NZ235812A - Gnrh containing an unnatural amino acid - unnatural amino acids - Google Patents
Gnrh containing an unnatural amino acid - unnatural amino acidsInfo
- Publication number
- NZ235812A NZ235812A NZ235812A NZ23581290A NZ235812A NZ 235812 A NZ235812 A NZ 235812A NZ 235812 A NZ235812 A NZ 235812A NZ 23581290 A NZ23581290 A NZ 23581290A NZ 235812 A NZ235812 A NZ 235812A
- Authority
- NZ
- New Zealand
- Prior art keywords
- unnatural amino
- peptides
- gnrh
- alkyl
- amino acid
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 4
- 101150108262 gnrh1 gene Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 210000002149 gonad Anatomy 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010062767 Hypophysitis Diseases 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 229940094892 gonadotropins Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 101150009274 nhr-1 gene Proteins 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 210000003635 pituitary gland Anatomy 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/18—Sulfenamides
- C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C313/30—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Radar Systems Or Details Thereof (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Optical Radar Systems And Details Thereof (AREA)
- Analogue/Digital Conversion (AREA)
- Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42882789A | 1989-10-30 | 1989-10-30 | |
| US07/545,239 US5169932A (en) | 1989-10-30 | 1990-06-27 | Gnrh analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ235812A true NZ235812A (en) | 1993-03-26 |
Family
ID=27027926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ235812A NZ235812A (en) | 1989-10-30 | 1990-10-24 | Gnrh containing an unnatural amino acid - unnatural amino acids |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5169932A (xx) |
| EP (1) | EP0500695B1 (xx) |
| JP (1) | JPH05503689A (xx) |
| KR (1) | KR920702351A (xx) |
| AT (1) | ATE163430T1 (xx) |
| CA (1) | CA2066184A1 (xx) |
| DE (1) | DE69032070D1 (xx) |
| IE (1) | IE903881A1 (xx) |
| IL (1) | IL96094A (xx) |
| NZ (1) | NZ235812A (xx) |
| PT (1) | PT95742B (xx) |
| WO (1) | WO1991006543A1 (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580957A (en) * | 1989-10-30 | 1996-12-03 | The Salk Institute For Biological Studies | GnRH analogs |
| IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
| US5744450A (en) * | 1991-03-14 | 1998-04-28 | The Salk Institute For Biological Studies | GnRH analogs |
| US5739037A (en) * | 1992-09-29 | 1998-04-14 | Drew Scientific Limited | Process for eliminating labile glycohaemoglobin from a sample |
| JP3568952B2 (ja) * | 1992-12-18 | 2004-09-22 | アボット・ラボラトリーズ | ５位及び６位に修飾アミノアシル残基を有するｌｈｒｈ拮抗薬 |
| IL108509A0 (en) * | 1993-02-22 | 1994-05-30 | Salk Inst For Biological Studi | GnRH antagonist peptides |
| US5502035A (en) * | 1993-08-06 | 1996-03-26 | Tap Holdings Inc. | N-terminus modified analogs of LHRH |
| US5413990A (en) * | 1993-08-06 | 1995-05-09 | Tap Pharmaceuticals Inc. | N-terminus modified analogs of LHRH |
| US5506207A (en) * | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| RU2181598C2 (ru) * | 1994-07-22 | 2002-04-27 | Дзе Медикал Колледж оф Хэмптон Роудс | Восстановление тонической секреции эстрогена из яичников для продолжительных схем лечения |
| US5550262A (en) * | 1994-11-14 | 1996-08-27 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| US5614649A (en) * | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| US5681928A (en) * | 1994-12-16 | 1997-10-28 | The Salk Institute For Biological Studies | Betides and methods for screening peptides using same |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5807983A (en) * | 1995-12-28 | 1998-09-15 | The Salk Institute For Biological Studies | GNRH antagonist betides |
| US5821230A (en) * | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
