE DE59902856T patent/DE59902856D1/en not_active Expired - Lifetime
- 1999-06-24 TR TR2000/03821T patent/TR200003821T2/en unknown
- 1999-06-24 EE EEP200000756A patent/EE200000756A/en unknown
- 1999-06-24 CA CA002334711A patent/CA2334711C/en not_active Expired - Fee Related
- 1999-06-24 SK SK1960-2000A patent/SK19602000A3/en unknown
- 1999-06-24 NZ NZ509505A patent/NZ509505A/en not_active IP Right Cessation
- 1999-06-24 IL IL13996699A patent/IL139966A0/en unknown
- 1999-06-24 ES ES99941383T patent/ES2184496T3/en not_active Expired - Lifetime
- 1999-06-24 MX MXPA00012338A patent/MXPA00012338A/en unknown
- 1999-06-24 ID IDW20002676A patent/ID27515A/en unknown
- 1999-06-24 PT PT99941383T patent/PT1089761E/en unknown
- 1999-06-24 KR KR1020007014813A patent/KR20010053211A/en not_active Application Discontinuation
- 1999-06-24 PL PL99345287A patent/PL345287A1/en unknown
-
2000
- 2000-11-29 HR HR20000820A patent/HRP20000820A2/en not_active Application Discontinuation
- 2000-12-01 IS IS5748A patent/IS5748A/en unknown
- 2000-12-21 NO NO20006572A patent/NO20006572L/en not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399756B2 (en) | 2001-07-20 | 2008-07-15 | Bioagency Ag | Organo-phosphorous compounds for activating gamma/delta T cells |
| US7871992B2 (en) | 2001-07-20 | 2011-01-18 | Bioagency Ag | Organophosphorous compounds for the activation of gamma/delta T cells |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE224734T1 (en) | 2002-10-15 |
| KR20010053211A (en) | 2001-06-25 |
| DE19828450A1 (en) | 1999-12-30 |
| WO2000000182A2 (en) | 2000-01-06 |
| HUP0102873A3 (en) | 2002-04-29 |
| AU740605B2 (en) | 2001-11-08 |
| PL345287A1 (en) | 2001-12-03 |
| TR200003821T2 (en) | 2001-06-21 |
| DK1089761T3 (en) | 2003-02-03 |
| EA200100080A1 (en) | 2001-06-25 |
| NO20006572L (en) | 2001-02-21 |
| HRP20000820A2 (en) | 2001-12-31 |
| HUP0102873A2 (en) | 2001-12-28 |
| NZ509505A (en) | 2002-11-26 |
| NO20006572D0 (en) | 2000-12-21 |
| PT1089761E (en) | 2003-02-28 |
| CA2334711C (en) | 2006-12-05 |
| EP1089761B1 (en) | 2002-09-25 |
| MXPA00012338A (en) | 2003-04-25 |
| EP1089761A2 (en) | 2001-04-11 |
| DE59902856D1 (en) | 2002-10-31 |
| IL139966A0 (en) | 2002-02-10 |
| JP2002519319A (en) | 2002-07-02 |
| AU5503399A (en) | 2000-01-17 |
| SK19602000A3 (en) | 2001-07-10 |
| ID27515A (en) | 2001-04-12 |
| IS5748A (en) | 2000-12-01 |
| ES2184496T3 (en) | 2003-04-01 |
| EE200000756A (en) | 2002-04-15 |
| WO2000000182A3 (en) | 2000-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150625 |