NZ500645A - 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors - Google Patents
9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptorsInfo
- Publication number
- NZ500645A NZ500645A NZ500645A NZ50064598A NZ500645A NZ 500645 A NZ500645 A NZ 500645A NZ 500645 A NZ500645 A NZ 500645A NZ 50064598 A NZ50064598 A NZ 50064598A NZ 500645 A NZ500645 A NZ 500645A
- Authority
- NZ
- New Zealand
- Prior art keywords
- azabicyclo
- ene
- methyl
- pyridyl
- disease
- Prior art date
Links
- ODYAYVUDAZHKHK-UHFFFAOYSA-N 9-azabicyclo[3.3.1]non-3-ene Chemical compound C1C=CC2CCCC1N2 ODYAYVUDAZHKHK-UHFFFAOYSA-N 0.000 title claims abstract description 8
- 108010009685 Cholinergic Receptors Proteins 0.000 title claims description 22
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- 230000001713 cholinergic effect Effects 0.000 title description 10
- 239000003446 ligand Substances 0.000 title description 4
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical class CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 title description 4
- -1 thiocycloalkoxy Chemical group 0.000 claims abstract description 89
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 9
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK62897 | 1997-05-30 | ||
| PCT/DK1998/000224 WO1998054182A1 (en) | 1997-05-30 | 1998-05-29 | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ500645A true NZ500645A (en) | 2001-06-29 |
Family
ID=8095743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ500645A NZ500645A (en) | 1997-05-30 | 1998-05-29 | 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6392045B1 (enExample) |
| EP (1) | EP0984966B1 (enExample) |
| JP (1) | JP2002502383A (enExample) |
| CN (1) | CN1205210C (enExample) |
| AT (1) | ATE231861T1 (enExample) |
| AU (1) | AU736798B2 (enExample) |
| CA (1) | CA2289570C (enExample) |
| DE (1) | DE69811070T2 (enExample) |
| DK (1) | DK0984966T3 (enExample) |
| NZ (1) | NZ500645A (enExample) |
| WO (1) | WO1998054182A1 (enExample) |
| ZA (1) | ZA984640B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE258176T1 (de) | 1999-01-28 | 2004-02-15 | Neurosearch As | Neue azabicyclo derivate und ihre verwendung |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| NZ512884A (en) * | 1999-01-29 | 2004-03-26 | Abbott Lab | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
| AU774867B2 (en) | 1999-05-04 | 2004-07-08 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| DE60018312T2 (de) * | 1999-12-14 | 2005-08-18 | Neurosearch A/S | Neue heteroaryl-diazabizykloalkane |
| MY137020A (en) * | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| JP2003534344A (ja) | 2000-05-25 | 2003-11-18 | ターガセプト，インコーポレイテッド | ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン |
| AU2001265229A1 (en) * | 2000-05-31 | 2001-12-11 | Board Of Control Of Michigan Technological University | Compositions and methods for wood preservation |
| WO2002002564A1 (en) * | 2000-07-04 | 2002-01-10 | Neurosearch A/S | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
| US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| MXPA03003264A (es) * | 2000-10-13 | 2003-06-06 | Neurosearch As | Tratamiento de trastornos afectivos mediante la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergica. |
| JP2004538268A (ja) * | 2001-06-01 | 2004-12-24 | ニューロサーチ、アクティーゼルスカブ | Ｃｎｓ−モジュレーターとしての新規ヘテロアリール−ジアザビシクロアルカン類 |
| CN102657651A (zh) † | 2002-12-06 | 2012-09-12 | 范因斯坦医学研究院 | 用α 7受体结合胆碱能激动剂抑制炎症 |
| US7238715B2 (en) | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| CA2580329C (en) | 2004-09-13 | 2015-01-06 | Chrono Therapeutics Inc. | Biosynchronous transdermal drug delivery |
| DE602006019561D1 (de) | 2005-02-16 | 2011-02-24 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| US8173658B2 (en) | 2005-12-06 | 2012-05-08 | Neurosearch A/S | Diazabicycylic aryl derivatives and their medical use |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2641678A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987031A1 (en) | 2006-02-10 | 2008-11-05 | NeuroSearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| WO2007093601A1 (en) | 2006-02-14 | 2007-08-23 | Neurosearch A/S | 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists |
| TW200845977A (en) * | 2007-03-30 | 2008-12-01 | Targacept Inc | Sub-type selective azabicycloalkane derivatives |
| EP2322168A1 (en) | 2007-04-02 | 2011-05-18 | Parkinson's Institute | Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments |
| WO2009058120A1 (en) * | 2007-11-02 | 2009-05-07 | Sri International | Nicotinic acetylcholine receptor modulators |
| US8697722B2 (en) | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| US20110142758A1 (en) * | 2008-06-10 | 2011-06-16 | Neurosearch A/S | Indolyl-pyridazinyl-diazabicyclononane derivatives in labelled and unlabelled form and their use in diagnostic methods |
| EP2676956A1 (en) | 2008-08-01 | 2013-12-25 | Purdue Pharma L.P. | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof |
| JP5840143B2 (ja) | 2010-01-11 | 2016-01-06 | アストライア セラピューティクス， エルエルシーＡｓｔｒａｅａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ | ニコチン性アセチルコリン受容体モジュレーター |
| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| JP2022507660A (ja) | 2018-11-16 | 2022-01-18 | モーニングサイド ベンチャー インベストメンツ リミテッド | 温度によって調節される経皮薬剤送達システム |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| DE1174793B (de) * | 1962-11-13 | 1964-07-30 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung von 3ª‡-Phenyl-granatanen und ihren Hydrohalogeniden |
| US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
| IL59004A0 (en) | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
| EP0093488A3 (en) | 1982-03-18 | 1984-05-23 | Beecham Group Plc | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them |
| DK0588917T3 (da) * | 1991-05-29 | 2001-02-12 | Abbott Lab | Isoxazol- og isothiazolforbindelser, som forstærker kognitiv funktion |
| EP0853621A1 (en) * | 1995-09-22 | 1998-07-22 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| IL130058A0 (en) * | 1996-11-26 | 2000-02-29 | Zeneca Ltd | 8-Azabicyclo(3.2.1)octane-8-azabicyclo(3.2.1)oct-6-ene-9-azabicyclo(3.3.1)nonane-9-aza-3-oxabicyclo (3.3.1)nonane- and 9-aza-3-thiabicyclo(3.3.1)nonane derivatives their preparation and their use as insecticides |
-
1998
- 1998-05-29 DE DE69811070T patent/DE69811070T2/de not_active Expired - Lifetime
- 1998-05-29 EP EP98921377A patent/EP0984966B1/en not_active Expired - Lifetime
- 1998-05-29 JP JP50012999A patent/JP2002502383A/ja not_active Withdrawn
- 1998-05-29 AU AU74260/98A patent/AU736798B2/en not_active Ceased
- 1998-05-29 CN CNB988054159A patent/CN1205210C/zh not_active Expired - Fee Related
- 1998-05-29 WO PCT/DK1998/000224 patent/WO1998054182A1/en not_active Ceased
- 1998-05-29 DK DK98921377T patent/DK0984966T3/da active
- 1998-05-29 CA CA002289570A patent/CA2289570C/en not_active Expired - Fee Related
- 1998-05-29 AT AT98921377T patent/ATE231861T1/de not_active IP Right Cessation
- 1998-05-29 NZ NZ500645A patent/NZ500645A/en unknown
- 1998-05-29 ZA ZA984640A patent/ZA984640B/xx unknown
-
1999
- 1999-11-29 US US09/450,635 patent/US6392045B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2289570C (en) | 2007-04-03 |
| WO1998054182A1 (en) | 1998-12-03 |
| ATE231861T1 (de) | 2003-02-15 |
| DE69811070D1 (de) | 2003-03-06 |
| AU7426098A (en) | 1998-12-30 |
| EP0984966B1 (en) | 2003-01-29 |
| ZA984640B (en) | 1998-12-11 |
| JP2002502383A (ja) | 2002-01-22 |
| EP0984966A1 (en) | 2000-03-15 |
| CN1205210C (zh) | 2005-06-08 |
| AU736798B2 (en) | 2001-08-02 |
| CA2289570A1 (en) | 1998-12-03 |
| US6392045B1 (en) | 2002-05-21 |
| DK0984966T3 (da) | 2003-05-05 |
| CN1257500A (zh) | 2000-06-21 |
| DE69811070T2 (de) | 2003-10-02 |
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Legal Events
| Date | Code | Title | Description |
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| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |