NZ501214A - Using adenovirus subgroup B vectors with deprived tissue tropism for liver cells provided by virus capsid - Google Patents
Using adenovirus subgroup B vectors with deprived tissue tropism for liver cells provided by virus capsidInfo
- Publication number
- NZ501214A NZ501214A NZ501214A NZ50121499A NZ501214A NZ 501214 A NZ501214 A NZ 501214A NZ 501214 A NZ501214 A NZ 501214A NZ 50121499 A NZ50121499 A NZ 50121499A NZ 501214 A NZ501214 A NZ 501214A
- Authority
- NZ
- New Zealand
- Prior art keywords
- seq
- adenovirus
- genbank
- adl6
- protein
- Prior art date
Links
- 230000005100 tissue tropism Effects 0.000 title claims abstract description 14
- 241000701161 unidentified adenovirus Species 0.000 title claims abstract 35
- 210000000234 capsid Anatomy 0.000 title claims abstract 14
- 241000700605 Viruses Species 0.000 title claims abstract 8
- 239000013598 vector Substances 0.000 title claims description 4
- 210000005229 liver cell Anatomy 0.000 title claims 4
- 238000001476 gene delivery Methods 0.000 claims abstract description 16
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 5
- 108090000623 proteins and genes Proteins 0.000 claims abstract 25
- 102000004169 proteins and genes Human genes 0.000 claims abstract 11
- 239000012634 fragment Substances 0.000 claims abstract 10
- 210000004027 cell Anatomy 0.000 claims abstract 7
- 239000003814 drug Substances 0.000 claims abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract 3
- 238000001415 gene therapy Methods 0.000 claims abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 2
- 241001135569 Human adenovirus 5 Species 0.000 claims 41
- 101710145505 Fiber protein Proteins 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 239000000835 fiber Substances 0.000 claims 8
- 101150076401 16 gene Proteins 0.000 claims 4
- 108700026758 Adenovirus hexon capsid Proteins 0.000 claims 4
- 238000005034 decoration Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- BZSALXKCVOJCJJ-IPEMHBBOSA-N (4s)-4-[[(2s)-2-acetamido-3-methylbutanoyl]amino]-5-[[(2s)-1-[[(2s)-1-[[(2s,3r)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy Chemical compound CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 BZSALXKCVOJCJJ-IPEMHBBOSA-N 0.000 claims 1
- 102000012936 Angiostatins Human genes 0.000 claims 1
- 108010079709 Angiostatins Proteins 0.000 claims 1
- 102000007592 Apolipoproteins Human genes 0.000 claims 1
- 108010071619 Apolipoproteins Proteins 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 241000701151 Human adenovirus 6 Species 0.000 claims 1
- 241000701096 Human adenovirus 7 Species 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 102100039064 Interleukin-3 Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108060001084 Luciferase Proteins 0.000 claims 1
- 239000005089 Luciferase Substances 0.000 claims 1
- 108700010674 N-acetylVal-Nle(7,8)- allatotropin (5-13) Proteins 0.000 claims 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 1
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 claims 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 102000006601 Thymidine Kinase Human genes 0.000 claims 1
- 108020004440 Thymidine kinase Proteins 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940076264 interleukin-3 Drugs 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203921 | 1998-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ501214A true NZ501214A (en) | 2002-02-01 |
Family
ID=8234363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ501214A NZ501214A (en) | 1998-11-20 | 1999-11-22 | Using adenovirus subgroup B vectors with deprived tissue tropism for liver cells provided by virus capsid |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP4683682B2 (enExample) |
| AT (1) | ATE296894T1 (enExample) |
| AU (1) | AU770780B2 (enExample) |
| CA (1) | CA2318492C (enExample) |
| DE (1) | DE69925567T2 (enExample) |
| ES (1) | ES2244145T3 (enExample) |
| IL (1) | IL133032A (enExample) |
| MX (1) | MXPA99010682A (enExample) |
| NO (1) | NO995697L (enExample) |
| NZ (1) | NZ501214A (enExample) |
| WO (1) | WO2000031285A1 (enExample) |
| ZA (1) | ZA997213B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| EP1159438B1 (en) * | 1999-03-04 | 2008-07-30 | Crucell Holland B.V. | Use of adenoviral vector for synovial cell transduction |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| EP1285079A2 (en) | 2000-05-31 | 2003-02-26 | University of Saskatchewan | Modified bovine adenovirus having altered tropism |
| US20040033605A1 (en) * | 2000-09-20 | 2004-02-19 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells |
| US7235233B2 (en) | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
| US6905678B2 (en) * | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| BR0308783A (pt) | 2002-04-25 | 2005-01-04 | Crucell Holland Bv | Vetor de adenovìrus recombinante, método para produzir um vetor de adenovìrus recombinante, composição farmacêutica, método para tratar um corpo humano, e, kit de partes |
| EP1482052A1 (en) * | 2003-05-27 | 2004-12-01 | Cytos Biotechnology AG | Modified polypeptides for targeting cell-entry of the adenoviruses of subtype B |
| US11253608B2 (en) | 2017-05-26 | 2022-02-22 | Epicentrx, Inc. | Recombinant adenoviruses carrying transgenes |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| EP1445322B2 (en) * | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| EP1518933A1 (en) * | 1995-11-28 | 2005-03-30 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
| FR2758822B1 (fr) * | 1997-01-30 | 1999-07-02 | Centre Nat Rech Scient | Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus |
| FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
-
1999
- 1999-11-18 IL IL133032A patent/IL133032A/en not_active IP Right Cessation
- 1999-11-19 NO NO995697A patent/NO995697L/no not_active Application Discontinuation
- 1999-11-19 ZA ZA9907213A patent/ZA997213B/xx unknown
- 1999-11-19 ES ES99203878T patent/ES2244145T3/es not_active Expired - Lifetime
- 1999-11-19 MX MXPA99010682A patent/MXPA99010682A/es not_active IP Right Cessation
- 1999-11-19 DE DE69925567T patent/DE69925567T2/de not_active Expired - Lifetime
- 1999-11-19 AT AT99203878T patent/ATE296894T1/de not_active IP Right Cessation
- 1999-11-22 CA CA2318492A patent/CA2318492C/en not_active Expired - Fee Related
- 1999-11-22 AU AU59600/99A patent/AU770780B2/en not_active Ceased
- 1999-11-22 WO PCT/NL1999/000717 patent/WO2000031285A1/en not_active Ceased
- 1999-11-22 JP JP33203399A patent/JP4683682B2/ja not_active Expired - Fee Related
- 1999-11-22 NZ NZ501214A patent/NZ501214A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000031285A1 (en) | 2000-06-02 |
| NO995697D0 (no) | 1999-11-19 |
| ZA997213B (en) | 2000-05-22 |
| AU5960099A (en) | 2000-05-25 |
| CA2318492A1 (en) | 2000-06-02 |
| IL133032A (en) | 2007-06-03 |
| JP2000157289A (ja) | 2000-06-13 |
| CA2318492C (en) | 2010-05-11 |
| MXPA99010682A (es) | 2002-03-08 |
| ATE296894T1 (de) | 2005-06-15 |
| DE69925567T2 (de) | 2006-05-04 |
| JP4683682B2 (ja) | 2011-05-18 |
| IL133032A0 (en) | 2001-03-19 |
| AU770780B2 (en) | 2004-03-04 |
| NO995697L (no) | 2000-05-22 |
| DE69925567D1 (de) | 2005-07-07 |
| ES2244145T3 (es) | 2005-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU777041B2 (en) | Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35 | |
| AU724189B2 (en) | Vectors and methods for gene transfer to cells | |
| US7906113B2 (en) | Serotype of adenovirus and uses thereof | |
| AU2002315947B2 (en) | Adenoviral vectors with cell type specificity for mesenchymal cells | |
| EP1070118B1 (en) | Modified adenovirus containing a fiber replacement protein | |
| EP1159438B1 (en) | Use of adenoviral vector for synovial cell transduction | |
| AU2002315947A1 (en) | Adenoviral vectors with cell type specificity for mesenchymal cells | |
| NZ501214A (en) | Using adenovirus subgroup B vectors with deprived tissue tropism for liver cells provided by virus capsid | |
| EP1067188A1 (en) | Infection with chimaeric adenoviruses of cells negative for the adenovirus serotype 5 Coxsacki adenovirus receptor (CAR) | |
| EP1325145A1 (en) | Adenoviral vectors for gene delivery in skeletal muscle cells or myoblasts | |
| AU2002212819A1 (en) | Adenoviral vectors for gene delivery in skeletal muscle cells or myoblasts | |
| EP1279738A1 (en) | Gene delivery vectors with cell type specificity for mesenchymal stem cells | |
| MXPA98004203A (en) | Vectors and methods for gene transfer acelu |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |