NZ237771A - Cosmetic compositions, particularly for acne treatment, containing an extract of zygophyllaceae of the genus larrea - Google Patents
Cosmetic compositions, particularly for acne treatment, containing an extract of zygophyllaceae of the genus larreaInfo
- Publication number
- NZ237771A NZ237771A NZ237771A NZ23777191A NZ237771A NZ 237771 A NZ237771 A NZ 237771A NZ 237771 A NZ237771 A NZ 237771A NZ 23777191 A NZ23777191 A NZ 23777191A NZ 237771 A NZ237771 A NZ 237771A
- Authority
- NZ
- New Zealand
- Prior art keywords
- extract
- larrea
- zygophyllaceae
- stems
- leaves
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A cosmetic composition for combatting, in particular, the formation of acne papulopustules and cutaneous redness, characterized in that it contains an extract which can be obtained from the leaves and stems of at least one zygophyllaceae of the genus Larrea, in a concentration of 0.01 to 0.10 % expressed in polyphenols, in a suitable cosmetic base.
Description
New Zealand Paient Spedficaiion for Paient Number £37771
237 7 7
Priority Date(s):
Complete Specification Filed: iQftptiI CIrrs:
2B"hAR'i993'
Publication Date:
P.O. Journal, No : ..J&feh
MO DRAWINGS
r N-Z-PA-reMTOFPtCE,,. J
[0 APR 19'3
Patents Form No. 5
NEW ZEALAND
PATENTS ACT 1953
COMPLETE SPECIFICATION
COSMETIC COMPOSITIONS CONTAINING AN EXTRACT OF A ZYGOPHYLLACEAE BELONGING TO THE GENUS LARREA
WE, CLAUDE BONNE, a French citizen of 316 Avenue d'Occitanie - 34000 Montpellier France, DANIEL SINCHOLLE, a
French citizen of 343 Avenue de la Tremoulette - St Clement
Mie-WEi-
La Riviere 34270 St Mathieu De Treviers, France, and ^MIGHAk DIOT, a French citizen of 2 Allee des Dimanches - 78430 Louveciennes France hereby declare the invention, for which We pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:
(followed by page la)
2 3 7 7 7
1 a
The present invention relates to a cosmetic composition which in particular prevents the formation of the papules and pustules characteristic of acne.
The present invention relates more particularly to a cosmetic composition containing as active ingredient an extract of the leaves and stems of at least one member of Zygophyllaceae belonging to the genus Larrea.
It is reported in the literature that Larrea extracts were used by the American Indians for the treatment of cancer as well as tubercolosis and renal infections. These empirical indications may have some foundation because recent scientific work has in fact shown that extracts of plants belonging to the Zygophyllaceae family do show an antitumor activity (KATO, R et al. Chemical Abstracts, vol. 100, 1984, N* 29365:3) as well as an antibacterial effect (KIMURA, M et al. Chemical Abstracts, vol. 101, 1984, N° 51606 p). Moreover, advantage is taken of the latter activity in various commercial preparations intended for the disinfection of the skin (LEWIS, W.H. in Medical botany plants affecting man's health. John Wiley and Sons, New York, 1977, p. 363, 366).
The applicants have discovered that, in addition to its known pharmacological effects, the Larrea extract exhibits a remarkable inhibitory activity towards the migration of leucocytes and that topical compositions containing from 0.01 to 0.1 % of polyphenols derived from the extract can prevent pustulation of the lesions in an experimental model of acne.
Acne vulgaris is a follicular dermatosis which affects adolescents and young adults with high frequency. It affects some pilosebaceous units of the
O' /
do/ / /
2
face and trunk called sebaceous follicles-. This disease manifests itself through polymorphic lesions : the primary lesion is the comedo from which inflammatory and cicatricial lesions may develop. The disorder may be reduced to a two-step sequence.
The first consists in the formation of a comedo : under the influence of various factors, principally that of androgens, the sebaceous gland secretes sebum, the triglycerides of which are hydrolysed by the lipases produced by the follicular flora. The free fatty acids formed and other metabolites produced by the flora then stimulate the formation of cohesive keratinized cells by the follicular infundibulum, thus forming a closed comedo.
The second step is characterized by the induction of an inflammatory papule or pustule : the closed comedo may either be transformed into an open comedo or cause the rupture of the follicular sac and the inflammatory lesions. Several factors combine to lead to the rupture of the epithelium, including : mechanical compression of the epithelial wall by the comedo and the release of lytic enzymes by the follicular flora. The passage of the contents of the comedo into the adjacent dermis induces the migration of leucocytes which, by sustaining the inflammation in their turn, create the papules and pustules characteristic of acne.
As a consequence of its inhibitory activity towards _ the migration of leucocytes,' the Larrea extract makes it possible to prevent the progression from comedones to unsightly papules and pustules.
Consequently, the present invention relates to cosmetic composition suitable for preventing the transformation of the comedones into papules and
237 7 7
3
pustules and the formation of cutaneous redness and comprises an extract obtainable from leaves and stems of at least one member of Zygophyllaceae belonging to the genus Larrea, at concentrations varying from 0.01 5 to 0.1 % as expressed in terms of the polyphenol content, in an appropriate cosmetic base.
The cosmetic composition according to the invention may also be used against minor cutaneous irritations such as those induced by insect stings and 10 superficial burns.
The present invention relates also to a method for preventing the formation of papules and pustules characteristic of acne, which comprises applying to the skin an extract obtainable from the 15 leaves and stems of at least one member of Zygophylla ceae belonging to the genus Larrea at a concentration from 0.01 to 0.10 % expressed in terms of the polyphenol content, in an appropriate cosmetic base.
The present invention relates also to a 20 process for the preparation of a composition according to the invention, comprising incorporating an extract obtainable from the leaves and stems of at least one member of Zygophyllaceae belonging to the genus Larrea at a concentration from 0.01 to 0.10 % expressed in 25 terms of the polyphenol content, in an appropriate cosmetic base.
In the present invention one of the three species of Larrea may be used :
.Larrea divaricata Cav. 30 Larrea cuneifolia Cav.
Larrea tridentata Coult.
The extract of the leaves and stems may be obtained by maceration of powdered vegetal organs in propylene glycol, in particular with 3 to 10 parts by
2 3 7 7 71
4
weight of propylene glycol for one part of vegetal organs, in alcaline medium, for 24 to 48 hours at ambient temperature (15 to 25' C) . After filtration the extract has a polyphenol content of 0.5 to 5 %.
For example: the dry plant is pulverized so as to obtain a powder having an oversize with the screen of 1 mm mesh below 5 %.
To 1 kg of powder is added 1 liter of sodium hydroxide 0.1 N and 9 liters of propylene glycol. The mixture is maintained under low stirring (150 to 200 r p m) for 24 hours. The mixture is filtered so as to obtain a clear liquid extract. Seven liters of extract are thus obtained.
The polyphenol content is checked by titration with the Arnow reagent. The polyphenol content should not be lower than 0.5 %, expressed as nor-dihydroguaiaretic acid.
Hereafter "Larrea extract" will designate such an extract obtained by maceration with propylene glycol.
The following studies demonstrate the anti-acne activity of the active ingredient used in the present invention.
1 - Inhibitory activity towards the migration of leucocytes
The migration of the neutrophilic leucocytes towards a sub-cutaneous site was triggered in the rat by the subcutaneous injection of 5 ml of a 1 % solution of carboxymethylcellulose in a sterile isotonic solution of sodium chloride.
Simultaneously, control rats received an injection of 0.1 ml of propylene glycol at the same site and treated rats received 0.1 ml
2 3 7 7 7 1
of Larrea extract containing 0.5 % of polyphenols. Six hours after these treatments, the inflammatory exudates were tapped by puncture and the leucocytes were counted in a Thomas cell after staining.
The results are presented in Table I. These results show that the Larrea extract inhibits the migration of the leucocytes towards the subcutaneous inflammatory site.
Table I
Inhibitory activity towards the migration of leucocytes
Larrea extract Leucocyte concentration x 10^/mm^
0 40 - 2
+ 21 - 1.5
2 - Inhibition of the pustulation of experimental acne lesions
Experimental acne lesions were induced in the dorsal skin of rabbits. After shaving, scarifications were made with a scalpel and a homogenate of human epidermis was applied to the cutaneous incisions (the homogenate of epidermis, the model for comedo matter, was prepared from skin removed during the course of surgical operations for mammaplasty; the epidermis was collected by means of a cryomicrotome and homogenized in isotonic phosphate buffer).
Some scarifications were also treated topically with 0.05 ml of either propylene glycol or Larrea extract containing 0.5 % of polyphenols, used neat or after dilution. After 24 hours, the cutaneous lesions were examined "blind" by two observers and the clinical appearance of the lesion was used to evaluate the reaction on a scale of + 1 to + 4.
The results are presented in Table II. These results show that the Larrea extract prevents the inflammatory reaction induced by the comedo-mimetic matter.
2 3 7 7 71
6
Table II
2 - Inhibition of the pustulation of experimental acne lesions
Larrea extract
Comedo-mimetic
Pustulation
matter reaction
0
0
+
0
+
++++
1/10 dilution
+
++
neat
+
+
The cosmetic compositions according to the invention may also contain, if necessary, any other substances known to have beneficial properties for the integument and, in particular, to have cosmetic activity in the care of skins with a tendency to acne. They may contain antiseptic, comedolytic and antiseborrheic agents, perfumes, preservatives and dyestuffs.
The cosmetic compositions according to the invention may be presented in all of the forms used in beauty care, creams or gels in jars or tubes, milks, lotions in glass or plastic bottles, ampoules or sprays.
Suitable excipients nay be used for each particular form. These excipients must meet all of the necessary requirements. As examples, mention may be made of : propylene glycol, glycerol,
cetyl alcohol, polyols, phospholipids in the form of liposomes or as such, vegetable, animal and mineral oils, wetting agents, thickeners, stabilizing and emulsifying agents commonly used.
The various cosmetic forms mentioned above are prepared according to the methods used in this domain.
Examples of cosmetic compositions (in parts by weight) are given below :
3
s
7
1 - Aqueous-alcoholic lotion
Larrea extract, 0.5 % polyphenols
Cetyl alcohol
Stearic acid
Glycerol
Na alginate
Triethanolamine
95° Alcohol
Water qs
2 - 0/W Milk
Larrea extract, 0.5 % polyphenols
Polyethoxyether phosphate of oleyl alcohol
Cetyl alcohol
Anhydrous lanolin
Liquid silicone
Wheat germ oil
Juniper oil
Stearic acid
Triethanolamine
Magnesium aluminium silicate
Aromatic composition
Preservatives
Water qs
3 - Alcoholic hydrogel
Larrea extract, 0.5 % polyphenols
Antiseptic ingredients
Triethylamine
Carbopol 940
Alcohol qs
2 3 7 7 7
8
0
'
4 - Glycerated hydrogel
Larrea extract, 0.5 % polyphenols 7
Sodium alginate 8
Glycerol 25
% Borax solution in glycerol 20
Thymol 2
Water qs 100
- 0/W Cream
Larrea extract, 0.5 % polyphenols 10
Wheat germ oil 7
Glycerol stearate 5
Propylene glycol 3
Triethanolamine 0.5
Soya lecithin 1
Preservatives qs
Water qs 100
6 - W/0 Cream
Larrea extract, 0.5 % polyphenols 8
Salicylic acid 0.5
Aluminium silicate 2
Titanium oxide 2
White beeswax 20
Paraffin oil 60
Water qs 100
23 7 7 7
9
Claims (6)
1. Cosmetic composition suitable for preventing in particular the formation of papules and pustules characteristic of acne and of cutaneous redness, comprising an extract obtainable from the leaves and stems of at least one member of Zygophyllaceae belonging to the genus Larrea at a concentration from 0.01 to 0.10 % expressed in terms of the polyphenol content, in an appropriate cosmetic base.
2. Composition as claimed in claim 1, in which the extract is an extract obtainable by maceration of the leaves and stems of Larrea in propylene glycol.
3. Process for the preparation of a composition as claimed in claim 1, comprising incorporating an extract obtainable from the leaves and stems of at least one member of Zygophyllaceae belonging to the genus Larrea at a concentration from 0.01 to 0.10 % expressed in terms of the polyphenol content, in an appropriate cosmetic base.
4. Process as claimed in claim 3, in which the extract is an extract obtained by maceration of the leaves and stems of Larrea in propylene glycol.
5. A cosmetic composition as claimed in claim 1 substantially as herein described with reference to any one of the examples.
6. A process as claimed in claim 3 substantially as herein described with reference to any one of the examples. CLAUDE BONNE, DANIEL SINCHOLLE AND MICHEL DIOT b srneys B & CAREY tr/specs/667072
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9004737A FR2660861B1 (en) | 1990-04-12 | 1990-04-12 | COSMETIC COMPOSITIONS CONTAINING AN EXTRACT OF A ZYGOPHYLLACEA BELONGING TO THE GENUS LARREA. |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ237771A true NZ237771A (en) | 1993-03-26 |
Family
ID=9395723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ237771A NZ237771A (en) | 1990-04-12 | 1991-04-10 | Cosmetic compositions, particularly for acne treatment, containing an extract of zygophyllaceae of the genus larrea |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0524266B1 (en) |
JP (1) | JPH05507069A (en) |
AT (1) | ATE96657T1 (en) |
AU (1) | AU645808B2 (en) |
CA (1) | CA2080003A1 (en) |
DE (1) | DE69100595T2 (en) |
DK (1) | DK0524266T3 (en) |
ES (1) | ES2062788T3 (en) |
FR (1) | FR2660861B1 (en) |
NZ (1) | NZ237771A (en) |
WO (1) | WO1991016036A1 (en) |
ZA (1) | ZA912657B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2785804B1 (en) * | 1998-11-17 | 2002-10-18 | Sederma Sa | COMPOSITIONS FOR COSMETIC OR DERMOPHARMACEUTICAL USE CONTAINING LARREA DIVARICATA OR LARREA TRIDENTATA EXTRACT FOR SLOWING SKIN AGING |
FR2795321B1 (en) * | 1999-06-28 | 2001-09-21 | Clarins Lab | COSMETIC COMPOSITION FOR THE CARE OF OILY SKIN BASED ON PLANT EXTRACTS |
FR2853246A1 (en) * | 2003-04-03 | 2004-10-08 | Claude Bonne | Pharmaceutical or food composition, useful for the treatment or prevention of inflammation, especially acne, contains alcoholic polyphenol containing extract of sunflower seeds |
DE102010060200A1 (en) | 2010-10-27 | 2012-05-03 | Tim Schüßler | Method for automated handling of e.g. cut plants for producing bouquet, involves holding cut plants in elongated hollow body designed as pipe that is opened at both ends during handling of cut plants for producing bouquet |
DE102010060202A1 (en) | 2010-10-27 | 2012-05-03 | Tim Schüßler | Assembly for packing bouquet used in carousel, has water-proof packaging material that is arranged on region of cavity which is formed below opening of support stand |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4774229A (en) * | 1982-04-05 | 1988-09-27 | Chemex Pharmaceuticals, Inc. | Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor |
JPS5944313A (en) * | 1982-09-07 | 1984-03-12 | Yakult Honsha Co Ltd | Antibacterial composition |
-
1990
- 1990-04-12 FR FR9004737A patent/FR2660861B1/en not_active Expired - Fee Related
-
1991
- 1991-04-09 WO PCT/FR1991/000289 patent/WO1991016036A1/en active IP Right Grant
- 1991-04-09 EP EP91908696A patent/EP0524266B1/en not_active Expired - Lifetime
- 1991-04-09 AU AU77540/91A patent/AU645808B2/en not_active Withdrawn - After Issue
- 1991-04-09 CA CA002080003A patent/CA2080003A1/en not_active Abandoned
- 1991-04-09 AT AT91908696T patent/ATE96657T1/en not_active IP Right Cessation
- 1991-04-09 ES ES91908696T patent/ES2062788T3/en not_active Expired - Lifetime
- 1991-04-09 DE DE91908696T patent/DE69100595T2/en not_active Expired - Fee Related
- 1991-04-09 DK DK91908696.7T patent/DK0524266T3/en active
- 1991-04-09 JP JP91508193A patent/JPH05507069A/en active Pending
- 1991-04-10 ZA ZA912657A patent/ZA912657B/en unknown
- 1991-04-10 NZ NZ237771A patent/NZ237771A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR2660861B1 (en) | 1994-11-04 |
AU645808B2 (en) | 1994-01-27 |
WO1991016036A1 (en) | 1991-10-31 |
AU7754091A (en) | 1991-11-11 |
ATE96657T1 (en) | 1993-11-15 |
DK0524266T3 (en) | 1993-11-29 |
JPH05507069A (en) | 1993-10-14 |
CA2080003A1 (en) | 1991-10-13 |
DE69100595T2 (en) | 1994-03-31 |
FR2660861A1 (en) | 1991-10-18 |
ZA912657B (en) | 1992-11-25 |
ES2062788T3 (en) | 1994-12-16 |
DE69100595D1 (en) | 1993-12-09 |
EP0524266B1 (en) | 1993-11-03 |
EP0524266A1 (en) | 1993-01-27 |
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