| AU1590699A (en) * | 1997-11-20 | 1999-06-15 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of gnrh peptides |
| US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
| US6598784B2 (en) * | 2000-12-20 | 2003-07-29 | Meadwestvaco Packaging Syatens, Llc | Beverage carton with strap type carrying handle |
| EP1827468B1 (en) * | 2004-12-23 | 2012-08-22 | Curaxis Pharmaceutical Corporation | Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease |
| EP1928381B1 (en) * | 2005-09-29 | 2011-11-02 | The Procter & Gamble Company | Side seam for disposable garment |
| WO2008095063A1 (en) | 2007-01-31 | 2008-08-07 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| AU2011242696A1 (en) * | 2010-04-21 | 2012-11-01 | Palatin Technologies, Inc. | Uses of natriuretic peptide constructs |
| CN103282510A (zh) | 2010-08-13 | 2013-09-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| KR20140100937A (ko) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| WO2013123266A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP6450192B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス，インコーポレイテッド | トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物 |
| CN102627687B (zh) * | 2012-03-23 | 2014-07-09 | 上海海洋大学 | 中华绒螯蟹促性腺释放激素类似物及其制备方法和应用 |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
| WO2014147124A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2825715A (en) * | 1953-06-26 | 1958-03-04 | Koppers Co Inc | Polymers of n-(amino-1, 2, 4-triazolyl) amides of alkenyl-1, 2-dioic acids |
| US2834754A (en) * | 1953-12-03 | 1958-05-13 | Gen Electric | Process for removing volatile organopolysiloxanes from high molecular weight organopolysiloxanes by stripping gas and kneading |
| US3183241A (en) * | 1963-02-11 | 1965-05-11 | Dow Chemical Co | Preparation of certain triazoles |
| US4234571A (en) * | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
| EP0079522B1 (en) * | 1981-11-09 | 1986-05-07 | Merck & Co. Inc. | N-carboxymethyl(amidino)lysyl-proline antihypertensive agents |
| US4698442A (en) * | 1982-12-21 | 1987-10-06 | Syntex (U.S.A.) Inc. | ω-Guanidino-substituted-α-amino acids |
| DE3341750A1 (de) * | 1983-11-18 | 1985-05-30 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | 1,2,4-triazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| US4815385A (en) * | 1987-12-16 | 1989-03-28 | The United States Of America As Represented By The Secretary Of The Army | Blast focusing method and apparatus |
-
1990
- 1990-06-27 US US07/545,239 patent/US5169932A/en not_active Expired - Fee Related
- 1990-10-24 NZ NZ235812A patent/NZ235812A/xx unknown
- 1990-10-24 IL IL9609490A patent/IL96094A/en not_active IP Right Cessation
- 1990-10-26 IE IE388190A patent/IE903881A1/en unknown
- 1990-10-30 AT AT90917025T patent/ATE163430T1/de not_active IP Right Cessation
- 1990-10-30 DE DE69032070T patent/DE69032070D1/de not_active Expired - Lifetime
- 1990-10-30 JP JP2515871A patent/JPH05503689A/ja active Pending
- 1990-10-30 PT PT95742A patent/PT95742B/pt not_active IP Right Cessation
- 1990-10-30 WO PCT/US1990/006309 patent/WO1991006543A1/en not_active Ceased
- 1990-10-30 EP EP90917025A patent/EP0500695B1/en not_active Expired - Lifetime
- 1990-10-30 CA CA002066184A patent/CA2066184A1/en not_active Abandoned
- 1990-10-30 KR KR1019920701034A patent/KR920702351A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL96094A0 (en) | 1991-07-18 |
| CA2066184A1 (en) | 1991-05-01 |
| JPH05503689A (ja) | 1993-06-17 |
| PT95742B (pt) | 1997-09-30 |
| EP0500695A1 (en) | 1992-09-02 |
| IL96094A (en) | 1995-03-15 |
| KR920702351A (ko) | 1992-09-03 |
| IE903881A1 (en) | 1991-05-08 |
| AU6739290A (en) | 1991-05-31 |
| EP0500695A4 (en) | 1993-06-09 |
| PT95742A (pt) | 1991-09-13 |
| US5169932A (en) | 1992-12-08 |
| EP0500695B1 (en) | 1998-02-25 |
| DE69032070D1 (de) | 1998-04-02 |
| WO1991006543A1 (en) | 1991-05-16 |
| AU633384B2 (en) | 1993-01-28 |
| ATE163430T1 (de) | 1998-03-15 |
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