NZ192780A - S-(+)- -((methylamino)methyl)-9 10-ethanoanthracene-9(10h)-ethanol pharmaceutical compositions - Google Patents

S-(+)- -((methylamino)methyl)-9 10-ethanoanthracene-9(10h)-ethanol pharmaceutical compositions

Info

Publication number
NZ192780A
NZ192780A NZ192780A NZ19278080A NZ192780A NZ 192780 A NZ192780 A NZ 192780A NZ 192780 A NZ192780 A NZ 192780A NZ 19278080 A NZ19278080 A NZ 19278080A NZ 192780 A NZ192780 A NZ 192780A
Authority
NZ
New Zealand
Prior art keywords
methylamino
methyl
alpha
compound
ethanol
Prior art date
Application number
NZ192780A
Inventor
A Storni
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NZ192780A publication Critical patent/NZ192780A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3207Positioning the beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3214Locking the beads on the drum; details of the drum in the bead locking areas, e.g. drum shoulders
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221Folding over means, e.g. bladders or rigid arms
    • B29D2030/3228Folding over means, e.g. bladders or rigid arms using one bladder acting on each side of the drum
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221Folding over means, e.g. bladders or rigid arms
    • B29D2030/3235Folding over means, e.g. bladders or rigid arms using two or more bladders acting on each side of the drum
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00Producing pneumatic or solid tyres or parts thereof
    • B29D30/06Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08Building tyres
    • B29D30/20Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221Folding over means, e.g. bladders or rigid arms
    • B29D2030/3242Folding over means, e.g. bladders or rigid arms and with means for pressing the bladder against the ply material, e.g. bladder guide shoes, cages, arms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

For all designated states : BE, CH, DE, FR, GB, IT, LU, NL, SE 1. S-(+)-alpha-[methylamino)methyl]-9-10-ethano anthracene-9(10H)-ethanol of the formula I see diagramm : EP0014434,P11,F1 or an acid addition salt thereof. For the contracting state : AT 1. A process for the production of S-(+)-alpha-([methylamino)methyl]-9-10-ethano anthracene-9(10H)-ethanol of the formula I ad indicated in claim 1, or of an acid addition salt thereof, which process comprises a) resolving the racemic alpha-[(methylamino)-methyl]-9-10-ethanoanthracene- 9(10H)-ethanol and isolating S-(+)-alpha-[(methylamino)-methyl]-9-10-ethano anthracene-9(10H)-ethanol, if desired in the form of an acid addition salt, or b) reacting a compound of the formula II see diagramm : EP0014434,P12,F1 with a compound of the formula III X2 -CH3 wherein one of X1 and X2 is the amino group and the other is a reactive esterified hydroxyl group, and Y1 is a free hydroxyl group, and X1 together with Y1 can also be an epoxy group, and A is the 9,10-ethanoanthracen-9(10H)-yl radical, or c) in a compound of the formula IV see diagramm : EP0014434,P12,F2 in which at least one of Z1 and Z2 is a removable radical and the other may be hydrogen, or Z1 and Z2 together are a divalent removable radical, and A is the 9,10-ethanoanthracen-9(10H)-yl radical, removing Z1 and/or Z2 , d) reducing a compound which differs from the compound of the formula I only in that, in said compound, a carbon atom adjacent to the nitrogen atom is attached to this latter through a double bond or is substituted by a hydroxyl group or an oxo radical, optionally together with lower alkoxy, or e) adding ethylene to S-alpha-[(methylamino)-methyl]-9(10H)-anthracene, or hydrolyzing the intermediate obtained, and, if desired, converting the resultant S-(+)-alpha-[(methylamino)methyl]-9,10-ethanoanthracen- e-9(10H)-ethanol into an acid addition salt and/or liberating the base from a resultant acid addition salt.
NZ192780A 1979-02-02 1980-02-01 S-(+)- -((methylamino)methyl)-9 10-ethanoanthracene-9(10h)-ethanol pharmaceutical compositions NZ192780A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH104779 1979-02-02
CH9480 1980-01-08

Publications (1)

Publication Number Publication Date
NZ192780A true NZ192780A (en) 1982-06-29

Family

ID=25683498

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ192780A NZ192780A (en) 1979-02-02 1980-02-01 S-(+)- -((methylamino)methyl)-9 10-ethanoanthracene-9(10h)-ethanol pharmaceutical compositions

Country Status (19)

Country Link
EP (1) EP0014434B1 (en)
KR (1) KR830001858A (en)
AT (1) ATE3414T1 (en)
AU (1) AU538114B2 (en)
CA (1) CA1140596A (en)
CS (1) CS215042B2 (en)
DD (1) DD148950A5 (en)
DE (1) DE3063221D1 (en)
DK (1) DK149102C (en)
ES (1) ES488191A0 (en)
FI (1) FI800269A (en)
GR (1) GR73703B (en)
HU (1) HU181019B (en)
IE (1) IE49741B1 (en)
IL (1) IL59284A (en)
NO (1) NO146952C (en)
NZ (1) NZ192780A (en)
PL (1) PL221743A1 (en)
PT (1) PT70765A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313571D0 (en) * 1983-05-17 1983-06-22 Wellcome Found Chemical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017542A (en) * 1971-02-23 1977-04-12 Ciba-Geigy Corporation 9-(2-Hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes and salts thereof

Also Published As

Publication number Publication date
ATE3414T1 (en) 1983-06-15
EP0014434A1 (en) 1980-08-20
CS215042B2 (en) 1982-06-25
NO800271L (en) 1980-08-04
IL59284A0 (en) 1980-05-30
FI800269A (en) 1980-08-03
IL59284A (en) 1983-05-15
CA1140596A (en) 1983-02-01
DE3063221D1 (en) 1983-07-07
DK44480A (en) 1980-08-03
PT70765A (en) 1980-03-01
ES8102078A1 (en) 1980-12-16
PL221743A1 (en) 1980-12-15
KR830001858A (en) 1983-05-19
NO146952C (en) 1983-01-05
AU538114B2 (en) 1984-08-02
HU181019B (en) 1983-05-30
DK149102C (en) 1986-06-09
GR73703B (en) 1984-04-03
IE800209L (en) 1980-08-02
NO146952B (en) 1982-09-27
DK149102B (en) 1986-01-27
DD148950A5 (en) 1981-06-17
IE49741B1 (en) 1985-12-11
ES488191A0 (en) 1980-12-16
EP0014434B1 (en) 1983-05-18
AU5511980A (en) 1980-08-07

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